1     M         1.053   1.055   1.081   1.242   1.244   1.278   1.100   1.103   1.134
2     V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
10    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
11    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
12    N        -0.273  -0.240  -0.280  -0.429  -0.376  -0.435  -0.467  -0.414  -0.480
13    S        -1.113  -1.127  -1.113  -1.164  -1.188  -1.148  -1.103  -1.119  -1.077
14    Q        -1.113  -1.080  -1.103  -1.092  -1.034  -1.090  -1.103  -1.062  -1.065
15    H        -0.118  -0.086  -0.239   0.078   0.123  -0.129  -0.222  -0.173  -0.414
16    P        -1.113  -1.127  -1.113  -1.055  -1.078  -1.071  -1.103  -1.119  -1.077
17    Y        -0.391  -0.386  -0.318  -0.359  -0.347  -0.239  -0.663  -0.654  -0.544
18    I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
19    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
20    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
21    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
22    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
23    K        -0.118  -0.174  -0.254  -0.139  -0.223  -0.353  -0.222  -0.308  -0.438
24    D        -0.118  -0.174  -0.254  -0.134  -0.222  -0.364  -0.222  -0.308  -0.438
25    G        -0.118  -0.174  -0.254  -0.033  -0.118  -0.247  -0.222  -0.308  -0.438
26    W         1.053   1.055   1.081   1.322   1.325   1.354   1.100   1.103   1.134
27    F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
28    R        -1.835  -1.826  -1.719  -1.533  -1.520  -1.359  -1.544  -1.533  -1.385
29    E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
30    I        -1.835  -1.826  -1.719  -1.715  -1.702  -1.532  -1.544  -1.533  -1.385
31    N        -0.118  -0.096  -0.240  -0.170  -0.137  -0.356  -0.222  -0.186  -0.415
32    D        -0.118  -0.174  -0.254  -0.115  -0.201  -0.334  -0.222  -0.308  -0.438
33    K        -0.391  -0.387  -0.319  -0.633  -0.622  -0.503  -0.663  -0.655  -0.545
34    S        -1.113  -1.127  -1.113  -1.094  -1.120  -1.065  -1.103  -1.119  -1.077
35    F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
36    P         1.053   1.055   1.081   1.148   1.152   1.188   1.100   1.103   1.134
37    G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
38    Q         1.053   1.055   1.081   1.129   1.132   1.171   1.100   1.103   1.134
39    A         1.053   1.055   1.081   1.074   1.077   1.119   1.100   1.103   1.134
40    F        -0.118  -0.086  -0.239  -0.128  -0.076  -0.358  -0.222  -0.173  -0.414
41    T        -1.113  -1.086  -1.106  -1.106  -1.063  -1.097  -1.103  -1.069  -1.069
42    M        -0.118  -0.096  -0.240  -0.217  -0.186  -0.365  -0.222  -0.186  -0.415
43    T        -1.113  -1.132  -1.111  -1.140  -1.172  -1.127  -1.103  -1.126  -1.075
44    V        -0.118  -0.174  -0.254  -0.196  -0.285  -0.420  -0.222  -0.308  -0.438
45    D        -1.113  -1.080  -1.103  -1.142  -1.086  -1.124  -1.103  -1.062  -1.065
46    S        -1.113  -1.086  -1.106  -1.110  -1.063  -1.117  -1.103  -1.069  -1.069
47    I        -0.118  -0.086  -0.239  -0.181  -0.133  -0.385  -0.222  -0.173  -0.414
48    L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
49    Y        -0.118  -0.100  -0.242  -0.007   0.021  -0.215  -0.222  -0.193  -0.418
50    E        -1.113  -1.077  -1.100  -0.963  -0.904  -0.959  -1.103  -1.058  -1.061
51    A        -1.835  -1.826  -1.719  -1.886  -1.873  -1.694  -1.544  -1.533  -1.385
52    R        -1.113  -1.132  -1.111  -1.001  -1.026  -0.964  -1.103  -1.126  -1.075
53    S        -0.118  -0.100  -0.242  -0.154  -0.127  -0.335  -0.222  -0.193  -0.418
54    E        -0.391  -0.386  -0.318  -0.548  -0.535  -0.420  -0.663  -0.654  -0.544
55    F        -0.118  -0.174  -0.254  -0.042  -0.128  -0.255  -0.222  -0.308  -0.438
56    Q         1.053   1.055   1.081   1.129   1.132   1.171   1.100   1.103   1.134
57    D         1.053   1.055   1.081   1.042   1.047   1.088   1.100   1.103   1.134
58    I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
59    L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
60    I        -0.118  -0.086  -0.239  -0.181  -0.133  -0.385  -0.222  -0.173  -0.414
61    F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
62    R        -1.113  -1.132  -1.111  -1.082  -1.116  -1.062  -1.103  -1.126  -1.075
63    N        -0.118  -0.096  -0.240  -0.170  -0.137  -0.356  -0.222  -0.186  -0.415
64    K        -1.113  -1.086  -1.106  -1.106  -1.059  -1.113  -1.103  -1.069  -1.069
65    V        -1.113  -1.132  -1.111  -1.098  -1.127  -1.099  -1.103  -1.126  -1.075
66    Y        -1.113  -1.127  -1.113  -0.959  -0.988  -0.957  -1.103  -1.119  -1.077
67    G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
68    T        -1.113  -1.077  -1.100  -1.098  -1.039  -1.079  -1.103  -1.058  -1.061
69    V        -0.118  -0.086  -0.239  -0.109  -0.062  -0.264  -0.222  -0.173  -0.414
70    L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
71    V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
72    L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
73    D        -0.118  -0.174  -0.254  -0.112  -0.197  -0.329  -0.222  -0.308  -0.438
74    G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
75    I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
76    V        -0.118  -0.096  -0.240  -0.181  -0.147  -0.386  -0.222  -0.186  -0.415
77    Q         1.053   1.055   1.081   1.129   1.132   1.171   1.100   1.103   1.134
78    C        -0.118  -0.100  -0.242   0.075   0.106  -0.164  -0.222  -0.193  -0.418
79    T        -0.391  -0.386  -0.318  -0.575  -0.564  -0.445  -0.663  -0.654  -0.544
80    E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
81    F        -1.113  -1.086  -1.106  -0.955  -0.908  -0.971  -1.103  -1.069  -1.069
82    D         1.053   1.055   1.081   1.042   1.047   1.088   1.100   1.103   1.134
83    E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
84    F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
85    A         1.053   1.055   1.081   1.074   1.077   1.119   1.100   1.103   1.134
86    Y         1.053   1.055   1.081   1.148   1.151   1.188   1.100   1.103   1.134
87    Q         1.053   1.055   1.081   1.129   1.132   1.171   1.100   1.103   1.134
88    E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
89    M        -0.391  -0.386  -0.318  -0.569  -0.572  -0.448  -0.663  -0.654  -0.544
90    I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
91    T        -1.113  -1.080  -1.103  -1.080  -1.025  -1.077  -1.103  -1.062  -1.065
92    H         1.053   1.055   1.081   1.224   1.224   1.261   1.100   1.103   1.134
93    I        -1.113  -1.135  -1.110  -1.280  -1.328  -1.287  -1.103  -1.129  -1.073
94    A        -0.118  -0.096  -0.240  -0.013   0.023  -0.220  -0.222  -0.186  -0.415
95    M        -1.113  -1.132  -1.111  -1.217  -1.254  -1.176  -1.103  -1.126  -1.075
96    F        -1.113  -1.132  -1.111  -0.951  -0.979  -0.945  -1.103  -1.126  -1.075
97    A        -1.113  -1.086  -1.106  -0.964  -0.917  -0.986  -1.103  -1.069  -1.069
98    H         1.053   1.055   1.081   1.224   1.224   1.261   1.100   1.103   1.134
99    S        -1.113  -1.086  -1.106  -1.154  -1.108  -1.153  -1.103  -1.069  -1.069
100   N        -0.118  -0.174  -0.254  -0.104  -0.197  -0.345  -0.222  -0.308  -0.438
101   P         1.053   1.055   1.081   1.148   1.152   1.188   1.100   1.103   1.134
102   K        -0.118  -0.174  -0.254  -0.082  -0.158  -0.265  -0.222  -0.308  -0.438
103   R        -0.391  -0.386  -0.318  -0.462  -0.446  -0.336  -0.663  -0.654  -0.544
104   V        -0.118  -0.100  -0.242  -0.196  -0.166  -0.399  -0.222  -0.193  -0.418
105   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
106   I        -0.118  -0.096  -0.240  -0.196  -0.159  -0.395  -0.222  -0.186  -0.415
107   I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
108   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
109   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
110   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
111   D         1.053   1.055   1.081   1.042   1.047   1.088   1.100   1.103   1.134
112   G        -0.118  -0.174  -0.254   0.006  -0.073  -0.187  -0.222  -0.308  -0.438
113   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
114   V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
115   L        -0.391  -0.387  -0.319  -0.766  -0.755  -0.628  -0.663  -0.655  -0.545
116   R         1.053   1.055   1.081   1.255   1.258   1.291   1.100   1.103   1.134
117   E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
118   V        -0.118  -0.174  -0.254  -0.237  -0.331  -0.485  -0.222  -0.308  -0.438
119   A        -1.113  -1.132  -1.111  -1.203  -1.238  -1.191  -1.103  -1.126  -1.075
120   K         1.053   1.055   1.081   1.014   1.020   1.062   1.100   1.103   1.134
121   H         1.053   1.055   1.081   1.224   1.224   1.261   1.100   1.103   1.134
122   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
123   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
124   S        -1.113  -1.127  -1.113  -1.209  -1.234  -1.201  -1.103  -1.119  -1.077
125   C        -1.113  -1.127  -1.113  -0.940  -0.964  -0.972  -1.103  -1.119  -1.077
126   V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
127   E        -0.118  -0.174  -0.254  -0.143  -0.229  -0.366  -0.222  -0.308  -0.438
128   D        -1.113  -1.077  -1.100  -1.191  -1.129  -1.170  -1.103  -1.058  -1.061
129   I        -1.113  -1.080  -1.103  -1.193  -1.141  -1.172  -1.103  -1.062  -1.065
130   T         1.053   1.055   1.081   1.134   1.137   1.176   1.100   1.103   1.134
131   M        -0.118  -0.100  -0.242   0.018   0.047  -0.235  -0.222  -0.193  -0.418
132   V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
133   E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
134   I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
135   D         1.053   1.055   1.081   1.042   1.047   1.088   1.100   1.103   1.134
136   S        -1.835  -1.826  -1.719  -1.857  -1.840  -1.666  -1.544  -1.533  -1.385
137   S        -1.835  -1.826  -1.719  -1.710  -1.686  -1.527  -1.544  -1.533  -1.385
138   V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
139   I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
140   E        -0.118  -0.174  -0.254  -0.152  -0.239  -0.380  -0.222  -0.308  -0.438
141   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
142   S        -1.113  -1.127  -1.113  -1.259  -1.294  -1.261  -1.103  -1.119  -1.077
143   R        -1.113  -1.132  -1.111  -1.065  -1.096  -1.039  -1.103  -1.126  -1.075
144   K         1.053   1.055   1.081   1.014   1.020   1.062   1.100   1.103   1.134
145   F        -0.391  -0.386  -0.318  -0.485  -0.480  -0.363  -0.663  -0.654  -0.544
146   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
147   P         1.053   1.055   1.081   1.148   1.152   1.188   1.100   1.103   1.134
148   T        -1.835  -1.826  -1.719  -1.728  -1.719  -1.544  -1.544  -1.533  -1.385
149   L        -0.118  -0.096  -0.240   0.018   0.055  -0.230  -0.222  -0.186  -0.415
150   S        -0.391  -0.386  -0.318  -0.620  -0.609  -0.487  -0.663  -0.654  -0.544
151   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
152   G        -1.113  -1.132  -1.111  -0.940  -0.979  -0.968  -1.103  -1.126  -1.075
153   A        -1.113  -1.135  -1.110  -1.124  -1.161  -1.124  -1.103  -1.129  -1.073
154   F        -1.113  -1.127  -1.113  -0.942  -0.965  -0.920  -1.103  -1.119  -1.077
155   D        -0.118  -0.100  -0.242  -0.134  -0.103  -0.342  -0.222  -0.193  -0.418
156   D        -0.118  -0.096  -0.240   0.051   0.084  -0.170  -0.222  -0.186  -0.415
157   E        -0.118  -0.096  -0.240  -0.029   0.009  -0.244  -0.222  -0.186  -0.415
158   R        -0.391  -0.386  -0.318  -0.462  -0.446  -0.336  -0.663  -0.654  -0.544
159   L        -0.391  -0.386  -0.318  -0.766  -0.753  -0.626  -0.663  -0.654  -0.544
160   D        -1.113  -1.086  -1.106  -1.154  -1.109  -1.136  -1.103  -1.069  -1.069
161   L        -1.113  -1.135  -1.110  -1.228  -1.250  -1.187  -1.103  -1.129  -1.073
162   K        -1.113  -1.127  -1.113  -1.170  -1.197  -1.166  -1.103  -1.119  -1.077
163   L        -0.118  -0.174  -0.254  -0.298  -0.388  -0.509  -0.222  -0.308  -0.438
164   C        -0.118  -0.174  -0.254   0.094   0.003  -0.160  -0.222  -0.308  -0.438
165   D         1.053   1.055   1.081   1.042   1.047   1.088   1.100   1.103   1.134
166   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
167   F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
168   K        -0.118  -0.100  -0.242  -0.124  -0.093  -0.310  -0.222  -0.193  -0.418
169   F        -0.118  -0.174  -0.254  -0.042  -0.128  -0.255  -0.222  -0.308  -0.438
170   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
171   Q        -1.113  -1.086  -1.106  -1.041  -1.001  -1.005  -1.103  -1.069  -1.069
172   D        -1.113  -1.127  -1.113  -1.183  -1.209  -1.189  -1.103  -1.119  -1.077
173   I        -1.835  -1.826  -1.719  -1.957  -1.954  -1.761  -1.544  -1.533  -1.385
174   G        -1.113  -1.086  -1.106  -1.160  -1.120  -1.133  -1.103  -1.069  -1.069
175   A        -1.113  -1.080  -1.103  -1.041  -0.992  -1.017  -1.103  -1.062  -1.065
176   S        -1.113  -1.127  -1.113  -1.234  -1.252  -1.231  -1.103  -1.119  -1.077
177   D        -1.236  -1.231  -1.138  -1.388  -1.378  -1.221  -1.250  -1.243  -1.105
178   V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
179   H        -1.113  -1.080  -1.103  -0.966  -0.912  -0.969  -1.103  -1.062  -1.065
180   K        -1.835  -1.826  -1.719  -1.799  -1.784  -1.611  -1.544  -1.533  -1.385
181   K         1.053   1.055   1.081   1.014   1.020   1.062   1.100   1.103   1.134
182   F        -0.118  -0.096  -0.240  -0.007   0.028  -0.211  -0.222  -0.186  -0.415
183   D         1.053   1.055   1.081   1.042   1.047   1.088   1.100   1.103   1.134
184   V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
185   I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
186   I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
187   T         1.053   1.055   1.081   1.134   1.137   1.176   1.100   1.103   1.134
188   D         1.053   1.055   1.081   1.042   1.047   1.088   1.100   1.103   1.134
189   S         1.053   1.055   1.081   0.981   0.983   1.031   1.100   1.103   1.134
190   S         1.053   1.055   1.081   0.981   0.983   1.031   1.100   1.103   1.134
191   D         1.053   1.055   1.081   1.042   1.047   1.088   1.100   1.103   1.134
192   P         1.053   1.055   1.081   1.148   1.152   1.188   1.100   1.103   1.134
193   E        -0.391  -0.387  -0.319  -0.613  -0.602  -0.483  -0.663  -0.655  -0.545
194   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
195   P         1.053   1.055   1.081   1.148   1.152   1.188   1.100   1.103   1.134
196   A         1.053   1.055   1.081   1.074   1.077   1.119   1.100   1.103   1.134
197   E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
198   A        -0.118  -0.174  -0.254  -0.094  -0.183  -0.323  -0.222  -0.308  -0.438
199   F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
200   F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
201   Q         1.053   1.055   1.081   1.129   1.132   1.171   1.100   1.103   1.134
202   E        -1.113  -1.132  -1.111  -1.140  -1.165  -1.127  -1.103  -1.126  -1.075
203   R        -1.113  -1.132  -1.111  -1.053  -1.085  -1.028  -1.103  -1.126  -1.075
204   Y         1.053   1.055   1.081   1.148   1.151   1.188   1.100   1.103   1.134
205   F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
206   E        -0.118  -0.174  -0.254  -0.152  -0.239  -0.380  -0.222  -0.308  -0.438
207   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
208   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
209   K        -1.835  -1.826  -1.719  -1.766  -1.760  -1.580  -1.544  -1.533  -1.385
210   D        -1.113  -1.086  -1.106  -1.124  -1.078  -1.120  -1.103  -1.069  -1.069
211   A         1.053   1.055   1.081   1.074   1.077   1.119   1.100   1.103   1.134
212   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
213   N        -1.113  -1.080  -1.103  -1.084  -1.030  -1.069  -1.103  -1.062  -1.065
214   P        -0.118  -0.100  -0.242  -0.029   0.002  -0.248  -0.222  -0.193  -0.418
215   N        -0.391  -0.387  -0.319  -0.569  -0.562  -0.442  -0.663  -0.655  -0.545
216   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
217   V        -0.391  -0.387  -0.319  -0.671  -0.664  -0.539  -0.663  -0.655  -0.545
218   V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
219   I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
220   M        -0.391  -0.386  -0.318  -0.430  -0.418  -0.306  -0.663  -0.654  -0.544
221   Q         1.053   1.055   1.081   1.129   1.132   1.171   1.100   1.103   1.134
222   S        -0.391  -0.386  -0.318  -0.620  -0.615  -0.491  -0.663  -0.654  -0.544
223   S         1.053   1.055   1.081   0.981   0.983   1.031   1.100   1.103   1.134
224   E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
225   N         1.053   1.055   1.081   1.084   1.086   1.128   1.100   1.103   1.134
226   F        -1.113  -1.132  -1.111  -1.195  -1.230  -1.182  -1.103  -1.126  -1.075
227   W         1.053   1.055   1.081   1.322   1.325   1.354   1.100   1.103   1.134
228   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
229   N        -0.118  -0.086  -0.239  -0.085  -0.035  -0.288  -0.222  -0.173  -0.414
230   L        -0.391  -0.387  -0.319  -0.748  -0.741  -0.610  -0.663  -0.655  -0.545
231   K        -1.113  -1.086  -1.106  -1.132  -1.085  -1.129  -1.103  -1.069  -1.069
232   Y         1.053   1.055   1.081   1.148   1.151   1.188   1.100   1.103   1.134
233   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
234   H        -1.835  -1.826  -1.719  -1.753  -1.749  -1.568  -1.544  -1.533  -1.385
235   D        -1.835  -1.826  -1.719  -1.758  -1.740  -1.573  -1.544  -1.533  -1.385
236   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
237   K        -1.835  -1.826  -1.719  -1.698  -1.676  -1.515  -1.544  -1.533  -1.385
238   N        -1.113  -1.127  -1.113  -1.086  -1.107  -1.088  -1.103  -1.119  -1.077
239   T        -0.118  -0.174  -0.254  -0.045  -0.135  -0.286  -0.222  -0.308  -0.438
240   A        -0.118  -0.100  -0.242  -0.113  -0.084  -0.330  -0.222  -0.193  -0.418
241   K        -1.113  -1.086  -1.106  -1.032  -0.990  -1.013  -1.103  -1.069  -1.069
242   K        -1.835  -1.826  -1.719  -1.763  -1.734  -1.577  -1.544  -1.533  -1.385
243   V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
244   F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
245   P        -1.113  -1.127  -1.113  -1.001  -1.026  -1.006  -1.103  -1.119  -1.077
246   N        -0.118  -0.100  -0.242  -0.104  -0.075  -0.322  -0.222  -0.193  -0.418
247   T        -1.113  -1.135  -1.110  -1.080  -1.123  -1.091  -1.103  -1.129  -1.073
248   E        -1.113  -1.127  -1.113  -1.063  -1.088  -1.041  -1.103  -1.119  -1.077
249   Y        -0.118  -0.086  -0.239  -0.035   0.015  -0.251  -0.222  -0.173  -0.414
250   C        -0.391  -0.387  -0.319  -0.476  -0.476  -0.357  -0.663  -0.655  -0.545
251   Y        -0.118  -0.174  -0.254   0.005  -0.082  -0.218  -0.222  -0.308  -0.438
252   T        -0.118  -0.174  -0.254   0.036  -0.043  -0.161  -0.222  -0.308  -0.438
253   M        -1.113  -1.127  -1.113  -0.895  -0.920  -0.910  -1.103  -1.119  -1.077
254   V        -1.113  -1.135  -1.110  -1.183  -1.206  -1.165  -1.103  -1.129  -1.073
255   P         1.053   1.055   1.081   1.148   1.152   1.188   1.100   1.103   1.134
256   T        -0.118  -0.174  -0.254  -0.055  -0.148  -0.302  -0.222  -0.308  -0.438
257   Y         1.053   1.055   1.081   1.148   1.151   1.188   1.100   1.103   1.134
258   T         1.053   1.055   1.081   1.134   1.137   1.176   1.100   1.103   1.134
259   S         1.053   1.055   1.081   0.981   0.983   1.031   1.100   1.103   1.134
260   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
261   Q         1.053   1.055   1.081   1.129   1.132   1.171   1.100   1.103   1.134
262   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
263   G         1.053   1.055   1.081   1.102   1.106   1.145   1.100   1.103   1.134
264   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
265   I         1.053   1.055   1.081   1.005   1.005   1.053   1.100   1.103   1.134
266   V        -0.118  -0.100  -0.242  -0.173  -0.143  -0.364  -0.222  -0.193  -0.418
267   C        -0.118  -0.174  -0.254   0.104   0.013  -0.145  -0.222  -0.308  -0.438
268   S        -1.113  -1.086  -1.106  -0.997  -0.954  -0.986  -1.103  -1.069  -1.069
269   N        -0.118  -0.100  -0.242  -0.094  -0.065  -0.307  -0.222  -0.193  -0.418
270   N        -1.113  -1.127  -1.113  -1.138  -1.163  -1.149  -1.103  -1.119  -1.077
271   A        -1.835  -1.826  -1.719  -1.676  -1.661  -1.494  -1.544  -1.533  -1.385
272   N        -1.113  -1.127  -1.113  -1.138  -1.168  -1.149  -1.103  -1.119  -1.077
273   I        -1.835  -1.826  -1.719  -1.713  -1.703  -1.530  -1.544  -1.533  -1.385
274   P        -1.835  -1.826  -1.719  -1.776  -1.767  -1.589  -1.544  -1.533  -1.385
275   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
276   N        -1.835  -1.826  -1.719  -1.804  -1.800  -1.616  -1.544  -1.533  -1.385
277   I        -1.113  -1.080  -1.103  -1.140  -1.092  -1.112  -1.103  -1.062  -1.065
278   P         1.053   1.055   1.081   1.148   1.152   1.188   1.100   1.103   1.134
279   Q        -1.113  -1.135  -1.110  -1.001  -1.046  -0.996  -1.103  -1.129  -1.073
280   R         1.053   1.055   1.081   1.255   1.258   1.291   1.100   1.103   1.134
281   K        -1.113  -1.080  -1.103  -1.120  -1.068  -1.091  -1.103  -1.062  -1.065
282   I        -1.113  -1.132  -1.111  -1.051  -1.085  -1.063  -1.103  -1.126  -1.075
283   S        -0.118  -0.100  -0.242  -0.154  -0.127  -0.335  -0.222  -0.193  -0.418
284   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
285   E        -0.118  -0.086  -0.239  -0.163  -0.109  -0.369  -0.222  -0.173  -0.414
286   Q        -1.835  -1.826  -1.719  -1.825  -1.812  -1.636  -1.544  -1.533  -1.385
287   E         1.053   1.055   1.081   1.023   1.029   1.071   1.100   1.103   1.134
288   Q        -0.118  -0.174  -0.254  -0.092  -0.190  -0.357  -0.222  -0.308  -0.438
289   G        -1.835  -1.826  -1.719  -1.701  -1.681  -1.518  -1.544  -1.533  -1.385
290   K        -1.113  -1.132  -1.111  -1.154  -1.198  -1.180  -1.103  -1.126  -1.075
291   L        -1.113  -1.135  -1.110  -1.178  -1.212  -1.129  -1.103  -1.129  -1.073
292   K        -0.391  -0.386  -0.318  -0.462  -0.459  -0.344  -0.663  -0.654  -0.544
293   Y         1.053   1.055   1.081   1.148   1.151   1.188   1.100   1.103   1.134
294   Y         1.053   1.055   1.081   1.148   1.151   1.188   1.100   1.103   1.134
295   N        -0.118  -0.174  -0.254  -0.104  -0.197  -0.345  -0.222  -0.308  -0.438
296   P        -1.113  -1.086  -1.106  -1.136  -1.097  -1.105  -1.103  -1.069  -1.069
297   Q        -1.113  -1.135  -1.110  -1.110  -1.154  -1.124  -1.103  -1.129  -1.073
298   I        -1.113  -1.135  -1.110  -1.118  -1.162  -1.096  -1.103  -1.129  -1.073
299   H         1.053   1.055   1.081   1.224   1.224   1.261   1.100   1.103   1.134
300   S        -0.118  -0.174  -0.254  -0.155  -0.241  -0.357  -0.222  -0.308  -0.438
301   S        -0.118  -0.096  -0.240  -0.113  -0.077  -0.326  -0.222  -0.186  -0.415
302   A        -0.391  -0.387  -0.319  -0.620  -0.616  -0.491  -0.663  -0.655  -0.545
303   F         1.053   1.055   1.081   1.093   1.095   1.136   1.100   1.103   1.134
304   V         1.053   1.055   1.081   0.981   0.987   1.031   1.100   1.103   1.134
305   L         1.053   1.055   1.081   0.877   0.880   0.932   1.100   1.103   1.134
306   P         1.053   1.055   1.081   1.148   1.152   1.188   1.100   1.103   1.134
307   T        -0.118  -0.086  -0.239  -0.023   0.026  -0.226  -0.222  -0.173  -0.414
308   W         1.053   1.055   1.081   1.322   1.325   1.354   1.100   1.103   1.134
309   A         1.053   1.055   1.081   1.074   1.077   1.119   1.100   1.103   1.134
310   D        -1.113  -1.135  -1.110  -0.978  -1.008  -0.944  -1.103  -1.129  -1.073
311   K        -0.118  -0.086  -0.239  -0.086  -0.039  -0.250  -0.222  -0.173  -0.414
312   V        -1.113  -1.127  -1.113  -1.232  -1.246  -1.228  -1.103  -1.119  -1.077
313   I        -0.391  -0.386  -0.318  -0.748  -0.746  -0.614  -0.663  -0.654  -0.544
314   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
315   -        -0.273  -0.238  -0.280  -0.327  -0.268  -0.348  -0.467  -0.410  -0.480
316   N        -1.113  -1.080  -1.103  -1.078  -1.024  -1.062  -1.103  -1.062  -1.065
317   E        -1.835  -1.826  -1.719  -1.921  -1.899  -1.727  -1.544  -1.533  -1.385
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q12455
Output conservation file - output/Q12455
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
