1     M         0.957   0.989   1.039   1.078   1.124   1.190   1.017   1.059   1.131
2     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
10    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
11    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
12    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
13    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
14    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
15    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
16    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
17    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
18    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
19    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
20    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
21    K        -1.317  -1.332  -1.166  -1.599  -1.596  -1.337  -1.384  -1.371  -1.150
22    A        -0.844  -0.835  -0.703  -1.118  -1.109  -0.879  -1.117  -1.078  -0.889
23    K        -0.665  -0.664  -0.686  -0.905  -0.899  -0.929  -0.850  -0.836  -0.867
24    P        -1.317  -1.332  -1.166  -1.516  -1.583  -1.343  -1.384  -1.371  -1.150
25    L        -1.317  -1.332  -1.166  -1.497  -1.536  -1.265  -1.384  -1.371  -1.150
26    S        -0.844  -0.835  -0.703  -1.001  -1.001  -0.819  -1.117  -1.078  -0.889
27    Q        -1.707  -1.557  -1.508  -1.718  -1.482  -1.453  -1.576  -1.398  -1.292
28    D        -1.298  -1.199  -1.139  -1.389  -1.237  -1.150  -1.379  -1.245  -1.124
29    P        -0.890  -0.824  -0.705  -1.038  -0.947  -0.753  -1.171  -1.066  -0.892
30    G        -2.297  -2.265  -2.059  -2.155  -2.140  -1.847  -1.796  -1.728  -1.479
31    S        -1.705  -1.672  -1.508  -1.568  -1.516  -1.269  -1.588  -1.512  -1.292
32    K        -0.003   0.106  -0.009  -0.258  -0.079  -0.278  -0.233  -0.049  -0.286
33    R         0.257   0.083   0.012   0.243  -0.030  -0.187   0.200  -0.088  -0.246
34    Y        -1.688  -1.677  -1.514  -1.633  -1.617  -1.411  -1.569  -1.517  -1.297
35    A        -0.402  -0.401  -0.632  -0.293  -0.303  -0.690  -0.480  -0.469  -0.793
36    Y         0.257   0.083   0.012   0.387   0.138  -0.000   0.200  -0.088  -0.246
37    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
38    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
39    R         0.314   0.177   0.039   0.351   0.172  -0.029   0.288   0.070  -0.197
40    I        -2.001  -1.873  -1.801  -1.835  -1.673  -1.560  -1.692  -1.559  -1.398
41    N        -1.593  -1.523  -1.488  -1.692  -1.600  -1.545  -1.484  -1.372  -1.275
42    K        -0.875  -1.068  -1.119  -0.908  -1.204  -1.266  -0.858  -1.076  -1.101
43    E        -0.875  -0.711  -1.086  -0.862  -0.635  -1.165  -0.858  -0.643  -1.065
44    E        -0.580  -0.556  -0.655  -0.708  -0.679  -0.781  -0.754  -0.721  -0.828
45    N        -2.001  -1.930  -1.799  -1.826  -1.726  -1.547  -1.692  -1.591  -1.396
46    R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
47    K        -0.875  -0.905  -1.094  -0.885  -0.922  -1.184  -0.858  -0.882  -1.074
48    E        -1.593  -1.606  -1.508  -1.635  -1.670  -1.458  -1.484  -1.463  -1.292
49    L        -0.580  -0.489  -0.648  -0.663  -0.538  -0.737  -0.754  -0.620  -0.818
50    K        -0.003  -0.033  -0.038  -0.258  -0.310  -0.329  -0.233  -0.294  -0.341
51    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
52    H        -1.223  -1.300  -1.155  -1.242  -1.382  -1.167  -1.297  -1.343  -1.140
53    V         0.257   0.083   0.012   0.294   0.036  -0.115   0.200  -0.088  -0.246
54    K        -0.209  -0.185  -0.064  -0.576  -0.510  -0.306  -0.616  -0.578  -0.389
55    I        -1.223  -1.285  -1.151  -1.241  -1.361  -1.153  -1.297  -1.331  -1.136
56    N        -1.561  -1.583  -1.507  -1.419  -1.469  -1.361  -1.433  -1.434  -1.291
57    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
58    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
59    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
60    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
61    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
62    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
63    E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
64    S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
65    S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
66    L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
67    V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
68    Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
69    E        -1.593  -1.641  -1.505  -1.649  -1.696  -1.497  -1.484  -1.490  -1.290
70    G        -1.593  -1.552  -1.494  -1.471  -1.407  -1.326  -1.484  -1.410  -1.282
71    Q        -2.001  -1.893  -1.802  -1.778  -1.655  -1.485  -1.692  -1.571  -1.398
72    K        -2.001  -1.902  -1.800  -2.066  -1.917  -1.711  -1.692  -1.572  -1.397
73    I        -2.001  -1.898  -1.797  -1.836  -1.679  -1.556  -1.692  -1.575  -1.395
74    D        -1.593  -1.527  -1.494  -1.696  -1.599  -1.539  -1.484  -1.379  -1.280
75    L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
76    P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
77    K        -0.299  -0.536  -0.631  -0.330  -0.637  -0.772  -0.338  -0.657  -0.792
78    K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
79    R        -0.003  -0.008  -0.035  -0.171  -0.196  -0.289  -0.233  -0.249  -0.334
80    Y        -0.706  -0.760  -0.668  -0.767  -0.835  -0.707  -0.963  -0.987  -0.848
81    Y         0.314   0.177   0.039   0.465   0.289   0.055   0.288   0.070  -0.197
82    R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
83    Q         0.957   0.989   1.039   1.025   1.068   1.142   1.017   1.059   1.131
84    R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
85    A         0.957   0.989   1.039   0.965   1.001   1.087   1.017   1.059   1.131
86    H         0.957   0.989   1.039   1.055   1.100   1.169   1.017   1.059   1.131
87    S        -0.003  -0.116  -0.053  -0.010  -0.223  -0.144  -0.233  -0.448  -0.368
88    N         0.957   0.989   1.039   1.014   1.061   1.132   1.017   1.059   1.131
89    P         0.314   0.177   0.039   0.405   0.220  -0.010   0.288   0.070  -0.197
90    F         0.314   0.177   0.039   0.415   0.225  -0.026   0.288   0.070  -0.197
91    S         0.957   0.989   1.039   0.999   1.050   1.118   1.017   1.059   1.131
92    D         0.957   0.989   1.039   0.965   1.018   1.087   1.017   1.059   1.131
93    H         0.957   0.989   1.039   1.055   1.100   1.169   1.017   1.059   1.131
94    Q        -1.114  -1.249  -1.141  -1.054  -1.270  -1.140  -1.171  -1.281  -1.126
95    L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
96    E         0.314   0.210   0.049   0.242   0.118  -0.119   0.288   0.123  -0.179
97    Y         0.957   0.989   1.039   1.019   1.066   1.136   1.017   1.059   1.131
98    P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
99    V        -2.297  -2.150  -2.045  -2.248  -2.032  -1.896  -1.796  -1.649  -1.471
100   S         0.314   0.210   0.049   0.450   0.325   0.067   0.288   0.123  -0.179
101   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
102   Q        -1.593  -1.530  -1.490  -1.602  -1.518  -1.401  -1.484  -1.393  -1.277
103   D        -2.001  -1.933  -1.796  -1.875  -1.787  -1.549  -1.692  -1.597  -1.395
104   M         0.957   0.989   1.039   1.078   1.124   1.190   1.017   1.059   1.131
105   D         0.957   0.989   1.039   0.965   1.018   1.087   1.017   1.059   1.131
106   W         0.957   0.989   1.039   1.162   1.210   1.265   1.017   1.059   1.131
107   S        -0.875  -0.843  -1.087  -0.632  -0.601  -0.958  -0.858  -0.815  -1.066
108   K        -1.409  -1.542  -1.497  -1.367  -1.546  -1.447  -1.275  -1.388  -1.283
109   L        -0.299  -0.378  -0.619  -0.247  -0.353  -0.682  -0.338  -0.449  -0.775
110   Y         0.957   0.989   1.039   1.019   1.066   1.136   1.017   1.059   1.131
111   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
112   Y        -1.889  -1.827  -1.787  -1.590  -1.514  -1.495  -1.588  -1.504  -1.388
113   Y        -0.674  -0.654  -0.669  -0.639  -0.625  -0.638  -0.888  -0.859  -0.848
114   K        -1.561  -1.549  -1.504  -1.434  -1.435  -1.415  -1.433  -1.407  -1.288
115   N        -0.674  -0.638  -0.680  -0.711  -0.715  -0.724  -0.888  -0.871  -0.861
116   A        -2.026  -1.776  -1.795  -2.027  -1.664  -1.678  -1.705  -1.449  -1.393
117   E         0.188   0.071   0.010   0.085  -0.078  -0.169   0.091  -0.109  -0.250
118   N        -1.313  -1.267  -1.150  -1.363  -1.282  -1.140  -1.391  -1.314  -1.134
119   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
120   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
121   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
122   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
123   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
124   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
125   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
126   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
127   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
128   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
129   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
130   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
131   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
132   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
133   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
134   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
135   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
136   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
137   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
138   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
139   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
140   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
141   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
142   G        -0.918  -0.840  -0.708  -1.242  -1.113  -0.906  -1.206  -1.083  -0.895
143   Q         0.188   0.316   0.015   0.060   0.245  -0.175   0.091   0.290  -0.242
144   M        -0.524  -0.661  -0.676  -0.410  -0.658  -0.770  -0.650  -0.837  -0.853
145   T         0.188   0.182   0.010   0.311   0.304   0.011   0.091   0.079  -0.250
146   K        -0.580  -0.501  -0.643  -0.724  -0.594  -0.770  -0.754  -0.628  -0.810
147   K        -0.875  -0.847  -1.089  -0.894  -0.844  -1.196  -0.858  -0.817  -1.069
148   V         0.957   0.989   1.039   0.930   0.973   1.056   1.017   1.059   1.131
149   T        -0.172  -0.031  -0.027  -0.462  -0.235  -0.222  -0.546  -0.291  -0.320
150   I        -0.003  -0.040  -0.031  -0.044  -0.105  -0.136  -0.233  -0.306  -0.327
151   A         0.314   0.177   0.039   0.403   0.212  -0.012   0.288   0.070  -0.197
152   D         0.957   0.989   1.039   0.965   1.018   1.087   1.017   1.059   1.131
153   I         0.957   0.989   1.039   0.976   1.036   1.097   1.017   1.059   1.131
154   G         0.957   0.989   1.039   0.984   1.027   1.105   1.017   1.059   1.131
155   C         0.957   0.989   1.039   1.143   1.192   1.248   1.017   1.059   1.131
156   G         0.957   0.989   1.039   0.984   1.027   1.105   1.017   1.059   1.131
157   F        -0.226  -0.186  -0.064  -0.395  -0.332  -0.140  -0.650  -0.580  -0.390
158   G         0.957   0.989   1.039   0.984   1.027   1.105   1.017   1.059   1.131
159   G         0.957   0.989   1.039   0.984   1.027   1.105   1.017   1.059   1.131
160   L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
161   M        -0.706  -0.746  -0.665  -0.811  -0.844  -0.701  -0.963  -0.965  -0.843
162   I        -0.172  -0.152  -0.060  -0.353  -0.322  -0.195  -0.546  -0.516  -0.381
163   D        -1.186  -1.064  -1.129  -1.223  -1.032  -1.129  -1.275  -1.106  -1.114
164   L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
165   S        -0.818  -0.852  -0.710  -0.882  -0.955  -0.744  -1.067  -1.098  -0.898
166   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
167   A        -1.186  -1.136  -1.128  -1.272  -1.175  -1.137  -1.275  -1.192  -1.114
168   F        -0.003  -0.040  -0.031  -0.059  -0.139  -0.170  -0.233  -0.306  -0.327
169   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
170   E        -1.114  -1.067  -1.119  -1.159  -1.092  -1.201  -1.171  -1.100  -1.104
171   D        -2.001  -1.846  -1.796  -1.897  -1.626  -1.623  -1.692  -1.519  -1.394
172   L         0.314   0.429   0.060   0.304   0.446  -0.020   0.288   0.455  -0.158
173   I        -0.580  -0.622  -0.670  -0.586  -0.694  -0.769  -0.754  -0.840  -0.849
174   L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
175   G         0.957   0.989   1.039   0.984   1.027   1.105   1.017   1.059   1.131
176   M        -0.003  -0.033  -0.038   0.028  -0.041  -0.116  -0.233  -0.294  -0.341
177   E         0.957   0.989   1.039   0.797   0.845   0.936   1.017   1.059   1.131
178   I         0.957   0.989   1.039   0.976   1.036   1.097   1.017   1.059   1.131
179   R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
180   V         0.314   0.177   0.039   0.390   0.218   0.018   0.288   0.070  -0.197
181   Q         0.314   0.210   0.049   0.473   0.341   0.081   0.288   0.123  -0.179
182   V         0.957   0.989   1.039   0.930   0.973   1.056   1.017   1.059   1.131
183   T         0.314   0.177   0.039   0.466   0.289   0.060   0.288   0.070  -0.197
184   N        -0.706  -0.782  -0.678  -0.718  -0.812  -0.658  -0.963  -1.020  -0.860
185   Y         0.314   0.210   0.049   0.465   0.335   0.072   0.288   0.123  -0.179
186   V         0.314   0.177   0.039   0.356   0.166  -0.075   0.288   0.070  -0.197
187   E         0.314   0.177   0.039   0.211   0.023  -0.220   0.288   0.070  -0.197
188   D         0.314   0.177   0.039   0.384   0.201  -0.064   0.288   0.070  -0.197
189   R         0.314   0.177   0.039   0.314   0.117  -0.132   0.288   0.070  -0.197
190   I         0.957   0.989   1.039   0.976   1.036   1.097   1.017   1.059   1.131
191   I        -0.875  -1.068  -1.119  -0.698  -0.981  -1.115  -0.858  -1.076  -1.101
192   A         0.957   0.989   1.039   0.965   1.001   1.087   1.017   1.059   1.131
193   L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
194   R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
195   N        -2.001  -2.014  -1.805  -1.806  -1.823  -1.545  -1.692  -1.653  -1.400
196   N        -0.706  -0.782  -0.675  -0.731  -0.836  -0.677  -0.963  -1.021  -0.856
197   T        -2.001  -1.917  -1.803  -1.704  -1.608  -1.432  -1.692  -1.584  -1.399
198   A        -2.001  -1.920  -1.800  -2.063  -1.957  -1.772  -1.692  -1.587  -1.397
199   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
200   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
201   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
202   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
203   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
204   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
205   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
206   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
207   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
208   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
209   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
210   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
211   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
212   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
213   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
214   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
215   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
216   S        -2.001  -1.917  -1.803  -2.033  -1.879  -1.674  -1.692  -1.584  -1.399
217   K        -1.409  -1.362  -1.471  -1.370  -1.292  -1.451  -1.275  -1.207  -1.260
218   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
219   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
220   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
221   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
222   H        -2.297  -2.232  -2.055  -2.006  -1.965  -1.688  -1.796  -1.709  -1.477
223   G        -0.875  -0.893  -1.101  -0.663  -0.707  -1.025  -0.858  -0.869  -1.081
224   F         0.314   0.457   0.062   0.465   0.641   0.096   0.288   0.495  -0.154
225   Q        -0.299  -0.536  -0.631  -0.124  -0.483  -0.699  -0.338  -0.657  -0.792
226   N         0.957   0.989   1.039   1.014   1.061   1.132   1.017   1.059   1.131
227   I         0.957   0.989   1.039   0.976   1.036   1.097   1.017   1.059   1.131
228   N        -0.890  -0.847  -0.703  -0.994  -0.930  -0.716  -1.171  -1.092  -0.889
229   V         0.957   0.989   1.039   0.930   0.973   1.056   1.017   1.059   1.131
230   L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
231   R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
232   G        -0.299  -0.536  -0.631  -0.103  -0.425  -0.580  -0.338  -0.657  -0.792
233   N         0.957   0.989   1.039   1.014   1.061   1.132   1.017   1.059   1.131
234   A        -0.299  -0.536  -0.631  -0.102  -0.415  -0.548  -0.338  -0.657  -0.792
235   M         0.314   0.177   0.039   0.529   0.354   0.119   0.288   0.070  -0.197
236   K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
237   F         0.957   0.989   1.039   0.989   1.033   1.109   1.017   1.059   1.131
238   L         0.314   0.210   0.049   0.304   0.182  -0.038   0.288   0.123  -0.179
239   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
240   N         0.957   0.989   1.039   1.014   1.061   1.132   1.017   1.059   1.131
241   F         0.957   0.989   1.039   0.989   1.033   1.109   1.017   1.059   1.131
242   F         0.957   0.989   1.039   0.989   1.033   1.109   1.017   1.059   1.131
243   E        -1.593  -1.453  -1.487  -1.567  -1.393  -1.363  -1.484  -1.329  -1.276
244   K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
245   G         0.314   0.393   0.056   0.427   0.526   0.047   0.288   0.403  -0.166
246   Q         0.957   0.989   1.039   1.025   1.068   1.142   1.017   1.059   1.131
247   L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
248   S         0.314   0.210   0.049   0.449   0.325   0.066   0.288   0.123  -0.179
249   K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
250   M        -0.172  -0.151  -0.059  -0.239  -0.208  -0.093  -0.546  -0.513  -0.379
251   F         0.957   0.989   1.039   0.989   1.033   1.109   1.017   1.059   1.131
252   F         0.314   0.210   0.049   0.433   0.303   0.042   0.288   0.123  -0.179
253   C         0.957   0.989   1.039   1.143   1.192   1.248   1.017   1.059   1.131
254   F         0.957   0.989   1.039   0.989   1.033   1.109   1.017   1.059   1.131
255   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
256   D         0.957   0.989   1.039   0.965   1.018   1.087   1.017   1.059   1.131
257   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
258   H         0.957   0.989   1.039   1.055   1.100   1.169   1.017   1.059   1.131
259   F         0.957   0.989   1.039   0.989   1.033   1.109   1.017   1.059   1.131
260   K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
261   Q        -0.003  -0.116  -0.053   0.015  -0.206  -0.125  -0.233  -0.448  -0.368
262   R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
263   K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
264   H         0.957   0.989   1.039   1.055   1.100   1.169   1.017   1.059   1.131
265   K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
266   A        -0.299  -0.536  -0.631  -0.122  -0.450  -0.596  -0.338  -0.657  -0.792
267   R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
268   I         0.957   0.989   1.039   0.976   1.036   1.097   1.017   1.059   1.131
269   I        -0.172  -0.151  -0.059  -0.353  -0.318  -0.193  -0.546  -0.513  -0.379
270   T         0.314   0.210   0.049   0.466   0.334   0.076   0.288   0.123  -0.179
271   N        -1.114  -1.166  -1.134  -0.975  -1.066  -1.010  -1.171  -1.218  -1.119
272   T         0.957   0.989   1.039   1.019   1.061   1.136   1.017   1.059   1.131
273   L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
274   L        -0.875  -1.068  -1.119  -0.747  -1.017  -1.043  -0.858  -1.076  -1.101
275   S         0.314   0.393   0.056   0.442   0.548   0.060   0.288   0.403  -0.166
276   E         0.957   0.989   1.039   0.797   0.845   0.936   1.017   1.059   1.131
277   Y         0.957   0.989   1.039   1.019   1.066   1.136   1.017   1.059   1.131
278   A         0.957   0.989   1.039   0.965   1.001   1.087   1.017   1.059   1.131
279   Y         0.957   0.989   1.039   1.019   1.066   1.136   1.017   1.059   1.131
280   V         0.314   0.177   0.039   0.377   0.197  -0.018   0.288   0.070  -0.197
281   L        -0.299  -0.409  -0.615  -0.265  -0.410  -0.716  -0.338  -0.488  -0.769
282   K        -0.172  -0.061  -0.040  -0.507  -0.297  -0.301  -0.546  -0.345  -0.345
283   E        -0.172  -0.186  -0.065  -0.490  -0.514  -0.302  -0.546  -0.579  -0.392
284   G         0.314   0.177   0.039   0.440   0.267   0.053   0.288   0.070  -0.197
285   G         0.957   0.989   1.039   0.984   1.027   1.105   1.017   1.059   1.131
286   V        -0.580  -0.618  -0.654  -0.554  -0.571  -0.671  -0.754  -0.773  -0.826
287   V        -0.580  -0.621  -0.654  -0.612  -0.663  -0.747  -0.754  -0.777  -0.825
288   Y         0.957   0.989   1.039   1.019   1.066   1.136   1.017   1.059   1.131
289   T         0.957   0.989   1.039   1.019   1.061   1.136   1.017   1.059   1.131
290   I         0.957   0.989   1.039   0.976   1.036   1.097   1.017   1.059   1.131
291   T         0.957   0.989   1.039   1.019   1.061   1.136   1.017   1.059   1.131
292   D         0.957   0.989   1.039   0.965   1.018   1.087   1.017   1.059   1.131
293   V         0.957   0.989   1.039   0.930   0.973   1.056   1.017   1.059   1.131
294   K        -1.186  -1.156  -1.131  -1.490  -1.415  -1.346  -1.275  -1.209  -1.116
295   D         0.314   0.177   0.039   0.384   0.201  -0.064   0.288   0.070  -0.197
296   L         0.957   0.989   1.039   0.844   0.891   0.978   1.017   1.059   1.131
297   H         0.957   0.989   1.039   1.055   1.100   1.169   1.017   1.059   1.131
298   E        -1.114  -1.079  -1.124  -1.187  -1.147  -1.165  -1.171  -1.113  -1.108
299   W         0.957   0.989   1.039   1.162   1.210   1.265   1.017   1.059   1.131
300   M         0.957   0.989   1.039   1.078   1.124   1.190   1.017   1.059   1.131
301   V         0.314   0.177   0.039   0.373   0.190  -0.028   0.288   0.070  -0.197
302   K        -0.299  -0.536  -0.631  -0.325  -0.630  -0.759  -0.338  -0.657  -0.792
303   H         0.957   0.989   1.039   1.055   1.100   1.169   1.017   1.059   1.131
304   L         0.314   0.210   0.049   0.291   0.162  -0.074   0.288   0.123  -0.179
305   E        -1.593  -1.564  -1.499  -1.599  -1.548  -1.400  -1.484  -1.432  -1.285
306   E        -0.172  -0.186  -0.065  -0.491  -0.520  -0.303  -0.546  -0.579  -0.392
307   H         0.957   0.989   1.039   1.055   1.100   1.169   1.017   1.059   1.131
308   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
309   L        -0.299  -0.348  -0.608  -0.241  -0.312  -0.651  -0.338  -0.405  -0.760
310   F         0.957   0.989   1.039   0.989   1.033   1.109   1.017   1.059   1.131
311   E         0.314   0.177   0.039   0.231   0.050  -0.166   0.288   0.070  -0.197
312   R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
313   L        -0.299  -0.536  -0.631  -0.262  -0.589  -0.737  -0.338  -0.657  -0.792
314   S        -0.580  -0.518  -0.655  -0.508  -0.459  -0.633  -0.754  -0.702  -0.829
315   K        -0.580  -0.556  -0.638  -0.824  -0.742  -0.898  -0.754  -0.685  -0.803
316   E         0.957   0.989   1.039   0.797   0.845   0.936   1.017   1.059   1.131
317   W        -0.172  -0.186  -0.065  -0.255  -0.347  -0.167  -0.546  -0.579  -0.392
318   E         0.314   0.210   0.049   0.249   0.125  -0.099   0.288   0.123  -0.179
319   E        -1.114  -0.968  -1.112  -1.249  -1.037  -1.237  -1.171  -0.986  -1.097
320   N        -1.298  -1.220  -1.153  -1.305  -1.217  -1.112  -1.379  -1.288  -1.139
321   D         0.957   0.989   1.039   0.965   1.018   1.087   1.017   1.059   1.131
322   E        -1.593  -1.524  -1.501  -1.690  -1.577  -1.513  -1.484  -1.404  -1.287
323   C         0.314   0.210   0.049   0.569   0.432   0.123   0.288   0.123  -0.179
324   V         0.957   0.989   1.039   0.930   0.973   1.056   1.017   1.059   1.131
325   K        -2.001  -1.899  -1.799  -2.005  -1.855  -1.713  -1.692  -1.575  -1.396
326   I        -0.299  -0.409  -0.615  -0.141  -0.290  -0.630  -0.338  -0.488  -0.769
327   M         0.957   0.989   1.039   1.078   1.124   1.190   1.017   1.059   1.131
328   R        -1.409  -1.429  -1.482  -1.205  -1.246  -1.291  -1.275  -1.275  -1.269
329   N        -0.299  -0.142  -0.588  -0.083   0.113  -0.510  -0.338  -0.122  -0.732
330   A        -0.706  -0.646  -0.673  -0.890  -0.849  -0.811  -0.963  -0.881  -0.854
331   T         0.957   0.989   1.039   1.019   1.061   1.136   1.017   1.059   1.131
332   E         0.957   0.989   1.039   0.797   0.845   0.936   1.017   1.059   1.131
333   E         0.957   0.989   1.039   0.797   0.845   0.936   1.017   1.059   1.131
334   G         0.957   0.989   1.039   0.984   1.027   1.105   1.017   1.059   1.131
335   K         0.314   0.372   0.056   0.218   0.306  -0.114   0.288   0.373  -0.166
336   K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
337   V         0.957   0.989   1.039   0.930   0.973   1.056   1.017   1.059   1.131
338   E        -0.890  -0.856  -0.706  -1.126  -1.050  -0.817  -1.171  -1.105  -0.893
339   R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
340   K        -0.580  -0.540  -0.633  -0.570  -0.456  -0.656  -0.754  -0.663  -0.795
341   K        -0.875  -1.068  -1.119  -0.892  -1.151  -1.234  -0.858  -1.076  -1.101
342   G         0.957   0.989   1.039   0.984   1.027   1.105   1.017   1.059   1.131
343   D        -1.114  -1.249  -1.141  -1.065  -1.262  -1.128  -1.171  -1.281  -1.126
344   K         0.957   0.989   1.039   0.766   0.823   0.907   1.017   1.059   1.131
345   F        -1.114  -1.086  -1.125  -0.910  -0.869  -0.906  -1.171  -1.114  -1.109
346   V         0.314   0.429   0.060   0.375   0.517   0.013   0.288   0.455  -0.158
347   A         0.957   0.989   1.039   0.965   1.001   1.087   1.017   1.059   1.131
348   C         0.314   0.210   0.049   0.569   0.432   0.123   0.288   0.123  -0.179
349   F        -0.003  -0.052  -0.044  -0.003  -0.092  -0.105  -0.233  -0.328  -0.351
350   T        -1.593  -1.513  -1.494  -1.699  -1.610  -1.540  -1.484  -1.381  -1.281
351   R         0.957   0.989   1.039   0.900   0.939   1.028   1.017   1.059   1.131
352   L        -0.299  -0.409  -0.615  -0.292  -0.437  -0.781  -0.338  -0.488  -0.769
353   P        -0.003  -0.040  -0.031  -0.094  -0.180  -0.210  -0.233  -0.306  -0.327
354   T        -1.114  -1.191  -1.140  -0.973  -1.099  -1.019  -1.171  -1.240  -1.125
355   P         0.957   0.989   1.039   0.967   1.009   1.089   1.017   1.059   1.131
356   A        -1.593  -1.615  -1.503  -1.620  -1.662  -1.495  -1.484  -1.468  -1.288
357   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
358   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
359   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
360   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
361   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
362   I        -0.769  -0.849  -0.699  -0.761  -0.863  -0.644  -1.021  -1.095  -0.885
363   L        -1.688  -1.666  -1.515  -1.704  -1.659  -1.419  -1.569  -1.510  -1.298
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q12009
Output conservation file - output/Q12009
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
