1     M         1.225   1.252   1.270   1.474   1.521   1.537   1.293   1.323   1.349
2     T        -0.151  -0.053  -0.131  -0.060   0.098  -0.040  -0.341  -0.177  -0.310
3     A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
10    M        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
11    T        -1.773  -1.691  -1.667  -1.763  -1.701  -1.594  -1.463  -1.351  -1.305
12    L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
13    F        -1.023  -1.048  -1.033  -0.739  -0.784  -0.764  -1.004  -1.017  -0.982
14    L        -1.023  -0.885  -0.990  -1.191  -0.988  -1.116  -1.004  -0.811  -0.932
15    L         0.009  -0.145  -0.128  -0.164  -0.377  -0.328  -0.085  -0.326  -0.304
16    R         1.225   1.252   1.270   1.251   1.297   1.321   1.293   1.323   1.349
17    H         1.225   1.252   1.270   1.450   1.494   1.514   1.293   1.323   1.349
18    G         1.225   1.252   1.270   1.191   1.227   1.263   1.293   1.323   1.349
19    Q         0.009  -0.145  -0.128   0.072  -0.202  -0.198  -0.085  -0.326  -0.304
20    S         1.225   1.252   1.270   1.260   1.309   1.331   1.293   1.323   1.349
21    E         0.009   0.125  -0.080  -0.139   0.039  -0.260  -0.085   0.094  -0.226
22    L        -1.023  -1.048  -1.033  -1.050  -1.021  -0.995  -1.004  -1.017  -0.982
23    N         1.225   1.252   1.270   1.246   1.299   1.316   1.293   1.323   1.349
24    H        -1.023  -1.048  -1.033  -0.787  -0.877  -0.840  -1.004  -1.017  -0.982
25    E        -1.023  -1.048  -1.033  -1.264  -1.341  -1.276  -1.004  -1.017  -0.982
26    N         1.225   1.252   1.270   1.246   1.299   1.316   1.293   1.323   1.349
27    I         0.009  -0.145  -0.128  -0.062  -0.351  -0.333  -0.085  -0.326  -0.304
28    F         1.225   1.252   1.270   1.397   1.450   1.463   1.293   1.323   1.349
29    C        -1.023  -1.048  -1.033  -0.683  -0.735  -0.732  -1.004  -1.017  -0.982
30    G         1.225   1.252   1.270   1.191   1.227   1.263   1.293   1.323   1.349
31    W         1.225   1.252   1.270   1.498   1.537   1.560   1.293   1.323   1.349
32    I        -1.023  -1.048  -1.033  -1.013  -1.081  -1.031  -1.004  -1.017  -0.982
33    D         1.225   1.252   1.270   1.251   1.295   1.321   1.293   1.323   1.349
34    A        -1.023  -1.048  -1.033  -0.783  -0.836  -0.805  -1.004  -1.017  -0.982
35    K        -1.023  -1.048  -1.033  -0.909  -0.941  -0.878  -1.004  -1.017  -0.982
36    L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
37    T         0.009  -0.145  -0.128   0.204  -0.052  -0.028  -0.085  -0.326  -0.304
38    E         0.009   0.125  -0.080  -0.139   0.039  -0.260  -0.085   0.094  -0.226
39    K         0.009  -0.145  -0.128  -0.009  -0.234  -0.192  -0.085  -0.326  -0.304
40    G         1.225   1.252   1.270   1.191   1.227   1.263   1.293   1.323   1.349
41    K        -1.773  -1.691  -1.667  -1.868  -1.709  -1.695  -1.463  -1.351  -1.305
42    E        -1.773  -1.691  -1.667  -1.789  -1.663  -1.619  -1.463  -1.351  -1.305
43    Q         0.009  -0.145  -0.128   0.072  -0.202  -0.198  -0.085  -0.326  -0.304
44    A         1.225   1.252   1.270   1.359   1.383   1.426   1.293   1.323   1.349
45    R        -0.274  -0.228  -0.191  -0.485  -0.417  -0.353  -0.545  -0.461  -0.409
46    H        -1.023  -1.035  -1.024  -0.967  -1.052  -0.975  -1.004  -1.004  -0.971
47    S        -1.023  -1.040  -1.029  -0.895  -0.950  -0.902  -1.004  -1.008  -0.977
48    A        -0.274  -0.228  -0.191  -0.347  -0.297  -0.221  -0.545  -0.461  -0.409
49    E        -1.023  -0.885  -0.990  -1.124  -0.909  -1.054  -1.004  -0.811  -0.932
50    L         0.009  -0.145  -0.128  -0.205  -0.430  -0.392  -0.085  -0.326  -0.304
51    I         0.009  -0.145  -0.128  -0.062  -0.351  -0.333  -0.085  -0.326  -0.304
52    E        -1.151  -1.117  -1.057  -1.259  -1.196  -1.107  -1.157  -1.091  -1.010
53    Q        -0.151  -0.163  -0.173  -0.058  -0.071  -0.090  -0.341  -0.354  -0.378
54    Y        -0.151  -0.114  -0.169   0.015   0.076  -0.011  -0.341  -0.276  -0.371
55    C         1.225   1.252   1.270   1.501   1.545   1.564   1.293   1.323   1.349
56    K         0.009   0.108  -0.089  -0.029   0.115  -0.164  -0.085   0.070  -0.241
57    A         0.009   0.132  -0.074   0.132   0.311   0.014  -0.085   0.105  -0.217
58    N        -1.023  -1.048  -1.033  -0.903  -0.935  -0.914  -1.004  -1.017  -0.982
59    N         0.009   0.132  -0.074   0.028   0.208  -0.097  -0.085   0.105  -0.217
60    L        -1.023  -1.040  -1.029  -1.163  -1.143  -1.126  -1.004  -1.008  -0.977
61    R        -1.773  -1.691  -1.667  -1.725  -1.621  -1.557  -1.463  -1.351  -1.305
62    L         0.009  -0.145  -0.128  -0.154  -0.351  -0.312  -0.085  -0.326  -0.304
63    P         1.225   1.252   1.270   1.322   1.364   1.390   1.293   1.323   1.349
64    Q        -1.023  -1.048  -1.033  -0.933  -0.972  -0.971  -1.004  -1.017  -0.982
65    I         0.009   0.108  -0.089  -0.062   0.103  -0.253  -0.085   0.070  -0.241
66    G         0.009  -0.145  -0.128   0.065  -0.171  -0.129  -0.085  -0.326  -0.304
67    Y        -0.274  -0.228  -0.191  -0.203  -0.111  -0.070  -0.545  -0.461  -0.409
68    T         1.225   1.252   1.270   1.368   1.400   1.435   1.293   1.323   1.349
69    S         1.225   1.252   1.270   1.260   1.309   1.331   1.293   1.323   1.349
70    R         0.009  -0.145  -0.128   0.123  -0.109  -0.079  -0.085  -0.326  -0.304
71    L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
72    I        -1.023  -1.040  -1.029  -1.074  -1.069  -1.098  -1.004  -1.008  -0.977
73    R         1.225   1.252   1.270   1.251   1.297   1.321   1.293   1.323   1.349
74    T         0.009  -0.145  -0.128   0.235  -0.017   0.020  -0.085  -0.326  -0.304
75    Q        -0.274  -0.229  -0.193  -0.507  -0.389  -0.354  -0.545  -0.463  -0.411
76    Q        -1.023  -1.048  -1.033  -1.032  -1.095  -1.094  -1.004  -1.017  -0.982
77    T         1.225   1.252   1.270   1.368   1.400   1.435   1.293   1.323   1.349
78    I        -1.023  -1.035  -1.024  -0.652  -0.644  -0.666  -1.004  -1.004  -0.971
79    E        -1.773  -1.691  -1.667  -1.682  -1.503  -1.516  -1.463  -1.351  -1.305
80    T        -1.773  -1.691  -1.667  -1.652  -1.530  -1.486  -1.463  -1.351  -1.305
81    M         0.009   0.132  -0.074   0.108   0.282   0.009  -0.085   0.105  -0.217
82    C         0.009   0.132  -0.074  -0.115   0.047  -0.190  -0.085   0.105  -0.217
83    E        -1.023  -0.885  -0.990  -1.193  -0.968  -1.129  -1.004  -0.811  -0.932
84    E         1.225   1.252   1.270   1.017   1.067   1.095   1.293   1.323   1.349
85    F        -1.023  -1.040  -1.029  -0.903  -0.919  -0.954  -1.004  -1.008  -0.977
86    K        -1.023  -0.867  -0.990  -1.010  -0.766  -0.957  -1.004  -0.789  -0.932
87    L        -0.151  -0.163  -0.173  -0.500  -0.514  -0.530  -0.341  -0.354  -0.378
88    K        -1.773  -1.691  -1.667  -1.795  -1.694  -1.625  -1.463  -1.351  -1.305
89    P         0.009   0.125  -0.080   0.115   0.299  -0.048  -0.085   0.094  -0.226
90    Q        -1.773  -1.691  -1.667  -1.763  -1.595  -1.594  -1.463  -1.351  -1.305
91    L        -1.023  -0.885  -0.990  -1.117  -0.924  -1.036  -1.004  -0.811  -0.932
92    Q        -1.023  -0.879  -0.993  -1.099  -0.880  -1.030  -1.004  -0.804  -0.935
93    V        -1.023  -1.048  -1.033  -0.859  -0.888  -0.877  -1.004  -1.017  -0.982
94    V        -1.023  -1.040  -1.029  -0.905  -0.947  -0.925  -1.004  -1.008  -0.977
95    Y        -1.151  -1.117  -1.057  -1.087  -1.033  -0.940  -1.157  -1.091  -1.010
96    D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
97    F        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
98    N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
99    K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
100   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
101   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
102   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
103   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
104   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
105   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
106   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
107   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
108   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
109   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
110   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
111   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
112   I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
113   K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
114   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
115   G        -0.151  -0.114  -0.169  -0.212  -0.151  -0.247  -0.341  -0.276  -0.371
116   D        -1.151  -1.117  -1.057  -1.275  -1.230  -1.122  -1.157  -1.091  -1.010
117   E        -1.151  -1.117  -1.057  -1.401  -1.349  -1.244  -1.157  -1.091  -1.010
118   F        -1.151  -1.117  -1.057  -1.182  -1.120  -1.031  -1.157  -1.091  -1.010
119   G        -1.151  -1.117  -1.057  -1.291  -1.223  -1.138  -1.157  -1.091  -1.010
120   S        -0.151  -0.163  -0.173  -0.139  -0.156  -0.181  -0.341  -0.354  -0.378
121   D        -1.151  -1.117  -1.057  -1.256  -1.192  -1.103  -1.157  -1.091  -1.010
122   D        -1.151  -1.117  -1.057  -1.113  -1.042  -0.965  -1.157  -1.091  -1.010
123   K        -1.151  -1.117  -1.057  -1.356  -1.285  -1.200  -1.157  -1.091  -1.010
124   D        -0.151  -0.114  -0.169  -0.281  -0.215  -0.350  -0.341  -0.276  -0.371
125   N         1.225   1.252   1.270   1.230   1.276   1.301   1.293   1.323   1.349
126   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
127   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
128   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
129   M        -1.151  -1.117  -1.057  -1.036  -0.988  -0.890  -1.157  -1.091  -1.010
130   K        -0.151  -0.114  -0.169  -0.400  -0.331  -0.455  -0.341  -0.276  -0.371
131   I        -0.151  -0.163  -0.173  -0.161  -0.170  -0.185  -0.341  -0.354  -0.378
132   P         1.225   1.252   1.270   1.322   1.364   1.390   1.293   1.323   1.349
133   I        -0.151  -0.086  -0.163  -0.156  -0.042  -0.195  -0.341  -0.230  -0.362
134   L        -0.151  -0.163  -0.173  -0.388  -0.393  -0.386  -0.341  -0.354  -0.378
135   Q        -1.023  -1.040  -1.029  -0.933  -0.991  -0.963  -1.004  -1.008  -0.977
136   T        -0.274  -0.224  -0.188  -0.290  -0.216  -0.157  -0.545  -0.455  -0.403
137   W         0.009  -0.145  -0.128   0.255  -0.040  -0.034  -0.085  -0.326  -0.304
138   R         0.009  -0.145  -0.128   0.043  -0.223  -0.204  -0.085  -0.326  -0.304
139   L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
140   N         1.225   1.252   1.270   1.246   1.299   1.316   1.293   1.323   1.349
141   E         1.225   1.252   1.270   1.017   1.067   1.095   1.293   1.323   1.349
142   R         1.225   1.252   1.270   1.251   1.297   1.321   1.293   1.323   1.349
143   H         0.009  -0.145  -0.128   0.311   0.072   0.086  -0.085  -0.326  -0.304
144   Y         1.225   1.252   1.270   1.354   1.397   1.421   1.293   1.323   1.349
145   G         1.225   1.252   1.270   1.191   1.227   1.263   1.293   1.323   1.349
146   S        -1.023  -1.040  -1.029  -0.870  -0.909  -0.872  -1.004  -1.008  -0.977
147   W         0.009  -0.145  -0.128   0.235  -0.075  -0.066  -0.085  -0.326  -0.304
148   Q         1.225   1.252   1.270   1.310   1.361   1.378   1.293   1.323   1.349
149   G         1.225   1.252   1.270   1.191   1.227   1.263   1.293   1.323   1.349
150   Q         0.009  -0.145  -0.128   0.051  -0.238  -0.232  -0.085  -0.326  -0.304
151   R        -1.023  -1.048  -1.033  -0.922  -0.956  -0.939  -1.004  -1.017  -0.982
152   K         1.225   1.252   1.270   1.110   1.148   1.185   1.293   1.323   1.349
153   P        -1.023  -1.048  -1.033  -0.777  -0.831  -0.787  -1.004  -1.017  -0.982
154   N        -1.023  -1.035  -1.024  -1.048  -1.060  -1.032  -1.004  -1.004  -0.971
155   V        -1.023  -1.048  -1.033  -0.747  -0.791  -0.741  -1.004  -1.017  -0.982
156   L         0.009  -0.145  -0.128  -0.205  -0.430  -0.392  -0.085  -0.326  -0.304
157   K         0.009   0.108  -0.089  -0.125   0.031  -0.301  -0.085   0.070  -0.241
158   E         0.009  -0.145  -0.128  -0.186  -0.436  -0.409  -0.085  -0.326  -0.304
159   Y         0.009  -0.145  -0.128   0.266   0.053   0.077  -0.085  -0.326  -0.304
160   G         1.225   1.252   1.270   1.191   1.227   1.263   1.293   1.323   1.349
161   K        -1.023  -1.035  -1.024  -1.140  -1.124  -1.114  -1.004  -1.004  -0.971
162   D         0.009   0.132  -0.074  -0.139   0.049  -0.250  -0.085   0.105  -0.217
163   K         0.009   0.132  -0.074   0.100   0.300  -0.050  -0.085   0.105  -0.217
164   Y         0.009  -0.145  -0.128   0.201  -0.040  -0.023  -0.085  -0.326  -0.304
165   M         0.009  -0.145  -0.128   0.320   0.079   0.085  -0.085  -0.326  -0.304
166   F        -1.023  -1.035  -1.024  -0.797  -0.844  -0.805  -1.004  -1.004  -0.971
167   I         0.009  -0.145  -0.128   0.116  -0.084  -0.053  -0.085  -0.326  -0.304
168   R         1.225   1.252   1.270   1.251   1.297   1.321   1.293   1.323   1.349
169   R         1.225   1.252   1.270   1.251   1.297   1.321   1.293   1.323   1.349
170   D         0.009  -0.145  -0.128   0.091  -0.147  -0.128  -0.085  -0.326  -0.304
171   Y         1.225   1.252   1.270   1.354   1.397   1.421   1.293   1.323   1.349
172   E        -1.773  -1.691  -1.667  -1.893  -1.703  -1.719  -1.463  -1.351  -1.305
173   G         0.009  -0.145  -0.128   0.012  -0.241  -0.212  -0.085  -0.326  -0.304
174   K        -1.023  -1.040  -1.029  -0.997  -1.009  -0.978  -1.004  -1.008  -0.977
175   P         1.225   1.252   1.270   1.324   1.371   1.393   1.293   1.323   1.349
176   P         1.225   1.252   1.270   1.322   1.364   1.390   1.293   1.323   1.349
177   P        -1.151  -1.117  -1.057  -1.315  -1.262  -1.161  -1.157  -1.091  -1.010
178   V        -0.151  -0.163  -0.173  -0.058  -0.071  -0.090  -0.341  -0.354  -0.378
179   D         1.225   1.252   1.270   1.248   1.292   1.319   1.293   1.323   1.349
180   L         1.225   1.252   1.270   0.956   1.001   1.036   1.293   1.323   1.349
181   D        -1.151  -1.117  -1.057  -1.295  -1.232  -1.142  -1.157  -1.091  -1.010
182   R        -0.151  -0.114  -0.169  -0.232  -0.167  -0.285  -0.341  -0.276  -0.371
183   E         1.225   1.252   1.270   1.002   1.044   1.081   1.293   1.323   1.349
184   M         1.225   1.252   1.270   1.466   1.508   1.529   1.293   1.323   1.349
185   I        -0.151  -0.163  -0.173  -0.201  -0.214  -0.235  -0.341  -0.354  -0.378
186   Q         1.225   1.252   1.270   1.291   1.334   1.360   1.293   1.323   1.349
187   Q        -1.151  -1.117  -1.057  -1.182  -1.120  -1.031  -1.157  -1.091  -1.010
188   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
189   N        -1.151  -1.117  -1.057  -0.946  -0.881  -0.803  -1.157  -1.091  -1.010
190   E        -0.151  -0.086  -0.163  -0.281  -0.161  -0.338  -0.341  -0.230  -0.362
191   K        -1.151  -1.117  -1.057  -1.364  -1.290  -1.208  -1.157  -1.091  -1.010
192   G         1.225   1.252   1.270   1.205   1.246   1.277   1.293   1.323   1.349
193   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
194   S        -1.151  -1.117  -1.057  -1.028  -0.971  -0.883  -1.157  -1.091  -1.010
195   T         1.225   1.252   1.270   1.400   1.443   1.466   1.293   1.323   1.349
196   G         1.225   1.252   1.270   1.205   1.246   1.277   1.293   1.323   1.349
197   Y         1.225   1.252   1.270   1.352   1.395   1.419   1.293   1.323   1.349
198   E         1.225   1.252   1.270   1.002   1.044   1.081   1.293   1.323   1.349
199   F         1.225   1.252   1.270   1.376   1.419   1.443   1.293   1.323   1.349
200   K         1.225   1.252   1.270   1.123   1.171   1.198   1.293   1.323   1.349
201   E         1.225   1.252   1.270   1.002   1.044   1.081   1.293   1.323   1.349
202   P         1.225   1.252   1.270   1.322   1.364   1.390   1.293   1.323   1.349
203   N         1.225   1.252   1.270   1.230   1.276   1.301   1.293   1.323   1.349
204   R         1.225   1.252   1.270   1.242   1.284   1.313   1.293   1.323   1.349
205   Q        -1.151  -1.117  -1.057  -0.978  -0.912  -0.834  -1.157  -1.091  -1.010
206   I        -1.151  -1.117  -1.057  -1.319  -1.250  -1.165  -1.157  -1.091  -1.010
207   K         1.225   1.252   1.270   1.123   1.171   1.198   1.293   1.323   1.349
208   Y         1.225   1.252   1.270   1.352   1.395   1.419   1.293   1.323   1.349
209   E        -0.151  -0.163  -0.173  -0.537  -0.566  -0.596  -0.341  -0.354  -0.378
210   L        -0.151  -0.163  -0.173  -0.559  -0.583  -0.607  -0.341  -0.354  -0.378
211   E         1.225   1.252   1.270   1.002   1.044   1.081   1.293   1.323   1.349
212   C        -0.151  -0.086  -0.163  -0.273  -0.178  -0.249  -0.341  -0.230  -0.362
213   S        -1.151  -1.117  -1.057  -1.340  -1.278  -1.184  -1.157  -1.091  -1.010
214   N        -0.151  -0.163  -0.173  -0.116  -0.125  -0.141  -0.341  -0.354  -0.378
215   H        -0.151  -0.114  -0.169   0.031   0.093  -0.023  -0.341  -0.276  -0.371
216   D        -0.151  -0.114  -0.169  -0.178  -0.112  -0.219  -0.341  -0.276  -0.371
217   I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
218   V        -1.151  -1.117  -1.057  -1.336  -1.289  -1.181  -1.157  -1.091  -1.010
219   L         1.225   1.252   1.270   0.956   1.001   1.036   1.293   1.323   1.349
220   P         1.225   1.252   1.270   1.324   1.371   1.393   1.293   1.323   1.349
221   D        -1.023  -0.867  -0.990  -0.884  -0.636  -0.828  -1.004  -0.789  -0.932
222   S        -0.274  -0.224  -0.188  -0.419  -0.339  -0.279  -0.545  -0.455  -0.403
223   E         1.225   1.252   1.270   1.017   1.067   1.095   1.293   1.323   1.349
224   S         1.225   1.252   1.270   1.260   1.309   1.331   1.293   1.323   1.349
225   L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
226   R        -1.773  -1.691  -1.667  -1.514  -1.428  -1.353  -1.463  -1.351  -1.305
227   E         0.009   0.132  -0.074   0.014   0.214  -0.143  -0.085   0.105  -0.217
228   V         0.009  -0.145  -0.128   0.168  -0.063  -0.036  -0.085  -0.326  -0.304
229   V         0.009  -0.145  -0.128   0.165  -0.071  -0.041  -0.085  -0.326  -0.304
230   Y        -1.773  -1.691  -1.667  -1.561  -1.499  -1.399  -1.463  -1.351  -1.305
231   R         1.225   1.252   1.270   1.251   1.297   1.321   1.293   1.323   1.349
232   L         0.009  -0.145  -0.128  -0.190  -0.408  -0.368  -0.085  -0.326  -0.304
233   N        -1.773  -1.691  -1.667  -1.981  -1.876  -1.805  -1.463  -1.351  -1.305
234   P         1.225   1.252   1.270   1.324   1.371   1.393   1.293   1.323   1.349
235   F        -1.023  -1.048  -1.033  -0.878  -0.900  -0.934  -1.004  -1.017  -0.982
236   L         0.009  -0.145  -0.128  -0.169  -0.378  -0.336  -0.085  -0.326  -0.304
237   Q        -1.773  -1.691  -1.667  -1.760  -1.642  -1.591  -1.463  -1.351  -1.305
238   N        -1.023  -1.040  -1.029  -1.024  -1.027  -1.052  -1.004  -1.008  -0.977
239   V        -1.773  -1.691  -1.667  -1.408  -1.277  -1.250  -1.463  -1.351  -1.305
240   I         1.225   1.252   1.270   1.196   1.241   1.268   1.293   1.323   1.349
241   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
242   K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
243   L        -0.274  -0.228  -0.191  -0.568  -0.451  -0.404  -0.545  -0.461  -0.409
244   A        -0.274  -0.224  -0.188  -0.251  -0.175  -0.115  -0.545  -0.455  -0.403
245   N        -1.023  -1.040  -1.029  -0.901  -0.882  -0.905  -1.004  -1.008  -0.977
246   Q        -1.773  -1.691  -1.667  -1.886  -1.718  -1.713  -1.463  -1.351  -1.305
247   Y        -1.773  -1.691  -1.667  -1.685  -1.627  -1.519  -1.463  -1.351  -1.305
248   D        -1.023  -1.048  -1.033  -1.086  -1.148  -1.139  -1.004  -1.017  -0.982
249   E        -1.773  -1.691  -1.667  -1.927  -1.756  -1.753  -1.463  -1.351  -1.305
250   S        -1.773  -1.691  -1.667  -1.742  -1.650  -1.574  -1.463  -1.351  -1.305
251   S        -1.023  -1.048  -1.033  -0.976  -1.045  -1.007  -1.004  -1.017  -0.982
252   C        -1.023  -1.048  -1.033  -0.685  -0.741  -0.734  -1.004  -1.017  -0.982
253   L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
254   I         1.225   1.252   1.270   1.196   1.241   1.268   1.293   1.323   1.349
255   V         0.009  -0.145  -0.128   0.165  -0.071  -0.041  -0.085  -0.326  -0.304
256   G         0.009  -0.145  -0.128   0.065  -0.171  -0.129  -0.085  -0.326  -0.304
257   H         1.225   1.252   1.270   1.450   1.494   1.514   1.293   1.323   1.349
258   G         1.225   1.252   1.270   1.191   1.227   1.263   1.293   1.323   1.349
259   S         0.009  -0.145  -0.128   0.096  -0.139  -0.127  -0.085  -0.326  -0.304
260   S         0.009   0.108  -0.089   0.135   0.283  -0.005  -0.085   0.070  -0.241
261   V         0.009  -0.145  -0.128   0.036  -0.258  -0.245  -0.085  -0.326  -0.304
262   R         1.225   1.252   1.270   1.251   1.297   1.321   1.293   1.323   1.349
263   S         0.009  -0.145  -0.128   0.132  -0.098  -0.070  -0.085  -0.326  -0.304
264   L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
265   L         0.009  -0.145  -0.128  -0.224  -0.460  -0.422  -0.085  -0.326  -0.304
266   K         0.009  -0.145  -0.128   0.027  -0.173  -0.137  -0.085  -0.326  -0.304
267   I         0.009  -0.145  -0.128   0.035  -0.203  -0.180  -0.085  -0.326  -0.304
268   L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
269   E         1.225   1.252   1.270   1.017   1.067   1.095   1.293   1.323   1.349
270   G         1.225   1.252   1.270   1.191   1.227   1.263   1.293   1.323   1.349
271   I        -1.023  -1.040  -1.029  -1.081  -1.167  -1.106  -1.004  -1.008  -0.977
272   S         0.009  -0.145  -0.128   0.135  -0.090  -0.065  -0.085  -0.326  -0.304
273   D         0.009  -0.145  -0.128   0.068  -0.186  -0.163  -0.085  -0.326  -0.304
274   D        -1.023  -0.885  -0.990  -0.971  -0.743  -0.925  -1.004  -0.811  -0.932
275   D         0.009  -0.145  -0.128   0.107  -0.122  -0.103  -0.085  -0.326  -0.304
276   I         1.225   1.252   1.270   1.196   1.241   1.268   1.293   1.323   1.349
277   K         0.009  -0.145  -0.128  -0.034  -0.265  -0.231  -0.085  -0.326  -0.304
278   N        -1.773  -1.691  -1.667  -1.834  -1.706  -1.663  -1.463  -1.351  -1.305
279   V         0.009  -0.145  -0.128   0.131  -0.112  -0.095  -0.085  -0.326  -0.304
280   D        -1.023  -1.048  -1.033  -1.026  -1.105  -1.065  -1.004  -1.017  -0.982
281   I         0.009  -0.145  -0.128  -0.062  -0.351  -0.333  -0.085  -0.326  -0.304
282   P         0.009  -0.145  -0.128   0.193  -0.043  -0.017  -0.085  -0.326  -0.304
283   N         0.009  -0.145  -0.128   0.121  -0.099  -0.078  -0.085  -0.326  -0.304
284   G         0.009   0.108  -0.089   0.065   0.199  -0.070  -0.085   0.070  -0.241
285   I         0.009  -0.145  -0.128   0.049  -0.181  -0.157  -0.085  -0.326  -0.304
286   P         1.225   1.252   1.270   1.324   1.371   1.393   1.293   1.323   1.349
287   L        -1.023  -1.048  -1.033  -1.207  -1.230  -1.183  -1.004  -1.017  -0.982
288   V         1.225   1.252   1.270   1.295   1.340   1.364   1.293   1.323   1.349
289   V        -1.023  -1.035  -1.024  -0.907  -0.909  -0.891  -1.004  -1.004  -0.971
290   E         0.009  -0.145  -0.128  -0.070  -0.259  -0.226  -0.085  -0.326  -0.304
291   L         1.225   1.252   1.270   0.949   0.989   1.030   1.293   1.323   1.349
292   D         1.225   1.252   1.270   1.251   1.295   1.321   1.293   1.323   1.349
293   K         0.009   0.108  -0.089  -0.049   0.096  -0.192  -0.085   0.070  -0.241
294   N        -1.023  -1.040  -1.029  -0.878  -0.910  -0.877  -1.004  -1.008  -0.977
295   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
296   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
297   L        -1.023  -1.035  -1.024  -0.948  -0.979  -0.996  -1.004  -1.004  -0.971
298   K         0.009   0.108  -0.089  -0.049   0.097  -0.192  -0.085   0.070  -0.241
299   F         0.009  -0.145  -0.128   0.261   0.033   0.042  -0.085  -0.326  -0.304
300   I        -1.023  -1.040  -1.029  -1.081  -1.083  -1.106  -1.004  -1.008  -0.977
301   R         0.009  -0.145  -0.128   0.091  -0.145  -0.128  -0.085  -0.326  -0.304
302   K         1.225   1.252   1.270   1.110   1.148   1.185   1.293   1.323   1.349
303   F        -1.023  -1.040  -1.029  -0.851  -0.931  -0.891  -1.004  -1.008  -0.977
304   Y         0.009  -0.145  -0.128   0.094  -0.204  -0.193  -0.085  -0.326  -0.304
305   L         0.009  -0.145  -0.128  -0.224  -0.460  -0.422  -0.085  -0.326  -0.304
306   D         1.225   1.252   1.270   1.251   1.295   1.321   1.293   1.323   1.349
307   P         1.225   1.252   1.270   1.322   1.364   1.390   1.293   1.323   1.349
308   E         1.225   1.252   1.270   1.002   1.044   1.081   1.293   1.323   1.349
309   S        -0.151  -0.114  -0.169  -0.290  -0.223  -0.365  -0.341  -0.276  -0.371
310   A         1.225   1.252   1.270   1.406   1.449   1.472   1.293   1.323   1.349
311   K         1.225   1.252   1.270   1.123   1.171   1.198   1.293   1.323   1.349
312   I        -0.151  -0.163  -0.173  -0.201  -0.214  -0.235  -0.341  -0.354  -0.378
313   N         1.225   1.252   1.270   1.230   1.276   1.301   1.293   1.323   1.349
314   A         1.225   1.252   1.270   1.406   1.449   1.472   1.293   1.323   1.349
315   E         1.225   1.252   1.270   1.002   1.044   1.081   1.293   1.323   1.349
316   K        -0.151  -0.163  -0.173  -0.421  -0.446  -0.493  -0.341  -0.354  -0.378
317   V         1.225   1.252   1.270   1.291   1.333   1.360   1.293   1.323   1.349
318   R         1.225   1.252   1.270   1.242   1.284   1.313   1.293   1.323   1.349
319   N        -1.151  -1.117  -1.057  -1.193  -1.126  -1.043  -1.157  -1.091  -1.010
320   E         1.225   1.252   1.270   1.002   1.044   1.081   1.293   1.323   1.349
321   G         1.225   1.252   1.270   1.205   1.246   1.277   1.293   1.323   1.349
322   F         1.225   1.252   1.270   1.376   1.419   1.443   1.293   1.323   1.349
323   I        -1.151  -1.117  -1.057  -1.401  -1.340  -1.244  -1.157  -1.091  -1.010
324   K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
325   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
326   P        -1.023  -1.048  -1.033  -0.961  -0.992  -1.011  -1.004  -1.017  -0.982
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q12008
Output conservation file - output/Q12008
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
