1     M         1.848   1.873   1.952   2.134   2.171   2.309   2.052   2.090   2.223
2     S        -0.381  -0.341  -0.543  -0.234  -0.185  -0.491  -0.330  -0.279  -0.520
3     A        -0.726  -0.676  -0.657  -0.866  -0.788  -0.771  -0.749  -0.690  -0.654
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
10    L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
11    P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
12    T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
13    H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
14    N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
15    G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
16    S        -0.161  -0.182  -0.133  -0.287  -0.333  -0.260  -0.380  -0.414  -0.351
17    Q        -0.831  -0.803  -0.721  -0.976  -0.925  -0.811  -0.866  -0.831  -0.726
18    G        -0.726  -0.756  -0.692  -0.774  -0.820  -0.714  -0.749  -0.782  -0.694
19    G         0.881   0.804   0.780   0.869   0.750   0.710   0.807   0.663   0.582
20    E        -1.262  -1.231  -1.151  -1.228  -1.196  -1.063  -1.061  -1.026  -0.922
21    V        -0.726  -0.690  -0.662  -0.746  -0.686  -0.648  -0.749  -0.707  -0.660
22    R         0.881   0.804   0.780   0.909   0.799   0.765   0.807   0.663   0.582
23    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
24    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
25    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
26    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
27    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
28    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
29    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
30    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
31    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
32    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
33    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
34    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
35    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
36    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
37    S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
38    P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
39    D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
40    Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
41    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
42    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
43    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
44    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
45    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
46    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
47    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
48    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
49    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
50    K        -1.168  -1.154  -1.125  -0.882  -0.840  -0.826  -0.974  -0.956  -0.899
51    F        -1.530  -1.525  -1.480  -1.257  -1.256  -1.191  -1.124  -1.114  -1.036
52    I         0.001   0.013  -0.034  -0.142  -0.114  -0.225  -0.171  -0.141  -0.220
53    V         1.848   1.873   1.952   1.929   1.967   2.102   2.052   2.090   2.223
54    I         1.056   1.103   0.889   1.124   1.194   0.893   1.099   1.174   0.788
55    R         1.848   1.873   1.952   1.853   1.888   2.026   2.052   2.090   2.223
56    F         1.848   1.873   1.952   1.994   2.029   2.168   2.052   2.090   2.223
57    S        -0.764  -0.735  -0.680  -0.796  -0.756  -0.669  -0.806  -0.772  -0.687
58    D        -0.237  -0.224  -0.142  -0.456  -0.439  -0.316  -0.489  -0.472  -0.365
59    V        -1.147  -1.121  -1.094  -1.132  -1.102  -1.048  -0.965  -0.935  -0.874
60    S        -0.191  -0.173  -0.123  -0.401  -0.375  -0.317  -0.438  -0.414  -0.342
61    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
62    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
63    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
64    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
65    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
66    V         0.528   0.571   0.634   0.268   0.344   0.434   0.146   0.219   0.294
67    R        -0.381  -0.269  -0.502   0.020   0.186  -0.172  -0.330  -0.185  -0.470
68    D         1.848   1.873   1.952   1.904   1.940   2.077   2.052   2.090   2.223
69    L         1.848   1.873   1.952   1.655   1.689   1.828   2.052   2.090   2.223
70    Q        -0.620  -0.602  -0.635  -0.582  -0.553  -0.581  -0.648  -0.618  -0.635
71    L         0.528   0.552   0.630   0.055   0.091   0.214   0.146   0.182   0.286
72    N        -0.764  -0.788  -0.689  -0.775  -0.811  -0.670  -0.806  -0.819  -0.695
73    I         0.001   0.010  -0.036  -0.206  -0.165  -0.270  -0.171  -0.145  -0.216
74    S         0.001   0.005  -0.032  -0.034  -0.022  -0.085  -0.171  -0.153  -0.213
75    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
76    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
77    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
78    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
79    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
80    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
81    N         0.001   0.073  -0.038   0.009   0.126  -0.022  -0.171  -0.066  -0.221
82    V         0.309   0.264   0.065   0.490   0.428   0.115   0.305   0.234  -0.061
83    P        -0.726  -0.708  -0.697  -0.735  -0.708  -0.685  -0.749  -0.724  -0.699
84    F        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
85    S        -1.530  -1.536  -1.484  -1.277  -1.297  -1.242  -1.124  -1.122  -1.039
86    N        -0.620  -0.636  -0.633  -0.737  -0.736  -0.701  -0.648  -0.666  -0.636
87    I        -0.093  -0.143  -0.080  -0.237  -0.293  -0.194  -0.330  -0.379  -0.291
88    N         0.692   0.672   0.663   0.625   0.592   0.552   0.464   0.416   0.354
89    T        -0.093  -0.144  -0.097  -0.175  -0.242  -0.173  -0.330  -0.381  -0.310
90    H        -1.147  -1.086  -1.082  -0.949  -0.849  -0.851  -0.965  -0.905  -0.864
91    W         1.056   0.957   0.861   1.454   1.315   1.159   1.099   0.933   0.736
92    L         1.056   1.021   0.872   0.929   0.885   0.675   1.099   1.040   0.757
93    R        -0.093  -0.144  -0.097  -0.120  -0.175  -0.096  -0.330  -0.381  -0.310
94    R        -1.002  -1.038  -1.083  -0.808  -0.853  -0.910  -0.806  -0.841  -0.860
95    M        -1.147  -1.182  -1.119  -1.015  -1.073  -1.011  -0.965  -0.987  -0.896
96    C        -0.093  -0.144  -0.097  -0.059  -0.128  -0.055  -0.330  -0.381  -0.310
97    R         1.848   1.873   1.952   1.853   1.888   2.026   2.052   2.090   2.223
98    E        -1.002  -1.034  -1.052  -1.003  -1.073  -1.122  -0.806  -0.838  -0.830
99    L         0.761   0.684   0.697   0.489   0.344   0.350   0.593   0.438   0.422
100   R        -0.093  -0.105  -0.078  -0.136  -0.154  -0.101  -0.330  -0.335  -0.288
101   P        -0.764  -0.787  -0.688  -0.776  -0.815  -0.669  -0.806  -0.817  -0.693
102   Q        -1.530  -1.477  -1.455  -1.263  -1.169  -1.172  -1.124  -1.072  -1.017
103   Q        -0.620  -0.627  -0.627  -0.701  -0.731  -0.742  -0.648  -0.657  -0.630
104   T        -0.093  -0.107  -0.089   0.029   0.025   0.056  -0.330  -0.339  -0.301
105   Q        -1.530  -1.479  -1.455  -1.303  -1.229  -1.184  -1.124  -1.073  -1.017
106   K        -1.530  -1.536  -1.484  -1.419  -1.434  -1.357  -1.124  -1.122  -1.039
107   R         0.692   0.743   0.722   0.760   0.850   0.779   0.464   0.550   0.471
108   R         1.056   0.957   0.861   1.130   0.998   0.856   1.099   0.933   0.736
109   L         1.848   1.873   1.952   1.655   1.689   1.828   2.052   2.090   2.223
110   K         0.692   0.665   0.665   0.631   0.586   0.581   0.464   0.404   0.357
111   F        -0.093  -0.144  -0.097  -0.288  -0.343  -0.246  -0.330  -0.381  -0.310
112   I         1.056   0.957   0.861   1.124   0.994   0.847   1.099   0.933   0.736
113   R        -1.147  -1.174  -1.119  -0.905  -0.948  -0.859  -0.965  -0.980  -0.896
114   N         0.692   0.629   0.657   0.613   0.501   0.523   0.464   0.334   0.342
115   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
116   S         0.309   0.381   0.103   0.400   0.502   0.083   0.305   0.408  -0.004
117   I        -0.764  -0.718  -0.689  -0.984  -0.946  -0.855  -0.806  -0.755  -0.695
118   L         1.848   1.873   1.952   1.655   1.689   1.828   2.052   2.090   2.223
119   N         0.692   0.629   0.657   0.589   0.466   0.487   0.464   0.334   0.342
120   T        -0.620  -0.635  -0.621  -0.610  -0.613  -0.576  -0.648  -0.654  -0.618
121   H        -1.530  -1.533  -1.480  -1.165  -1.202  -1.126  -1.124  -1.120  -1.036
122   S        -0.620  -0.640  -0.647  -0.545  -0.565  -0.573  -0.648  -0.660  -0.649
123   K        -1.147  -1.180  -1.092  -1.070  -1.109  -0.974  -0.965  -0.985  -0.873
124   I        -0.620  -0.638  -0.646  -0.716  -0.728  -0.779  -0.648  -0.658  -0.648
125   A        -1.147  -1.139  -1.094  -1.079  -1.074  -0.991  -0.965  -0.952  -0.874
126   E        -1.147  -1.080  -1.102  -1.094  -1.004  -1.051  -0.965  -0.897  -0.880
127   E         0.001  -0.077  -0.062  -0.073  -0.182  -0.168  -0.171  -0.271  -0.259
128   L        -0.620  -0.535  -0.611  -0.732  -0.583  -0.743  -0.648  -0.545  -0.612
129   T        -1.147  -1.180  -1.090  -1.229  -1.280  -1.137  -0.965  -0.985  -0.871
130   H        -1.002  -0.997  -1.034  -0.654  -0.656  -0.721  -0.806  -0.799  -0.812
131   Y        -0.161  -0.182  -0.133  -0.039  -0.087  -0.038  -0.380  -0.411  -0.351
132   F        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
133   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
134   T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
135   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
136   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
137   A        -0.831  -0.812  -0.721  -0.925  -0.885  -0.760  -0.866  -0.841  -0.726
138   N         0.012   0.138  -0.009   0.030   0.232  -0.017  -0.127   0.058  -0.169
139   N        -0.726  -0.756  -0.691  -0.657  -0.699  -0.599  -0.749  -0.782  -0.694
140   S         0.001   0.031  -0.045   0.120   0.157   0.012  -0.171  -0.136  -0.237
141   N         0.309   0.406   0.101   0.486   0.626   0.197   0.305   0.444  -0.007
142   V        -0.191  -0.167  -0.122  -0.585  -0.530  -0.456  -0.438  -0.404  -0.340
143   A        -0.831  -0.804  -0.721  -0.983  -0.930  -0.817  -0.866  -0.832  -0.726
144   T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
145   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
146   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
147   T        -0.161  -0.189  -0.133  -0.333  -0.398  -0.338  -0.380  -0.421  -0.351
148   S        -0.831  -0.811  -0.721  -1.137  -1.106  -0.972  -0.866  -0.840  -0.726
149   V         0.761   0.820   0.747   0.646   0.739   0.606   0.593   0.691   0.519
150   A        -0.831  -0.811  -0.721  -0.815  -0.774  -0.649  -0.866  -0.840  -0.726
151   P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
152   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
153   Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
154   N        -1.912  -1.887  -1.800  -1.772  -1.702  -1.609  -1.283  -1.256  -1.147
155   N        -1.530  -1.476  -1.453  -1.404  -1.298  -1.317  -1.124  -1.071  -1.015
156   Y        -1.002  -0.994  -1.071  -0.720  -0.715  -0.777  -0.806  -0.795  -0.848
157   Y         1.056   0.957   0.861   1.459   1.326   1.182   1.099   0.933   0.736
158   I         0.001   0.003  -0.034  -0.142  -0.133  -0.226  -0.171  -0.157  -0.221
159   H         1.848   1.873   1.952   2.176   2.214   2.351   2.052   2.090   2.223
160   C         1.056   1.125   0.886   1.450   1.548   1.196   1.099   1.208   0.781
161   I         0.001   0.010  -0.036  -0.090  -0.062  -0.146  -0.171  -0.145  -0.216
162   I         0.528   0.531   0.616   0.268   0.270   0.404   0.146   0.140   0.259
163   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
164   T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
165   E        -0.620  -0.647  -0.630  -0.604  -0.631  -0.587  -0.648  -0.675  -0.631
166   E        -0.620  -0.589  -0.630  -0.659  -0.617  -0.672  -0.648  -0.623  -0.633
167   L         1.848   1.873   1.952   1.655   1.689   1.828   2.052   2.090   2.223
168   T         1.056   1.021   0.872   1.245   1.202   0.976   1.099   1.040   0.757
169   Q        -1.147  -1.081  -1.089  -1.114  -1.023  -1.029  -0.965  -0.898  -0.870
170   A         0.309   0.306   0.088   0.434   0.433   0.116   0.305   0.300  -0.026
171   E         0.528   0.570   0.633   0.283   0.355   0.448   0.146   0.216   0.293
172   L         1.848   1.873   1.952   1.655   1.689   1.828   2.052   2.090   2.223
173   A         1.056   1.125   0.886   1.255   1.350   1.004   1.099   1.208   0.781
174   N        -0.764  -0.727  -0.683  -0.920  -0.869  -0.788  -0.806  -0.766  -0.690
175   E         1.056   0.957   0.861   1.130   1.000   0.856   1.099   0.933   0.736
176   D         0.618   0.662   0.684   0.467   0.545   0.555   0.323   0.398   0.395
177   L        -0.553  -0.467  -0.615  -0.540  -0.387  -0.687  -0.542  -0.432  -0.606
178   K        -0.553  -0.595  -0.624  -0.568  -0.630  -0.624  -0.542  -0.594  -0.617
179   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
180   D         0.761   0.684   0.697   0.764   0.626   0.638   0.593   0.438   0.422
181   D         0.309   0.245   0.071   0.481   0.390   0.130   0.305   0.208  -0.051
182   A        -1.530  -1.536  -1.484  -1.311  -1.336  -1.233  -1.124  -1.122  -1.039
183   T        -1.147  -1.117  -1.096  -1.013  -0.979  -0.948  -0.965  -0.931  -0.876
184   P         0.309   0.264   0.065   0.618   0.535   0.189   0.305   0.234  -0.061
185   S        -0.620  -0.632  -0.647  -0.605  -0.620  -0.644  -0.648  -0.654  -0.649
186   N        -1.168  -1.175  -1.125  -1.154  -1.170  -1.098  -0.974  -0.977  -0.899
187   D        -1.147  -1.137  -1.106  -1.190  -1.174  -1.129  -0.965  -0.950  -0.884
188   S         0.309   0.410   0.110   0.451   0.585   0.156   0.305   0.449   0.006
189   M        -1.002  -0.994  -1.071  -0.762  -0.759  -0.886  -0.806  -0.795  -0.848
190   T        -1.002  -1.038  -1.083  -0.869  -0.951  -1.056  -0.806  -0.841  -0.860
191   T         0.528   0.568   0.637   0.517   0.593   0.690   0.146   0.213   0.300
192   Q        -0.093  -0.144  -0.097  -0.239  -0.302  -0.229  -0.330  -0.381  -0.310
193   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
194   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
195   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
196   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
197   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
198   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
199   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
200   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
201   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
202   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
203   A        -0.237  -0.231  -0.156  -0.476  -0.505  -0.398  -0.489  -0.482  -0.385
204   I         0.692   0.629   0.657   0.540   0.416   0.436   0.464   0.334   0.342
205   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
206   F         1.848   1.873   1.952   1.994   2.029   2.168   2.052   2.090   2.223
207   D         1.848   1.873   1.952   1.904   1.940   2.077   2.052   2.090   2.223
208   R         1.848   1.873   1.952   1.853   1.888   2.026   2.052   2.090   2.223
209   L         1.848   1.873   1.952   1.655   1.689   1.828   2.052   2.090   2.223
210   R         0.001   0.075  -0.010  -0.187  -0.056  -0.192  -0.171  -0.061  -0.178
211   S        -0.620  -0.686  -0.658  -0.632  -0.729  -0.685  -0.648  -0.708  -0.660
212   V        -0.237  -0.231  -0.156  -0.345  -0.332  -0.221  -0.489  -0.482  -0.385
213   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
214   F         1.848   1.873   1.952   1.994   2.029   2.168   2.052   2.090   2.223
215   T         0.692   0.665   0.665   0.622   0.565   0.552   0.464   0.404   0.357
216   E         0.692   0.758   0.730   0.580   0.691   0.629   0.464   0.578   0.487
217   Q        -0.620  -0.628  -0.617  -0.644  -0.644  -0.628  -0.648  -0.648  -0.615
218   E         0.692   0.758   0.730   0.563   0.674   0.608   0.464   0.578   0.487
219   I         0.692   0.671   0.666   0.570   0.529   0.496   0.464   0.414   0.360
220   E        -1.147  -1.114  -1.096  -1.166  -1.115  -1.079  -0.965  -0.929  -0.875
221   L        -0.093  -0.144  -0.097  -0.421  -0.479  -0.402  -0.330  -0.381  -0.310
222   L         1.848   1.873   1.952   1.655   1.689   1.828   2.052   2.090   2.223
223   R         1.848   1.873   1.952   1.853   1.888   2.026   2.052   2.090   2.223
224   Q        -0.093  -0.144  -0.097  -0.244  -0.312  -0.236  -0.330  -0.381  -0.310
225   Q         1.848   1.873   1.952   1.947   1.988   2.121   2.052   2.090   2.223
226   F         1.848   1.873   1.952   1.994   2.029   2.168   2.052   2.090   2.223
227   R        -0.620  -0.627  -0.625  -0.743  -0.715  -0.731  -0.648  -0.646  -0.627
228   A        -1.147  -1.176  -1.101  -1.197  -1.250  -1.157  -0.965  -0.982  -0.880
229   T        -0.093  -0.144  -0.097  -0.278  -0.361  -0.303  -0.330  -0.381  -0.310
230   Y         1.056   0.957   0.861   1.437   1.297   1.138   1.099   0.933   0.736
231   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
232   D        -0.620  -0.627  -0.645  -0.622  -0.639  -0.664  -0.648  -0.656  -0.649
233   L        -1.147  -1.122  -1.095  -1.266  -1.215  -1.153  -0.965  -0.935  -0.875
234   E        -0.620  -0.627  -0.645  -0.815  -0.843  -0.872  -0.648  -0.656  -0.649
235   E        -1.147  -1.176  -1.104  -1.055  -1.105  -0.973  -0.965  -0.982  -0.883
236   E        -0.620  -0.594  -0.635  -0.626  -0.592  -0.621  -0.648  -0.611  -0.635
237   E        -1.262  -1.249  -1.151  -1.249  -1.222  -1.085  -1.061  -1.041  -0.922
238   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
239   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
240   E         0.761   0.763   0.725   0.691   0.688   0.592   0.593   0.587   0.475
241   R        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
242   L         0.509   0.529   0.616   0.074   0.100   0.240   0.107   0.134   0.258
243   A         0.509   0.528   0.616   0.287   0.317   0.457   0.107   0.133   0.257
244   Q        -0.161  -0.160  -0.139  -0.306  -0.308  -0.294  -0.380  -0.379  -0.359
245   N        -0.831  -0.816  -0.721  -1.130  -1.102  -0.965  -0.866  -0.845  -0.726
246   G         0.761   0.763   0.725   0.640   0.637   0.551   0.593   0.587   0.475
247   N        -0.161  -0.160  -0.139  -0.377  -0.378  -0.360  -0.380  -0.379  -0.359
248   R        -0.831  -0.816  -0.721  -1.030  -1.005  -0.865  -0.866  -0.845  -0.726
249   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
250   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
251   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
252   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
253   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
254   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
255   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
256   D        -0.726  -0.708  -0.697  -0.881  -0.851  -0.853  -0.749  -0.724  -0.699
257   D        -1.147  -1.141  -1.100  -1.028  -1.052  -0.997  -0.965  -0.953  -0.879
258   E        -1.530  -1.529  -1.461  -1.361  -1.357  -1.275  -1.124  -1.117  -1.022
259   G        -1.002  -1.054  -1.064  -0.960  -1.068  -1.130  -0.806  -0.857  -0.842
260   H        -1.530  -1.531  -1.474  -1.397  -1.409  -1.311  -1.124  -1.119  -1.032
261   D        -1.002  -1.038  -1.083  -0.832  -0.884  -0.967  -0.806  -0.841  -0.860
262   I         0.309   0.317   0.092   0.403   0.427   0.071   0.305   0.315  -0.020
263   R         1.056   1.021   0.872   1.130   1.087   0.874   1.099   1.040   0.757
264   Q         0.309   0.174   0.044   0.488   0.290   0.060   0.305   0.108  -0.091
265   L         1.056   0.957   0.861   0.941   0.810   0.680   1.099   0.933   0.736
266   E         1.848   1.873   1.952   1.853   1.890   2.026   2.052   2.090   2.223
267   E         1.056   0.957   0.861   1.123   0.990   0.841   1.099   0.933   0.736
268   Q        -1.147  -1.182  -1.119  -1.081  -1.132  -1.021  -0.965  -0.987  -0.896
269   W         1.848   1.873   1.952   2.188   2.226   2.363   2.052   2.090   2.223
270   M         0.528   0.568   0.637   0.398   0.457   0.569   0.146   0.213   0.300
271   E         0.692   0.629   0.657   0.563   0.443   0.468   0.464   0.334   0.342
272   S         0.001  -0.004  -0.062  -0.055  -0.099  -0.159  -0.171  -0.204  -0.260
273   G         0.692   0.758   0.730   0.601   0.707   0.652   0.464   0.578   0.487
274   S        -0.620  -0.641  -0.614  -0.653  -0.683  -0.651  -0.648  -0.661  -0.615
275   G        -0.381  -0.411  -0.545  -0.249  -0.289  -0.518  -0.330  -0.369  -0.522
276   T        -1.147  -1.121  -1.085  -0.996  -0.957  -0.891  -0.965  -0.935  -0.867
277   A        -1.530  -1.531  -1.459  -1.234  -1.262  -1.132  -1.124  -1.119  -1.020
278   Q        -1.147  -1.176  -1.101  -1.085  -1.137  -1.026  -0.965  -0.982  -0.880
279   G        -1.147  -1.123  -1.097  -0.999  -0.963  -0.900  -0.965  -0.936  -0.876
280   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
281   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
282   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
283   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
284   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
285   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
286   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
287   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
288   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
289   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
290   N        -0.831  -0.816  -0.721  -0.951  -0.930  -0.785  -0.866  -0.845  -0.726
291   G        -0.161  -0.145  -0.105  -0.359  -0.334  -0.294  -0.380  -0.357  -0.311
292   A        -0.161  -0.143  -0.104  -0.252  -0.225  -0.187  -0.380  -0.355  -0.310
293   G        -0.831  -0.816  -0.721  -0.921  -0.902  -0.756  -0.866  -0.845  -0.726
294   G        -0.161  -0.127  -0.133  -0.298  -0.244  -0.269  -0.380  -0.332  -0.351
295   G        -0.831  -0.816  -0.721  -1.016  -0.995  -0.851  -0.866  -0.845  -0.726
296   N        -0.831  -0.816  -0.721  -0.927  -0.904  -0.761  -0.866  -0.845  -0.726
297   E         0.761   0.790   0.730   0.680   0.723   0.617   0.593   0.637   0.485
298   D        -0.191  -0.173  -0.127  -0.319  -0.292  -0.210  -0.438  -0.414  -0.346
299   R        -0.191  -0.173  -0.127  -0.366  -0.339  -0.260  -0.438  -0.414  -0.346
300   F         0.012   0.024  -0.083   0.140   0.161  -0.035  -0.127  -0.110  -0.278
301   N        -0.093  -0.144  -0.097  -0.091  -0.149  -0.080  -0.330  -0.381  -0.310
302   S        -0.381  -0.465  -0.566  -0.216  -0.361  -0.500  -0.330  -0.434  -0.547
303   V        -1.147  -1.139  -1.094  -1.131  -1.144  -1.042  -0.965  -0.952  -0.874
304   P         0.001  -0.004  -0.062   0.137   0.089  -0.001  -0.171  -0.204  -0.260
305   I        -0.764  -0.735  -0.684  -0.911  -0.854  -0.770  -0.806  -0.773  -0.691
306   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
307   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
308   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
309   A        -0.721  -0.743  -0.689  -0.649  -0.666  -0.580  -0.758  -0.773  -0.693
310   N        -0.721  -0.734  -0.672  -0.863  -0.884  -0.794  -0.758  -0.764  -0.676
311   I        -0.721  -0.677  -0.676  -0.772  -0.717  -0.675  -0.758  -0.707  -0.680
312   K        -0.721  -0.736  -0.671  -0.642  -0.675  -0.562  -0.758  -0.766  -0.675
313   H        -1.147  -1.117  -1.097  -0.947  -0.915  -0.891  -0.965  -0.931  -0.877
314   N         0.309   0.174   0.044   0.515   0.343   0.160   0.305   0.108  -0.091
315   K        -0.620  -0.594  -0.635  -0.501  -0.465  -0.486  -0.648  -0.611  -0.635
316   D         0.309   0.174   0.044   0.464   0.270   0.055   0.305   0.108  -0.091
317   L         1.056   1.021   0.872   0.925   0.879   0.666   1.099   1.040   0.757
318   L         1.848   1.873   1.952   1.655   1.689   1.828   2.052   2.090   2.223
319   L         0.001  -0.042  -0.040  -0.190  -0.230  -0.275  -0.171  -0.216  -0.229
320   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
321   I        -1.147  -1.175  -1.103  -1.224  -1.239  -1.125  -0.965  -0.981  -0.881
322   C        -0.620  -0.536  -0.611  -0.672  -0.571  -0.629  -0.648  -0.545  -0.612
323   V        -0.620  -0.637  -0.629  -0.570  -0.594  -0.566  -0.648  -0.666  -0.632
324   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
325   F        -0.620  -0.587  -0.624  -0.630  -0.578  -0.662  -0.648  -0.600  -0.621
326   F         0.309   0.395   0.103   0.557   0.680   0.244   0.305   0.429  -0.004
327   F         0.309   0.250   0.079   0.220   0.126  -0.116   0.305   0.215  -0.040
328   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
329   V        -0.093  -0.144  -0.072  -0.233  -0.290  -0.177  -0.330  -0.380  -0.281
330   F        -0.237  -0.240  -0.164  -0.518  -0.540  -0.450  -0.489  -0.494  -0.395
331   G         0.001   0.007  -0.052  -0.032  -0.044  -0.121  -0.171  -0.178  -0.248
332   I        -0.620  -0.651  -0.623  -0.797  -0.815  -0.758  -0.648  -0.680  -0.626
333   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
334   L        -0.237  -0.231  -0.156  -0.430  -0.391  -0.259  -0.489  -0.482  -0.385
335   L         0.001  -0.009  -0.064  -0.246  -0.271  -0.331  -0.171  -0.209  -0.263
336   M         0.001   0.076  -0.008  -0.158  -0.055  -0.151  -0.171  -0.065  -0.177
337   K        -1.002  -1.038  -1.083  -0.611  -0.651  -0.748  -0.806  -0.841  -0.860
338   F        -1.147  -1.080  -1.102  -1.133  -1.035  -1.056  -0.965  -0.897  -0.880
339   D        -0.620  -0.659  -0.630  -0.651  -0.713  -0.676  -0.648  -0.686  -0.633
340   G        -0.237  -0.240  -0.164  -0.436  -0.445  -0.323  -0.489  -0.493  -0.395
341   L        -0.381  -0.390  -0.554  -0.426  -0.426  -0.663  -0.330  -0.343  -0.534
342   F         1.056   1.119   0.892   1.311   1.394   1.118   1.099   1.198   0.794
343   N         0.528   0.532   0.616   0.272   0.266   0.400   0.146   0.140   0.258
344   R        -0.381  -0.395  -0.549  -0.122  -0.163  -0.446  -0.330  -0.349  -0.527
345   R         1.848   1.873   1.952   1.853   1.888   2.026   2.052   2.090   2.223
346   Q         1.056   0.957   0.861   1.256   1.138   1.009   1.099   0.933   0.736
347   K         0.001  -0.020  -0.065   0.121   0.061  -0.015  -0.171  -0.222  -0.265
348   M         0.309   0.174   0.044   0.629   0.409   0.153   0.305   0.108  -0.091
349   A         0.692   0.699   0.674   0.628   0.627   0.577   0.464   0.467   0.375
350   I         1.848   1.873   1.952   1.850   1.888   2.023   2.052   2.090   2.223
351   F        -1.002  -1.042  -1.057  -0.947  -1.034  -1.056  -0.806  -0.845  -0.835
352   A         0.692   0.663   0.663   0.706   0.645   0.615   0.464   0.399   0.352
353   G         1.848   1.873   1.952   1.862   1.896   2.036   2.052   2.090   2.223
354   V        -0.093  -0.144  -0.071  -0.411  -0.483  -0.371  -0.330  -0.381  -0.281
355   I        -0.620  -0.557  -0.617  -0.609  -0.524  -0.589  -0.648  -0.580  -0.619
356   V        -1.530  -1.495  -1.455  -1.350  -1.262  -1.244  -1.124  -1.089  -1.017
357   N         1.848   1.873   1.952   1.888   1.929   2.061   2.052   2.090   2.223
358   V        -0.620  -0.531  -0.613  -0.494  -0.358  -0.461  -0.648  -0.542  -0.609
359   M        -0.620  -0.539  -0.603  -0.515  -0.392  -0.504  -0.648  -0.549  -0.602
360   F        -0.381  -0.385  -0.540  -0.070  -0.067  -0.302  -0.330  -0.338  -0.516
361   C        -0.721  -0.748  -0.689  -0.582  -0.625  -0.554  -0.758  -0.777  -0.694
362   L        -0.620  -0.587  -0.624  -0.797  -0.751  -0.753  -0.648  -0.600  -0.621
363   V         0.001  -0.004  -0.062  -0.149  -0.212  -0.306  -0.171  -0.204  -0.260
364   R         1.056   0.957   0.861   1.170   1.049   0.934   1.099   0.933   0.736
365   G         0.001  -0.052  -0.062  -0.030  -0.114  -0.109  -0.171  -0.247  -0.262
366   -        -0.831  -0.811  -0.721  -0.972  -0.925  -0.807  -0.866  -0.840  -0.726
367   -        -0.161  -0.182  -0.139   0.051   0.000   0.056  -0.380  -0.412  -0.359
368   F        -0.620  -0.686  -0.658  -0.527  -0.598  -0.561  -0.648  -0.708  -0.660
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q12015
Output conservation file - output/Q12015
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
