1     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
2     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     M         1.664   1.666   1.683   1.855   1.858   1.884   1.772   1.774   1.796
5     K        -1.111  -1.109  -1.094  -1.443  -1.434  -1.413  -0.977  -0.974  -0.946
6     A        -1.111  -1.109  -1.094  -0.828  -0.824  -0.798  -0.977  -0.974  -0.946
7     T         1.664   1.666   1.683   1.800   1.803   1.829   1.772   1.774   1.796
8     L         0.056   0.044   0.013  -0.210  -0.235  -0.284  -0.061  -0.080  -0.129
9     L        -1.111  -1.109  -1.094  -0.985  -0.974  -0.955  -0.977  -0.974  -0.946
10    L         1.664   1.666   1.683   1.457   1.456   1.486   1.772   1.774   1.796
11    K        -1.111  -1.109  -1.094  -1.055  -1.034  -1.025  -0.977  -0.974  -0.946
12    A         1.664   1.666   1.683   1.776   1.778   1.805   1.772   1.774   1.796
13    Q         0.056   0.086   0.025   0.040   0.084  -0.007  -0.061  -0.014  -0.109
14    L        -1.111  -1.109  -1.094  -1.015  -1.004  -0.985  -0.977  -0.974  -0.946
15    S         1.664   1.666   1.683   1.574   1.575   1.603   1.772   1.774   1.796
16    P        -1.111  -1.109  -1.094  -0.903  -0.906  -0.873  -0.977  -0.974  -0.946
17    V        -1.111  -1.109  -1.094  -1.080  -1.088  -1.050  -0.977  -0.974  -0.946
18    S        -1.111  -1.109  -1.094  -1.213  -1.212  -1.184  -0.977  -0.974  -0.946
19    Y         0.056   0.086   0.025   0.236   0.284   0.184  -0.061  -0.014  -0.109
20    T         0.056   0.044   0.015   0.110   0.087   0.027  -0.061  -0.080  -0.126
21    T        -1.111  -1.109  -1.094  -0.809  -0.805  -0.779  -0.977  -0.974  -0.946
22    K         1.664   1.666   1.683   1.381   1.391   1.410   1.772   1.774   1.796
23    K         1.664   1.666   1.683   1.381   1.391   1.410   1.772   1.774   1.796
24    S         0.056   0.044   0.015  -0.005  -0.026  -0.067  -0.061  -0.080  -0.126
25    F         1.664   1.666   1.683   1.768   1.769   1.797   1.772   1.774   1.796
26    Q         0.056   0.086   0.025  -0.182  -0.132  -0.222  -0.061  -0.014  -0.109
27    R         0.056   0.044   0.015  -0.143  -0.166  -0.233  -0.061  -0.080  -0.126
28    Q        -0.087  -0.086  -0.069  -0.209  -0.203  -0.180  -0.290  -0.288  -0.260
29    L         0.056   0.044   0.015  -0.112  -0.134  -0.170  -0.061  -0.080  -0.126
30    N        -1.111  -1.109  -1.094  -0.903  -0.897  -0.873  -0.977  -0.974  -0.946
31    R        -1.111  -1.109  -1.094  -1.229  -1.224  -1.199  -0.977  -0.974  -0.946
32    T        -1.111  -1.109  -1.094  -0.932  -0.932  -0.902  -0.977  -0.974  -0.946
33    P         0.056   0.044   0.015   0.261   0.239   0.185  -0.061  -0.080  -0.126
34    Y        -1.111  -1.109  -1.094  -0.951  -0.947  -0.921  -0.977  -0.974  -0.946
35    T         0.056   0.044   0.013   0.229   0.210   0.161  -0.061  -0.080  -0.129
36    A         0.056   0.086   0.025   0.236   0.284   0.184  -0.061  -0.014  -0.109
37    F         1.664   1.666   1.683   1.768   1.769   1.797   1.772   1.774   1.796
38    Q         0.056   0.044   0.015   0.143   0.121   0.069  -0.061  -0.080  -0.126
39    Y         1.664   1.666   1.683   1.776   1.778   1.805   1.772   1.774   1.796
40    F         0.056   0.086   0.025   0.175   0.222   0.124  -0.061  -0.014  -0.109
41    F        -1.111  -1.109  -1.094  -1.090  -1.095  -1.060  -0.977  -0.974  -0.946
42    Q         0.056   0.044   0.015   0.143   0.121   0.069  -0.061  -0.080  -0.126
43    L         0.056   0.044   0.015  -0.074  -0.094  -0.126  -0.061  -0.080  -0.126
44    E         0.056   0.086   0.025   0.121   0.171   0.064  -0.061  -0.014  -0.109
45    V         0.056   0.044   0.013   0.211   0.189   0.134  -0.061  -0.080  -0.129
46    Q        -1.111  -1.109  -1.094  -1.090  -1.087  -1.060  -0.977  -0.974  -0.946
47    K         0.056   0.044   0.013  -0.257  -0.271  -0.326  -0.061  -0.080  -0.129
48    L         0.056   0.044   0.015  -0.116  -0.138  -0.174  -0.061  -0.080  -0.126
49    H        -1.111  -1.109  -1.094  -0.735  -0.731  -0.706  -0.977  -0.974  -0.946
50    N         0.056   0.044   0.013   0.080   0.059   0.008  -0.061  -0.080  -0.129
51    V        -1.111  -1.109  -1.094  -0.875  -0.875  -0.845  -0.977  -0.974  -0.946
52    S        -1.111  -1.109  -1.094  -1.000  -0.992  -0.970  -0.977  -0.974  -0.946
53    K        -0.087  -0.086  -0.069  -0.319  -0.308  -0.290  -0.290  -0.288  -0.260
54    Y         1.664   1.666   1.683   1.786   1.785   1.815   1.772   1.774   1.796
55    E        -0.087  -0.086  -0.069  -0.440  -0.429  -0.410  -0.290  -0.288  -0.260
56    D         1.664   1.666   1.683   1.819   1.818   1.848   1.772   1.774   1.796
57    I        -0.087  -0.086  -0.069   0.006   0.003   0.036  -0.290  -0.288  -0.260
58    I        -0.087  -0.086  -0.069  -0.211  -0.216  -0.181  -0.290  -0.288  -0.260
59    N        -0.087  -0.086  -0.069  -0.236  -0.241  -0.206  -0.290  -0.288  -0.260
60    H         0.056   0.044   0.015   0.161   0.133   0.067  -0.061  -0.080  -0.126
61    V        -1.111  -1.109  -1.094  -0.842  -0.841  -0.812  -0.977  -0.974  -0.946
62    R         1.664   1.666   1.683   1.617   1.617   1.646   1.772   1.774   1.796
63    G        -0.087  -0.086  -0.069   0.054   0.062   0.084  -0.290  -0.288  -0.260
64    N         1.664   1.666   1.683   1.605   1.617   1.634   1.772   1.774   1.796
65    S        -0.087  -0.086  -0.069  -0.357  -0.342  -0.327  -0.290  -0.288  -0.260
66    N        -1.111  -1.109  -1.094  -0.990  -0.987  -0.960  -0.977  -0.974  -0.946
67    F         0.056   0.044   0.013   0.028   0.001  -0.064  -0.061  -0.080  -0.129
68    K         0.056   0.044   0.013  -0.151  -0.161  -0.204  -0.061  -0.080  -0.129
69    R         1.664   1.666   1.683   1.623   1.624   1.652   1.772   1.774   1.796
70    F        -1.111  -1.109  -1.094  -0.990  -0.991  -0.960  -0.977  -0.974  -0.946
71    A         0.056   0.086   0.025   0.128   0.174   0.079  -0.061  -0.014  -0.109
72    R         1.664   1.666   1.683   1.623   1.624   1.652   1.772   1.774   1.796
73    N        -1.111  -1.109  -1.094  -1.065  -1.064  -1.035  -0.977  -0.974  -0.946
74    E         1.664   1.666   1.683   1.647   1.648   1.676   1.772   1.774   1.796
75    W         1.664   1.666   1.683   1.994   1.997   2.023   1.772   1.774   1.796
76    D         0.056   0.044   0.013   0.179   0.156   0.097  -0.061  -0.080  -0.129
77    S         0.056   0.044   0.015  -0.043  -0.064  -0.110  -0.061  -0.080  -0.126
78    M         0.056   0.086   0.025  -0.074  -0.035  -0.111  -0.061  -0.014  -0.109
79    S         1.664   1.666   1.683   1.574   1.575   1.603   1.772   1.774   1.796
80    L        -1.111  -1.109  -1.094  -1.120  -1.113  -1.090  -0.977  -0.974  -0.946
81    T         1.664   1.666   1.683   1.800   1.803   1.829   1.772   1.774   1.796
82    K         1.664   1.666   1.683   1.381   1.391   1.410   1.772   1.774   1.796
83    K         0.056   0.044   0.013  -0.257  -0.271  -0.326  -0.061  -0.080  -0.129
84    R         1.664   1.666   1.683   1.623   1.624   1.652   1.772   1.774   1.796
85    L         0.056   0.044   0.013  -0.081  -0.102  -0.137  -0.061  -0.080  -0.129
86    Y         1.664   1.666   1.683   1.776   1.778   1.805   1.772   1.774   1.796
87    Y         0.056   0.044   0.013   0.240   0.220   0.177  -0.061  -0.080  -0.129
88    A         1.664   1.666   1.683   1.776   1.778   1.805   1.772   1.774   1.796
89    S        -1.111  -1.109  -1.094  -1.161  -1.159  -1.131  -0.977  -0.974  -0.946
90    F         1.664   1.666   1.683   1.768   1.769   1.797   1.772   1.774   1.796
91    C         0.056   0.086   0.025   0.261   0.303   0.221  -0.061  -0.014  -0.109
92    Q        -1.111  -1.109  -1.094  -1.213  -1.215  -1.184  -0.977  -0.974  -0.946
93    S        -1.111  -1.109  -1.094  -1.020  -1.012  -0.990  -0.977  -0.974  -0.946
94    M        -1.111  -1.109  -1.094  -0.814  -0.813  -0.784  -0.977  -0.974  -0.946
95    D        -1.111  -1.109  -1.094  -1.141  -1.142  -1.111  -0.977  -0.974  -0.946
96    I         0.056   0.044   0.015  -0.017  -0.044  -0.104  -0.061  -0.080  -0.126
97    D         0.056   0.044   0.015   0.146   0.123   0.063  -0.061  -0.080  -0.126
98    I        -1.111  -1.109  -1.094  -0.860  -0.856  -0.831  -0.977  -0.974  -0.946
99    L        -1.111  -1.109  -1.094  -1.315  -1.312  -1.285  -0.977  -0.974  -0.946
100   N        -1.111  -1.109  -1.094  -1.267  -1.266  -1.237  -0.977  -0.974  -0.946
101   V         0.056   0.086   0.025  -0.081  -0.043  -0.120  -0.061  -0.014  -0.109
102   S        -1.111  -1.109  -1.094  -0.870  -0.854  -0.840  -0.977  -0.974  -0.946
103   K        -1.111  -1.109  -1.094  -1.315  -1.301  -1.285  -0.977  -0.974  -0.946
104   I        -1.111  -1.109  -1.094  -1.005  -1.005  -0.975  -0.977  -0.974  -0.946
105   E         1.664   1.666   1.683   1.647   1.648   1.676   1.772   1.774   1.796
106   L         1.664   1.666   1.683   1.457   1.456   1.486   1.772   1.774   1.796
107   A         1.664   1.666   1.683   1.776   1.778   1.805   1.772   1.774   1.796
108   K         0.056   0.086   0.025  -0.143  -0.085  -0.211  -0.061  -0.014  -0.109
109   R        -1.111  -1.109  -1.094  -0.865  -0.857  -0.835  -0.977  -0.974  -0.946
110   L         1.664   1.666   1.683   1.457   1.456   1.486   1.772   1.774   1.796
111   E         0.056   0.044   0.013   0.062   0.040  -0.005  -0.061  -0.080  -0.129
112   I         1.664   1.666   1.683   1.720   1.721   1.749   1.772   1.774   1.796
113   P        -1.111  -1.109  -1.094  -1.020  -1.027  -0.990  -0.977  -0.974  -0.946
114   I        -1.111  -1.109  -1.094  -1.040  -1.034  -1.010  -0.977  -0.974  -0.946
115   P         1.664   1.666   1.683   1.894   1.897   1.923   1.772   1.774   1.796
116   A         0.056   0.044   0.013   0.154   0.131   0.078  -0.061  -0.080  -0.129
117   M        -1.111  -1.109  -1.094  -0.966  -0.969  -0.936  -0.977  -0.974  -0.946
118   S         1.664   1.666   1.683   1.574   1.575   1.603   1.772   1.774   1.796
119   E         0.056   0.044   0.013   0.062   0.040  -0.005  -0.061  -0.080  -0.129
120   Y         1.664   1.666   1.683   1.776   1.778   1.805   1.772   1.774   1.796
121   L         1.664   1.666   1.683   1.457   1.456   1.486   1.772   1.774   1.796
122   L         0.056   0.044   0.015  -0.074  -0.094  -0.126  -0.061  -0.080  -0.126
123   F         1.664   1.666   1.683   1.768   1.769   1.797   1.772   1.774   1.796
124   R         1.664   1.666   1.683   1.623   1.624   1.652   1.772   1.774   1.796
125   N         0.056   0.044   0.013   0.013  -0.010  -0.069  -0.061  -0.080  -0.129
126   K         0.056   0.044   0.015  -0.257  -0.271  -0.323  -0.061  -0.080  -0.126
127   F         0.056   0.044   0.013   0.172   0.150   0.101  -0.061  -0.080  -0.129
128   K         1.664   1.666   1.683   1.381   1.391   1.410   1.772   1.774   1.796
129   V        -1.111  -1.109  -1.094  -1.172  -1.182  -1.142  -0.977  -0.974  -0.946
130   K         0.056   0.044   0.013  -0.182  -0.193  -0.239  -0.061  -0.080  -0.129
131   F         1.664   1.666   1.683   1.768   1.769   1.797   1.772   1.774   1.796
132   D         0.056   0.044   0.013   0.200   0.179   0.122  -0.061  -0.080  -0.129
133   S        -1.111  -1.109  -1.094  -1.315  -1.318  -1.285  -0.977  -0.974  -0.946
134   H        -1.111  -1.109  -1.094  -1.035  -1.045  -1.005  -0.977  -0.974  -0.946
135   C         0.056   0.086   0.025   0.462   0.507   0.415  -0.061  -0.014  -0.109
136   S        -1.111  -1.109  -1.094  -1.192  -1.191  -1.163  -0.977  -0.974  -0.946
137   S         0.056   0.086   0.025   0.088   0.141   0.027  -0.061  -0.014  -0.109
138   L        -1.111  -1.109  -1.094  -1.235  -1.229  -1.205  -0.977  -0.974  -0.946
139   E        -1.111  -1.109  -1.094  -1.095  -1.093  -1.065  -0.977  -0.974  -0.946
140   R        -1.111  -1.109  -1.094  -1.100  -1.099  -1.070  -0.977  -0.974  -0.946
141   K         0.056   0.044   0.015  -0.151  -0.161  -0.201  -0.061  -0.080  -0.126
142   D        -1.111  -1.109  -1.094  -0.903  -0.903  -0.873  -0.977  -0.974  -0.946
143   R        -1.111  -1.109  -1.094  -1.015  -1.011  -0.985  -0.977  -0.974  -0.946
144   K         0.056   0.044   0.013  -0.245  -0.259  -0.312  -0.061  -0.080  -0.129
145   S        -1.111  -1.109  -1.094  -1.213  -1.213  -1.184  -0.977  -0.974  -0.946
146   V        -1.111  -1.109  -1.094  -0.818  -0.817  -0.789  -0.977  -0.974  -0.946
147   -        -0.087  -0.086  -0.069  -0.012  -0.005   0.018  -0.290  -0.288  -0.260
148   P        -1.111  -1.109  -1.094  -0.745  -0.743  -0.715  -0.977  -0.974  -0.946
149   R         0.056   0.044   0.015  -0.055  -0.079  -0.131  -0.061  -0.080  -0.126
150   P         0.056   0.044   0.015   0.380   0.366   0.320  -0.061  -0.080  -0.126
151   S         0.056   0.044   0.013   0.006  -0.014  -0.057  -0.061  -0.080  -0.129
152   I         0.056   0.044   0.013   0.128   0.107   0.059  -0.061  -0.080  -0.129
153   T        -1.111  -1.109  -1.094  -1.070  -1.075  -1.040  -0.977  -0.974  -0.946
154   R        -1.111  -1.109  -1.094  -1.115  -1.114  -1.085  -0.977  -0.974  -0.946
155   K        -1.111  -1.109  -1.094  -1.283  -1.268  -1.253  -0.977  -0.974  -0.946
156   V        -1.111  -1.109  -1.094  -0.777  -0.775  -0.747  -0.977  -0.974  -0.946
157   A        -0.087  -0.086  -0.069   0.014   0.014   0.044  -0.290  -0.288  -0.260
158   T        -0.087  -0.086  -0.069  -0.150  -0.152  -0.121  -0.290  -0.288  -0.260
159   T        -0.087  -0.086  -0.069  -0.075  -0.076  -0.046  -0.290  -0.288  -0.260
160   E        -0.087  -0.086  -0.069  -0.322  -0.316  -0.292  -0.290  -0.288  -0.260
161   I        -0.087  -0.086  -0.069  -0.261  -0.254  -0.231  -0.290  -0.288  -0.260
162   C         1.664   1.666   1.683   1.959   1.961   1.988   1.772   1.774   1.796
163   S        -0.087  -0.086  -0.069  -0.348  -0.342  -0.318  -0.290  -0.288  -0.260
164   K        -0.087  -0.086  -0.069  -0.366  -0.369  -0.336  -0.290  -0.288  -0.260
165   S        -0.087  -0.086  -0.069  -0.510  -0.505  -0.480  -0.290  -0.288  -0.260
166   R         1.664   1.666   1.683   1.617   1.617   1.646   1.772   1.774   1.796
167   S         1.664   1.666   1.683   1.546   1.558   1.575   1.772   1.774   1.796
168   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
169   T         1.664   1.666   1.683   1.808   1.807   1.837   1.772   1.774   1.796
170   P         1.664   1.666   1.683   1.862   1.863   1.891   1.772   1.774   1.796
171   V        -1.111  -1.109  -1.094  -1.080  -1.088  -1.050  -0.977  -0.974  -0.946
172   G        -1.111  -1.109  -1.094  -0.722  -0.720  -0.692  -0.977  -0.974  -0.946
173   K         0.056   0.044   0.015  -0.116  -0.126  -0.162  -0.061  -0.080  -0.126
174   I         1.664   1.666   1.683   1.720   1.721   1.749   1.772   1.774   1.796
175   N        -0.087  -0.086  -0.069  -0.125  -0.118  -0.096  -0.290  -0.288  -0.260
176   P         1.664   1.666   1.683   1.914   1.916   1.943   1.772   1.774   1.796
177   R        -0.087  -0.086  -0.069  -0.304  -0.298  -0.275  -0.290  -0.288  -0.260
178   K        -0.087  -0.086  -0.069  -0.455  -0.459  -0.426  -0.290  -0.288  -0.260
179   R        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
180   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
181   V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
182   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
183   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
184   K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
185   R        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
186   I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
187   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
188   R        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
189   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
190   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
191   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
192   T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
193   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
194   K        -0.087  -0.086  -0.069  -0.388  -0.377  -0.358  -0.290  -0.288  -0.260
195   N        -0.087  -0.086  -0.069  -0.236  -0.241  -0.206  -0.290  -0.288  -0.260
196   H         1.664   1.666   1.683   1.917   1.917   1.946   1.772   1.774   1.796
197   S         1.664   1.666   1.683   1.561   1.558   1.590   1.772   1.774   1.796
198   H        -0.087  -0.086  -0.069   0.029   0.027   0.059  -0.290  -0.288  -0.260
199   E        -0.087  -0.086  -0.069  -0.121  -0.125  -0.092  -0.290  -0.288  -0.260
200   A        -0.087  -0.086  -0.069  -0.328  -0.317  -0.298  -0.290  -0.288  -0.260
201   Q        -0.087  -0.086  -0.069  -0.010  -0.005   0.020  -0.290  -0.288  -0.260
202   N        -0.087  -0.086  -0.069  -0.049  -0.052  -0.020  -0.290  -0.288  -0.260
203   Y        -0.087  -0.086  -0.069  -0.211  -0.216  -0.181  -0.290  -0.288  -0.260
204   L        -0.087  -0.086  -0.069  -0.269  -0.258  -0.239  -0.290  -0.288  -0.260
205   Y        -0.087  -0.086  -0.069  -0.328  -0.325  -0.298  -0.290  -0.288  -0.260
206   D         0.056   0.044   0.013   0.200   0.179   0.122  -0.061  -0.080  -0.129
207   Y         0.056   0.044   0.013   0.179   0.158   0.107  -0.061  -0.080  -0.129
208   M        -1.111  -1.109  -1.094  -0.800  -0.799  -0.770  -0.977  -0.974  -0.946
209   K         0.056   0.086   0.025  -0.302  -0.247  -0.366  -0.061  -0.014  -0.109
210   R         1.664   1.666   1.683   1.623   1.624   1.652   1.772   1.774   1.796
211   F         0.056   0.044   0.013   0.172   0.150   0.101  -0.061  -0.080  -0.129
212   Q         0.056   0.044   0.015   0.002  -0.020  -0.092  -0.061  -0.080  -0.126
213   Q         0.056   0.086   0.025   0.062   0.106   0.015  -0.061  -0.014  -0.109
214   M         1.664   1.666   1.683   1.855   1.858   1.884   1.772   1.774   1.796
215   C         1.664   1.666   1.683   1.971   1.974   2.000   1.772   1.774   1.796
216   K         1.664   1.666   1.683   1.381   1.391   1.410   1.772   1.774   1.796
217   E         0.056   0.044   0.013  -0.032  -0.057  -0.112  -0.061  -0.080  -0.129
218   C         1.664   1.666   1.683   1.971   1.974   2.000   1.772   1.774   1.796
219   R         0.056   0.044   0.013  -0.143  -0.166  -0.236  -0.061  -0.080  -0.129
220   Y        -1.111  -1.109  -1.094  -1.229  -1.231  -1.199  -0.977  -0.974  -0.946
221   A        -1.111  -1.109  -1.094  -0.889  -0.888  -0.859  -0.977  -0.974  -0.946
222   W         1.664   1.666   1.683   1.994   1.997   2.023   1.772   1.774   1.796
223   N         0.056   0.044   0.013  -0.074  -0.096  -0.169  -0.061  -0.080  -0.129
224   E         0.056   0.044   0.015   0.073   0.052   0.010  -0.061  -0.080  -0.126
225   E         0.056   0.086   0.025  -0.245  -0.193  -0.293  -0.061  -0.014  -0.109
226   V         1.664   1.666   1.683   1.839   1.842   1.868   1.772   1.774   1.796
227   D        -1.111  -1.109  -1.094  -0.717  -0.708  -0.688  -0.977  -0.974  -0.946
228   Y        -1.111  -1.109  -1.094  -0.932  -0.932  -0.902  -0.977  -0.974  -0.946
229   D         0.056   0.086   0.025   0.091   0.134   0.048  -0.061  -0.014  -0.109
230   Q         0.056   0.044   0.015   0.121   0.098   0.044  -0.061  -0.080  -0.126
231   K         1.664   1.666   1.683   1.381   1.391   1.410   1.772   1.774   1.796
232   L        -1.111  -1.109  -1.094  -1.337  -1.327  -1.307  -0.977  -0.974  -0.946
233   E        -1.111  -1.109  -1.094  -1.151  -1.152  -1.121  -0.977  -0.974  -0.946
234   I         0.056   0.044   0.013  -0.017  -0.044  -0.108  -0.061  -0.080  -0.129
235   R        -1.111  -1.109  -1.094  -0.903  -0.896  -0.873  -0.977  -0.974  -0.946
236   K        -1.111  -1.109  -1.094  -1.172  -1.155  -1.142  -0.977  -0.974  -0.946
237   K         0.056   0.044   0.015  -0.116  -0.126  -0.162  -0.061  -0.080  -0.126
238   L        -1.111  -1.109  -1.094  -0.980  -0.969  -0.951  -0.977  -0.974  -0.946
239   Q        -1.111  -1.109  -1.094  -1.337  -1.343  -1.307  -0.977  -0.974  -0.946
240   V        -1.111  -1.109  -1.094  -1.025  -1.029  -0.995  -0.977  -0.974  -0.946
241   W        -1.111  -1.109  -1.094  -0.879  -0.887  -0.850  -0.977  -0.974  -0.946
242   R        -1.111  -1.109  -1.094  -1.229  -1.224  -1.199  -0.977  -0.974  -0.946
243   A        -1.111  -1.109  -1.094  -0.971  -0.972  -0.941  -0.977  -0.974  -0.946
244   K        -1.111  -1.109  -1.094  -1.315  -1.303  -1.285  -0.977  -0.974  -0.946
245   F         1.664   1.666   1.683   1.768   1.769   1.797   1.772   1.774   1.796
246   E        -0.087  -0.086  -0.069  -0.428  -0.432  -0.399  -0.290  -0.288  -0.260
247   E        -0.087  -0.086  -0.069  -0.278  -0.272  -0.248  -0.290  -0.288  -0.260
248   M        -0.087  -0.086  -0.069  -0.018  -0.019   0.011  -0.290  -0.288  -0.260
249   M        -0.087  -0.086  -0.069  -0.192  -0.194  -0.163  -0.290  -0.288  -0.260
250   D         0.056   0.044   0.013   0.200   0.179   0.122  -0.061  -0.080  -0.129
251   N        -1.111  -1.109  -1.094  -0.961  -0.957  -0.931  -0.977  -0.974  -0.946
252   E         1.664   1.666   1.683   1.647   1.648   1.676   1.772   1.774   1.796
253   I         0.056   0.044   0.013   0.164   0.144   0.100  -0.061  -0.080  -0.129
254   Q         0.056   0.044   0.015   0.121   0.098   0.044  -0.061  -0.080  -0.126
255   I         0.056   0.044   0.015   0.157   0.137   0.094  -0.061  -0.080  -0.126
256   L        -1.111  -1.109  -1.094  -1.203  -1.198  -1.173  -0.977  -0.974  -0.946
257   Q        -1.111  -1.109  -1.094  -1.229  -1.231  -1.199  -0.977  -0.974  -0.946
258   K         0.056   0.044   0.015  -0.338  -0.355  -0.416  -0.061  -0.080  -0.126
259   N         0.056   0.044   0.013   0.047   0.024  -0.030  -0.061  -0.080  -0.129
260   M         0.056   0.086   0.025  -0.074  -0.035  -0.111  -0.061  -0.014  -0.109
261   D        -1.111  -1.109  -1.094  -0.894  -0.895  -0.864  -0.977  -0.974  -0.946
262   I        -1.111  -1.109  -1.094  -1.376  -1.381  -1.346  -0.977  -0.974  -0.946
263   M         0.056   0.086   0.025  -0.074  -0.035  -0.111  -0.061  -0.014  -0.109
264   S        -1.111  -1.109  -1.094  -1.000  -0.992  -0.970  -0.977  -0.974  -0.946
265   K         0.056   0.044   0.015  -0.222  -0.234  -0.282  -0.061  -0.080  -0.126
266   F        -1.111  -1.109  -1.094  -0.860  -0.858  -0.831  -0.977  -0.974  -0.946
267   G        -1.111  -1.109  -1.094  -1.192  -1.200  -1.163  -0.977  -0.974  -0.946
268   L        -1.111  -1.109  -1.094  -1.267  -1.263  -1.237  -0.977  -0.974  -0.946
269   R        -1.111  -1.109  -1.094  -0.908  -0.900  -0.878  -0.977  -0.974  -0.946
270   S         0.056   0.044   0.015   0.095   0.082   0.047  -0.061  -0.080  -0.126
271   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
272   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
273   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
274   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
275   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
276   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
277   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
278   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
279   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
280   E        -1.111  -1.109  -1.094  -1.020  -1.017  -0.990  -0.977  -0.974  -0.946
281   S         0.056   0.044   0.013   0.025   0.006  -0.035  -0.061  -0.080  -0.129
282   Y        -1.111  -1.109  -1.094  -1.015  -1.016  -0.985  -0.977  -0.974  -0.946
283   L         0.056   0.044   0.015  -0.112  -0.134  -0.170  -0.061  -0.080  -0.126
284   T        -1.111  -1.109  -1.094  -0.961  -0.961  -0.931  -0.977  -0.974  -0.946
285   A        -1.111  -1.109  -1.094  -1.015  -1.016  -0.985  -0.977  -0.974  -0.946
286   A        -1.111  -1.109  -1.094  -0.777  -0.772  -0.747  -0.977  -0.974  -0.946
287   N         0.056   0.044   0.015   0.168   0.149   0.111  -0.061  -0.080  -0.126
288   H        -1.111  -1.109  -1.094  -0.695  -0.690  -0.665  -0.977  -0.974  -0.946
289   D        -1.111  -1.109  -1.094  -0.980  -0.984  -0.951  -0.977  -0.974  -0.946
290   T        -1.111  -1.109  -1.094  -0.879  -0.878  -0.850  -0.977  -0.974  -0.946
291   N        -0.087  -0.086  -0.069  -0.371  -0.360  -0.341  -0.290  -0.288  -0.260
292   T        -0.087  -0.086  -0.069  -0.328  -0.317  -0.298  -0.290  -0.288  -0.260
293   Q        -0.087  -0.086  -0.069  -0.153  -0.158  -0.124  -0.290  -0.288  -0.260
294   P        -0.087  -0.086  -0.069   0.029   0.027   0.059  -0.290  -0.288  -0.260
295   N         1.664   1.666   1.683   1.752   1.752   1.782   1.772   1.774   1.796
296   N         1.664   1.666   1.683   1.752   1.752   1.782   1.772   1.774   1.796
297   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
298   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
299   I        -0.087  -0.086  -0.069  -0.371  -0.368  -0.341  -0.290  -0.288  -0.260
300   L        -0.087  -0.086  -0.069  -0.303  -0.300  -0.273  -0.290  -0.288  -0.260
301   P        -0.087  -0.086  -0.069  -0.153  -0.158  -0.124  -0.290  -0.288  -0.260
302   M         0.056   0.044   0.013   0.110   0.083   0.015  -0.061  -0.080  -0.129
303   T         0.056   0.044   0.013   0.254   0.236   0.189  -0.061  -0.080  -0.129
304   Y         0.056   0.044   0.015   0.036   0.009  -0.054  -0.061  -0.080  -0.126
305   L         0.056   0.044   0.013  -0.139  -0.162  -0.203  -0.061  -0.080  -0.129
306   L         0.056   0.044   0.015  -0.074  -0.094  -0.126  -0.061  -0.080  -0.126
307   K        -1.111  -1.109  -1.094  -1.177  -1.160  -1.147  -0.977  -0.974  -0.946
308   K         1.664   1.666   1.683   1.381   1.391   1.410   1.772   1.774   1.796
309   K         0.056   0.044   0.015  -0.170  -0.181  -0.224  -0.061  -0.080  -0.126
310   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
311   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
312   -        -0.087  -0.086  -0.069  -0.167  -0.162  -0.138  -0.290  -0.288  -0.260
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q12219
Output conservation file - output/Q12219
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
