1     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
2     M         0.996   1.032   1.085   1.255   1.285   1.362   1.050   1.098   1.173
3     H         0.159  -0.080  -0.141   0.543   0.200   0.079   0.140  -0.228  -0.356
4     R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
5     T         0.159  -0.080  -0.141   0.299  -0.068  -0.239   0.140  -0.228  -0.356
6     Y         0.996   1.032   1.085   1.168   1.214   1.286   1.050   1.098   1.173
7     S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
8     L         0.159   0.134  -0.121   0.165   0.134  -0.171   0.140   0.105  -0.322
9     R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
10    N        -0.956  -0.877  -0.916  -0.897  -0.762  -0.921  -1.074  -0.933  -0.964
11    Q        -0.630  -0.374  -0.874  -0.575  -0.253  -0.917  -0.619  -0.281  -0.910
12    R        -0.226  -0.107  -0.177  -0.307  -0.136  -0.266  -0.467  -0.271  -0.418
13    A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
14    P         0.996   1.032   1.085   1.113   1.155   1.237   1.050   1.098   1.173
15    T         0.996   1.032   1.085   1.077   1.130   1.206   1.050   1.098   1.173
16    A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
17    A        -0.399  -0.362  -0.204  -0.883  -0.820  -0.533  -0.771  -0.710  -0.466
18    E        -0.226  -0.054  -0.159  -0.339  -0.044  -0.297  -0.467  -0.186  -0.386
19    L        -0.630  -0.527  -0.882  -0.536  -0.423  -0.830  -0.619  -0.479  -0.921
20    Q        -0.630  -0.768  -0.912  -0.474  -0.727  -1.022  -0.619  -0.806  -0.958
21    A        -1.612  -1.448  -1.479  -1.612  -1.361  -1.394  -1.529  -1.354  -1.280
22    P         0.996   1.032   1.085   1.113   1.155   1.237   1.050   1.098   1.173
23    P         0.159   0.278  -0.111   0.335   0.488  -0.146   0.140   0.312  -0.305
24    P         0.996   1.032   1.085   1.113   1.155   1.237   1.050   1.098   1.173
25    P         0.996   1.032   1.085   1.113   1.155   1.237   1.050   1.098   1.173
26    P        -1.612  -1.623  -1.484  -1.475  -1.554  -1.321  -1.529  -1.501  -1.283
27    S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
28    S         0.159   0.278  -0.111   0.152   0.298  -0.217   0.140   0.312  -0.305
29    T         0.996   1.032   1.085   1.077   1.130   1.206   1.050   1.098   1.173
30    K         0.159  -0.080  -0.141   0.265  -0.073  -0.199   0.140  -0.228  -0.356
31    S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
32    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
33    K        -0.399  -0.283  -0.193  -0.626  -0.441  -0.296  -0.771  -0.570  -0.446
34    F        -0.226  -0.328  -0.211  -0.144  -0.402  -0.265  -0.467  -0.649  -0.477
35    F         0.996   1.032   1.085   1.235   1.288   1.345   1.050   1.098   1.173
36    G         0.996   1.032   1.085   1.098   1.146   1.224   1.050   1.098   1.173
37    K        -0.776  -0.879  -0.944  -0.625  -0.793  -0.867  -0.809  -0.934  -0.998
38    A        -0.226  -0.269  -0.206  -0.283  -0.388  -0.370  -0.467  -0.545  -0.469
39    S        -1.055  -1.138  -0.943  -1.150  -1.229  -0.928  -1.226  -1.269  -0.999
40    I        -0.630  -0.760  -0.910  -0.358  -0.608  -0.808  -0.619  -0.798  -0.956
41    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
42    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
43    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
44    A        -1.361  -1.497  -1.486  -1.369  -1.596  -1.519  -1.226  -1.364  -1.284
45    S        -0.399  -0.361  -0.206  -0.570  -0.487  -0.220  -0.771  -0.709  -0.469
46    S        -0.956  -1.013  -0.940  -1.106  -1.208  -1.083  -1.074  -1.131  -0.996
47    F        -1.361  -1.491  -1.480  -0.903  -1.124  -1.164  -1.226  -1.358  -1.279
48    R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
49    K        -0.956  -1.098  -0.952  -0.955  -1.161  -0.941  -1.074  -1.214  -1.009
50    N        -0.956  -0.770  -0.909  -0.836  -0.548  -0.804  -1.074  -0.807  -0.957
51    A        -1.612  -1.616  -1.479  -1.639  -1.590  -1.364  -1.529  -1.490  -1.278
52    A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
53    G         0.159  -0.080  -0.141   0.337  -0.024  -0.208   0.140  -0.228  -0.356
54    N        -2.170  -2.147  -1.918  -2.052  -2.057  -1.715  -1.833  -1.759  -1.465
55    F        -0.630  -0.468  -0.883  -0.181   0.025  -0.577  -0.619  -0.397  -0.922
56    G         0.159  -0.080  -0.141   0.383   0.055  -0.085   0.140  -0.228  -0.356
57    P         0.996   1.032   1.085   1.113   1.155   1.237   1.050   1.098   1.173
58    E        -1.055  -0.907  -0.933  -1.412  -1.139  -1.170  -1.226  -1.019  -0.986
59    L         0.159   0.258  -0.111   0.165   0.282  -0.156   0.140   0.284  -0.305
60    A        -0.399  -0.289  -0.188  -0.883  -0.684  -0.515  -0.771  -0.581  -0.438
61    R        -0.226  -0.328  -0.211  -0.307  -0.524  -0.330  -0.467  -0.649  -0.477
62    K         0.159  -0.080  -0.141   0.265  -0.073  -0.199   0.140  -0.228  -0.356
63    L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
64    S        -0.226  -0.293  -0.206  -0.508  -0.666  -0.538  -0.467  -0.586  -0.470
65    Q        -0.630  -0.760  -0.910  -0.423  -0.638  -0.907  -0.619  -0.798  -0.956
66    L         0.159   0.258  -0.111   0.161   0.283  -0.165   0.140   0.284  -0.305
67    V         0.159   0.278  -0.111   0.308   0.473  -0.086   0.140   0.312  -0.305
68    K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
69    T        -0.399  -0.261  -0.179  -0.383  -0.152  -0.053  -0.771  -0.532  -0.422
70    E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
71    K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
72    G        -0.226  -0.054  -0.159  -0.082   0.174  -0.031  -0.467  -0.186  -0.386
73    V         0.159   0.278  -0.111   0.320   0.483  -0.057   0.140   0.312  -0.305
74    L        -0.399  -0.261  -0.179  -0.507  -0.250  -0.156  -0.771  -0.532  -0.422
75    R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
76    A        -0.399  -0.361  -0.206  -0.883  -0.819  -0.537  -0.771  -0.709  -0.469
77    M        -1.055  -0.945  -0.931  -1.064  -0.914  -0.838  -1.226  -1.075  -0.986
78    E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
79    V        -1.361  -1.258  -1.457  -1.097  -0.948  -1.261  -1.226  -1.087  -1.256
80    V        -0.956  -0.931  -0.938  -0.905  -0.899  -0.880  -1.074  -1.053  -0.994
81    A        -0.630  -0.718  -0.902  -0.682  -0.804  -1.065  -0.619  -0.750  -0.946
82    S        -1.612  -1.440  -1.467  -1.595  -1.354  -1.344  -1.529  -1.305  -1.267
83    E         0.159  -0.080  -0.141   0.047  -0.246  -0.336   0.140  -0.228  -0.356
84    R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
85    R         0.159   0.134  -0.121   0.307   0.261  -0.059   0.140   0.105  -0.322
86    E        -1.612  -1.462  -1.471  -1.868  -1.639  -1.618  -1.529  -1.365  -1.272
87    A        -1.055  -1.133  -0.945  -1.213  -1.207  -0.918  -1.226  -1.262  -1.001
88    A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
89    K        -0.956  -1.013  -0.940  -0.962  -1.075  -0.939  -1.074  -1.131  -0.996
90    Q         0.996   1.032   1.085   1.067   1.115   1.197   1.050   1.098   1.173
91    L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
92    S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
93    L         0.159  -0.080  -0.141   0.149  -0.173  -0.238   0.140  -0.228  -0.356
94    W         0.996   1.032   1.085   1.306   1.350   1.407   1.050   1.098   1.173
95    G         0.996   1.032   1.085   1.115   1.175   1.239   1.050   1.098   1.173
96    A        -0.956  -0.688  -0.908  -1.307  -0.868  -1.229  -1.074  -0.713  -0.954
97    D        -1.612  -1.497  -1.465  -1.788  -1.575  -1.548  -1.529  -1.361  -1.265
98    N        -0.956  -0.947  -0.946  -0.697  -0.709  -0.745  -1.074  -1.078  -1.002
99    D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
100   D        -0.399  -0.338  -0.209  -0.814  -0.704  -0.507  -0.771  -0.667  -0.475
101   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
102   V         0.159  -0.080  -0.141   0.308  -0.011  -0.137   0.140  -0.228  -0.356
103   S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
104   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
105   V         0.996   1.032   1.085   1.036   1.102   1.170   1.050   1.098   1.173
106   T         0.996   1.032   1.085   1.077   1.130   1.206   1.050   1.098   1.173
107   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
108   K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
109   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
110   G         0.996   1.032   1.085   1.115   1.175   1.239   1.050   1.098   1.173
111   V         0.996   1.032   1.085   1.036   1.102   1.170   1.050   1.098   1.173
112   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
113   I        -0.630  -0.878  -0.927  -0.358  -0.712  -0.836  -0.619  -0.934  -0.977
114   Y         0.159   0.329  -0.102   0.461   0.661   0.087   0.140   0.381  -0.289
115   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
116   L        -1.055  -1.133  -0.945  -1.141  -1.188  -0.881  -1.226  -1.262  -1.001
117   G        -0.226  -0.290  -0.208  -0.283  -0.434  -0.379  -0.467  -0.582  -0.474
118   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
119   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
120   Q        -0.399  -0.261  -0.179  -0.784  -0.554  -0.416  -0.771  -0.532  -0.422
121   D         0.159  -0.080  -0.141   0.249  -0.069  -0.148   0.140  -0.228  -0.356
122   Q         0.159  -0.080  -0.141   0.350   0.022  -0.082   0.140  -0.228  -0.356
123   F        -0.956  -1.100  -0.948  -0.731  -0.999  -0.804  -1.074  -1.218  -1.004
124   I         0.159   0.134  -0.121   0.358   0.329  -0.081   0.140   0.105  -0.322
125   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
126   K        -0.226  -0.328  -0.211  -0.307  -0.515  -0.330  -0.467  -0.649  -0.477
127   Y         0.996   1.032   1.085   1.168   1.214   1.286   1.050   1.098   1.173
128   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
129   Q         0.996   1.032   1.085   1.067   1.115   1.197   1.050   1.098   1.173
130   Y         0.996   1.032   1.085   1.168   1.214   1.286   1.050   1.098   1.173
131   R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
132   V        -1.055  -1.141  -0.944  -1.021  -1.095  -0.800  -1.226  -1.273  -1.000
133   T         0.996   1.032   1.085   1.077   1.130   1.206   1.050   1.098   1.173
134   L        -0.226  -0.153  -0.188  -0.345  -0.254  -0.256  -0.467  -0.348  -0.438
135   K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
136   S         0.159   0.258  -0.111   0.152   0.274  -0.217   0.140   0.284  -0.305
137   I         0.159   0.269  -0.111   0.358   0.500  -0.063   0.140   0.299  -0.306
138   R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
139   N         0.996   1.032   1.085   1.205   1.245   1.319   1.050   1.098   1.173
140   I         0.996   1.032   1.085   1.097   1.147   1.224   1.050   1.098   1.173
141   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
142   A         0.159  -0.080  -0.141   0.031  -0.310  -0.427   0.140  -0.228  -0.356
143   S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
144   V         0.996   1.032   1.085   1.036   1.102   1.170   1.050   1.098   1.173
145   Q         0.996   1.032   1.085   1.067   1.115   1.197   1.050   1.098   1.173
146   P         0.996   1.032   1.085   1.113   1.155   1.237   1.050   1.098   1.173
147   S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
148   R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
149   D         0.159  -0.080  -0.141   0.177  -0.192  -0.345   0.140  -0.228  -0.356
150   R        -0.630  -0.878  -0.927  -0.487  -0.889  -0.992  -0.619  -0.934  -0.977
151   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
152   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
153   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
154   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
155   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
156   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
157   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
158   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
159   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
160   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
161   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
162   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
163   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
164   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
165   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
166   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
167   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
168   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
169   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
170   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
171   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
172   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
173   K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
174   E        -0.226  -0.023  -0.146  -0.339   0.008  -0.268  -0.467  -0.136  -0.364
175   K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
176   I         0.159  -0.080  -0.141   0.331  -0.039  -0.192   0.140  -0.228  -0.356
177   T         0.159  -0.080  -0.141   0.310  -0.054  -0.208   0.140  -0.228  -0.356
178   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
179   E        -0.399  -0.361  -0.206  -0.784  -0.680  -0.419  -0.771  -0.709  -0.469
180   I         0.996   1.032   1.085   1.097   1.147   1.224   1.050   1.098   1.173
181   A         0.159  -0.080  -0.141   0.080  -0.217  -0.292   0.140  -0.228  -0.356
182   H        -0.630  -0.878  -0.927  -0.247  -0.681  -0.829  -0.619  -0.934  -0.977
183   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
184   K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
185   Y         0.159  -0.080  -0.141   0.464   0.141   0.034   0.140  -0.228  -0.356
186   K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
187   D        -0.226  -0.181  -0.187  -0.443  -0.374  -0.449  -0.467  -0.394  -0.437
188   P         0.996   1.032   1.085   1.113   1.155   1.237   1.050   1.098   1.173
189   Q        -1.612  -1.616  -1.490  -1.520  -1.597  -1.407  -1.529  -1.503  -1.289
190   S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
191   T        -0.399  -0.261  -0.179  -0.498  -0.269  -0.157  -0.771  -0.532  -0.422
192   K        -0.226  -0.328  -0.211  -0.307  -0.515  -0.330  -0.467  -0.649  -0.477
193   I         0.159  -0.080  -0.141   0.331  -0.039  -0.192   0.140  -0.228  -0.356
194   P        -1.612  -1.503  -1.484  -1.489  -1.371  -1.336  -1.529  -1.397  -1.284
195   V         0.159  -0.080  -0.141   0.304  -0.016  -0.146   0.140  -0.228  -0.356
196   L         0.159  -0.080  -0.141   0.165  -0.149  -0.197   0.140  -0.228  -0.356
197   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
198   Q         0.996   1.032   1.085   1.067   1.115   1.197   1.050   1.098   1.173
199   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
200   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
201   V         0.996   1.032   1.085   1.036   1.102   1.170   1.050   1.098   1.173
202   R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
203   A         0.159  -0.080  -0.141   0.012  -0.334  -0.479   0.140  -0.228  -0.356
204   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
205   A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
206   E         0.159  -0.080  -0.141  -0.009  -0.345  -0.488   0.140  -0.228  -0.356
207   S         0.159  -0.080  -0.141   0.198  -0.104  -0.144   0.140  -0.228  -0.356
208   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
209   V         0.996   1.032   1.085   1.036   1.102   1.170   1.050   1.098   1.173
210   A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
211   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
212   A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
213   Q         0.996   1.032   1.085   1.067   1.115   1.197   1.050   1.098   1.173
214   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
215   S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
216   N         0.996   1.032   1.085   1.205   1.245   1.319   1.050   1.098   1.173
217   I         0.159  -0.080  -0.141   0.365   0.027  -0.099   0.140  -0.228  -0.356
218   T         0.996   1.032   1.085   1.077   1.130   1.206   1.050   1.098   1.173
219   R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
220   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
221   K        -0.630  -0.459  -0.880  -0.451  -0.219  -0.835  -0.619  -0.386  -0.918
222   L        -1.612  -1.649  -1.491  -1.578  -1.582  -1.319  -1.529  -1.529  -1.290
223   K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
224   A         0.159  -0.080  -0.141   0.063  -0.250  -0.340   0.140  -0.228  -0.356
225   A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
226   Y        -0.956  -1.076  -0.943  -0.649  -0.812  -0.647  -1.074  -1.185  -0.999
227   S        -0.956  -0.891  -0.941  -0.794  -0.784  -0.853  -1.074  -1.026  -0.997
228   Y         0.159  -0.080  -0.141   0.461   0.139   0.025   0.140  -0.228  -0.356
229   M        -0.630  -0.699  -0.904  -0.318  -0.453  -0.674  -0.619  -0.730  -0.948
230   F         0.159  -0.080  -0.141   0.468   0.099  -0.083   0.140  -0.228  -0.356
231   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
232   S        -0.399  -0.261  -0.179  -0.883  -0.631  -0.498  -0.771  -0.532  -0.422
233   L        -1.612  -1.401  -1.458  -1.623  -1.338  -1.364  -1.529  -1.264  -1.259
234   R         0.159  -0.080  -0.141   0.307  -0.025  -0.087   0.140  -0.228  -0.356
235   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
236   L        -0.399  -0.361  -0.206  -0.585  -0.498  -0.230  -0.771  -0.709  -0.469
237   S        -0.956  -0.862  -0.922  -1.149  -0.961  -1.003  -1.074  -0.912  -0.973
238   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
239   K         0.996   1.032   1.085   1.008   1.072   1.145   1.050   1.098   1.173
240   F        -1.612  -1.578  -1.486  -1.419  -1.450  -1.284  -1.529  -1.462  -1.286
241   A         0.159  -0.080  -0.141   0.087  -0.207  -0.274   0.140  -0.228  -0.356
242   L         0.159   0.134  -0.121   0.137   0.106  -0.240   0.140   0.105  -0.322
243   I         0.996   1.032   1.085   1.097   1.147   1.224   1.050   1.098   1.173
244   A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
245   G         0.159  -0.080  -0.141   0.383   0.055  -0.085   0.140  -0.228  -0.356
246   Y         0.996   1.032   1.085   1.168   1.214   1.286   1.050   1.098   1.173
247   G         0.996   1.032   1.085   1.115   1.175   1.239   1.050   1.098   1.173
248   K         0.159  -0.080  -0.141   0.265  -0.073  -0.199   0.140  -0.228  -0.356
249   A        -0.226  -0.328  -0.211  -0.409  -0.539  -0.310  -0.467  -0.649  -0.477
250   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
251   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
252   E         0.159  -0.080  -0.141   0.063  -0.223  -0.293   0.140  -0.228  -0.356
253   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
254   L        -0.226  -0.328  -0.211  -0.408  -0.588  -0.368  -0.467  -0.649  -0.477
255   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
256   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
257   S        -0.399  -0.361  -0.206  -0.685  -0.615  -0.346  -0.771  -0.709  -0.469
258   P         0.159   0.258  -0.111   0.335   0.462  -0.146   0.140   0.284  -0.305
259   V         0.996   1.032   1.085   1.036   1.102   1.170   1.050   1.098   1.173
260   T         0.996   1.032   1.085   1.077   1.130   1.206   1.050   1.098   1.173
261   P         0.996   1.032   1.085   1.113   1.155   1.237   1.050   1.098   1.173
262   G         0.996   1.032   1.085   1.115   1.175   1.239   1.050   1.098   1.173
263   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
264   A        -1.055  -0.947  -0.932  -1.298  -1.150  -1.093  -1.226  -1.078  -0.988
265   R         0.996   1.032   1.085   1.008   1.040   1.145   1.050   1.098   1.173
266   P         0.159   0.278  -0.111   0.335   0.488  -0.146   0.140   0.312  -0.305
267   A         0.996   1.032   1.085   0.796   0.866   0.958   1.050   1.098   1.173
268   Y         0.996   1.032   1.085   1.168   1.214   1.286   1.050   1.098   1.173
269   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
270   G         0.996   1.032   1.085   1.115   1.175   1.239   1.050   1.098   1.173
271   Y         0.996   1.032   1.085   1.168   1.214   1.286   1.050   1.098   1.173
272   E        -0.226  -0.079  -0.160  -0.553  -0.297  -0.443  -0.467  -0.225  -0.389
273   A         0.159  -0.080  -0.141   0.064  -0.245  -0.335   0.140  -0.228  -0.356
274   S         0.996   1.032   1.085   0.883   0.929   1.035   1.050   1.098   1.173
275   R        -0.399  -0.338  -0.209  -0.626  -0.543  -0.327  -0.771  -0.667  -0.475
276   Q         0.159   0.134  -0.121   0.289   0.253  -0.205   0.140   0.105  -0.322
277   I         0.159   0.269  -0.111   0.358   0.500  -0.063   0.140   0.299  -0.306
278   I         0.159  -0.080  -0.141   0.358   0.018  -0.117   0.140  -0.228  -0.356
279   M        -0.956  -0.902  -0.930  -0.702  -0.631  -0.713  -1.074  -0.969  -0.982
280   D         0.996   1.032   1.085   0.959   1.010   1.102   1.050   1.098   1.173
281   A         0.159   0.134  -0.121   0.111   0.108  -0.187   0.140   0.105  -0.322
282   E         0.996   1.032   1.085   0.771   0.850   0.936   1.050   1.098   1.173
283   S        -2.170  -2.131  -1.917  -1.923  -1.852  -1.547  -1.833  -1.750  -1.464
284   A         0.159   0.134  -0.121   0.031   0.016  -0.391   0.140   0.105  -0.322
285   L         0.996   1.032   1.085   0.865   0.913   1.019   1.050   1.098   1.173
286   E        -1.612  -1.697  -1.497  -1.929  -2.031  -1.691  -1.529  -1.564  -1.296
287   S        -0.630  -0.527  -0.882  -0.588  -0.450  -0.958  -0.619  -0.479  -0.921
288   W         0.996   1.032   1.085   1.306   1.350   1.407   1.050   1.098   1.173
289   T        -0.226  -0.328  -0.211  -0.231  -0.430  -0.267  -0.467  -0.649  -0.477
290   L        -0.630  -0.878  -0.927  -0.570  -0.925  -0.957  -0.619  -0.934  -0.977
291   D        -0.630  -0.878  -0.927  -0.524  -0.925  -1.000  -0.619  -0.934  -0.977
292   M        -2.170  -2.004  -1.906  -1.911  -1.698  -1.526  -1.833  -1.643  -1.456
293   A         0.159  -0.080  -0.141   0.071  -0.237  -0.318   0.140  -0.228  -0.356
294   A        -0.630  -0.468  -0.883  -0.695  -0.457  -1.063  -0.619  -0.397  -0.922
295   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
296   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
297   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
298   V         0.159   0.278  -0.111   0.308   0.473  -0.086   0.140   0.312  -0.305
299   K        -0.630  -0.590  -0.891  -0.487  -0.435  -0.927  -0.619  -0.556  -0.932
300   P         0.159   0.134  -0.121   0.335   0.293  -0.168   0.140   0.105  -0.322
301   T        -0.630  -0.878  -0.927  -0.383  -0.753  -0.863  -0.619  -0.934  -0.977
302   L         0.159  -0.080  -0.141   0.137  -0.194  -0.271   0.140  -0.228  -0.356
303   S         0.159  -0.080  -0.141   0.100  -0.272  -0.407   0.140  -0.228  -0.356
304   F        -2.017  -2.053  -1.918  -1.622  -1.756  -1.606  -1.681  -1.682  -1.465
305   H        -0.956  -1.098  -0.952  -0.761  -1.037  -0.848  -1.074  -1.214  -1.009
306   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
307   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
308   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
309   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
310   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
311   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
312   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
313   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
314   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
315   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
316   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
317   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
318   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
319   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
320   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
321   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
322   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
323   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
324   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
325   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
326   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
327   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
328   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
329   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
330   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
331   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
332   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
333   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
334   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
335   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
336   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
337   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
338   Q        -0.630  -0.581  -0.894  -0.433  -0.383  -0.896  -0.619  -0.544  -0.936
339   T        -1.612  -1.572  -1.483  -1.595  -1.581  -1.432  -1.529  -1.457  -1.282
340   V        -1.055  -0.918  -0.931  -1.236  -1.019  -1.061  -1.226  -1.027  -0.984
341   D        -2.017  -2.053  -1.918  -1.868  -2.013  -1.749  -1.681  -1.682  -1.465
342   D         0.159  -0.080  -0.141   0.216  -0.133  -0.238   0.140  -0.228  -0.356
343   V        -1.612  -1.503  -1.484  -1.708  -1.596  -1.574  -1.529  -1.397  -1.284
344   Y        -0.956  -0.955  -0.944  -0.748  -0.761  -0.790  -1.074  -1.085  -1.001
345   E        -1.612  -1.647  -1.486  -1.721  -1.698  -1.443  -1.529  -1.527  -1.286
346   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
347   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
348   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
349   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
350   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
351   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
352   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
353   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
354   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
355   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
356   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
357   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
358   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
359   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
360   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
361   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
362   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
363   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
364   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
365   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
366   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
367   D        -1.361  -1.369  -1.458  -1.192  -1.235  -1.349  -1.226  -1.235  -1.258
368   E        -0.630  -0.777  -0.912  -0.691  -0.922  -1.064  -0.619  -0.817  -0.958
369   D         0.159   0.269  -0.111   0.177   0.328  -0.284   0.140   0.299  -0.306
370   G        -0.956  -1.098  -0.952  -0.966  -1.176  -1.014  -1.074  -1.214  -1.009
371   E         0.159  -0.080  -0.141   0.006  -0.326  -0.446   0.140  -0.228  -0.356
372   E        -0.776  -0.743  -0.912  -0.953  -0.884  -1.172  -0.809  -0.752  -0.959
373   E        -1.836  -1.729  -1.509  -2.017  -1.816  -1.522  -1.738  -1.592  -1.306
374   E        -1.128  -0.918  -0.939  -1.218  -0.855  -0.977  -1.273  -0.979  -0.992
375   E        -0.152  -0.138  -0.164  -0.361  -0.327  -0.329  -0.344  -0.322  -0.396
376   P        -1.836  -1.729  -1.509  -1.820  -1.663  -1.348  -1.738  -1.592  -1.306
377   E        -0.152  -0.138  -0.164  -0.477  -0.447  -0.504  -0.344  -0.322  -0.396
378   I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
379   Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
380   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
381   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
382   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
383   I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
384   P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
385   G         0.159   0.258  -0.111   0.363   0.503  -0.079   0.140   0.284  -0.305
386   Q        -2.017  -2.043  -1.913  -1.858  -1.893  -1.809  -1.681  -1.674  -1.461
387   V        -2.170  -1.904  -1.902  -2.095  -1.642  -1.707  -1.833  -1.562  -1.453
388   V        -2.574  -2.477  -2.259  -2.267  -2.169  -1.923  -1.985  -1.861  -1.576
389   E        -1.612  -1.694  -1.491  -1.756  -1.762  -1.433  -1.529  -1.561  -1.290
390   E        -1.361  -1.491  -1.480  -1.482  -1.665  -1.690  -1.226  -1.358  -1.279
391   E        -0.956  -1.098  -0.952  -1.155  -1.295  -1.039  -1.074  -1.214  -1.009
392   E        -2.017  -2.021  -1.906  -1.976  -2.023  -1.754  -1.681  -1.657  -1.456
393   V        -2.017  -1.678  -1.869  -2.044  -1.549  -1.807  -1.681  -1.315  -1.426
394   E        -2.170  -2.104  -1.916  -2.219  -2.120  -1.761  -1.833  -1.728  -1.463
395   W        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
396   T        -1.725  -1.678  -1.495  -1.873  -1.774  -1.493  -1.627  -1.545  -1.293
397   T        -2.291  -2.177  -1.926  -2.173  -2.052  -1.659  -1.924  -1.777  -1.471
398   E        -1.725  -1.695  -1.503  -1.808  -1.759  -1.422  -1.627  -1.561  -1.301
399   V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
400   P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
401   V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
402   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
403   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
404   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
405   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
406   H        -1.542  -1.576  -1.490  -1.295  -1.422  -1.373  -1.428  -1.443  -1.288
407   E        -0.776  -0.700  -0.896  -0.904  -0.784  -1.074  -0.809  -0.695  -0.937
408   A        -0.945  -0.931  -0.926  -0.929  -0.938  -1.012  -1.032  -1.010  -0.976
409   D        -2.664  -2.514  -2.267  -2.660  -2.461  -2.088  -2.048  -1.882  -1.581
410   H        -2.192  -2.146  -1.923  -1.817  -1.826  -1.505  -1.841  -1.756  -1.468
411   H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
412   V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
413   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
414   Q        -0.420  -0.344  -0.201  -0.810  -0.632  -0.413  -0.809  -0.678  -0.460
415   N        -1.128  -1.117  -0.966  -1.136  -1.154  -0.981  -1.273  -1.247  -1.025
416   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
417   H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
418   T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
419   S        -1.725  -1.498  -1.481  -1.849  -1.456  -1.525  -1.627  -1.349  -1.280
420   G        -2.291  -2.171  -1.926  -2.368  -2.247  -1.831  -1.924  -1.773  -1.471
421   S        -1.725  -1.550  -1.479  -1.686  -1.421  -1.344  -1.627  -1.408  -1.277
422   E        -1.542  -1.576  -1.490  -1.665  -1.703  -1.561  -1.428  -1.443  -1.288
423   N        -1.720  -1.607  -1.482  -1.679  -1.538  -1.379  -1.635  -1.480  -1.281
424   I        -1.070  -0.883  -0.932  -1.322  -1.048  -1.060  -1.222  -0.968  -0.985
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q12230
Output conservation file - output/Q12230
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
