1     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
2     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
10    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
11    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
12    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
13    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
14    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
15    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
16    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
17    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
18    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
19    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
20    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
21    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
22    M        -0.082   0.019  -0.344   0.268   0.407  -0.200  -0.114   0.028  -0.492
23    A        -0.880  -0.816  -0.883  -0.918  -0.798  -0.912  -0.945  -0.847  -0.896
24    -        -1.543  -1.485  -1.318  -1.526  -1.428  -1.197  -1.423  -1.349  -1.139
25    A        -0.930  -0.774  -0.885  -0.947  -0.741  -0.862  -0.980  -0.783  -0.897
26    G        -0.441  -0.333  -0.438  -0.437  -0.258  -0.504  -0.625  -0.471  -0.626
27    V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
28    P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
29    K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
30    I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
31    D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
32    A        -1.462  -1.359  -1.289  -1.551  -1.364  -1.301  -1.349  -1.233  -1.114
33    L        -1.462  -1.452  -1.308  -1.539  -1.565  -1.290  -1.349  -1.324  -1.131
34    E        -1.075  -0.995  -0.935  -1.153  -1.042  -0.955  -1.164  -1.063  -0.954
35    S        -1.319  -1.299  -1.270  -1.265  -1.292  -1.229  -1.206  -1.178  -1.097
36    L        -1.640  -1.662  -1.586  -1.716  -1.801  -1.675  -1.361  -1.366  -1.228
37    G        -1.460  -1.423  -1.298  -1.697  -1.634  -1.390  -1.361  -1.306  -1.123
38    N        -1.351  -1.354  -1.282  -1.233  -1.221  -1.121  -1.257  -1.237  -1.109
39    P        -0.880  -0.796  -0.896  -0.836  -0.764  -0.901  -0.945  -0.866  -0.914
40    L        -0.591  -0.581  -0.492  -0.936  -0.933  -0.795  -0.841  -0.831  -0.701
41    E         1.148   1.174   1.231   1.221   1.267   1.349   1.237   1.273   1.354
42    D        -1.460  -1.389  -1.291  -1.562  -1.462  -1.309  -1.361  -1.277  -1.118
43    A         0.518   0.373   0.276   0.489   0.285   0.135   0.510   0.272   0.069
44    K         1.148   1.174   1.231   1.101   1.156   1.238   1.237   1.273   1.354
45    R        -0.357  -0.408  -0.425  -0.259  -0.306  -0.390  -0.529  -0.577  -0.609
46    A        -1.061  -0.962  -0.920  -1.365  -1.200  -1.121  -1.153  -1.027  -0.938
47    A         1.148   1.174   1.231   1.062   1.097   1.202   1.237   1.273   1.354
48    A         0.518   0.485   0.286   0.524   0.485   0.236   0.510   0.455   0.086
49    Y        -0.357  -0.495  -0.459  -0.108  -0.306  -0.275  -0.529  -0.709  -0.659
50    R        -0.880  -0.820  -0.898  -0.679  -0.588  -0.721  -0.945  -0.870  -0.916
51    A         1.148   1.174   1.231   1.062   1.097   1.202   1.237   1.273   1.354
52    V         1.148   1.174   1.231   1.039   1.079   1.181   1.237   1.273   1.354
53    D        -0.082  -0.229  -0.385   0.053  -0.143  -0.390  -0.114  -0.324  -0.550
54    E         0.518   0.523   0.297   0.664   0.682   0.347   0.510   0.514   0.106
55    N         0.208   0.132   0.162   0.338   0.220   0.241  -0.010  -0.160  -0.148
56    L        -0.662  -0.635  -0.504  -0.801  -0.769  -0.550  -0.945  -0.901  -0.717
57    K        -1.170  -1.116  -1.248  -0.933  -0.874  -1.117  -1.049  -0.992  -1.077
58    F        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
59    D        -1.061  -1.084  -0.936  -1.229  -1.222  -1.005  -1.153  -1.151  -0.956
60    D        -1.351  -1.318  -1.272  -1.304  -1.247  -1.185  -1.257  -1.214  -1.102
61    H        -0.951  -1.030  -0.926  -0.889  -0.984  -0.811  -1.049  -1.101  -0.946
62    K         0.208   0.165   0.164   0.113   0.053   0.039  -0.010  -0.098  -0.143
63    I        -0.357  -0.396  -0.421  -0.501  -0.513  -0.550  -0.529  -0.559  -0.603
64    I         0.042   0.087   0.149  -0.284  -0.198  -0.127  -0.322  -0.247  -0.173
65    G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
66    I         0.042   0.112   0.157  -0.284  -0.142  -0.106  -0.322  -0.198  -0.157
67    G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
68    S         1.148   1.174   1.231   1.196   1.240   1.326   1.237   1.273   1.354
69    G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
70    S         0.518   0.594   0.302   0.641   0.743   0.340   0.510   0.622   0.117
71    T         1.148   1.174   1.231   1.319   1.353   1.440   1.237   1.273   1.354
72    V         1.148   1.174   1.231   1.039   1.079   1.181   1.237   1.273   1.354
73    V         0.042   0.054   0.141  -0.321  -0.307  -0.161  -0.322  -0.312  -0.189
74    Y         0.518   0.373   0.276   0.831   0.647   0.485   0.510   0.272   0.069
75    V         0.518   0.639   0.310   0.447   0.606   0.127   0.510   0.687   0.131
76    A         0.208   0.117   0.154  -0.023  -0.220  -0.177  -0.010  -0.189  -0.163
77    E         0.518   0.373   0.276   0.644   0.448   0.264   0.510   0.272   0.069
78    R        -0.082  -0.229  -0.385   0.157  -0.080  -0.397  -0.114  -0.324  -0.550
79    I         0.208   0.228   0.178   0.070   0.103  -0.033  -0.010   0.016  -0.117
80    G        -0.880  -0.946  -0.917  -1.088  -1.212  -1.154  -0.945  -1.014  -0.937
81    Q        -1.170  -1.270  -1.273  -0.911  -1.091  -1.131  -1.049  -1.147  -1.099
82    Y        -0.481  -0.454  -0.446  -0.615  -0.575  -0.554  -0.737  -0.673  -0.642
83    L        -1.080  -1.088  -0.956  -1.204  -1.257  -0.993  -1.157  -1.156  -0.975
84    H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
85    D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
86    P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
87    K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
88    F        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
89    Y        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
90    E        -1.351  -1.400  -1.281  -1.317  -1.363  -1.198  -1.257  -1.280  -1.109
91    V        -2.040  -1.998  -1.845  -2.066  -2.030  -1.848  -1.568  -1.514  -1.313
92    A        -1.061  -1.001  -0.942  -1.304  -1.201  -1.113  -1.153  -1.089  -0.962
93    S        -1.750  -1.732  -1.588  -1.771  -1.782  -1.539  -1.464  -1.424  -1.230
94    K        -1.351  -1.354  -1.282  -1.344  -1.319  -1.217  -1.257  -1.237  -1.109
95    F        -0.647  -0.815  -0.894  -0.348  -0.593  -0.748  -0.633  -0.836  -0.907
96    I        -0.481  -0.523  -0.444  -0.757  -0.774  -0.635  -0.737  -0.753  -0.639
97    C         0.042   0.026   0.133   0.105   0.043   0.200  -0.322  -0.367  -0.204
98    I        -0.082  -0.183  -0.377   0.008  -0.118  -0.443  -0.114  -0.264  -0.538
99    P         0.518   0.523   0.297   0.724   0.733   0.378   0.510   0.514   0.106
100   T         1.148   1.174   1.231   1.319   1.353   1.440   1.237   1.273   1.354
101   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
102   F        -0.082  -0.157  -0.372   0.190   0.066  -0.257  -0.114  -0.232  -0.531
103   Q         1.148   1.174   1.231   1.305   1.348   1.427   1.237   1.273   1.354
104   S         1.148   1.174   1.231   1.196   1.240   1.326   1.237   1.273   1.354
105   R         0.042   0.058   0.142  -0.160  -0.126   0.008  -0.322  -0.303  -0.187
106   N        -0.357  -0.396  -0.421  -0.238  -0.282  -0.364  -0.529  -0.559  -0.603
107   L         1.148   1.174   1.231   1.088   1.123   1.226   1.237   1.273   1.354
108   I         1.148   1.174   1.231   1.141   1.190   1.275   1.237   1.273   1.354
109   L        -1.061  -0.992  -0.919  -1.218  -1.069  -1.009  -1.153  -1.049  -0.936
110   D        -0.880  -0.950  -0.920  -0.889  -1.013  -0.965  -0.945  -1.019  -0.939
111   N         0.042   0.035   0.135  -0.123  -0.171  -0.029  -0.322  -0.348  -0.201
112   K         0.208   0.317   0.219  -0.028   0.148  -0.032  -0.010   0.174  -0.038
113   L         0.518   0.373   0.276   0.531   0.336   0.198   0.510   0.272   0.069
114   Q        -0.357  -0.208  -0.405  -0.215   0.013  -0.321  -0.529  -0.311  -0.582
115   L         1.148   1.174   1.231   1.088   1.123   1.226   1.237   1.273   1.354
116   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
117   S        -1.750  -1.758  -1.597  -1.561  -1.548  -1.339  -1.464  -1.443  -1.236
118   I        -0.082  -0.261  -0.395   0.003  -0.259  -0.485  -0.114  -0.368  -0.564
119   E        -0.357  -0.495  -0.459  -0.364  -0.580  -0.558  -0.529  -0.709  -0.659
120   Q        -0.082  -0.261  -0.395   0.199  -0.055  -0.275  -0.114  -0.368  -0.564
121   Y        -0.647  -0.668  -0.857  -0.279  -0.350  -0.628  -0.633  -0.667  -0.864
122   P         0.208   0.132   0.162   0.256   0.104   0.113  -0.010  -0.160  -0.148
123   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
124   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
125   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
126   R        -1.750  -1.720  -1.586  -1.603  -1.598  -1.345  -1.464  -1.418  -1.229
127   I        -0.591  -0.551  -0.483  -0.958  -0.916  -0.796  -0.841  -0.791  -0.689
128   D         1.148   1.174   1.231   1.166   1.213   1.298   1.237   1.273   1.354
129   I         0.042   0.026   0.133  -0.284  -0.347  -0.170  -0.322  -0.367  -0.204
130   A        -0.082  -0.261  -0.395  -0.035  -0.275  -0.456  -0.114  -0.368  -0.564
131   F         1.148   1.174   1.231   1.305   1.346   1.427   1.237   1.273   1.354
132   D         1.148   1.174   1.231   1.166   1.213   1.298   1.237   1.273   1.354
133   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
134   A         1.148   1.174   1.231   1.062   1.097   1.202   1.237   1.273   1.354
135   D         1.148   1.174   1.231   1.166   1.213   1.298   1.237   1.273   1.354
136   E         1.148   1.174   1.231   1.221   1.267   1.349   1.237   1.273   1.354
137   V         0.518   0.523   0.297   0.485   0.496   0.193   0.510   0.514   0.106
138   D         1.148   1.174   1.231   1.166   1.213   1.298   1.237   1.273   1.354
139   E        -1.640  -1.505  -1.555  -1.366  -1.179  -1.278  -1.361  -1.219  -1.204
140   N        -1.351  -1.344  -1.279  -1.263  -1.278  -1.212  -1.257  -1.233  -1.107
141   L         1.148   1.174   1.231   1.088   1.123   1.226   1.237   1.273   1.354
142   Q        -0.011   0.026   0.135  -0.104  -0.036   0.124  -0.425  -0.367  -0.201
143   L         0.208   0.191   0.174   0.131   0.100   0.092  -0.010  -0.050  -0.124
144   I         1.148   1.174   1.231   1.141   1.190   1.275   1.237   1.273   1.354
145   K         1.148   1.174   1.231   1.101   1.156   1.238   1.237   1.273   1.354
146   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
147   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
148   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
149   A         1.148   1.174   1.231   1.062   1.097   1.202   1.237   1.273   1.354
150   C         1.148   1.174   1.231   1.427   1.464   1.540   1.237   1.273   1.354
151   L         1.148   1.174   1.231   1.088   1.123   1.226   1.237   1.273   1.354
152   F         0.518   0.373   0.276   0.717   0.506   0.310   0.510   0.272   0.069
153   Q         1.148   1.174   1.231   1.305   1.348   1.427   1.237   1.273   1.354
154   E         1.148   1.174   1.231   1.221   1.267   1.349   1.237   1.273   1.354
155   K         1.148   1.174   1.231   1.101   1.156   1.238   1.237   1.273   1.354
156   L         0.518   0.523   0.297   0.507   0.514   0.173   0.510   0.514   0.106
157   V         0.518   0.485   0.286   0.458   0.419   0.111   0.510   0.455   0.086
158   S         0.042   0.132   0.172  -0.270  -0.117  -0.055  -0.322  -0.161  -0.129
159   T        -0.880  -0.860  -0.897  -0.801  -0.749  -0.839  -0.945  -0.896  -0.912
160   S        -0.880  -0.946  -0.917  -0.914  -1.054  -0.982  -0.945  -1.014  -0.937
161   A         1.148   1.174   1.231   1.062   1.097   1.202   1.237   1.273   1.354
162   K        -0.357  -0.386  -0.445  -0.412  -0.460  -0.529  -0.529  -0.594  -0.641
163   T        -0.647  -0.545  -0.844  -0.546  -0.395  -0.823  -0.633  -0.505  -0.850
164   F         0.518   0.485   0.286   0.717   0.675   0.328   0.510   0.455   0.086
165   I         0.042   0.132   0.172  -0.321  -0.156  -0.103  -0.322  -0.161  -0.129
166   V        -0.357  -0.476  -0.451  -0.501  -0.651  -0.601  -0.529  -0.680  -0.648
167   V         1.148   1.174   1.231   1.039   1.079   1.181   1.237   1.273   1.354
168   A         1.148   1.174   1.231   1.062   1.097   1.202   1.237   1.273   1.354
169   D         1.148   1.174   1.231   1.166   1.213   1.298   1.237   1.273   1.354
170   S        -0.357  -0.270  -0.412  -0.289  -0.158  -0.356  -0.529  -0.401  -0.593
171   R         1.148   1.174   1.231   1.336   1.373   1.456   1.237   1.273   1.354
172   K         1.148   1.174   1.231   1.101   1.156   1.238   1.237   1.273   1.354
173   K        -1.170  -1.282  -1.274  -1.043  -1.206  -1.169  -1.049  -1.158  -1.100
174   S         1.148   1.174   1.231   1.196   1.240   1.326   1.237   1.273   1.354
175   P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
176   K        -1.640  -1.620  -1.571  -1.473  -1.421  -1.344  -1.361  -1.332  -1.216
177   H        -1.750  -1.690  -1.580  -1.623  -1.523  -1.372  -1.464  -1.391  -1.224
178   L         1.148   1.174   1.231   1.088   1.123   1.226   1.237   1.273   1.354
179   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
180   K        -1.351  -1.216  -1.259  -1.260  -1.047  -1.138  -1.257  -1.109  -1.089
181   N        -1.351  -1.325  -1.283  -1.188  -1.153  -1.112  -1.257  -1.222  -1.110
182   W         1.148   1.174   1.231   1.465   1.505   1.575   1.237   1.273   1.354
183   R        -0.481  -0.423  -0.432  -0.620  -0.516  -0.529  -0.737  -0.633  -0.624
184   Q        -0.481  -0.375  -0.431  -0.599  -0.440  -0.478  -0.737  -0.588  -0.625
185   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
186   V         0.208   0.132   0.162  -0.012  -0.156  -0.122  -0.010  -0.160  -0.148
187   P         1.148   1.174   1.231   1.297   1.335   1.420   1.237   1.273   1.354
188   I         1.148   1.174   1.231   1.141   1.190   1.275   1.237   1.273   1.354
189   E         1.148   1.174   1.231   1.221   1.267   1.349   1.237   1.273   1.354
190   I        -0.011   0.041   0.146  -0.418  -0.332  -0.152  -0.425  -0.337  -0.180
191   V        -0.082  -0.261  -0.395  -0.038  -0.276  -0.431  -0.114  -0.368  -0.564
192   P         1.148   1.174   1.231   1.297   1.335   1.420   1.237   1.273   1.354
193   S        -1.351  -1.283  -1.283  -1.131  -1.028  -0.998  -1.257  -1.187  -1.111
194   S         0.042   0.145   0.175  -0.270  -0.094  -0.048  -0.322  -0.137  -0.123
195   Y        -0.082  -0.157  -0.372   0.252   0.113  -0.211  -0.114  -0.232  -0.531
196   V        -1.460  -1.465  -1.298  -1.632  -1.608  -1.339  -1.361  -1.335  -1.123
197   R        -0.951  -1.030  -0.926  -0.967  -1.056  -0.903  -1.049  -1.101  -0.946
198   V         0.208   0.250   0.186  -0.012   0.057  -0.075  -0.010   0.058  -0.101
199   K        -1.351  -1.189  -1.254  -1.461  -1.219  -1.297  -1.257  -1.082  -1.084
200   N        -2.329  -2.245  -2.062  -2.118  -2.064  -1.746  -1.672  -1.590  -1.372
201   D        -0.357  -0.420  -0.444  -0.374  -0.466  -0.505  -0.529  -0.616  -0.641
202   L         1.148   1.174   1.231   1.088   1.123   1.226   1.237   1.273   1.354
203   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
204   E        -1.351  -1.270  -1.261  -1.386  -1.255  -1.256  -1.257  -1.160  -1.091
205   Q        -1.640  -1.624  -1.570  -1.580  -1.540  -1.477  -1.361  -1.334  -1.216
206   L         0.208   0.240   0.188   0.133   0.174   0.114  -0.010   0.039  -0.098
207   H        -0.357  -0.211  -0.401  -0.415  -0.218  -0.439  -0.529  -0.313  -0.576
208   A        -0.082  -0.166  -0.374  -0.011  -0.136  -0.374  -0.114  -0.243  -0.534
209   E        -1.640  -1.650  -1.580  -1.581  -1.623  -1.491  -1.361  -1.356  -1.223
210   K        -0.880  -0.777  -0.882  -0.895  -0.720  -0.890  -0.945  -0.808  -0.896
211   V        -0.481  -0.451  -0.439  -0.807  -0.729  -0.676  -0.737  -0.667  -0.633
212   D        -2.040  -2.016  -1.842  -1.873  -1.842  -1.586  -1.568  -1.525  -1.311
213   I        -0.481  -0.397  -0.449  -0.820  -0.722  -0.745  -0.737  -0.643  -0.651
214   R         1.148   1.174   1.231   1.336   1.373   1.456   1.237   1.273   1.354
215   Q        -0.647  -0.815  -0.894  -0.324  -0.574  -0.700  -0.633  -0.836  -0.907
216   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
217   G        -0.647  -0.815  -0.894  -0.703  -0.996  -1.131  -0.633  -0.836  -0.907
218   S        -0.481  -0.399  -0.453  -0.575  -0.462  -0.520  -0.737  -0.650  -0.655
219   A         0.042   0.026   0.133  -0.357  -0.430  -0.228  -0.322  -0.367  -0.204
220   K         1.148   1.174   1.231   1.101   1.156   1.238   1.237   1.273   1.354
221   A         1.148   1.174   1.231   1.062   1.097   1.202   1.237   1.273   1.354
222   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
223   P         0.518   0.373   0.276   0.706   0.489   0.294   0.510   0.272   0.069
224   V        -0.357  -0.434  -0.432  -0.501  -0.577  -0.572  -0.529  -0.616  -0.621
225   V         0.208   0.274   0.204  -0.012   0.098  -0.041  -0.010   0.101  -0.067
226   T         1.148   1.174   1.231   1.319   1.353   1.440   1.237   1.273   1.354
227   D         1.148   1.174   1.231   1.166   1.213   1.298   1.237   1.273   1.354
228   N         1.148   1.174   1.231   1.307   1.357   1.429   1.237   1.273   1.354
229   N        -0.951  -0.830  -0.904  -0.945  -0.822  -0.807  -1.049  -0.903  -0.923
230   N         0.518   0.373   0.276   0.719   0.517   0.312   0.510   0.272   0.069
231   F         0.518   0.373   0.276   0.751   0.561   0.396   0.510   0.272   0.069
232   I         0.042   0.127   0.166  -0.258  -0.091  -0.060  -0.322  -0.170  -0.140
233   I        -0.357  -0.336  -0.437  -0.509  -0.533  -0.688  -0.529  -0.538  -0.630
234   D         1.148   1.174   1.231   1.166   1.213   1.298   1.237   1.273   1.354
235   A         1.148   1.174   1.231   1.062   1.097   1.202   1.237   1.273   1.354
236   D        -0.647  -0.815  -0.894  -0.473  -0.729  -0.829  -0.633  -0.836  -0.907
237   F         1.148   1.174   1.231   1.305   1.346   1.427   1.237   1.273   1.354
238   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
239   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
240   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
241   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
242   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
243   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
244   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
245   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
246   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
247   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
248   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
249   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
250   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
251   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
252   E         0.518   0.485   0.286   0.633   0.596   0.254   0.510   0.455   0.086
253   I         0.518   0.373   0.276   0.572   0.384   0.213   0.510   0.272   0.069
254   S        -1.750  -1.722  -1.586  -1.669  -1.674  -1.450  -1.464  -1.419  -1.228
255   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
256   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
257   D        -0.880  -0.967  -0.913  -0.861  -0.974  -0.908  -0.945  -1.025  -0.932
258   P         0.042   0.044   0.138  -0.143  -0.175  -0.038  -0.322  -0.331  -0.195
259   R        -1.351  -1.301  -1.268  -1.433  -1.360  -1.339  -1.257  -1.191  -1.096
260   K        -1.170  -1.263  -1.271  -1.194  -1.367  -1.415  -1.049  -1.141  -1.098
261   L         1.148   1.174   1.231   1.088   1.123   1.226   1.237   1.273   1.354
262   H        -0.082  -0.261  -0.395   0.280   0.001  -0.262  -0.114  -0.368  -0.564
263   R        -1.750  -1.698  -1.577  -1.592  -1.522  -1.351  -1.464  -1.396  -1.222
264   E        -1.460  -1.424  -1.297  -1.479  -1.413  -1.217  -1.361  -1.307  -1.122
265   I         0.518   0.373   0.276   0.553   0.351   0.165   0.510   0.272   0.069
266   K         0.518   0.373   0.276   0.520   0.332   0.148   0.510   0.272   0.069
267   L        -0.647  -0.684  -0.859  -0.526  -0.602  -0.795  -0.633  -0.684  -0.867
268   L         0.518   0.373   0.276   0.507   0.300   0.137   0.510   0.272   0.069
269   V        -0.082  -0.229  -0.385  -0.100  -0.307  -0.553  -0.114  -0.324  -0.550
270   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
271   V         1.148   1.174   1.231   1.039   1.079   1.181   1.237   1.273   1.354
272   V         0.518   0.373   0.276   0.447   0.234   0.064   0.510   0.272   0.069
273   E         1.148   1.174   1.231   1.221   1.267   1.349   1.237   1.273   1.354
274   T        -0.082  -0.261  -0.395   0.193  -0.063  -0.309  -0.114  -0.368  -0.564
275   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
276   L         1.148   1.174   1.231   1.088   1.123   1.226   1.237   1.273   1.354
277   F         1.148   1.174   1.231   1.305   1.346   1.427   1.237   1.273   1.354
278   I        -1.351  -1.399  -1.292  -1.249  -1.282  -1.125  -1.257  -1.279  -1.118
279   D        -0.880  -0.919  -0.908  -0.870  -0.945  -0.916  -0.945  -0.973  -0.925
280   N        -0.531  -0.593  -0.475  -0.475  -0.564  -0.408  -0.799  -0.849  -0.680
281   A        -0.082  -0.261  -0.395  -0.085  -0.351  -0.570  -0.114  -0.368  -0.564
282   S        -2.040  -1.969  -1.834  -1.802  -1.763  -1.511  -1.568  -1.494  -1.306
283   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
284   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
285   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
286   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
287   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
288   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
289   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
290   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
291   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
292   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
293   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
294   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
295   K        -0.880  -0.885  -0.915  -1.036  -1.096  -1.098  -0.945  -0.962  -0.935
296   A        -0.082  -0.082  -0.364  -0.081  -0.092  -0.509  -0.114  -0.113  -0.520
297   Y         1.148   1.174   1.231   1.372   1.414   1.489   1.237   1.273   1.354
298   F         1.148   1.174   1.231   1.305   1.346   1.427   1.237   1.273   1.354
299   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
300   N        -1.750  -1.734  -1.587  -1.524  -1.467  -1.283  -1.464  -1.427  -1.229
301   S        -1.351  -1.283  -1.272  -1.328  -1.230  -1.245  -1.257  -1.170  -1.100
302   D         0.518   0.575   0.301   0.593   0.679   0.270   0.510   0.593   0.115
303   G         1.148   1.174   1.231   1.037   1.069   1.178   1.237   1.273   1.354
304   S        -0.082  -0.047  -0.350   0.083   0.136  -0.310  -0.114  -0.064  -0.501
305   V         0.518   0.523   0.297   0.458   0.470   0.130   0.510   0.514   0.106
306   E        -1.750  -1.743  -1.592  -1.620  -1.564  -1.378  -1.464  -1.432  -1.233
307   V        -0.647  -0.570  -0.837  -0.598  -0.495  -0.847  -0.633  -0.532  -0.842
308   T        -1.460  -1.395  -1.290  -1.321  -1.242  -1.092  -1.361  -1.282  -1.117
309   E        -1.460  -1.394  -1.297  -1.468  -1.349  -1.231  -1.361  -1.277  -1.123
310   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
311   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
312   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
313   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
314   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
315   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
316   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
317   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
318   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
319   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
320   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
321   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
322   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
323   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
324   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
325   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
326   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
327   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
328   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
329   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
330   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
331   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
332   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
333   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
334   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
335   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
336   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
337   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
338   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
339   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
340   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
341   K        -0.647  -0.761  -0.878  -0.615  -0.794  -1.005  -0.633  -0.775  -0.889
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q12189
Output conservation file - output/Q12189
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
