1     M         1.008   1.033   1.096   1.286   1.314   1.388   1.069   1.101   1.189
2     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     V         0.305   0.143   0.023   0.265   0.058  -0.128   0.293   0.040  -0.194
8     V        -0.994  -0.876  -1.184  -0.813  -0.662  -1.135  -0.926  -0.795  -1.097
9     I        -0.364  -0.626  -0.701  -0.219  -0.610  -0.801  -0.372  -0.722  -0.819
10    A        -1.455  -1.458  -1.252  -1.626  -1.609  -1.292  -1.480  -1.447  -1.170
11    N        -0.364  -0.626  -0.701  -0.186  -0.577  -0.757  -0.372  -0.722  -0.819
12    A        -0.994  -1.223  -1.226  -0.907  -1.234  -1.221  -0.926  -1.185  -1.142
13    H         1.008   1.033   1.096   1.136   1.171   1.255   1.069   1.101   1.189
14    N        -0.671  -0.459  -0.697  -0.714  -0.394  -0.784  -0.815  -0.510  -0.816
15    E        -0.041   0.107  -0.007  -0.126   0.103  -0.096  -0.261  -0.020  -0.247
16    L        -0.041  -0.168  -0.075  -0.084  -0.267  -0.101  -0.261  -0.498  -0.371
17    I         1.008   1.033   1.096   1.038   1.080   1.169   1.069   1.101   1.189
18    H         1.008   1.033   1.096   1.136   1.171   1.255   1.069   1.101   1.189
19    D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
20    A         1.008   1.033   1.096   0.878   0.911   1.028   1.069   1.101   1.189
21    V         0.305   0.143   0.023   0.269   0.066  -0.117   0.293   0.040  -0.194
22    L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
23    D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
24    Y         1.008   1.033   1.096   1.200   1.234   1.312   1.069   1.101   1.189
25    Y         1.008   1.033   1.096   1.200   1.234   1.312   1.069   1.101   1.189
26    G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
27    K         0.305   0.191   0.024   0.421   0.288   0.047   0.293   0.116  -0.192
28    R         0.305   0.436   0.044   0.567   0.725   0.157   0.293   0.477  -0.156
29    L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
30    A         1.008   1.033   1.096   0.878   0.911   1.028   1.069   1.101   1.189
31    T         1.008   1.033   1.096   1.010   1.046   1.144   1.069   1.101   1.189
32    C         1.008   1.033   1.096   1.230   1.259   1.338   1.069   1.101   1.189
33    S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
34    S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
35    D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
36    K        -0.994  -1.168  -1.213  -0.707  -0.938  -0.978  -0.926  -1.129  -1.128
37    T         1.008   1.033   1.096   1.010   1.046   1.144   1.069   1.101   1.189
38    I         0.305   0.393   0.042   0.409   0.529  -0.010   0.293   0.417  -0.160
39    K         1.008   1.033   1.096   1.007   1.047   1.142   1.069   1.101   1.189
40    I        -0.364  -0.422  -0.673  -0.211  -0.310  -0.727  -0.372  -0.465  -0.782
41    F         1.008   1.033   1.096   1.206   1.234   1.317   1.069   1.101   1.189
42    E        -0.364  -0.430  -0.674  -0.239  -0.353  -0.756  -0.372  -0.474  -0.784
43    V        -0.809  -0.717  -0.737  -1.034  -0.881  -0.873  -1.037  -0.928  -0.873
44    E        -0.041   0.029  -0.041  -0.104   0.012  -0.148  -0.261  -0.150  -0.309
45    G         0.305   0.143   0.023   0.335   0.122  -0.057   0.293   0.040  -0.194
46    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
47    E        -0.671  -0.756  -0.726  -0.666  -0.767  -0.757  -0.815  -0.903  -0.855
48    T        -1.455  -1.465  -1.253  -1.544  -1.544  -1.231  -1.480  -1.453  -1.170
49    H        -0.931  -0.909  -0.765  -0.814  -0.802  -0.591  -1.148  -1.121  -0.905
50    K        -0.364  -0.626  -0.701  -0.177  -0.528  -0.650  -0.372  -0.722  -0.819
51    L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
52    I        -0.671  -0.682  -0.711  -0.799  -0.795  -0.850  -0.815  -0.799  -0.835
53    D        -0.809  -0.636  -0.715  -0.941  -0.658  -0.758  -1.037  -0.794  -0.842
54    T         1.008   1.033   1.096   1.010   1.046   1.144   1.069   1.101   1.189
55    L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
56    T        -2.224  -2.081  -1.943  -1.966  -1.742  -1.588  -1.813  -1.667  -1.438
57    G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
58    H         1.008   1.033   1.096   1.136   1.171   1.255   1.069   1.101   1.189
59    E        -0.364  -0.626  -0.701  -0.239  -0.625  -0.806  -0.372  -0.722  -0.819
60    G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
61    P         0.305   0.191   0.024   0.522   0.359   0.049   0.293   0.116  -0.192
62    V         1.008   1.033   1.096   0.876   0.919   1.026   1.069   1.101   1.189
63    W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
64    R        -0.671  -0.632  -0.705  -0.501  -0.446  -0.614  -0.815  -0.731  -0.826
65    V         0.305   0.143   0.023   0.253   0.039  -0.161   0.293   0.040  -0.194
66    D        -1.455  -1.489  -1.257  -1.740  -1.806  -1.442  -1.480  -1.477  -1.175
67    W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
68    A         1.008   1.033   1.096   0.878   0.911   1.028   1.069   1.101   1.189
69    H         1.008   1.033   1.096   1.136   1.171   1.255   1.069   1.101   1.189
70    P         1.008   1.033   1.096   1.151   1.181   1.268   1.069   1.101   1.189
71    K         1.008   1.033   1.096   1.007   1.047   1.142   1.069   1.101   1.189
72    F         0.305   0.191   0.024   0.621   0.475   0.213   0.293   0.116  -0.192
73    G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
74    T        -1.333  -1.321  -1.234  -1.525  -1.482  -1.325  -1.369  -1.328  -1.152
75    I         1.008   1.033   1.096   1.038   1.080   1.169   1.069   1.101   1.189
76    L         0.305   0.319   0.038   0.321   0.344  -0.049   0.293   0.310  -0.167
77    A         1.008   1.033   1.096   0.878   0.911   1.028   1.069   1.101   1.189
78    S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
79    C        -0.226  -0.241  -0.087  -0.300  -0.411  -0.170  -0.594  -0.634  -0.394
80    S         0.305   0.191   0.024   0.188   0.039  -0.210   0.293   0.116  -0.192
81    Y         1.008   1.033   1.096   1.200   1.234   1.312   1.069   1.101   1.189
82    D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
83    G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
84    K         0.305   0.143   0.023   0.415   0.214   0.029   0.293   0.040  -0.194
85    V        -0.041   0.095  -0.007  -0.270  -0.048  -0.238  -0.261  -0.039  -0.248
86    L        -0.671  -0.696  -0.728  -0.695  -0.740  -0.735  -0.815  -0.852  -0.860
87    I         0.305   0.143   0.023   0.409   0.189  -0.046   0.293   0.040  -0.194
88    W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
89    K        -0.226  -0.241  -0.087  -0.339  -0.357  -0.113  -0.594  -0.634  -0.394
90    E         1.008   1.033   1.096   1.012   1.058   1.146   1.069   1.101   1.189
91    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
92    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
93    E        -0.994  -1.168  -1.213  -0.787  -1.031  -1.137  -0.926  -1.129  -1.128
94    N        -1.254  -1.367  -1.238  -1.206  -1.393  -1.235  -1.259  -1.345  -1.155
95    G        -0.671  -0.457  -0.689  -0.682  -0.388  -0.698  -0.815  -0.519  -0.804
96    R        -1.254  -1.367  -1.238  -1.061  -1.270  -1.140  -1.259  -1.345  -1.155
97    W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
98    S        -0.364  -0.474  -0.686  -0.378  -0.514  -0.783  -0.372  -0.519  -0.800
99    Q        -1.779  -1.855  -1.641  -1.501  -1.600  -1.318  -1.591  -1.620  -1.337
100   I         0.305   0.143   0.023   0.416   0.199  -0.027   0.293   0.040  -0.194
101   A        -0.364  -0.626  -0.701  -0.253  -0.573  -0.620  -0.372  -0.722  -0.819
102   V        -1.901  -1.763  -1.636  -1.977  -1.737  -1.558  -1.702  -1.543  -1.333
103   H         0.305   0.191   0.024   0.552   0.414   0.160   0.293   0.116  -0.192
104   A        -1.333  -1.256  -1.231  -1.417  -1.304  -1.198  -1.369  -1.269  -1.150
105   V        -0.477  -0.737  -0.730  -0.519  -0.929  -0.955  -0.524  -0.874  -0.858
106   H         1.008   1.033   1.096   1.136   1.171   1.255   1.069   1.101   1.189
107   S        -1.779  -1.705  -1.624  -1.666  -1.528  -1.450  -1.591  -1.489  -1.324
108   A         1.008   1.033   1.096   0.878   0.911   1.028   1.069   1.101   1.189
109   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
110   V         1.008   1.033   1.096   0.876   0.919   1.026   1.069   1.101   1.189
111   N         1.008   1.033   1.096   1.060   1.093   1.188   1.069   1.101   1.189
112   S        -0.364  -0.626  -0.701  -0.422  -0.797  -0.909  -0.372  -0.722  -0.819
113   V         0.305   0.393   0.042   0.269   0.387  -0.085   0.293   0.417  -0.160
114   Q        -0.809  -0.714  -0.724  -1.022  -0.886  -0.874  -1.037  -0.879  -0.853
115   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
116   A         0.305   0.191   0.024   0.238   0.077  -0.204   0.293   0.116  -0.192
117   P         1.008   1.033   1.096   1.151   1.181   1.268   1.069   1.101   1.189
118   H         0.305   0.319   0.038   0.545   0.567   0.165   0.293   0.310  -0.167
119   E         1.008   1.033   1.096   1.012   1.058   1.146   1.069   1.101   1.189
120   Y        -0.671  -0.665  -0.710  -0.541  -0.516  -0.678  -0.815  -0.778  -0.833
121   G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
122   P        -0.809  -0.836  -0.736  -0.897  -0.908  -0.706  -1.037  -1.031  -0.870
123   L        -0.364  -0.169  -0.657  -0.303  -0.050  -0.745  -0.372  -0.113  -0.761
124   L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
125   L        -0.041  -0.168  -0.075  -0.219  -0.475  -0.333  -0.261  -0.498  -0.371
126   V        -0.671  -0.435  -0.702  -0.531  -0.178  -0.663  -0.815  -0.497  -0.823
127   A        -0.041   0.095  -0.007  -0.224  -0.020  -0.178  -0.261  -0.039  -0.248
128   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
129   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
130   D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
131   G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
132   K        -0.041  -0.094  -0.063  -0.082  -0.176  -0.152  -0.261  -0.363  -0.350
133   V         1.008   1.033   1.096   0.876   0.919   1.026   1.069   1.101   1.189
134   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
135   V         1.008   1.033   1.096   0.876   0.919   1.026   1.069   1.101   1.189
136   V        -0.041  -0.168  -0.075  -0.254  -0.490  -0.343  -0.261  -0.498  -0.371
137   E        -0.041   0.095  -0.007  -0.104   0.117  -0.084  -0.261  -0.039  -0.248
138   F         1.008   1.033   1.096   1.206   1.234   1.317   1.069   1.101   1.189
139   K        -0.041   0.095  -0.007  -0.082   0.127  -0.053  -0.261  -0.039  -0.248
140   E        -0.285  -0.225  -0.082  -0.566  -0.462  -0.233  -0.704  -0.604  -0.384
141   N        -0.809  -0.782  -0.740  -0.916  -0.885  -0.802  -1.037  -0.990  -0.876
142   G         1.008   1.033   1.096   0.945   0.980   1.087   1.069   1.101   1.189
143   T        -0.671  -0.765  -0.746  -0.732  -0.957  -0.889  -0.815  -0.961  -0.882
144   T        -1.254  -1.288  -1.239  -1.125  -1.172  -1.101  -1.259  -1.298  -1.157
145   S        -1.254  -1.306  -1.240  -1.397  -1.480  -1.323  -1.259  -1.313  -1.158
146   P        -1.333  -1.376  -1.241  -1.200  -1.263  -1.095  -1.369  -1.374  -1.159
147   I        -2.102  -2.114  -1.946  -1.855  -1.863  -1.677  -1.702  -1.690  -1.440
148   I         0.305   0.319   0.038   0.427   0.454   0.031   0.293   0.310  -0.167
149   I        -0.041   0.107  -0.007   0.101   0.323   0.096  -0.261  -0.020  -0.247
150   D        -0.994  -1.223  -1.226  -0.823  -1.158  -1.188  -0.926  -1.185  -1.142
151   A         1.008   1.033   1.096   0.878   0.911   1.028   1.069   1.101   1.189
152   H         1.008   1.033   1.096   1.136   1.171   1.255   1.069   1.101   1.189
153   A        -1.577  -1.713  -1.623  -1.563  -1.792  -1.677  -1.369  -1.492  -1.322
154   I        -0.994  -1.223  -1.226  -0.778  -1.114  -1.176  -0.926  -1.185  -1.142
155   G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
156   V        -0.809  -0.875  -0.735  -1.070  -1.110  -0.861  -1.037  -1.079  -0.871
157   N         1.008   1.033   1.096   1.060   1.093   1.188   1.069   1.101   1.189
158   S        -0.671  -0.637  -0.724  -0.910  -0.893  -0.972  -0.815  -0.785  -0.854
159   A        -0.041  -0.168  -0.075  -0.269  -0.520  -0.371  -0.261  -0.498  -0.371
160   S        -0.671  -0.632  -0.722  -0.768  -0.726  -0.775  -0.815  -0.788  -0.853
161   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
162   A         0.305   0.143   0.023   0.238   0.004  -0.206   0.293   0.040  -0.194
163   P         1.008   1.033   1.096   1.151   1.181   1.268   1.069   1.101   1.189
164   A        -1.254  -1.152  -1.227  -1.310  -1.182  -1.257  -1.259  -1.163  -1.145
165   T        -0.809  -0.782  -0.740  -1.075  -1.047  -0.958  -1.037  -0.990  -0.876
166   I        -1.901  -1.738  -1.628  -1.991  -1.781  -1.557  -1.702  -1.545  -1.328
167   E        -1.779  -1.651  -1.614  -1.762  -1.578  -1.447  -1.591  -1.438  -1.315
168   E        -0.610  -0.369  -0.687  -0.588  -0.260  -0.695  -0.704  -0.375  -0.801
169   -        -0.764  -0.605  -0.717  -0.942  -0.706  -0.853  -0.917  -0.693  -0.841
170   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
171   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
172   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
173   D        -2.224  -2.134  -1.943  -2.125  -1.999  -1.703  -1.813  -1.709  -1.438
174   G        -1.882  -1.757  -1.631  -1.830  -1.644  -1.473  -1.681  -1.543  -1.330
175   E        -2.252  -2.082  -1.948  -2.078  -1.805  -1.691  -1.826  -1.656  -1.441
176   H        -0.477  -0.282  -0.682  -0.439  -0.187  -0.765  -0.524  -0.261  -0.794
177   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
178   N        -2.252  -2.159  -1.953  -2.225  -2.123  -1.777  -1.826  -1.727  -1.444
179   G        -2.224  -2.155  -1.944  -2.263  -2.128  -1.835  -1.813  -1.723  -1.439
180   T        -1.901  -1.816  -1.635  -1.961  -1.891  -1.598  -1.702  -1.591  -1.333
181   K        -2.102  -2.131  -1.945  -1.924  -2.037  -1.746  -1.702  -1.702  -1.439
182   E        -1.901  -1.752  -1.633  -1.878  -1.676  -1.502  -1.702  -1.537  -1.332
183   S        -2.224  -2.080  -1.948  -2.104  -1.865  -1.688  -1.813  -1.672  -1.441
184   R        -0.364  -0.517  -0.686  -0.032  -0.252  -0.556  -0.372  -0.580  -0.800
185   K        -0.041  -0.057  -0.062   0.065   0.025  -0.052  -0.261  -0.299  -0.348
186   F        -0.671  -0.756  -0.726  -0.486  -0.619  -0.641  -0.815  -0.903  -0.855
187   V         0.305   0.143   0.023   0.245   0.026  -0.181   0.293   0.040  -0.194
188   T         0.305   0.417   0.047   0.371   0.515  -0.048   0.293   0.450  -0.152
189   G        -0.671  -0.704  -0.714  -0.672  -0.733  -0.741  -0.815  -0.829  -0.838
190   G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
191   A        -1.010  -0.978  -0.777  -1.329  -1.242  -0.904  -1.259  -1.202  -0.919
192   D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
193   N         1.008   1.033   1.096   1.060   1.093   1.188   1.069   1.101   1.189
194   L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
195   V        -0.671  -0.665  -0.710  -0.862  -0.824  -0.924  -0.815  -0.778  -0.833
196   K         1.008   1.033   1.096   1.007   1.047   1.142   1.069   1.101   1.189
197   I         1.008   1.033   1.096   1.038   1.080   1.169   1.069   1.101   1.189
198   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
199   K        -0.994  -1.135  -1.212  -0.786  -1.033  -1.129  -0.926  -1.096  -1.127
200   Y        -0.226  -0.236  -0.088  -0.160  -0.199   0.019  -0.594  -0.625  -0.395
201   N        -0.226  -0.094  -0.049  -0.428  -0.206  -0.149  -0.594  -0.363  -0.324
202   S        -1.010  -0.968  -0.777  -1.303  -1.221  -0.931  -1.259  -1.188  -0.919
203   D        -1.901  -1.841  -1.633  -2.135  -2.063  -1.707  -1.702  -1.617  -1.331
204   A        -2.224  -2.144  -1.948  -2.283  -2.187  -1.876  -1.813  -1.716  -1.441
205   Q        -1.254  -1.079  -1.207  -1.124  -0.863  -1.087  -1.259  -1.026  -1.123
206   T        -1.577  -1.618  -1.608  -1.443  -1.533  -1.582  -1.369  -1.408  -1.309
207   Y         0.305   0.143   0.023   0.594   0.378   0.152   0.293   0.040  -0.194
208   V        -1.455  -1.459  -1.249  -1.654  -1.624  -1.306  -1.480  -1.449  -1.167
209   L        -1.254  -1.075  -1.203  -1.304  -1.024  -1.225  -1.259  -1.031  -1.118
210   E         1.008   1.033   1.096   1.012   1.058   1.146   1.069   1.101   1.189
211   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
212   S        -1.901  -1.742  -1.631  -2.003  -1.759  -1.581  -1.702  -1.544  -1.330
213   T        -0.994  -0.929  -1.193  -0.791  -0.704  -1.109  -0.926  -0.852  -1.107
214   L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
215   E        -0.671  -0.765  -0.746  -0.752  -0.964  -0.950  -0.815  -0.961  -0.882
216   G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
217   H         1.008   1.033   1.096   1.136   1.171   1.255   1.069   1.101   1.189
218   S        -1.333  -1.376  -1.241  -1.539  -1.576  -1.353  -1.369  -1.374  -1.159
219   D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
220   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
221   V         0.305   0.143   0.023   0.265   0.058  -0.128   0.293   0.040  -0.194
222   R         1.008   1.033   1.096   1.179   1.212   1.293   1.069   1.101   1.189
223   D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
224   V         1.008   1.033   1.096   0.876   0.919   1.026   1.069   1.101   1.189
225   A         0.305   0.426   0.047   0.300   0.439  -0.003   0.293   0.463  -0.151
226   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
227   S         0.305   0.143   0.023   0.179  -0.045  -0.236   0.293   0.040  -0.194
228   P         0.305   0.319   0.038   0.512   0.526   0.053   0.293   0.310  -0.167
229   T        -0.226  -0.182  -0.078  -0.605  -0.536  -0.347  -0.594  -0.524  -0.377
230   V        -0.364  -0.169  -0.657  -0.324  -0.073  -0.718  -0.372  -0.113  -0.761
231   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
232   L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
233   L        -1.901  -1.914  -1.641  -1.991  -1.969  -1.568  -1.702  -1.666  -1.337
234   R        -0.226  -0.241  -0.087  -0.280  -0.353  -0.119  -0.594  -0.634  -0.394
235   S         0.305   0.143   0.023   0.198  -0.013  -0.183   0.293   0.040  -0.194
236   Y         1.008   1.033   1.096   1.200   1.234   1.312   1.069   1.101   1.189
237   L        -0.226  -0.197  -0.080  -0.445  -0.405  -0.237  -0.594  -0.552  -0.381
238   A         1.008   1.033   1.096   0.878   0.911   1.028   1.069   1.101   1.189
239   S        -0.041   0.095  -0.007  -0.291  -0.083  -0.233  -0.261  -0.039  -0.248
240   V        -0.226  -0.094  -0.049  -0.617  -0.377  -0.320  -0.594  -0.363  -0.324
241   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
242   Q         1.008   1.033   1.096   1.157   1.192   1.274   1.069   1.101   1.189
243   D         1.008   1.033   1.096   0.979   1.015   1.117   1.069   1.101   1.189
244   R        -0.226  -0.241  -0.087  -0.280  -0.353  -0.119  -0.594  -0.634  -0.394
245   T         0.305   0.143   0.023   0.406   0.195   0.001   0.293   0.040  -0.194
246   C        -0.226  -0.094  -0.049  -0.425  -0.226  -0.140  -0.594  -0.363  -0.324
247   I        -1.779  -1.797  -1.631  -1.601  -1.583  -1.339  -1.591  -1.576  -1.329
248   I         0.305   0.319   0.038   0.409   0.436  -0.017   0.293   0.310  -0.167
249   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
250   T         0.305   0.426   0.047   0.371   0.526  -0.048   0.293   0.463  -0.151
251   Q        -0.364  -0.626  -0.701  -0.089  -0.482  -0.684  -0.372  -0.722  -0.819
252   D        -0.226  -0.217  -0.086  -0.453  -0.448  -0.240  -0.594  -0.589  -0.391
253   N        -2.224  -2.084  -1.944  -2.169  -2.011  -1.779  -1.813  -1.668  -1.438
254   E        -1.779  -1.708  -1.617  -1.706  -1.655  -1.497  -1.591  -1.513  -1.319
255   Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
256   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
257   G        -0.364  -0.291  -0.660  -0.254  -0.160  -0.659  -0.372  -0.273  -0.765
258   P        -1.254  -1.201  -1.215  -1.080  -0.990  -1.054  -1.259  -1.171  -1.131
259   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
260   K        -0.809  -0.699  -0.735  -0.861  -0.713  -0.745  -1.037  -0.909  -0.870
261   K         0.305   0.191   0.024   0.429   0.298   0.067   0.293   0.116  -0.192
262   T        -0.931  -0.874  -0.758  -0.999  -0.931  -0.751  -1.148  -1.068  -0.895
263   L        -0.994  -1.135  -1.212  -0.841  -1.063  -1.137  -0.926  -1.096  -1.127
264   L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
265   K        -0.774  -0.698  -0.728  -0.806  -0.670  -0.714  -0.958  -0.829  -0.856
266   E        -0.477  -0.416  -0.700  -0.335  -0.253  -0.674  -0.524  -0.442  -0.818
267   E        -0.477  -0.442  -0.700  -0.358  -0.300  -0.720  -0.524  -0.475  -0.819
268   K        -1.577  -1.504  -1.596  -1.248  -1.170  -1.257  -1.369  -1.286  -1.299
269   F         1.008   1.033   1.096   1.206   1.234   1.317   1.069   1.101   1.189
270   P         0.305   0.191   0.024   0.535   0.379   0.087   0.293   0.116  -0.192
271   D         0.305   0.191   0.024   0.349   0.194  -0.093   0.293   0.116  -0.192
272   V        -0.364  -0.626  -0.701  -0.355  -0.722  -0.858  -0.372  -0.722  -0.819
273   L        -1.455  -1.475  -1.258  -1.570  -1.636  -1.284  -1.480  -1.464  -1.175
274   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
275   R         0.305   0.319   0.038   0.567   0.586   0.146   0.293   0.310  -0.167
276   A        -1.010  -0.874  -0.754  -1.284  -1.084  -0.862  -1.259  -1.068  -0.890
277   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
278   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
279   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
280   L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
281   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
282   G         1.008   1.033   1.096   0.939   0.972   1.081   1.069   1.101   1.189
283   N         1.008   1.033   1.096   1.060   1.093   1.188   1.069   1.101   1.189
284   V        -0.226  -0.200  -0.083  -0.472  -0.435  -0.274  -0.594  -0.556  -0.386
285   L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
286   A         1.008   1.033   1.096   0.878   0.911   1.028   1.069   1.101   1.189
287   L        -1.254  -1.161  -1.220  -1.392  -1.249  -1.327  -1.259  -1.129  -1.136
288   S         1.008   1.033   1.096   0.809   0.847   0.968   1.069   1.101   1.189
289   G        -0.671  -0.805  -0.737  -0.685  -0.890  -0.779  -0.815  -0.984  -0.872
290   G         0.305   0.191   0.024   0.323   0.172  -0.087   0.293   0.116  -0.192
291   D         0.305   0.191   0.024   0.375   0.231  -0.022   0.293   0.116  -0.192
292   N         1.008   1.033   1.096   1.060   1.093   1.188   1.069   1.101   1.189
293   K         0.305   0.393   0.042   0.397   0.512   0.013   0.293   0.417  -0.160
294   V         1.008   1.033   1.096   0.876   0.919   1.026   1.069   1.101   1.189
295   T        -0.671  -0.704  -0.714  -0.704  -0.701  -0.752  -0.815  -0.829  -0.838
296   L         1.008   1.033   1.096   0.927   0.964   1.072   1.069   1.101   1.189
297   W         0.305   0.143   0.023   0.471   0.269   0.093   0.293   0.040  -0.194
298   K         1.008   1.033   1.096   1.007   1.047   1.142   1.069   1.101   1.189
299   E         1.008   1.033   1.096   1.012   1.058   1.146   1.069   1.101   1.189
300   N         0.305   0.143   0.023   0.421   0.186  -0.053   0.293   0.040  -0.194
301   L         1.008   1.033   1.096   0.936   0.978   1.079   1.069   1.101   1.189
302   E        -1.779  -1.705  -1.624  -1.560  -1.444  -1.364  -1.591  -1.489  -1.324
303   G         0.305   0.143   0.023   0.335   0.122  -0.057   0.293   0.040  -0.194
304   K        -0.041  -0.094  -0.063  -0.098  -0.190  -0.177  -0.261  -0.363  -0.350
305   W         1.008   1.033   1.096   1.054   1.088   1.183   1.069   1.101   1.189
306   E         0.305   0.143   0.023   0.422   0.229   0.041   0.293   0.040  -0.194
307   P        -1.254  -1.360  -1.231  -1.329  -1.481  -1.251  -1.259  -1.337  -1.148
308   A        -0.364  -0.626  -0.701  -0.372  -0.761  -0.904  -0.372  -0.722  -0.819
309   G        -0.364  -0.626  -0.701  -0.266  -0.630  -0.749  -0.372  -0.722  -0.819
310   E        -0.994  -1.036  -1.199  -0.787  -0.851  -1.114  -0.926  -0.970  -1.113
311   V        -0.364  -0.626  -0.701  -0.347  -0.711  -0.838  -0.372  -0.722  -0.819
312   H        -2.252  -2.088  -1.949  -2.131  -1.944  -1.714  -1.826  -1.668  -1.442
313   Q        -0.809  -0.836  -0.728  -0.821  -0.826  -0.671  -1.037  -1.020  -0.860
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q04491
Output conservation file - output/Q04491
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
