1     M         1.946   1.974   2.028   2.201   2.241   2.328   2.139   2.179   2.268
2     V        -1.304  -1.279  -1.234  -1.413  -1.345  -1.309  -0.984  -0.954  -0.889
3     L        -0.956  -0.922  -0.886  -0.970  -0.933  -0.857  -0.836  -0.798  -0.744
4     I        -0.531  -0.552  -0.503  -0.620  -0.635  -0.547  -0.615  -0.636  -0.574
5     I        -0.531  -0.552  -0.503  -0.565  -0.631  -0.568  -0.615  -0.636  -0.574
6     R         0.013   0.036   0.060  -0.029   0.011   0.035  -0.252  -0.220  -0.199
7     P        -0.631  -0.610  -0.531  -0.535  -0.502  -0.383  -0.730  -0.700  -0.605
8     S        -0.015   0.013   0.044  -0.330  -0.283  -0.246  -0.309  -0.271  -0.229
9     Q        -1.046  -1.026  -0.943  -1.020  -0.987  -0.863  -0.921  -0.892  -0.797
10    T        -0.526  -0.487  -0.472  -0.571  -0.501  -0.493  -0.624  -0.577  -0.544
11    L        -0.956  -0.947  -0.894  -0.912  -0.905  -0.826  -0.836  -0.818  -0.752
12    I         0.066   0.125   0.082  -0.042   0.016  -0.009  -0.199  -0.132  -0.177
13    L         0.763   0.754   0.783   0.572   0.559   0.601   0.439   0.407   0.423
14    -        -0.015   0.003   0.047  -0.245  -0.219  -0.145  -0.309  -0.283  -0.225
15    F        -0.526  -0.485  -0.481  -0.717  -0.662  -0.632  -0.624  -0.574  -0.554
16    R        -0.364  -0.385  -0.415  -0.348  -0.369  -0.397  -0.411  -0.434  -0.471
17    K        -0.956  -0.952  -0.910  -1.010  -0.980  -0.923  -0.836  -0.825  -0.767
18    A        -0.531  -0.552  -0.503  -0.582  -0.592  -0.519  -0.615  -0.636  -0.574
19    M        -1.046  -1.017  -0.943  -0.953  -0.910  -0.797  -0.921  -0.885  -0.797
20    L        -0.015   0.029   0.035  -0.084  -0.006  -0.017  -0.309  -0.248  -0.239
21    K         0.013   0.028   0.064   0.015   0.038   0.067  -0.252  -0.232  -0.193
22    P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
23    I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
24    G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
25    R        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
26    Y        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
27    P        -0.531  -0.504  -0.476  -0.634  -0.590  -0.557  -0.615  -0.579  -0.543
28    L        -0.015  -0.011   0.047  -0.166  -0.169  -0.078  -0.309  -0.297  -0.224
29    K        -0.531  -0.527  -0.493  -0.653  -0.637  -0.574  -0.615  -0.609  -0.564
30    R         1.946   1.974   2.028   2.032   2.079   2.161   2.139   2.179   2.268
31    N        -0.956  -0.930  -0.896  -0.883  -0.846  -0.771  -0.836  -0.803  -0.754
32    F         1.946   1.974   2.028   1.954   1.993   2.084   2.139   2.179   2.268
33    F         1.946   1.974   2.028   1.954   1.993   2.084   2.139   2.179   2.268
34    G        -0.956  -0.920  -0.895  -0.806  -0.762  -0.726  -0.836  -0.793  -0.752
35    L        -0.364  -0.344  -0.399  -0.459  -0.440  -0.525  -0.411  -0.386  -0.451
36    S        -0.531  -0.436  -0.486  -0.643  -0.469  -0.604  -0.615  -0.497  -0.555
37    G        -0.531  -0.436  -0.486  -0.643  -0.514  -0.557  -0.615  -0.497  -0.555
38    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
39    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
40    T        -1.046  -1.001  -0.943  -1.111  -1.066  -0.953  -0.921  -0.871  -0.797
41    N        -1.046  -1.001  -0.943  -0.836  -0.739  -0.680  -0.921  -0.871  -0.797
42    H        -0.015  -0.042   0.043  -0.148  -0.205  -0.071  -0.309  -0.337  -0.229
43    T        -0.531  -0.509  -0.476  -0.727  -0.715  -0.659  -0.615  -0.589  -0.543
44    I        -1.304  -1.318  -1.257  -1.189  -1.204  -1.138  -0.984  -0.985  -0.908
45    R        -0.936  -0.899  -0.878  -0.950  -0.883  -0.842  -0.827  -0.783  -0.742
46    E        -0.567  -0.494  -0.492  -0.693  -0.603  -0.568  -0.671  -0.595  -0.568
47    Q         0.466   0.343   0.240   0.735   0.552   0.386   0.422   0.237   0.072
48    R        -1.304  -1.249  -1.244  -1.115  -1.011  -1.030  -0.984  -0.930  -0.897
49    Y         1.184   1.184   1.033   1.415   1.423   1.191   1.202   1.197   0.912
50    V        -0.797  -0.877  -0.872  -0.941  -1.072  -1.086  -0.671  -0.750  -0.731
51    L        -0.428  -0.493  -0.460  -0.629  -0.716  -0.657  -0.515  -0.581  -0.532
52    R        -0.936  -0.823  -0.878  -1.009  -0.862  -0.921  -0.827  -0.720  -0.741
53    K         0.169   0.140   0.119   0.020  -0.024  -0.039  -0.047  -0.095  -0.127
54    A        -0.936  -0.918  -0.889  -0.856  -0.849  -0.784  -0.827  -0.803  -0.751
55    I        -0.797  -0.877  -0.872  -0.659  -0.777  -0.818  -0.671  -0.750  -0.731
56    N        -0.797  -0.760  -0.817  -0.469  -0.420  -0.495  -0.671  -0.634  -0.675
57    A        -0.428  -0.414  -0.439  -0.304  -0.293  -0.334  -0.515  -0.504  -0.510
58    P        -0.428  -0.485  -0.435  -0.448  -0.550  -0.480  -0.515  -0.570  -0.505
59    P         1.946   1.974   2.028   2.086   2.128   2.215   2.139   2.179   2.268
60    S        -0.797  -0.764  -0.833  -0.806  -0.760  -0.856  -0.671  -0.629  -0.692
61    T        -0.797  -0.807  -0.828  -0.603  -0.642  -0.687  -0.671  -0.681  -0.686
62    V        -0.199  -0.308  -0.376  -0.193  -0.361  -0.444  -0.203  -0.341  -0.424
63    Y         0.834   0.784   0.802   0.858   0.752   0.752   0.578   0.466   0.463
64    A        -1.304  -1.301  -1.242  -1.082  -1.107  -0.998  -0.984  -0.972  -0.896
65    A        -0.199  -0.252  -0.338  -0.233  -0.325  -0.444  -0.203  -0.273  -0.377
66    V         1.184   1.069   1.016   1.127   0.978   0.900   1.202   1.000   0.880
67    S         1.946   1.974   2.028   1.835   1.874   1.966   2.139   2.179   2.268
68    E        -0.428  -0.448  -0.454  -0.356  -0.379  -0.363  -0.515  -0.537  -0.526
69    V         1.946   1.974   2.028   1.818   1.862   1.949   2.139   2.179   2.268
70    A        -0.797  -0.846  -0.839  -0.704  -0.767  -0.738  -0.671  -0.720  -0.698
71    Q        -1.304  -1.279  -1.236  -1.049  -1.012  -0.957  -0.984  -0.955  -0.891
72    Y         1.946   1.974   2.028   2.126   2.172   2.254   2.139   2.179   2.268
73    K        -0.428  -0.483  -0.435  -0.521  -0.605  -0.519  -0.515  -0.563  -0.505
74    E        -0.199  -0.239  -0.337  -0.034  -0.107  -0.238  -0.203  -0.258  -0.375
75    F         1.946   1.974   2.028   1.944   1.982   2.074   2.139   2.179   2.268
76    I         0.676   0.746   0.785   0.346   0.460   0.518   0.266   0.390   0.428
77    P         1.946   1.974   2.028   2.086   2.128   2.215   2.139   2.179   2.268
78    Y         0.676   0.746   0.785   0.491   0.602   0.663   0.266   0.390   0.428
79    C         0.834   0.850   0.828   0.884   0.904   0.817   0.578   0.596   0.515
80    V        -0.199  -0.202  -0.323  -0.075  -0.079  -0.273  -0.203  -0.212  -0.358
81    D        -0.428  -0.411  -0.440  -0.422  -0.429  -0.451  -0.515  -0.501  -0.512
82    S         1.946   1.974   2.028   1.835   1.874   1.966   2.139   2.179   2.268
83    F        -0.199  -0.308  -0.376  -0.172  -0.364  -0.491  -0.203  -0.341  -0.424
84    V         0.676   0.694   0.753   0.346   0.378   0.472   0.266   0.286   0.361
85    D        -0.428  -0.334  -0.419  -0.380  -0.224  -0.364  -0.515  -0.388  -0.482
86    K        -0.428  -0.385  -0.418  -0.594  -0.529  -0.564  -0.515  -0.467  -0.487
87    R        -0.199  -0.308  -0.376  -0.029  -0.187  -0.316  -0.203  -0.341  -0.424
88    N         0.834   0.879   0.831   0.879   0.953   0.851   0.578   0.651   0.520
89    P        -0.797  -0.690  -0.794  -0.573  -0.411  -0.583  -0.671  -0.552  -0.652
90    V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
91    D        -0.428  -0.430  -0.418  -0.485  -0.468  -0.482  -0.515  -0.509  -0.485
92    N        -0.428  -0.441  -0.453  -0.287  -0.307  -0.317  -0.515  -0.531  -0.525
93    K        -0.936  -0.942  -0.896  -1.031  -1.002  -0.932  -0.827  -0.823  -0.757
94    P         1.946   1.974   2.028   2.086   2.128   2.215   2.139   2.179   2.268
95    L        -0.428  -0.345  -0.419  -0.657  -0.526  -0.643  -0.515  -0.435  -0.489
96    I        -0.797  -0.771  -0.821  -0.765  -0.745  -0.831  -0.671  -0.645  -0.679
97    A         1.184   1.198   1.042   1.369   1.391   1.184   1.202   1.220   0.929
98    G         0.169   0.076   0.104   0.185   0.038   0.057  -0.047  -0.171  -0.145
99    L         1.946   1.974   2.028   1.865   1.910   1.995   2.139   2.179   2.268
100   R        -0.199  -0.303  -0.358  -0.093  -0.258  -0.379  -0.203  -0.335  -0.401
101   V         1.946   1.974   2.028   1.818   1.862   1.949   2.139   2.179   2.268
102   G         1.946   1.974   2.028   2.126   2.166   2.254   2.139   2.179   2.268
103   F         0.676   0.694   0.753   0.580   0.607   0.710   0.266   0.286   0.361
104   K         0.169   0.191   0.133   0.060   0.104   0.028  -0.047  -0.008  -0.105
105   Q         0.466   0.361   0.256   0.774   0.629   0.475   0.422   0.262   0.095
106   Y        -0.428  -0.493  -0.460  -0.388  -0.509  -0.460  -0.515  -0.581  -0.532
107   D        -0.199  -0.303  -0.358   0.067  -0.079  -0.185  -0.203  -0.335  -0.401
108   E         1.946   1.974   2.028   1.977   2.013   2.106   2.139   2.179   2.268
109   E        -0.428  -0.429  -0.420  -0.484  -0.475  -0.472  -0.515  -0.507  -0.487
110   F         1.946   1.974   2.028   1.944   1.982   2.074   2.139   2.179   2.268
111   I        -1.304  -1.323  -1.258  -1.236  -1.235  -1.135  -0.984  -0.989  -0.908
112   C         0.676   0.682   0.749   0.527   0.492   0.599   0.266   0.260   0.353
113   N         0.169   0.266   0.154   0.047   0.194   0.043  -0.047   0.096  -0.072
114   V         0.169   0.174   0.122  -0.041  -0.030  -0.115  -0.047  -0.043  -0.119
115   T        -1.672  -1.633  -1.564  -1.369  -1.349  -1.209  -1.140  -1.099  -1.016
116   C         1.946   1.974   2.028   2.201   2.241   2.328   2.139   2.179   2.268
117   K         0.079   0.027   0.087  -0.278  -0.321  -0.225  -0.203  -0.252  -0.174
118   D        -1.304  -1.286  -1.238  -1.311  -1.274  -1.222  -0.984  -0.960  -0.892
119   T        -1.304  -1.257  -1.240  -1.249  -1.176  -1.175  -0.984  -0.937  -0.894
120   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
121   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
122   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
123   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
124   H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
125   T         0.013  -0.013   0.032  -0.237  -0.278  -0.204  -0.252  -0.297  -0.240
126   Y        -0.428  -0.460  -0.419  -0.548  -0.602  -0.535  -0.515  -0.535  -0.482
127   T        -0.936  -0.876  -0.873  -1.121  -1.011  -1.030  -0.827  -0.765  -0.738
128   V         1.946   1.974   2.028   1.818   1.862   1.949   2.139   2.179   2.268
129   V        -0.936  -0.925  -0.882  -1.025  -1.026  -0.937  -0.827  -0.810  -0.745
130   A         0.466   0.456   0.266   0.594   0.578   0.250   0.422   0.407   0.111
131   E        -0.428  -0.501  -0.459  -0.571  -0.683  -0.630  -0.515  -0.588  -0.530
132   T         0.169   0.168   0.118   0.012  -0.009  -0.052  -0.047  -0.073  -0.128
133   I        -0.199  -0.267  -0.348  -0.185  -0.303  -0.415  -0.203  -0.292  -0.389
134   S        -0.797  -0.877  -0.872  -0.674  -0.765  -0.737  -0.671  -0.750  -0.731
135   H         0.466   0.474   0.275   0.780   0.797   0.474   0.422   0.434   0.124
136   N        -0.797  -0.877  -0.872  -0.643  -0.783  -0.808  -0.671  -0.750  -0.731
137   L         1.184   1.184   1.033   1.198   1.209   1.015   1.202   1.197   0.912
138   F         1.946   1.974   2.028   1.944   1.982   2.074   2.139   2.179   2.268
139   H        -0.567  -0.588  -0.499  -0.445  -0.472  -0.338  -0.671  -0.678  -0.574
140   L        -1.304  -1.279  -1.234  -1.386  -1.340  -1.274  -0.984  -0.954  -0.889
141   L         1.946   1.974   2.028   1.865   1.910   1.995   2.139   2.179   2.268
142   I        -1.304  -1.284  -1.234  -1.179  -1.159  -1.087  -0.984  -0.958  -0.889
143   S         0.676   0.683   0.749   0.349   0.362   0.473   0.266   0.262   0.353
144   K        -0.797  -0.805  -0.832  -0.702  -0.704  -0.728  -0.671  -0.679  -0.691
145   W         1.946   1.974   2.028   2.267   2.309   2.394   2.139   2.179   2.268
146   T        -0.797  -0.828  -0.841  -0.753  -0.824  -0.875  -0.671  -0.702  -0.700
147   I         0.834   0.850   0.828   0.793   0.818   0.747   0.578   0.596   0.515
148   M        -0.015   0.020   0.051  -0.330  -0.285  -0.208  -0.309  -0.263  -0.220
149   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
150   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
151   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
152   P        -0.531  -0.485  -0.477  -0.571  -0.513  -0.506  -0.615  -0.558  -0.545
153   H         0.169   0.076   0.104   0.221   0.057   0.074  -0.047  -0.171  -0.145
154   P        -0.428  -0.451  -0.451  -0.300  -0.349  -0.322  -0.515  -0.540  -0.524
155   N        -1.304  -1.249  -1.244  -0.959  -0.885  -0.863  -0.984  -0.930  -0.897
156   R        -0.428  -0.441  -0.453  -0.527  -0.582  -0.585  -0.515  -0.531  -0.525
157   P        -1.304  -1.249  -1.244  -1.156  -1.071  -1.064  -0.984  -0.930  -0.897
158   N        -0.428  -0.455  -0.419  -0.267  -0.281  -0.232  -0.515  -0.528  -0.482
159   A        -0.797  -0.828  -0.841  -0.652  -0.723  -0.749  -0.671  -0.702  -0.700
160   A        -0.797  -0.729  -0.827  -0.554  -0.470  -0.648  -0.671  -0.601  -0.685
161   M        -1.304  -1.284  -1.234  -1.128  -1.109  -1.019  -0.984  -0.958  -0.889
162   V         1.946   1.974   2.028   1.818   1.862   1.949   2.139   2.179   2.268
163   E         0.169   0.122   0.112   0.115   0.030   0.013  -0.047  -0.125  -0.138
164   L         1.184   1.204   1.037   1.154   1.189   0.944   1.202   1.231   0.919
165   L        -1.304  -1.318  -1.257  -1.267  -1.278  -1.180  -0.984  -0.985  -0.908
166   L         1.184   1.069   1.016   1.133   0.968   0.871   1.202   1.000   0.880
167   R        -0.936  -0.970  -0.889  -0.961  -0.992  -0.877  -0.827  -0.846  -0.750
168   F         0.834   0.884   0.831   0.755   0.832   0.740   0.578   0.661   0.521
169   K        -0.428  -0.485  -0.442  -0.559  -0.641  -0.568  -0.515  -0.569  -0.513
170   F         1.946   1.974   2.028   1.944   1.982   2.074   2.139   2.179   2.268
171   K         1.184   1.069   1.016   1.147   0.995   0.918   1.202   1.000   0.880
172   S         0.834   0.840   0.830   0.635   0.641   0.620   0.578   0.576   0.518
173   R        -0.428  -0.501  -0.459  -0.409  -0.532  -0.460  -0.515  -0.588  -0.530
174   I         0.169   0.187   0.139   0.081   0.122   0.061  -0.047  -0.015  -0.096
175   Y         1.184   1.069   1.016   1.454   1.311   1.233   1.202   1.000   0.880
176   N        -0.199  -0.239  -0.337   0.091   0.037  -0.111  -0.203  -0.258  -0.375
177   S        -0.428  -0.441  -0.453  -0.494  -0.486  -0.496  -0.515  -0.531  -0.525
178   V        -0.428  -0.471  -0.430  -0.540  -0.571  -0.516  -0.515  -0.551  -0.499
179   S         1.184   1.271   1.049   1.143   1.257   0.966   1.202   1.339   0.942
180   L         0.466   0.404   0.264   0.388   0.283   0.055   0.422   0.321   0.108
181   I        -0.936  -0.971  -0.894  -0.866  -0.912  -0.785  -0.827  -0.846  -0.755
182   F         1.184   1.069   1.016   1.212   1.040   0.949   1.202   1.000   0.880
183   A         0.466   0.355   0.249   0.654   0.495   0.317   0.422   0.254   0.085
184   K        -0.428  -0.496  -0.456  -0.546  -0.647  -0.563  -0.515  -0.583  -0.528
185   T        -0.428  -0.399  -0.430  -0.483  -0.442  -0.459  -0.515  -0.478  -0.499
186   V         1.946   1.974   2.028   1.818   1.862   1.949   2.139   2.179   2.268
187   T         0.169   0.078   0.113   0.105  -0.039  -0.008  -0.047  -0.168  -0.134
188   E        -0.199  -0.308  -0.376  -0.120  -0.311  -0.429  -0.203  -0.341  -0.424
189   L        -0.428  -0.501  -0.459  -0.581  -0.682  -0.623  -0.515  -0.588  -0.530
190   V        -0.060  -0.020   0.024  -0.144  -0.058  -0.017  -0.359  -0.305  -0.252
191   M        -0.428  -0.342  -0.409  -0.367  -0.227  -0.357  -0.515  -0.400  -0.471
192   N        -0.936  -0.945  -0.876  -0.837  -0.834  -0.728  -0.827  -0.826  -0.740
193   A         1.184   1.069   1.016   1.369   1.216   1.143   1.202   1.000   0.880
194   F         1.946   1.974   2.028   1.944   1.982   2.074   2.139   2.179   2.268
195   A        -0.936  -0.942  -0.896  -0.903  -0.942  -0.843  -0.827  -0.823  -0.757
196   K        -0.060  -0.060   0.006  -0.243  -0.236  -0.148  -0.359  -0.360  -0.277
197   R         1.184   1.069   1.016   1.336   1.186   1.111   1.202   1.000   0.880
198   A         0.169   0.258   0.171   0.063   0.238   0.061  -0.047   0.097  -0.041
199   Y        -0.364  -0.426  -0.452  -0.176  -0.274  -0.341  -0.411  -0.484  -0.515
200   H        -0.526  -0.540  -0.483  -0.377  -0.399  -0.317  -0.624  -0.628  -0.555
201   L        -0.364  -0.426  -0.452  -0.522  -0.632  -0.702  -0.411  -0.484  -0.515
202   V         0.466   0.506   0.286   0.426   0.493   0.150   0.422   0.479   0.140
203   R        -0.428  -0.420  -0.429  -0.626  -0.578  -0.599  -0.515  -0.491  -0.493
204   L        -0.797  -0.702  -0.800  -0.772  -0.624  -0.769  -0.671  -0.564  -0.658
205   A        -0.936  -0.937  -0.891  -0.755  -0.747  -0.664  -0.827  -0.818  -0.752
206   M        -0.428  -0.296  -0.418  -0.666  -0.460  -0.636  -0.515  -0.359  -0.485
207   L        -0.797  -0.764  -0.833  -0.717  -0.665  -0.756  -0.671  -0.629  -0.692
208   K         0.676   0.700   0.760   0.311   0.346   0.444   0.266   0.298   0.377
209   P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
210   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
211   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
212   K        -1.046  -1.020  -0.943  -1.146  -1.116  -0.988  -0.921  -0.887  -0.797
213   E        -0.531  -0.476  -0.466  -0.644  -0.553  -0.551  -0.615  -0.546  -0.532
214   G        -0.526  -0.523  -0.474  -0.463  -0.459  -0.390  -0.624  -0.611  -0.546
215   S        -1.304  -1.257  -1.240  -1.340  -1.293  -1.236  -0.984  -0.937  -0.894
216   P        -1.304  -1.239  -1.228  -1.267  -1.181  -1.144  -0.984  -0.917  -0.884
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q08058
Output conservation file - output/Q08058
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
