1     M         1.702   1.717   1.817   2.055   2.082   2.248   1.924   1.945   2.114
2     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     F        -0.677  -0.661  -0.594  -0.785  -0.759  -0.648  -0.805  -0.781  -0.680
6     N        -0.583  -0.561  -0.533  -0.554  -0.523  -0.468  -0.698  -0.670  -0.613
7     N        -0.778  -0.659  -0.870  -0.557  -0.388  -0.692  -0.674  -0.534  -0.752
8     H        -0.971  -1.015  -0.966  -0.665  -0.739  -0.675  -0.910  -0.947  -0.857
9     E        -0.008  -0.068  -0.036  -0.114  -0.211  -0.173  -0.235  -0.320  -0.284
10    I        -0.041  -0.044  -0.017  -0.110  -0.090  -0.026  -0.319  -0.307  -0.263
11    D        -0.544  -0.539  -0.532  -0.547  -0.520  -0.468  -0.674  -0.655  -0.612
12    T         0.696   0.667   0.671   0.767   0.716   0.675   0.507   0.445   0.391
13    I        -0.158  -0.203  -0.098  -0.288  -0.364  -0.199  -0.437  -0.505  -0.367
14    L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
15    S        -0.041  -0.070  -0.030  -0.094  -0.129  -0.035  -0.319  -0.354  -0.284
16    T         0.386   0.328   0.128   0.660   0.583   0.248   0.389   0.304  -0.018
17    L         0.092   0.019   0.008  -0.346  -0.452  -0.451  -0.083  -0.190  -0.216
18    R         0.386   0.411   0.151   0.711   0.751   0.350   0.389   0.422   0.018
19    M        -1.708  -1.715  -1.591  -1.546  -1.594  -1.423  -1.264  -1.259  -1.106
20    E        -0.218  -0.320  -0.437  -0.037  -0.181  -0.366  -0.201  -0.331  -0.482
21    A        -0.218  -0.246  -0.427   0.040  -0.002  -0.284  -0.201  -0.239  -0.469
22    D        -0.468  -0.471  -0.507  -0.381  -0.387  -0.433  -0.555  -0.566  -0.580
23    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
24    P        -0.661  -0.687  -0.587  -0.619  -0.676  -0.528  -0.792  -0.813  -0.676
25    S         0.696   0.724   0.683   0.639   0.684   0.584   0.507   0.555   0.415
26    L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
27    H        -1.398  -1.370  -1.305  -1.229  -1.204  -1.090  -1.146  -1.114  -1.003
28    P        -0.971  -0.965  -0.959  -0.697  -0.714  -0.687  -0.910  -0.904  -0.849
29    L        -0.468  -0.514  -0.529  -0.899  -0.967  -0.940  -0.555  -0.616  -0.605
30    F        -0.218  -0.320  -0.437   0.096  -0.050  -0.255  -0.201  -0.331  -0.482
31    E        -0.971  -0.928  -0.945  -1.013  -0.935  -1.039  -0.910  -0.853  -0.835
32    Q        -1.281  -1.239  -1.269  -1.266  -1.209  -1.338  -1.028  -0.981  -0.970
33    F        -0.041  -0.071  -0.033  -0.303  -0.374  -0.280  -0.319  -0.356  -0.287
34    E         1.702   1.717   1.817   1.762   1.785   1.958   1.924   1.945   2.114
35    K        -0.218  -0.119  -0.394  -0.003   0.140  -0.251  -0.201  -0.071  -0.427
36    F        -0.468  -0.447  -0.508  -0.812  -0.776  -0.811  -0.555  -0.527  -0.583
37    Y         0.092   0.058   0.018   0.335   0.291   0.236  -0.083  -0.128  -0.199
38    E         1.702   1.717   1.817   1.762   1.785   1.958   1.924   1.945   2.114
39    E         0.386   0.523   0.172   0.709   0.899   0.380   0.389   0.589   0.050
40    K         1.702   1.717   1.817   1.771   1.800   1.966   1.924   1.945   2.114
41    L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
42    W         1.028   0.995   0.861   1.461   1.424   1.237   1.098   1.040   0.771
43    F         0.386   0.427   0.158   0.795   0.849   0.449   0.389   0.445   0.028
44    Q         1.702   1.717   1.817   1.857   1.883   2.052   1.924   1.945   2.114
45    L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
46    S         1.028   1.121   0.876   1.284   1.410   1.073   1.098   1.243   0.799
47    E        -1.088  -1.096  -0.987  -1.285  -1.304  -1.154  -1.028  -1.022  -0.877
48    S        -1.708  -1.671  -1.595  -1.685  -1.632  -1.549  -1.264  -1.227  -1.108
49    L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
50    T        -1.398  -1.402  -1.302  -1.455  -1.493  -1.345  -1.146  -1.139  -1.001
51    K        -0.971  -0.912  -0.932  -0.969  -0.881  -0.913  -0.910  -0.847  -0.824
52    F         0.386   0.353   0.149   0.592   0.550   0.156   0.389   0.339   0.014
53    F         0.519   0.509   0.606   0.501   0.479   0.625   0.153   0.125   0.253
54    D        -1.708  -1.696  -1.591  -1.385  -1.385  -1.206  -1.264  -1.245  -1.106
55    D        -0.468  -0.541  -0.531  -0.376  -0.478  -0.444  -0.555  -0.646  -0.611
56    A        -0.778  -0.670  -0.860  -0.502  -0.349  -0.722  -0.674  -0.548  -0.741
57    K        -1.088  -1.098  -0.984  -1.051  -1.054  -0.880  -1.028  -1.022  -0.874
58    S         1.028   0.994   0.858   1.195   1.157   0.972   1.098   1.039   0.765
59    T        -0.971  -0.966  -0.932  -0.907  -0.891  -0.845  -0.910  -0.897  -0.825
60    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
61    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
62    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
63    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
64    P        -0.218  -0.246  -0.427   0.215   0.175  -0.123  -0.201  -0.239  -0.469
65    L         0.386   0.428   0.152   0.124   0.180  -0.180   0.389   0.448   0.020
66    R         1.028   0.979   0.863   1.318   1.260   1.079   1.098   1.013   0.773
67    L         0.386   0.299   0.126   0.089  -0.033  -0.288   0.389   0.260  -0.022
68    R        -0.218  -0.307  -0.436   0.155   0.034  -0.182  -0.201  -0.314  -0.481
69    L        -0.041  -0.046  -0.018  -0.575  -0.576  -0.481  -0.319  -0.319  -0.268
70    Y         1.028   1.055   0.865   1.324   1.362   1.108   1.098   1.139   0.777
71    D        -0.544  -0.581  -0.531  -0.555  -0.594  -0.519  -0.674  -0.702  -0.615
72    N        -1.088  -1.060  -0.988  -1.326  -1.332  -1.134  -1.028  -0.994  -0.878
73    F         1.702   1.717   1.817   1.908   1.937   2.102   1.924   1.945   2.114
74    V         0.519   0.556   0.626   0.315   0.380   0.481   0.153   0.222   0.296
75    S        -1.281  -1.308  -1.279  -1.254  -1.320  -1.318  -1.028  -1.047  -0.978
76    K        -0.468  -0.514  -0.529  -0.445  -0.520  -0.538  -0.555  -0.616  -0.605
77    F         1.702   1.717   1.817   1.908   1.937   2.102   1.924   1.945   2.114
78    Y        -1.708  -1.682  -1.586  -1.477  -1.437  -1.308  -1.264  -1.235  -1.102
79    D        -1.281  -1.317  -1.283  -1.194  -1.263  -1.233  -1.028  -1.055  -0.982
80    K         0.519   0.536   0.609   0.332   0.363   0.464   0.153   0.182   0.261
81    I         0.519   0.509   0.606   0.041  -0.012   0.115   0.153   0.125   0.253
82    N         1.702   1.717   1.817   1.837   1.855   2.031   1.924   1.945   2.114
83    Q        -0.218  -0.252  -0.433   0.059   0.017  -0.271  -0.201  -0.245  -0.476
84    L         0.696   0.650   0.688   0.196   0.113   0.168   0.507   0.411   0.426
85    S        -0.468  -0.393  -0.488  -0.461  -0.326  -0.480  -0.555  -0.447  -0.552
86    V        -0.041  -0.056  -0.028  -0.405  -0.415  -0.389  -0.319  -0.329  -0.280
87    V         1.702   1.717   1.817   1.847   1.871   2.042   1.924   1.945   2.114
88    K        -1.281  -1.173  -1.260  -1.156  -0.978  -1.146  -1.028  -0.917  -0.962
89    Y        -0.544  -0.574  -0.523  -0.485  -0.523  -0.462  -0.674  -0.694  -0.606
90    L         0.092   0.064   0.001  -0.262  -0.295  -0.338  -0.083  -0.124  -0.226
91    L         1.028   1.055   0.865   0.716   0.754   0.509   1.098   1.139   0.777
92    A        -1.398  -1.358  -1.302  -1.486  -1.428  -1.369  -1.146  -1.105  -1.001
93    S         0.519   0.522   0.611   0.379   0.379   0.506   0.153   0.153   0.264
94    L        -0.234  -0.212  -0.108  -0.674  -0.574  -0.423  -0.555  -0.521  -0.383
95    K        -0.971  -0.891  -0.937  -0.922  -0.793  -0.862  -0.910  -0.815  -0.827
96    D        -1.090  -1.046  -0.998  -1.077  -1.000  -0.960  -1.015  -0.964  -0.884
97    S        -0.521  -0.416  -0.538  -0.216  -0.038  -0.303  -0.595  -0.456  -0.609
98    K        -1.088  -1.055  -0.979  -1.110  -1.057  -0.938  -1.028  -0.992  -0.871
99    D         0.696   0.690   0.679   0.659   0.649   0.601   0.507   0.488   0.406
100   F        -1.779  -1.754  -1.622  -1.538  -1.497  -1.314  -1.315  -1.286  -1.127
101   D        -0.544  -0.581  -0.525  -0.654  -0.696  -0.604  -0.674  -0.702  -0.608
102   E         1.702   1.717   1.817   1.762   1.785   1.958   1.924   1.945   2.114
103   S        -1.088  -1.096  -0.985  -0.932  -0.916  -0.744  -1.028  -1.021  -0.875
104   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
105   K        -1.398  -1.383  -1.306  -1.237  -1.205  -1.076  -1.146  -1.123  -1.004
106   Y        -0.971  -1.043  -0.976  -0.762  -0.871  -0.782  -0.910  -0.970  -0.865
107   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
108   D        -1.398  -1.355  -1.311  -1.636  -1.613  -1.479  -1.146  -1.102  -1.008
109   D        -1.398  -1.384  -1.305  -1.223  -1.190  -1.063  -1.146  -1.123  -1.003
110   L         0.386   0.328   0.128   0.091   0.012  -0.281   0.389   0.304  -0.018
111   K        -0.468  -0.430  -0.518  -0.438  -0.392  -0.509  -0.555  -0.518  -0.593
112   A        -1.281  -1.238  -1.251  -1.155  -1.092  -1.130  -1.028  -0.981  -0.954
113   Q        -1.088  -1.067  -0.985  -1.118  -1.088  -0.956  -1.028  -1.002  -0.876
114   F        -0.158  -0.150  -0.093  -0.387  -0.374  -0.368  -0.437  -0.425  -0.360
115   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
116   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
117   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
118   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
119   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
120   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
121   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
122   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
123   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
124   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
125   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
126   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
127   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
128   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
129   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
130   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
131   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
132   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
133   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
134   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
135   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
136   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
137   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
138   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
139   Q        -1.071  -0.986  -0.975  -1.155  -1.033  -1.009  -1.006  -0.924  -0.864
140   E        -0.008   0.047  -0.012  -0.007   0.073  -0.015  -0.235  -0.161  -0.245
141   L        -0.583  -0.470  -0.535  -0.829  -0.614  -0.796  -0.698  -0.553  -0.611
142   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
143   D         0.278   0.137   0.070   0.354   0.141   0.007   0.228   0.012  -0.108
144   S        -0.937  -0.973  -0.947  -0.782  -0.845  -0.806  -0.852  -0.891  -0.832
145   K         0.480   0.478   0.592   0.270   0.265   0.446   0.073   0.060   0.224
146   K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
147   Q        -0.681  -0.708  -0.615  -0.712  -0.772  -0.638  -0.796  -0.825  -0.702
148   R         0.498   0.484   0.596   0.425   0.376   0.545   0.110   0.073   0.233
149   N         0.002  -0.076  -0.064  -0.201  -0.392  -0.450  -0.192  -0.312  -0.316
150   N        -0.681  -0.689  -0.607  -0.856  -0.883  -0.772  -0.796  -0.804  -0.693
151   G         0.002  -0.076  -0.064   0.183   0.040   0.002  -0.192  -0.312  -0.316
152   S         0.002   0.034  -0.015  -0.444  -0.391  -0.451  -0.192  -0.146  -0.240
153   K        -0.185  -0.147  -0.101  -0.501  -0.445  -0.368  -0.494  -0.439  -0.375
154   D        -0.681  -0.650  -0.588  -0.665  -0.624  -0.525  -0.796  -0.756  -0.670
155   H         0.002  -0.076  -0.064   0.196   0.048   0.009  -0.192  -0.312  -0.316
156   G         0.002   0.102  -0.015   0.059   0.219   0.032  -0.192  -0.039  -0.241
157   D        -0.158  -0.139  -0.072  -0.334  -0.309  -0.215  -0.437  -0.412  -0.327
158   G         0.092   0.134   0.062   0.213   0.290   0.173  -0.083   0.000  -0.127
159   I        -0.971  -0.921  -0.945  -0.827  -0.756  -0.795  -0.910  -0.854  -0.837
160   L        -0.234  -0.233  -0.112  -0.772  -0.729  -0.546  -0.555  -0.550  -0.388
161   L        -0.158  -0.081  -0.064  -0.340  -0.167  -0.210  -0.437  -0.321  -0.317
162   I        -0.971  -0.988  -0.953  -1.092  -1.105  -1.107  -0.910  -0.921  -0.844
163   D        -0.778  -0.854  -0.909  -0.621  -0.735  -0.846  -0.674  -0.754  -0.793
164   S        -0.468  -0.469  -0.515  -0.710  -0.767  -0.812  -0.555  -0.569  -0.588
165   E        -0.158  -0.203  -0.098  -0.297  -0.377  -0.215  -0.437  -0.505  -0.367
166   I         1.028   1.013   0.858   1.131   1.112   0.901   1.098   1.069   0.764
167   A         1.702   1.717   1.817   1.845   1.869   2.040   1.924   1.945   2.114
168   R         1.702   1.717   1.817   1.944   1.972   2.138   1.924   1.945   2.114
169   T        -0.971  -0.929  -0.950  -0.954  -0.892  -0.970  -0.910  -0.871  -0.840
170   Y         0.462   0.476   0.592   0.293   0.316   0.500   0.035   0.056   0.224
171   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
172   L        -1.708  -1.648  -1.582  -1.722  -1.606  -1.548  -1.264  -1.208  -1.099
173   K        -0.041  -0.025  -0.013  -0.582  -0.553  -0.511  -0.319  -0.273  -0.252
174   N        -1.088  -1.106  -0.983  -0.962  -0.970  -0.792  -1.028  -1.030  -0.874
175   D        -0.778  -0.837  -0.900  -0.634  -0.722  -0.850  -0.674  -0.738  -0.784
176   L         1.028   1.055   0.865   0.750   0.788   0.578   1.098   1.139   0.777
177   V        -0.971  -0.955  -0.952  -1.083  -1.031  -1.105  -0.910  -0.878  -0.840
178   K        -0.158  -0.148  -0.093  -0.262  -0.242  -0.173  -0.437  -0.422  -0.359
179   A         0.386   0.412   0.158   0.619   0.653   0.279   0.389   0.424   0.029
180   R         0.696   0.650   0.688   0.802   0.715   0.742   0.507   0.411   0.426
181   D        -0.468  -0.521  -0.527  -0.482  -0.557  -0.578  -0.555  -0.614  -0.604
182   L        -0.971  -0.931  -0.939  -1.185  -1.123  -1.125  -0.910  -0.862  -0.831
183   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
184   D        -0.778  -0.865  -0.909  -0.642  -0.782  -0.879  -0.674  -0.767  -0.793
185   D        -1.708  -1.692  -1.588  -1.480  -1.444  -1.303  -1.264  -1.242  -1.104
186   L        -0.661  -0.637  -0.586  -1.113  -1.064  -0.951  -0.792  -0.770  -0.675
187   E        -1.281  -1.313  -1.277  -1.067  -1.128  -1.056  -1.028  -1.052  -0.977
188   K        -0.468  -0.502  -0.530  -0.305  -0.345  -0.351  -0.555  -0.602  -0.606
189   T        -0.158  -0.203  -0.098  -0.254  -0.351  -0.206  -0.437  -0.505  -0.367
190   L        -0.158  -0.191  -0.094  -0.697  -0.731  -0.568  -0.437  -0.488  -0.362
191   D         0.696   0.650   0.688   0.635   0.553   0.585   0.507   0.411   0.426
192   K        -1.281  -1.199  -1.266  -1.035  -0.908  -1.015  -1.028  -0.943  -0.967
193   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
194   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
195   K        -1.708  -1.728  -1.608  -1.769  -1.806  -1.654  -1.264  -1.268  -1.117
196   D         0.519   0.509   0.606   0.332   0.309   0.457   0.153   0.125   0.253
197   S        -0.468  -0.526  -0.521  -0.418  -0.504  -0.501  -0.555  -0.618  -0.599
198   I        -0.218  -0.232  -0.424  -0.065  -0.099  -0.458  -0.201  -0.221  -0.466
199   P        -0.971  -1.021  -0.972  -0.793  -0.893  -0.842  -0.910  -0.952  -0.862
200   L        -0.041   0.021  -0.005  -0.406  -0.242  -0.261  -0.319  -0.216  -0.239
201   R        -1.088  -1.072  -0.993  -1.365  -1.347  -1.240  -1.028  -1.002  -0.882
202   I         0.092   0.164   0.034  -0.026   0.090  -0.175  -0.083   0.019  -0.177
203   T        -0.158  -0.203  -0.098  -0.111  -0.192  -0.029  -0.437  -0.505  -0.367
204   N        -0.468  -0.360  -0.492  -0.381  -0.239  -0.399  -0.555  -0.430  -0.561
205   S         0.519   0.554   0.623   0.379   0.446   0.533   0.153   0.219   0.290
206   F         0.462   0.477   0.592   0.391   0.416   0.600   0.035   0.057   0.224
207   Y         1.702   1.717   1.817   1.930   1.952   2.124   1.924   1.945   2.114
208   S        -0.468  -0.502  -0.530  -0.625  -0.727  -0.745  -0.555  -0.602  -0.606
209   T        -0.971  -0.935  -0.931  -0.763  -0.729  -0.694  -0.910  -0.872  -0.823
210   N         0.092   0.018   0.007   0.119  -0.014  -0.036  -0.083  -0.197  -0.214
211   S        -0.218  -0.232  -0.424   0.090   0.077  -0.198  -0.201  -0.221  -0.466
212   Q        -1.088  -1.062  -0.981  -1.165  -1.126  -1.003  -1.028  -0.998  -0.873
213   Y         0.386   0.299   0.126   0.660   0.531   0.219   0.389   0.260  -0.022
214   F         0.092   0.074   0.031   0.266   0.249   0.163  -0.083  -0.097  -0.181
215   K         0.092   0.129   0.023   0.003   0.071  -0.168  -0.083  -0.026  -0.193
216   F        -1.398  -1.303  -1.310  -1.472  -1.323  -1.364  -1.146  -1.062  -1.008
217   K         0.386   0.299   0.126   0.468   0.337   0.005   0.389   0.260  -0.022
218   N        -1.398  -1.385  -1.297  -1.292  -1.276  -1.136  -1.146  -1.126  -0.998
219   D         0.696   0.650   0.688   0.659   0.579   0.619   0.507   0.411   0.426
220   F        -0.041  -0.062  -0.032   0.052   0.025   0.107  -0.319  -0.348  -0.287
221   N        -0.218  -0.225  -0.427   0.050   0.038  -0.260  -0.201  -0.210  -0.469
222   S        -1.281  -1.313  -1.277  -1.235  -1.314  -1.290  -1.028  -1.052  -0.977
223   F         0.462   0.481   0.595   0.391   0.426   0.607   0.035   0.067   0.231
224   Y         1.702   1.717   1.817   1.930   1.952   2.124   1.924   1.945   2.114
225   Y        -0.971  -1.037  -0.973  -0.898  -1.024  -0.977  -0.910  -0.965  -0.863
226   T        -0.041  -0.025  -0.013  -0.029   0.016   0.061  -0.319  -0.273  -0.252
227   S        -0.661  -0.692  -0.602  -0.580  -0.601  -0.447  -0.792  -0.819  -0.690
228   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
229   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
230   Y         1.702   1.717   1.817   1.930   1.952   2.124   1.924   1.945   2.114
231   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
232   S         0.696   0.700   0.686   0.690   0.696   0.646   0.507   0.508   0.422
233   T        -0.234  -0.233  -0.112  -0.189  -0.183  -0.004  -0.555  -0.550  -0.388
234   L         0.092   0.117   0.058  -0.125  -0.037  -0.196  -0.083  -0.024  -0.134
235   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
236   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
237   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
238   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
239   P        -0.937  -0.869  -0.942  -0.831  -0.739  -0.847  -0.852  -0.780  -0.827
240   S        -0.937  -0.921  -0.932  -1.264  -1.245  -1.218  -0.852  -0.836  -0.818
241   T        -0.971  -0.957  -0.941  -0.877  -0.867  -0.853  -0.910  -0.895  -0.834
242   S        -1.281  -1.258  -1.254  -1.088  -1.059  -1.062  -1.028  -1.000  -0.956
243   I         0.092   0.130   0.050  -0.317  -0.235  -0.322  -0.083  -0.007  -0.146
244   T        -0.041   0.024  -0.010  -0.095  -0.002  -0.026  -0.319  -0.232  -0.254
245   L        -1.708  -1.702  -1.592  -1.899  -1.869  -1.682  -1.264  -1.250  -1.107
246   A        -0.218  -0.130  -0.401  -0.131   0.008  -0.461  -0.201  -0.086  -0.435
247   E         0.386   0.461   0.158   0.574   0.672   0.268   0.389   0.499   0.028
248   R        -1.281  -1.247  -1.250  -1.184  -1.156  -1.191  -1.028  -0.990  -0.953
249   Q        -0.778  -0.826  -0.884  -0.478  -0.552  -0.645  -0.674  -0.724  -0.767
250   Q        -0.661  -0.682  -0.589  -0.702  -0.726  -0.581  -0.792  -0.807  -0.678
251   L         0.519   0.516   0.606   0.006   0.011   0.177   0.153   0.140   0.254
252   A         0.386   0.299   0.126   0.684   0.575   0.348   0.389   0.260  -0.022
253   Y         0.386   0.367   0.138   0.739   0.712   0.389   0.389   0.360  -0.003
254   D        -0.158  -0.153  -0.090  -0.334  -0.329  -0.250  -0.437  -0.430  -0.355
255   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
256   S        -0.041  -0.043  -0.022   0.081   0.089   0.110  -0.319  -0.313  -0.273
257   I         0.519   0.536   0.609   0.315   0.342   0.449   0.153   0.182   0.261
258   S         1.028   1.121   0.876   1.224   1.346   1.015   1.098   1.243   0.799
259   A         1.702   1.717   1.817   1.845   1.869   2.040   1.924   1.945   2.114
260   L         1.028   0.994   0.858   0.699   0.656   0.465   1.098   1.039   0.765
261   L         1.028   1.013   0.858   0.716   0.699   0.498   1.098   1.069   0.764
262   G         1.028   1.013   0.858   1.377   1.363   1.132   1.098   1.069   0.764
263   D         0.092   0.112   0.023   0.053   0.104  -0.073  -0.083  -0.041  -0.194
264   K         0.278   0.296   0.093   0.375   0.404   0.083   0.228   0.251  -0.073
265   I         1.702   1.717   1.817   1.745   1.767   1.940   1.924   1.945   2.114
266   Y         1.028   1.055   0.865   1.340   1.376   1.139   1.098   1.139   0.777
267   N         1.702   1.717   1.817   1.837   1.855   2.031   1.924   1.945   2.114
268   F         1.702   1.717   1.817   1.908   1.937   2.102   1.924   1.945   2.114
269   G         1.702   1.717   1.817   1.999   2.026   2.192   1.924   1.945   2.114
270   E         1.702   1.717   1.817   1.762   1.785   1.958   1.924   1.945   2.114
271   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
272   L         1.028   0.979   0.863   0.699   0.635   0.472   1.098   1.013   0.773
273   H         0.092   0.229   0.049  -0.286  -0.096  -0.297  -0.083   0.123  -0.150
274   H         1.702   1.717   1.817   2.019   2.044   2.212   1.924   1.945   2.114
275   P         0.696   0.650   0.688   0.879   0.792   0.815   0.507   0.411   0.426
276   I         0.696   0.690   0.679   0.637   0.622   0.582   0.507   0.488   0.406
277   M        -0.661  -0.602  -0.570  -0.952  -0.889  -0.796  -0.792  -0.725  -0.656
278   E        -1.088  -1.074  -0.985  -1.151  -1.128  -0.987  -1.028  -1.007  -0.876
279   T        -1.398  -1.402  -1.302  -1.534  -1.538  -1.352  -1.146  -1.139  -1.001
280   I        -0.041  -0.068  -0.033  -0.483  -0.542  -0.459  -0.319  -0.350  -0.287
281   V        -1.088  -1.065  -0.979  -1.096  -1.062  -0.924  -1.028  -1.000  -0.871
282   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
283   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
284   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
285   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
286   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
287   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
288   N        -0.681  -0.724  -0.615  -0.733  -0.818  -0.660  -0.796  -0.846  -0.702
289   D        -0.778  -0.796  -0.880  -0.548  -0.571  -0.693  -0.674  -0.691  -0.763
290   S        -0.661  -0.645  -0.581  -0.746  -0.704  -0.620  -0.792  -0.763  -0.667
291   N        -0.971  -0.877  -0.934  -0.888  -0.733  -0.831  -0.910  -0.805  -0.826
292   Y         0.696   0.667   0.671   0.870   0.820   0.815   0.507   0.445   0.391
293   D        -1.398  -1.392  -1.299  -1.316  -1.314  -1.157  -1.146  -1.131  -0.999
294   W         1.702   1.717   1.817   2.065   2.091   2.258   1.924   1.945   2.114
295   L         1.028   1.096   0.869   0.699   0.792   0.483   1.098   1.205   0.785
296   F        -1.088  -1.040  -0.995  -0.833  -0.759  -0.684  -1.028  -0.977  -0.884
297   Q        -0.544  -0.522  -0.518  -0.548  -0.517  -0.478  -0.674  -0.646  -0.602
298   L         1.028   1.103   0.871   0.725   0.823   0.538   1.098   1.215   0.789
299   L         0.092   0.018   0.007  -0.373  -0.490  -0.480  -0.083  -0.197  -0.214
300   N        -0.661  -0.691  -0.597  -0.666  -0.717  -0.556  -0.792  -0.818  -0.686
301   A         0.696   0.650   0.688   0.731   0.643   0.686   0.507   0.411   0.426
302   L         0.386   0.328   0.128   0.162   0.095  -0.143   0.389   0.304  -0.018
303   T         0.519   0.592   0.651   0.426   0.555   0.639   0.153   0.295   0.348
304   V        -1.281  -1.304  -1.278  -1.045  -1.081  -1.063  -1.028  -1.043  -0.978
305   G         1.702   1.717   1.817   1.999   2.026   2.192   1.924   1.945   2.114
306   D         0.696   0.650   0.688   0.659   0.579   0.619   0.507   0.411   0.426
307   F        -0.468  -0.437  -0.475  -0.842  -0.794  -0.827  -0.555  -0.498  -0.535
308   D        -1.708  -1.692  -1.588  -1.529  -1.491  -1.355  -1.264  -1.242  -1.104
309   K        -0.971  -1.008  -0.978  -1.086  -1.166  -1.158  -0.910  -0.942  -0.867
310   F         1.028   1.013   0.858   1.305   1.294   1.082   1.098   1.069   0.764
311   D        -0.158  -0.191  -0.094  -0.334  -0.397  -0.259  -0.437  -0.488  -0.362
312   S        -1.281  -1.267  -1.257  -1.183  -1.158  -1.175  -1.028  -1.010  -0.960
313   L         0.092   0.105   0.023  -0.254  -0.233  -0.316  -0.083  -0.087  -0.190
314   I        -1.398  -1.377  -1.321  -1.577  -1.568  -1.397  -1.146  -1.117  -1.016
315   K        -0.468  -0.470  -0.485  -0.413  -0.382  -0.411  -0.555  -0.536  -0.547
316   V        -0.677  -0.661  -0.604  -0.789  -0.769  -0.683  -0.805  -0.780  -0.690
317   Q        -0.971  -0.987  -0.953  -0.690  -0.709  -0.640  -0.910  -0.920  -0.843
318   I        -0.218  -0.189  -0.409  -0.006   0.031  -0.260  -0.201  -0.162  -0.446
319   S        -0.971  -1.019  -0.947  -0.817  -0.888  -0.783  -0.910  -0.941  -0.837
320   K         1.028   1.013   0.858   1.150   1.139   0.912   1.098   1.069   0.764
321   I        -2.018  -1.993  -1.858  -1.928  -1.869  -1.701  -1.382  -1.355  -1.195
322   P         1.028   1.096   0.869   1.338   1.440   1.049   1.098   1.205   0.785
323   I        -0.468  -0.504  -0.527  -0.639  -0.728  -0.742  -0.555  -0.601  -0.604
324   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
325   A        -0.468  -0.537  -0.528  -0.426  -0.539  -0.542  -0.555  -0.635  -0.607
326   Q        -0.218  -0.273  -0.427   0.052  -0.024  -0.273  -0.201  -0.271  -0.469
327   H        -0.778  -0.785  -0.882  -0.362  -0.375  -0.558  -0.674  -0.678  -0.764
328   E        -0.778  -0.854  -0.909  -0.536  -0.647  -0.711  -0.674  -0.754  -0.793
329   S        -1.708  -1.730  -1.610  -1.416  -1.451  -1.263  -1.264  -1.270  -1.119
330   F         0.092   0.064   0.001   0.040  -0.012  -0.190  -0.083  -0.124  -0.226
331   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
332   R         0.092   0.018   0.007   0.257   0.136   0.120  -0.083  -0.197  -0.214
333   Q         0.696   0.659   0.663   0.718   0.648   0.609   0.507   0.429   0.373
334   K         1.702   1.717   1.817   1.771   1.800   1.966   1.924   1.945   2.114
335   I         0.386   0.299   0.126   0.443   0.306  -0.017   0.389   0.260  -0.022
336   C        -0.971  -1.032  -0.953  -0.599  -0.695  -0.595  -0.910  -0.959  -0.845
337   L         0.696   0.650   0.688   0.196   0.113   0.168   0.507   0.411   0.426
338   M         0.386   0.384   0.135   0.842   0.843   0.464   0.389   0.386  -0.006
339   T        -0.158  -0.088  -0.062  -0.224  -0.108  -0.092  -0.437  -0.332  -0.314
340   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
341   I        -0.778  -0.757  -0.632  -1.160  -1.163  -0.933  -0.910  -0.881  -0.720
342   E         1.702   1.717   1.817   1.762   1.785   1.958   1.924   1.945   2.114
343   T        -0.971  -0.846  -0.936  -1.204  -1.067  -1.082  -0.910  -0.782  -0.827
344   V         0.092   0.117   0.026   0.127   0.165   0.002  -0.083  -0.046  -0.190
345   F         0.696   0.650   0.688   0.780   0.697   0.727   0.507   0.411   0.426
346   V        -1.425  -1.438  -1.330  -1.196  -1.185  -1.052  -1.160  -1.164  -1.022
347   K        -0.008  -0.032  -0.035  -0.131  -0.172  -0.239  -0.235  -0.265  -0.280
348   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
349   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
350   N        -0.778  -0.820  -0.888  -0.489  -0.554  -0.655  -0.674  -0.719  -0.771
351   I        -0.544  -0.576  -0.538  -0.650  -0.676  -0.605  -0.674  -0.692  -0.619
352   R         0.696   0.650   0.688   0.805   0.721   0.746   0.507   0.411   0.426
353   M        -1.281  -1.270  -1.264  -1.088  -1.071  -1.114  -1.028  -1.013  -0.965
354   L         1.028   1.013   0.858   0.750   0.737   0.568   1.098   1.069   0.764
355   S         0.092   0.050   0.016   0.142   0.082   0.025  -0.083  -0.143  -0.203
356   F         1.702   1.717   1.817   1.908   1.937   2.102   1.924   1.945   2.114
357   E        -1.708  -1.641  -1.584  -1.559  -1.459  -1.382  -1.264  -1.203  -1.101
358   D        -0.971  -1.021  -0.972  -0.935  -1.005  -0.940  -0.910  -0.952  -0.862
359   I         0.696   0.748   0.689   0.637   0.721   0.602   0.507   0.600   0.428
360   S         0.519   0.522   0.611   0.379   0.379   0.506   0.153   0.153   0.264
361   K        -1.088  -1.092  -0.992  -1.153  -1.141  -0.987  -1.028  -1.018  -0.881
362   A        -0.468  -0.537  -0.530  -0.414  -0.518  -0.522  -0.555  -0.631  -0.607
363   T         1.702   1.717   1.817   1.905   1.933   2.099   1.924   1.945   2.114
364   H        -1.708  -1.706  -1.594  -1.318  -1.321  -1.149  -1.264  -1.254  -1.108
365   L        -0.661  -0.680  -0.589  -1.107  -1.095  -0.948  -0.792  -0.807  -0.677
366   P         0.386   0.422   0.151   0.813   0.869   0.469   0.389   0.440   0.018
367   K        -1.398  -1.419  -1.308  -1.314  -1.331  -1.161  -1.146  -1.150  -1.006
368   D         0.696   0.658   0.658   0.659   0.594   0.561   0.507   0.427   0.364
369   N        -0.971  -0.907  -0.943  -0.954  -0.866  -0.911  -0.910  -0.843  -0.835
370   V         0.696   0.700   0.686   0.703   0.706   0.642   0.507   0.508   0.422
371   E         1.702   1.717   1.817   1.762   1.785   1.958   1.924   1.945   2.114
372   H         0.696   0.650   0.662   0.747   0.634   0.552   0.507   0.410   0.372
373   L         1.028   0.979   0.863   0.699   0.635   0.472   1.098   1.013   0.773
374   V         0.462   0.488   0.597   0.213   0.249   0.428   0.035   0.080   0.235
375   M         0.519   0.517   0.608   0.535   0.519   0.637   0.153   0.142   0.258
376   R         0.519   0.556   0.626   0.390   0.460   0.559   0.153   0.222   0.296
377   A        -0.218  -0.246  -0.427   0.090   0.057  -0.203  -0.201  -0.239  -0.469
378   I        -0.544  -0.584  -0.550  -0.902  -0.956  -0.839  -0.674  -0.701  -0.633
379   S         1.702   1.717   1.817   1.800   1.826   1.995   1.924   1.945   2.114
380   L         1.028   0.994   0.858   0.716   0.675   0.499   1.098   1.039   0.765
381   G        -1.281  -1.307  -1.281  -0.927  -0.965  -0.976  -1.028  -1.046  -0.981
382   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
383   L         0.462   0.483   0.595  -0.170  -0.105   0.070   0.035   0.070   0.230
384   K        -0.218  -0.320  -0.437  -0.020  -0.159  -0.345  -0.201  -0.331  -0.482
385   G         1.702   1.717   1.817   1.999   2.026   2.192   1.924   1.945   2.114
386   S        -0.971  -1.008  -0.978  -0.784  -0.831  -0.759  -0.910  -0.942  -0.867
387   I         1.702   1.717   1.817   1.745   1.767   1.940   1.924   1.945   2.114
388   D         0.696   0.650   0.688   0.659   0.579   0.619   0.507   0.411   0.426
389   Q         1.028   0.994   0.858   1.231   1.190   0.985   1.098   1.039   0.765
390   V         0.386   0.299   0.126   0.599   0.476   0.184   0.389   0.260  -0.022
391   N        -1.088  -1.081  -0.981  -1.066  -1.050  -0.895  -1.028  -1.010  -0.872
392   E         0.462   0.477   0.592   0.233   0.259   0.444   0.035   0.057   0.224
393   L        -0.971  -1.021  -0.965  -1.275  -1.306  -1.157  -0.910  -0.952  -0.856
394   V        -0.218  -0.258  -0.429  -0.078  -0.149  -0.490  -0.201  -0.251  -0.472
395   T         0.092   0.032   0.011   0.252   0.154   0.137  -0.083  -0.179  -0.208
396   I         0.519   0.517   0.608   0.315   0.305   0.447   0.153   0.142   0.258
397   S        -0.041  -0.054  -0.015  -0.074  -0.093  -0.025  -0.319  -0.333  -0.266
398   W         1.028   0.994   0.858   1.443   1.403   1.196   1.098   1.039   0.765
399   V         0.092   0.037   0.004  -0.043  -0.144  -0.289  -0.083  -0.159  -0.224
400   Q         1.702   1.717   1.817   1.857   1.883   2.052   1.924   1.945   2.114
401   P         1.028   0.994   0.858   1.399   1.359   1.153   1.098   1.039   0.765
402   R         1.028   1.013   0.858   1.318   1.306   1.071   1.098   1.069   0.764
403   I         0.696   0.700   0.686   0.637   0.640   0.596   0.507   0.508   0.422
404   I         0.519   0.592   0.651  -0.114   0.010   0.103   0.153   0.295   0.348
405   S         0.386   0.444   0.160   0.598   0.672   0.252   0.389   0.472   0.031
406   G        -1.708  -1.642  -1.602  -1.693  -1.624  -1.459  -1.264  -1.203  -1.114
407   D        -0.661  -0.652  -0.581  -0.790  -0.759  -0.662  -0.792  -0.768  -0.666
408   Q         1.702   1.717   1.817   1.857   1.883   2.052   1.924   1.945   2.114
409   I         0.696   0.650   0.688   0.637   0.553   0.600   0.507   0.411   0.426
410   T        -0.971  -0.915  -0.929  -1.042  -0.950  -1.004  -0.910  -0.853  -0.821
411   K        -0.971  -1.015  -0.966  -0.955  -1.020  -0.946  -0.910  -0.947  -0.857
412   M         0.696   0.650   0.688   0.783   0.672   0.661   0.507   0.411   0.426
413   K        -0.778  -0.893  -0.914  -0.595  -0.769  -0.816  -0.674  -0.797  -0.799
414   D        -0.661  -0.640  -0.570  -0.730  -0.679  -0.586  -0.792  -0.753  -0.654
415   R         0.278   0.235   0.091   0.590   0.533   0.312   0.228   0.154  -0.076
416   L         1.702   1.717   1.817   1.331   1.353   1.530   1.924   1.945   2.114
417   V        -1.425  -1.444  -1.333  -1.207  -1.197  -1.072  -1.160  -1.169  -1.025
418   E        -0.583  -0.541  -0.544  -0.676  -0.619  -0.618  -0.698  -0.653  -0.625
419   W         1.702   1.717   1.817   2.061   2.087   2.254   1.924   1.945   2.114
420   N        -0.094  -0.037  -0.037  -0.219  -0.138  -0.110  -0.389  -0.319  -0.293
421   D        -1.425  -1.446  -1.336  -1.325  -1.326  -1.190  -1.160  -1.170  -1.027
422   Q        -0.544  -0.510  -0.525  -0.553  -0.508  -0.515  -0.674  -0.632  -0.608
423   V         1.028   0.994   0.858   1.218   1.175   0.970   1.098   1.039   0.765
424   E        -0.971  -0.916  -0.944  -0.972  -0.898  -0.923  -0.910  -0.853  -0.835
425   K        -1.281  -1.317  -1.283  -1.009  -1.047  -0.994  -1.028  -1.055  -0.982
426   L         1.702   1.717   1.817   1.332   1.356   1.531   1.924   1.945   2.114
427   G        -0.158  -0.179  -0.103  -0.119  -0.169  -0.082  -0.437  -0.470  -0.375
428   K        -0.544  -0.492  -0.525  -0.547  -0.482  -0.480  -0.674  -0.616  -0.609
429   K        -1.398  -1.414  -1.320  -1.146  -1.160  -1.031  -1.146  -1.147  -1.015
430   M        -0.468  -0.392  -0.496  -0.528  -0.434  -0.591  -0.555  -0.480  -0.570
431   E         0.092   0.037   0.004   0.144   0.066   0.020  -0.083  -0.159  -0.224
432   A        -1.708  -1.695  -1.593  -1.665  -1.685  -1.553  -1.264  -1.245  -1.107
433   R        -0.468  -0.549  -0.531  -0.298  -0.433  -0.424  -0.555  -0.652  -0.611
434   G         1.028   0.979   0.863   1.419   1.365   1.223   1.098   1.013   0.773
435   Q        -0.468  -0.463  -0.497  -0.419  -0.395  -0.450  -0.555  -0.540  -0.568
436   S        -0.971  -0.985  -0.952  -0.785  -0.808  -0.738  -0.910  -0.919  -0.843
437   I         0.480   0.487   0.594   0.251   0.257   0.431   0.073   0.078   0.229
438   W         0.969   0.939   0.825   1.374   1.338   1.162   0.999   0.945   0.700
439   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
440   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
441   V        -0.468  -0.537  -0.530  -0.469  -0.586  -0.624  -0.555  -0.631  -0.607
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/Q04062
Output conservation file - output/Q04062
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
