1     M         1.045   1.057   1.094   1.154   1.170   1.223   1.106   1.123   1.180
2     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     D         0.319   0.248  -0.014   0.385   0.302  -0.115   0.338   0.234  -0.208
10    L        -1.292  -1.406  -1.326  -1.453  -1.599  -1.447  -1.198  -1.303  -1.187
11    T        -1.040  -0.956  -0.834  -1.251  -1.110  -0.944  -1.198  -1.087  -0.930
12    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
13    V        -1.374  -1.433  -1.329  -1.478  -1.543  -1.340  -1.307  -1.338  -1.189
14    E        -0.372  -0.518  -0.753  -0.227  -0.413  -0.749  -0.320  -0.507  -0.827
15    P         0.319   0.248  -0.014   0.536   0.441   0.024   0.338   0.234  -0.208
16    N        -1.500  -1.386  -1.323  -1.523  -1.361  -1.280  -1.417  -1.295  -1.184
17    L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
18    H        -1.833  -1.674  -1.723  -1.670  -1.488  -1.485  -1.527  -1.395  -1.353
19    S        -0.689  -0.709  -0.794  -0.711  -0.758  -0.875  -0.759  -0.808  -0.883
20    L        -0.230  -0.239  -0.131  -0.637  -0.645  -0.442  -0.540  -0.565  -0.414
21    I        -0.689  -0.702  -0.795  -0.727  -0.807  -0.940  -0.759  -0.801  -0.883
22    T        -1.833  -1.812  -1.740  -1.731  -1.725  -1.628  -1.527  -1.501  -1.366
23    S        -0.832  -0.707  -0.789  -0.877  -0.677  -0.733  -0.978  -0.809  -0.874
24    T        -1.500  -1.478  -1.335  -1.537  -1.471  -1.260  -1.417  -1.374  -1.195
25    T        -0.290  -0.242  -0.124  -0.568  -0.492  -0.299  -0.649  -0.569  -0.402
26    H        -0.230  -0.123  -0.087  -0.517  -0.362  -0.276  -0.540  -0.359  -0.336
27    K        -0.230  -0.238  -0.132  -0.353  -0.360  -0.190  -0.540  -0.562  -0.416
28    W         1.045   1.057   1.094   1.346   1.359   1.394   1.106   1.123   1.180
29    I         1.045   1.057   1.094   1.076   1.093   1.153   1.106   1.123   1.180
30    F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
31    V         1.045   1.057   1.094   1.092   1.104   1.167   1.106   1.123   1.180
32    G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
33    G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
34    K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
35    G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
36    G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
37    V         1.045   1.057   1.094   1.092   1.104   1.167   1.106   1.123   1.180
38    G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
39    K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
40    T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
41    T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
42    S        -0.230  -0.123  -0.087  -0.430  -0.234  -0.208  -0.540  -0.359  -0.336
43    S         1.045   1.057   1.094   0.982   0.999   1.070   1.106   1.123   1.180
44    C        -0.038   0.035  -0.064   0.116   0.231  -0.004  -0.210  -0.096  -0.296
45    S         1.045   1.057   1.094   0.982   0.999   1.070   1.106   1.123   1.180
46    I        -0.832  -0.783  -0.815  -1.058  -1.041  -1.008  -0.978  -0.929  -0.910
47    A         1.045   1.057   1.094   1.111   1.124   1.185   1.106   1.123   1.180
48    I        -0.038   0.035  -0.064  -0.041   0.070  -0.113  -0.210  -0.096  -0.296
49    Q         1.045   1.057   1.094   1.099   1.110   1.174   1.106   1.123   1.180
50    M        -0.290  -0.257  -0.132  -0.650  -0.610  -0.389  -0.649  -0.597  -0.416
51    A         1.045   1.057   1.094   1.129   1.148   1.201   1.106   1.123   1.180
52    L         1.045   1.057   1.094   0.770   0.791   0.881   1.106   1.123   1.180
53    S        -0.689  -0.631  -0.782  -0.620  -0.547  -0.795  -0.759  -0.688  -0.869
54    Q        -0.832  -0.789  -0.816  -0.860  -0.827  -0.779  -0.978  -0.934  -0.911
55    P        -0.689  -0.816  -0.815  -0.527  -0.734  -0.749  -0.759  -0.923  -0.909
56    N        -1.374  -1.218  -1.320  -1.147  -0.939  -1.062  -1.307  -1.150  -1.181
57    K        -1.833  -1.874  -1.734  -1.765  -1.814  -1.614  -1.527  -1.546  -1.362
58    Q        -1.374  -1.228  -1.320  -1.412  -1.224  -1.331  -1.307  -1.157  -1.181
59    F        -0.832  -0.777  -0.815  -0.803  -0.756  -0.730  -0.978  -0.923  -0.910
60    L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
61    L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
62    I         1.045   1.057   1.094   1.076   1.093   1.153   1.106   1.123   1.180
63    S         1.045   1.057   1.094   0.982   0.999   1.070   1.106   1.123   1.180
64    T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
65    D         1.045   1.057   1.094   1.018   1.042   1.102   1.106   1.123   1.180
66    P         1.045   1.057   1.094   1.162   1.173   1.230   1.106   1.123   1.180
67    A         1.045   1.057   1.094   1.111   1.124   1.185   1.106   1.123   1.180
68    H         1.045   1.057   1.094   1.287   1.302   1.342   1.106   1.123   1.180
69    N         1.045   1.057   1.094   1.125   1.147   1.197   1.106   1.123   1.180
70    L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
71    S         1.045   1.057   1.094   0.982   0.999   1.070   1.106   1.123   1.180
72    D         1.045   1.057   1.094   1.018   1.042   1.102   1.106   1.123   1.180
73    A         1.045   1.057   1.094   1.111   1.124   1.185   1.106   1.123   1.180
74    F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
75    G        -0.689  -0.703  -0.781  -0.605  -0.620  -0.751  -0.759  -0.758  -0.864
76    E        -0.832  -0.813  -0.800  -0.921  -0.853  -0.835  -0.978  -0.922  -0.888
77    K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
78    F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
79    G         0.319   0.441   0.002   0.404   0.551  -0.061   0.338   0.505  -0.181
80    K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
81    D         0.319   0.235  -0.014   0.385   0.286  -0.114   0.338   0.216  -0.207
82    A         1.045   1.057   1.094   1.111   1.124   1.185   1.106   1.123   1.180
83    R         1.045   1.057   1.094   1.236   1.246   1.296   1.106   1.123   1.180
84    K        -0.372  -0.529  -0.756  -0.253  -0.462  -0.859  -0.320  -0.521  -0.830
85    V         0.319   0.235  -0.014   0.472   0.364  -0.017   0.338   0.216  -0.207
86    T        -1.833  -1.919  -1.747  -1.691  -1.798  -1.562  -1.527  -1.577  -1.371
87    G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
88    M        -1.500  -1.515  -1.349  -1.550  -1.561  -1.341  -1.417  -1.414  -1.208
89    N        -1.292  -1.129  -1.289  -1.200  -0.957  -1.196  -1.198  -1.006  -1.148
90    N         1.045   1.057   1.094   1.125   1.147   1.197   1.106   1.123   1.180
91    L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
92    S         0.319   0.238  -0.015   0.394   0.303  -0.026   0.338   0.220  -0.210
93    C        -0.038  -0.116  -0.105   0.155   0.013  -0.029  -0.210  -0.348  -0.367
94    M         1.045   1.057   1.094   1.154   1.170   1.223   1.106   1.123   1.180
95    E         1.045   1.057   1.094   0.982   1.001   1.070   1.106   1.123   1.180
96    I         1.045   1.057   1.094   1.076   1.093   1.153   1.106   1.123   1.180
97    D         1.045   1.057   1.094   1.018   1.042   1.102   1.106   1.123   1.180
98    P         1.045   1.057   1.094   1.162   1.173   1.230   1.106   1.123   1.180
99    S        -0.958  -0.952  -0.832  -1.123  -1.109  -0.936  -1.088  -1.082  -0.928
100   A        -0.689  -0.812  -0.815  -0.659  -0.882  -0.948  -0.759  -0.920  -0.908
101   A        -0.230  -0.257  -0.133  -0.399  -0.481  -0.284  -0.540  -0.596  -0.417
102   L        -1.040  -0.956  -0.834  -1.328  -1.152  -0.968  -1.198  -1.087  -0.930
103   K        -1.040  -0.956  -0.834  -1.240  -1.086  -0.924  -1.198  -1.087  -0.930
104   D        -0.038  -0.115  -0.104  -0.132  -0.265  -0.286  -0.210  -0.345  -0.366
105   M        -0.230  -0.210  -0.124  -0.460  -0.435  -0.341  -0.540  -0.513  -0.402
106   N        -1.833  -1.919  -1.747  -1.685  -1.831  -1.632  -1.527  -1.577  -1.371
107   D        -1.500  -1.516  -1.349  -1.557  -1.579  -1.323  -1.417  -1.415  -1.207
108   M        -0.832  -0.822  -0.798  -0.825  -0.791  -0.764  -0.978  -0.932  -0.885
109   A         0.319   0.235  -0.014   0.495   0.387   0.008   0.338   0.216  -0.207
110   V        -1.833  -1.870  -1.734  -1.689  -1.759  -1.589  -1.527  -1.544  -1.362
111   S        -1.374  -1.356  -1.318  -1.387  -1.367  -1.286  -1.307  -1.277  -1.180
112   R        -2.293  -2.225  -2.056  -1.867  -1.794  -1.592  -1.746  -1.681  -1.470
113   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
114   N        -0.230  -0.230  -0.130  -0.360  -0.373  -0.237  -0.540  -0.549  -0.413
115   N        -1.374  -1.313  -1.310  -1.264  -1.174  -1.166  -1.307  -1.237  -1.172
116   N        -1.500  -1.438  -1.338  -1.500  -1.424  -1.271  -1.417  -1.354  -1.197
117   G        -0.903  -1.013  -0.843  -0.964  -1.141  -0.883  -1.039  -1.157  -0.942
118   S        -0.903  -0.992  -0.829  -0.943  -1.040  -0.828  -1.039  -1.130  -0.924
119   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
120   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
121   Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
122   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
123   D        -1.292  -1.397  -1.323  -1.221  -1.361  -1.256  -1.198  -1.295  -1.184
124   D        -1.500  -1.410  -1.334  -1.495  -1.374  -1.277  -1.417  -1.325  -1.194
125   L        -1.023  -1.107  -1.287  -1.010  -1.118  -1.321  -0.869  -0.964  -1.145
126   G        -1.500  -1.501  -1.333  -1.603  -1.594  -1.351  -1.417  -1.399  -1.193
127   S        -1.374  -1.348  -1.311  -1.424  -1.370  -1.294  -1.307  -1.266  -1.173
128   L        -0.832  -0.715  -0.787  -0.993  -0.759  -0.863  -0.978  -0.817  -0.873
129   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
130   Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
131   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
132   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
133   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
134   L        -0.230  -0.123  -0.087  -0.460  -0.236  -0.239  -0.540  -0.359  -0.336
135   A        -1.500  -1.347  -1.331  -1.485  -1.247  -1.241  -1.417  -1.244  -1.191
136   D         0.319   0.396  -0.003   0.385   0.488  -0.095   0.338   0.443  -0.189
137   L        -0.689  -0.700  -0.784  -0.867  -0.862  -0.952  -0.759  -0.755  -0.867
138   T        -0.230  -0.257  -0.133  -0.362  -0.423  -0.226  -0.540  -0.596  -0.417
139   G        -0.230  -0.257  -0.133  -0.398  -0.454  -0.252  -0.540  -0.596  -0.417
140   S        -0.372  -0.521  -0.756  -0.242  -0.436  -0.787  -0.320  -0.510  -0.830
141   I         1.045   1.057   1.094   1.076   1.093   1.153   1.106   1.123   1.180
142   P         1.045   1.057   1.094   1.162   1.173   1.230   1.106   1.123   1.180
143   G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
144   I         0.319   0.238  -0.015   0.458   0.359  -0.026   0.338   0.220  -0.210
145   D         1.045   1.057   1.094   1.018   1.042   1.102   1.106   1.123   1.180
146   E         1.045   1.057   1.094   0.982   1.001   1.070   1.106   1.123   1.180
147   A         1.045   1.057   1.094   1.111   1.124   1.185   1.106   1.123   1.180
148   L        -0.038  -0.121  -0.103  -0.300  -0.420  -0.366  -0.210  -0.356  -0.363
149   S         0.319   0.248  -0.014   0.367   0.282  -0.094   0.338   0.234  -0.208
150   F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
151   M        -0.230  -0.257  -0.133  -0.293  -0.362  -0.174  -0.540  -0.596  -0.417
152   E         1.045   1.057   1.094   0.982   1.001   1.070   1.106   1.123   1.180
153   V         0.319   0.248  -0.014   0.472   0.380  -0.018   0.338   0.234  -0.208
154   M        -0.230  -0.123  -0.087  -0.593  -0.423  -0.346  -0.540  -0.359  -0.336
155   K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
156   H        -0.230  -0.257  -0.133  -0.184  -0.269  -0.095  -0.540  -0.596  -0.417
157   I        -0.038  -0.121  -0.103  -0.041  -0.185  -0.183  -0.210  -0.356  -0.363
158   K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
159   R        -1.374  -1.198  -1.320  -1.331  -1.121  -1.217  -1.307  -1.135  -1.181
160   Q        -1.023  -1.220  -1.312  -0.767  -1.068  -1.276  -0.869  -1.086  -1.171
161   E        -0.252  -0.255  -0.132  -0.559  -0.579  -0.371  -0.579  -0.592  -0.416
162   Q        -0.252  -0.255  -0.132  -0.377  -0.398  -0.204  -0.579  -0.592  -0.416
163   G        -0.786  -0.855  -0.841  -0.867  -0.990  -1.039  -0.860  -0.950  -0.939
164   E         0.081   0.181  -0.088   0.025   0.169  -0.276  -0.017   0.134  -0.337
165   G         0.081   0.029  -0.094   0.072  -0.006  -0.252  -0.017  -0.104  -0.348
166   E        -0.252  -0.243  -0.132  -0.550  -0.544  -0.362  -0.579  -0.572  -0.417
167   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
168   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
169   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
170   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
171   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
172   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
173   T        -1.023  -0.938  -1.266  -0.829  -0.733  -1.179  -0.869  -0.776  -1.123
174   F        -0.230  -0.177  -0.116  -0.196  -0.109  -0.058  -0.540  -0.455  -0.387
175   D        -1.626  -1.664  -1.712  -1.400  -1.473  -1.571  -1.307  -1.341  -1.343
176   T        -0.372  -0.518  -0.753  -0.118  -0.304  -0.643  -0.320  -0.507  -0.827
177   V        -0.290  -0.257  -0.132  -0.488  -0.437  -0.237  -0.649  -0.597  -0.416
178   I         1.045   1.057   1.094   1.076   1.093   1.153   1.106   1.123   1.180
179   F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
180   D         1.045   1.057   1.094   1.018   1.042   1.102   1.106   1.123   1.180
181   T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
182   A         1.045   1.057   1.094   1.111   1.124   1.185   1.106   1.123   1.180
183   P         1.045   1.057   1.094   1.162   1.173   1.230   1.106   1.123   1.180
184   T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
185   G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
186   H         1.045   1.057   1.094   1.287   1.302   1.342   1.106   1.123   1.180
187   T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
188   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
189   R         1.045   1.057   1.094   1.236   1.246   1.296   1.106   1.123   1.180
190   F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
191   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
192   Q        -0.372  -0.518  -0.753  -0.123  -0.319  -0.689  -0.320  -0.507  -0.827
193   L        -0.230  -0.257  -0.133  -0.615  -0.638  -0.413  -0.540  -0.596  -0.417
194   P         1.045   1.057   1.094   1.162   1.173   1.230   1.106   1.123   1.180
195   N        -0.832  -0.744  -0.795  -0.950  -0.848  -0.848  -0.978  -0.890  -0.889
196   T        -0.230  -0.257  -0.133  -0.372  -0.437  -0.238  -0.540  -0.596  -0.417
197   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
198   S        -0.832  -0.715  -0.787  -1.015  -0.821  -0.889  -0.978  -0.817  -0.873
199   K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
200   L        -0.230  -0.257  -0.133  -0.617  -0.642  -0.416  -0.540  -0.596  -0.417
201   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
202   E        -1.833  -1.717  -1.712  -1.783  -1.596  -1.614  -1.527  -1.406  -1.343
203   K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
204   F        -1.023  -1.220  -1.312  -0.764  -1.065  -1.292  -0.869  -1.086  -1.171
205   G        -1.374  -1.282  -1.306  -1.433  -1.314  -1.304  -1.307  -1.212  -1.169
206   E        -1.292  -1.306  -1.316  -1.266  -1.296  -1.304  -1.198  -1.211  -1.177
207   I        -0.230  -0.123  -0.087  -0.637  -0.458  -0.387  -0.540  -0.359  -0.336
208   T        -0.230  -0.123  -0.087  -0.464  -0.281  -0.235  -0.540  -0.359  -0.336
209   N        -1.292  -1.207  -1.307  -1.231  -1.165  -1.248  -1.198  -1.131  -1.168
210   K        -0.832  -0.840  -0.800  -0.787  -0.762  -0.728  -0.978  -0.959  -0.891
211   L        -0.689  -0.817  -0.815  -0.844  -1.004  -0.921  -0.759  -0.924  -0.909
212   G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
213   P         1.045   1.057   1.094   1.162   1.173   1.230   1.106   1.123   1.180
214   M         0.319   0.235  -0.014   0.495   0.380  -0.073   0.338   0.216  -0.207
215   L        -0.372  -0.394  -0.737  -0.430  -0.453  -0.894  -0.320  -0.351  -0.806
216   N        -0.689  -0.700  -0.784  -0.619  -0.613  -0.801  -0.759  -0.755  -0.867
217   S        -1.292  -1.357  -1.318  -1.222  -1.306  -1.252  -1.198  -1.245  -1.177
218   F        -1.040  -1.007  -0.847  -1.290  -1.242  -0.982  -1.198  -1.152  -0.946
219   M        -1.374  -1.356  -1.318  -1.356  -1.351  -1.296  -1.307  -1.277  -1.180
220   G         0.319   0.248  -0.014   0.399   0.307  -0.103   0.338   0.234  -0.208
221   A        -1.500  -1.475  -1.334  -1.550  -1.509  -1.307  -1.417  -1.372  -1.194
222   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
223   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
224   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
225   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
226   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
227   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
228   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
229   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
230   G        -1.374  -1.347  -1.311  -1.335  -1.283  -1.230  -1.307  -1.263  -1.173
231   N        -1.833  -1.919  -1.747  -1.701  -1.852  -1.657  -1.527  -1.577  -1.371
232   V        -1.374  -1.433  -1.329  -1.296  -1.364  -1.219  -1.307  -1.338  -1.189
233   D         0.319   0.235  -0.014   0.385   0.286  -0.114   0.338   0.216  -0.207
234   I        -1.040  -0.995  -0.846  -1.243  -1.166  -0.984  -1.198  -1.135  -0.945
235   S        -1.626  -1.472  -1.695  -1.276  -1.075  -1.433  -1.307  -1.155  -1.329
236   G        -0.958  -0.966  -0.846  -1.085  -1.110  -0.938  -1.088  -1.097  -0.945
237   K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
238   L        -0.038  -0.037  -0.108  -0.300  -0.292  -0.373  -0.210  -0.214  -0.373
239   N        -0.689  -0.695  -0.796  -0.629  -0.676  -0.851  -0.759  -0.793  -0.885
240   E        -0.372  -0.521  -0.756  -0.264  -0.462  -0.839  -0.320  -0.510  -0.830
241   L        -1.292  -1.355  -1.318  -1.408  -1.471  -1.369  -1.198  -1.243  -1.177
242   K        -1.040  -0.956  -0.834  -1.093  -0.931  -0.780  -1.198  -1.087  -0.930
243   A        -0.689  -0.568  -0.770  -0.631  -0.452  -0.793  -0.759  -0.601  -0.850
244   N        -0.038  -0.121  -0.103   0.002  -0.140  -0.154  -0.210  -0.356  -0.363
245   V        -0.230  -0.257  -0.133  -0.367  -0.435  -0.238  -0.540  -0.596  -0.417
246   E        -0.290  -0.242  -0.124  -0.638  -0.549  -0.355  -0.649  -0.569  -0.402
247   T        -0.689  -0.508  -0.765  -0.724  -0.452  -0.841  -0.759  -0.512  -0.842
248   I        -0.230  -0.123  -0.087  -0.367  -0.183  -0.150  -0.540  -0.359  -0.336
249   R        -0.689  -0.496  -0.771  -0.570  -0.288  -0.688  -0.759  -0.506  -0.850
250   Q        -1.292  -1.307  -1.325  -1.264  -1.313  -1.306  -1.198  -1.227  -1.185
251   Q         1.045   1.057   1.094   1.099   1.110   1.174   1.106   1.123   1.180
252   F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
253   T        -0.230  -0.257  -0.133  -0.415  -0.483  -0.290  -0.540  -0.596  -0.417
254   D        -0.230  -0.182  -0.118  -0.368  -0.276  -0.215  -0.540  -0.462  -0.390
255   P         0.319   0.235  -0.014   0.529   0.416   0.006   0.338   0.216  -0.207
256   D        -0.372  -0.397  -0.736  -0.200  -0.220  -0.716  -0.320  -0.355  -0.804
257   L         0.319   0.396  -0.003   0.178   0.278  -0.222   0.338   0.443  -0.189
258   T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
259   T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
260   F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
261   V         0.319   0.386  -0.003   0.472   0.550   0.002   0.338   0.431  -0.189
262   C         1.045   1.057   1.094   1.274   1.289   1.330   1.106   1.123   1.180
263   V         1.045   1.057   1.094   1.092   1.104   1.167   1.106   1.123   1.180
264   C         1.045   1.057   1.094   1.274   1.289   1.330   1.106   1.123   1.180
265   I         1.045   1.057   1.094   1.076   1.093   1.153   1.106   1.123   1.180
266   S        -0.038  -0.121  -0.103  -0.108  -0.243  -0.216  -0.210  -0.356  -0.363
267   E         1.045   1.057   1.094   0.982   1.001   1.070   1.106   1.123   1.180
268   F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
269   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
270   S         1.045   1.057   1.094   0.982   0.999   1.070   1.106   1.123   1.180
271   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
272   Y         1.045   1.057   1.094   1.264   1.278   1.321   1.106   1.123   1.180
273   E         1.045   1.057   1.094   0.982   1.001   1.070   1.106   1.123   1.180
274   T         1.045   1.057   1.094   1.076   1.091   1.153   1.106   1.123   1.180
275   E         1.045   1.057   1.094   0.982   1.001   1.070   1.106   1.123   1.180
276   R         1.045   1.057   1.094   1.236   1.246   1.296   1.106   1.123   1.180
277   L        -0.230  -0.123  -0.087  -0.460  -0.236  -0.239  -0.540  -0.359  -0.336
278   I        -0.038  -0.043  -0.108  -0.041  -0.054  -0.194  -0.210  -0.224  -0.374
279   Q         1.045   1.057   1.094   1.099   1.110   1.174   1.106   1.123   1.180
280   E         0.319   0.238  -0.015   0.354   0.256  -0.133   0.338   0.220  -0.210
281   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
282   I        -1.500  -1.516  -1.349  -1.437  -1.459  -1.217  -1.417  -1.415  -1.207
283   S         1.045   1.057   1.094   0.982   0.999   1.070   1.106   1.123   1.180
284   Y         0.319   0.238  -0.015   0.649   0.547   0.137   0.338   0.220  -0.210
285   D        -1.626  -1.658  -1.712  -1.394  -1.454  -1.560  -1.307  -1.335  -1.343
286   M        -0.230  -0.257  -0.133  -0.312  -0.383  -0.197  -0.540  -0.596  -0.417
287   D         1.045   1.057   1.094   1.018   1.042   1.102   1.106   1.123   1.180
288   V        -0.230  -0.257  -0.133  -0.367  -0.436  -0.238  -0.540  -0.596  -0.417
289   N        -0.230  -0.257  -0.133  -0.227  -0.263  -0.083  -0.540  -0.596  -0.417
290   S        -0.038  -0.115  -0.104  -0.121  -0.244  -0.238  -0.210  -0.345  -0.366
291   I         1.045   1.057   1.094   1.076   1.093   1.153   1.106   1.123   1.180
292   I        -0.230  -0.123  -0.087  -0.367  -0.183  -0.150  -0.540  -0.359  -0.336
293   V         1.045   1.057   1.094   1.092   1.104   1.167   1.106   1.123   1.180
294   N         1.045   1.057   1.094   1.125   1.147   1.197   1.106   1.123   1.180
295   Q         1.045   1.057   1.094   1.099   1.110   1.174   1.106   1.123   1.180
296   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
297   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
298   F        -0.372  -0.518  -0.753  -0.130  -0.328  -0.731  -0.320  -0.507  -0.827
299   A        -0.108  -0.220  -0.123  -0.090  -0.294  -0.149  -0.327  -0.530  -0.400
300   E        -0.958  -0.997  -0.848  -1.158  -1.227  -1.006  -1.088  -1.138  -0.947
301   N        -2.627  -2.465  -2.339  -2.189  -1.974  -1.843  -1.856  -1.727  -1.553
302   D         1.045   1.057   1.094   0.997   1.016   1.083   1.106   1.123   1.180
303   Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
304   E        -1.374  -1.342  -1.311  -1.424  -1.355  -1.293  -1.307  -1.258  -1.173
305   H        -1.833  -1.873  -1.725  -1.531  -1.620  -1.455  -1.527  -1.546  -1.355
306   N        -1.959  -1.902  -1.739  -1.886  -1.801  -1.563  -1.637  -1.568  -1.365
307   C         1.045   1.057   1.094   1.274   1.289   1.330   1.106   1.123   1.180
308   K        -0.689  -0.812  -0.815  -0.704  -0.896  -0.891  -0.759  -0.920  -0.908
309   R        -0.689  -0.816  -0.815  -0.515  -0.747  -0.826  -0.759  -0.923  -0.909
310   C         1.045   1.057   1.094   1.274   1.289   1.330   1.106   1.123   1.180
311   Q        -2.167  -2.220  -2.071  -1.857  -1.963  -1.791  -1.637  -1.667  -1.479
312   A        -0.290  -0.260  -0.132  -0.542  -0.491  -0.282  -0.649  -0.603  -0.416
313   R         1.045   1.057   1.094   1.236   1.246   1.296   1.106   1.123   1.180
314   W        -0.689  -0.816  -0.815  -0.281  -0.477  -0.507  -0.759  -0.923  -0.909
315   K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
316   M         1.045   1.057   1.094   1.154   1.170   1.223   1.106   1.123   1.180
317   Q         1.045   1.057   1.094   1.099   1.110   1.174   1.106   1.123   1.180
318   K        -0.038  -0.115  -0.104  -0.102  -0.225  -0.230  -0.210  -0.345  -0.366
319   K         1.045   1.057   1.094   1.010   1.036   1.095   1.106   1.123   1.180
320   Y         1.045   1.057   1.094   1.264   1.278   1.321   1.106   1.123   1.180
321   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
322   D        -0.372  -0.518  -0.753  -0.221  -0.410  -0.793  -0.320  -0.507  -0.827
323   Q         1.045   1.057   1.094   1.099   1.110   1.174   1.106   1.123   1.180
324   I        -0.038   0.035  -0.064  -0.020   0.089  -0.085  -0.210  -0.096  -0.296
325   D        -1.833  -1.816  -1.739  -1.846  -1.857  -1.746  -1.527  -1.504  -1.365
326   E         0.319   0.238  -0.015   0.354   0.256  -0.133   0.338   0.220  -0.210
327   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
328   Y         1.045   1.057   1.094   1.264   1.278   1.321   1.106   1.123   1.180
329   E         0.319   0.235  -0.014   0.354   0.252  -0.130   0.338   0.216  -0.207
330   D         0.319   0.235  -0.014   0.385   0.286  -0.114   0.338   0.216  -0.207
331   F        -0.038   0.035  -0.064   0.053   0.156  -0.004  -0.210  -0.096  -0.296
332   H         0.319   0.235  -0.014   0.673   0.569   0.161   0.338   0.216  -0.207
333   V        -0.958  -0.910  -0.825  -1.132  -1.048  -0.959  -1.088  -1.024  -0.920
334   V         1.045   1.057   1.094   1.092   1.104   1.167   1.106   1.123   1.180
335   K         0.319   0.238  -0.015   0.414   0.328  -0.023   0.338   0.220  -0.210
336   M        -0.372  -0.518  -0.753  -0.120  -0.328  -0.769  -0.320  -0.507  -0.827
337   P         1.045   1.057   1.094   1.162   1.173   1.230   1.106   1.123   1.180
338   L        -0.038  -0.115  -0.104  -0.319  -0.437  -0.399  -0.210  -0.345  -0.366
339   C        -1.374  -1.427  -1.330  -1.370  -1.455  -1.296  -1.307  -1.332  -1.189
340   A        -1.833  -1.919  -1.747  -1.628  -1.747  -1.511  -1.527  -1.577  -1.371
341   G        -2.167  -2.220  -2.071  -1.868  -1.970  -1.757  -1.637  -1.667  -1.479
342   E         1.045   1.057   1.094   0.982   1.001   1.070   1.106   1.123   1.180
343   I        -0.230  -0.257  -0.133  -0.372  -0.436  -0.238  -0.540  -0.596  -0.417
344   R         1.045   1.057   1.094   1.236   1.246   1.296   1.106   1.123   1.180
345   G         1.045   1.057   1.094   1.032   1.047   1.114   1.106   1.123   1.180
346   L        -1.374  -1.428  -1.330  -1.537  -1.565  -1.402  -1.307  -1.333  -1.190
347   N        -0.832  -0.820  -0.800  -0.925  -0.879  -0.838  -0.978  -0.930  -0.888
348   N        -0.689  -0.817  -0.815  -0.575  -0.775  -0.807  -0.759  -0.924  -0.909
349   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
350   T        -0.689  -0.668  -0.791  -0.721  -0.734  -0.887  -0.759  -0.768  -0.879
351   K         0.319   0.248  -0.014   0.377   0.296  -0.122   0.338   0.234  -0.208
352   F         1.045   1.057   1.094   1.115   1.130   1.188   1.106   1.123   1.180
353   S         1.045   1.057   1.094   0.982   0.999   1.070   1.106   1.123   1.180
354   Q        -1.500  -1.515  -1.349  -1.537  -1.562  -1.319  -1.417  -1.414  -1.208
355   F        -0.689  -0.816  -0.815  -0.609  -0.820  -0.877  -0.759  -0.923  -0.909
356   L         1.045   1.057   1.094   0.786   0.811   0.895   1.106   1.123   1.180
357   N        -2.167  -1.906  -2.045  -1.846  -1.480  -1.731  -1.637  -1.400  -1.462
358   K         0.319   0.238  -0.015   0.422   0.339  -0.003   0.338   0.220  -0.210
359   E        -0.038   0.103  -0.036   0.008   0.226  -0.036  -0.210   0.014  -0.246
360   Y         0.319   0.235  -0.014   0.649   0.543   0.139   0.338   0.216  -0.207
361   N        -1.292  -1.311  -1.324  -1.197  -1.247  -1.230  -1.198  -1.230  -1.185
362   P        -0.372  -0.518  -0.753  -0.003  -0.185  -0.511  -0.320  -0.507  -0.827
363   I        -1.626  -1.562  -1.350  -1.641  -1.536  -1.247  -1.527  -1.453  -1.208
364   T        -0.786  -0.752  -0.820  -0.673  -0.627  -0.777  -0.860  -0.819  -0.912
365   D         1.045   1.057   1.094   0.997   1.016   1.083   1.106   1.123   1.180
366   G        -1.521  -1.435  -1.343  -1.493  -1.357  -1.234  -1.422  -1.325  -1.202
367   K        -1.521  -1.503  -1.355  -1.616  -1.597  -1.381  -1.422  -1.395  -1.213
368   V        -0.252  -0.255  -0.132  -0.387  -0.404  -0.217  -0.579  -0.592  -0.416
369   I         0.081   0.044  -0.092   0.154   0.101  -0.147  -0.017  -0.081  -0.345
370   Y        -0.786  -0.855  -0.841  -0.544  -0.666  -0.723  -0.860  -0.950  -0.939
371   E        -0.252  -0.255  -0.132  -0.550  -0.566  -0.361  -0.579  -0.592  -0.416
372   L         0.177  -0.079  -0.079  -0.022  -0.393  -0.380   0.131  -0.285  -0.322
373   E        -0.626  -0.794  -0.812  -0.635  -0.928  -0.971  -0.649  -0.889  -0.903
374   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
375   K        -0.890  -0.809  -0.819  -1.076  -0.960  -0.928  -1.043  -0.951  -0.914
376   E        -1.959  -1.872  -1.727  -1.900  -1.776  -1.579  -1.637  -1.554  -1.358
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q12154
Output conservation file - output/Q12154
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
