1     M         0.843   0.862   0.924   1.064   1.085   1.153   0.891   0.918   1.004
2     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
10    S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
11    V         0.843   0.862   0.924   0.670   0.717   0.823   0.891   0.918   1.004
12    I        -0.361  -0.346  -0.369  -0.413  -0.415  -0.501  -0.577  -0.562  -0.625
13    L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
14    V        -1.474  -1.405  -1.156  -1.766  -1.632  -1.229  -1.678  -1.573  -1.215
15    S         0.037  -0.169  -0.316  -0.074  -0.339  -0.565   0.034  -0.274  -0.534
16    A        -0.361  -0.398  -0.373  -0.567  -0.659  -0.651  -0.577  -0.650  -0.633
17    G         0.037   0.065  -0.301   0.150   0.185  -0.406   0.034   0.074  -0.509
18    Y         0.843   0.862   0.924   1.007   1.033   1.106   0.891   0.918   1.004
19    D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
20    H         0.037   0.065  -0.301   0.185   0.225  -0.326   0.034   0.074  -0.509
21    T         0.843   0.862   0.924   0.762   0.792   0.900   0.891   0.918   1.004
22    I         0.843   0.862   0.924   0.875   0.894   0.995   0.891   0.918   1.004
23    R         0.037   0.065  -0.301   0.187   0.221  -0.279   0.034   0.074  -0.509
24    F         0.843   0.862   0.924   1.045   1.063   1.137   0.891   0.918   1.004
25    W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
26    E        -0.361  -0.174  -0.331  -0.336  -0.054  -0.356  -0.577  -0.283  -0.560
27    A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
28    L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
29    T        -0.573  -0.573  -0.387  -0.966  -1.015  -0.685  -0.944  -0.958  -0.658
30    G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
31    V        -0.573  -0.573  -0.387  -0.916  -0.906  -0.578  -0.944  -0.958  -0.658
32    C         0.843   0.862   0.924   1.002   1.020   1.102   0.891   0.918   1.004
33    S         0.037   0.179  -0.292  -0.079   0.109  -0.538   0.034   0.229  -0.494
34    R         0.843   0.862   0.924   0.860   0.884   0.983   0.891   0.918   1.004
35    T         0.843   0.862   0.924   0.762   0.792   0.900   0.891   0.918   1.004
36    I         0.843   0.862   0.924   0.875   0.894   0.995   0.891   0.918   1.004
37    Q         0.843   0.862   0.924   0.940   0.964   1.050   0.891   0.918   1.004
38    H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
39    S        -1.754  -1.550  -1.659  -1.625  -1.368  -1.580  -1.678  -1.458  -1.455
40    D        -0.361  -0.387  -0.376  -0.450  -0.490  -0.476  -0.577  -0.630  -0.637
41    S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
42    Q         0.843   0.862   0.924   0.940   0.964   1.050   0.891   0.918   1.004
43    V         0.843   0.862   0.924   0.670   0.717   0.823   0.891   0.918   1.004
44    N         0.843   0.862   0.924   0.812   0.861   0.942   0.891   0.918   1.004
45    R         0.843   0.862   0.924   0.860   0.884   0.983   0.891   0.918   1.004
46    L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
47    E        -1.084  -1.162  -1.137  -0.914  -1.080  -1.036  -1.189  -1.313  -1.194
48    I         0.843   0.862   0.924   0.875   0.894   0.995   0.891   0.918   1.004
49    T        -0.361  -0.498  -0.385  -0.555  -0.839  -0.671  -0.577  -0.824  -0.654
50    N        -1.474  -1.279  -1.139  -1.710  -1.335  -1.164  -1.678  -1.419  -1.194
51    D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
52    K         0.843   0.862   0.924   0.964   0.994   1.070   0.891   0.918   1.004
53    K        -0.641  -0.570  -0.389  -0.813  -0.710  -0.420  -1.067  -0.953  -0.661
54    L        -1.383  -1.229  -1.132  -1.319  -1.082  -0.983  -1.556  -1.350  -1.186
55    L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
56    A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
57    T         0.037   0.178  -0.291   0.048   0.214  -0.428   0.034   0.229  -0.492
58    A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
59    G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
60    H        -1.243  -1.163  -1.130  -1.325  -1.197  -1.116  -1.433  -1.315  -1.185
61    Q        -2.356  -2.390  -2.119  -2.211  -2.244  -1.830  -2.045  -2.023  -1.657
62    N        -2.496  -2.419  -2.116  -2.366  -2.273  -1.852  -2.167  -2.047  -1.654
63    V         0.037   0.179  -0.292  -0.016   0.171  -0.446   0.034   0.229  -0.494
64    R        -0.361  -0.387  -0.376  -0.351  -0.405  -0.401  -0.577  -0.630  -0.637
65    L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
66    Y         0.037  -0.169  -0.316   0.344   0.083  -0.163   0.034  -0.274  -0.534
67    D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
68    I         0.843   0.862   0.924   0.875   0.894   0.995   0.891   0.918   1.004
69    R        -0.732  -0.717  -1.083  -0.496  -0.499  -1.004  -0.700  -0.691  -1.124
70    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
71    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
72    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
73    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
74    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
75    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
76    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
77    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
78    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
79    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
80    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
81    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
82    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
83    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
84    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
85    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
86    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
87    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
88    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
89    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
90    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
91    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
92    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
93    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
94    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
95    T        -1.474  -1.318  -1.143  -1.878  -1.644  -1.335  -1.678  -1.478  -1.199
96    T        -1.474  -1.407  -1.158  -1.866  -1.754  -1.349  -1.678  -1.576  -1.217
97    N         0.037  -0.076  -0.309   0.091  -0.041  -0.468   0.034  -0.132  -0.522
98    P        -1.754  -1.590  -1.665  -1.598  -1.344  -1.510  -1.678  -1.478  -1.460
99    N        -1.455  -1.684  -1.681  -1.137  -1.431  -1.396  -1.311  -1.562  -1.474
100   P        -0.361  -0.447  -0.378  -0.287  -0.478  -0.426  -0.577  -0.734  -0.642
101   V        -0.361  -0.498  -0.385  -0.614  -0.863  -0.676  -0.577  -0.824  -0.654
102   A        -1.084  -0.811  -1.096  -0.915  -0.514  -1.042  -1.189  -0.826  -1.142
103   S        -0.573  -0.411  -0.358  -0.966  -0.665  -0.607  -0.944  -0.672  -0.606
104   F         0.843   0.862   0.924   1.045   1.063   1.137   0.891   0.918   1.004
105   E         0.037  -0.169  -0.316   0.266  -0.009  -0.253   0.034  -0.274  -0.534
106   G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
107   H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
108   R        -1.383  -1.100  -1.119  -1.505  -1.091  -1.102  -1.556  -1.176  -1.170
109   G        -0.573  -0.500  -0.381  -0.773  -0.653  -0.486  -0.944  -0.827  -0.647
110   N         0.843   0.862   0.924   0.812   0.861   0.942   0.891   0.918   1.004
111   V         0.843   0.862   0.924   0.670   0.717   0.823   0.891   0.918   1.004
112   T         0.843   0.862   0.924   0.762   0.792   0.900   0.891   0.918   1.004
113   S        -1.084  -1.263  -1.139  -1.286  -1.550  -1.312  -1.189  -1.400  -1.196
114   V        -1.474  -1.385  -1.157  -1.843  -1.703  -1.310  -1.678  -1.550  -1.216
115   S        -1.084  -0.781  -1.086  -1.201  -0.774  -1.174  -1.189  -0.793  -1.129
116   F         0.843   0.862   0.924   1.045   1.063   1.137   0.891   0.918   1.004
117   Q        -0.361  -0.498  -0.385  -0.302  -0.564  -0.412  -0.577  -0.824  -0.654
118   Q        -2.356  -2.149  -2.109  -2.070  -1.804  -1.769  -2.045  -1.845  -1.649
119   D        -0.361  -0.400  -0.378  -0.450  -0.511  -0.480  -0.577  -0.653  -0.642
120   N        -0.573  -0.573  -0.387  -0.794  -0.800  -0.500  -0.944  -0.958  -0.658
121   R        -0.361  -0.182  -0.332  -0.285  -0.017  -0.299  -0.577  -0.295  -0.561
122   W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
123   M         0.037  -0.076  -0.309   0.357   0.198  -0.236   0.034  -0.132  -0.522
124   V         0.037  -0.076  -0.309  -0.035  -0.165  -0.527   0.034  -0.132  -0.522
125   T        -0.361  -0.195  -0.342  -0.555  -0.289  -0.573  -0.577  -0.315  -0.578
126   S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
127   S         0.037   0.157  -0.294  -0.079   0.084  -0.540   0.034   0.201  -0.496
128   E         0.843   0.862   0.924   0.943   0.963   1.052   0.891   0.918   1.004
129   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
130   G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
131   T         0.037   0.157  -0.294   0.104   0.246  -0.301   0.034   0.201  -0.496
132   I        -0.573  -0.411  -0.358  -0.916  -0.642  -0.550  -0.944  -0.672  -0.606
133   K         0.843   0.862   0.924   0.964   0.994   1.070   0.891   0.918   1.004
134   V         0.037  -0.169  -0.316  -0.016  -0.267  -0.484   0.034  -0.274  -0.534
135   W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
136   D         0.037  -0.169  -0.316   0.089  -0.162  -0.384   0.034  -0.274  -0.534
137   V        -1.754  -1.790  -1.684  -1.723  -1.776  -1.558  -1.678  -1.708  -1.478
138   R         0.843   0.862   0.924   0.860   0.884   0.983   0.891   0.918   1.004
139   S        -1.084  -1.230  -1.139  -1.305  -1.543  -1.357  -1.189  -1.371  -1.196
140   P        -0.732  -0.901  -1.103  -0.386  -0.643  -1.007  -0.700  -0.926  -1.149
141   S        -0.361  -0.447  -0.378  -0.642  -0.793  -0.672  -0.577  -0.734  -0.642
142   I        -0.361  -0.404  -0.377  -0.565  -0.630  -0.580  -0.577  -0.659  -0.640
143   P        -0.361  -0.187  -0.328  -0.264  -0.020  -0.251  -0.577  -0.303  -0.555
144   R         0.843   0.862   0.924   0.860   0.884   0.983   0.891   0.918   1.004
145   N         0.037  -0.169  -0.316   0.091  -0.179  -0.482   0.034  -0.274  -0.534
146   Y         0.843   0.862   0.924   1.007   1.033   1.106   0.891   0.918   1.004
147   K        -0.732  -1.021  -1.110  -0.426  -0.840  -1.062  -0.700  -1.073  -1.159
148   H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
149   N        -2.727  -2.672  -2.467  -2.360  -2.314  -2.000  -2.167  -2.094  -1.770
150   A        -1.474  -1.407  -1.156  -1.708  -1.666  -1.249  -1.678  -1.576  -1.215
151   P         0.843   0.862   0.924   0.998   1.019   1.098   0.891   0.918   1.004
152   V         0.037  -0.169  -0.316  -0.035  -0.298  -0.539   0.034  -0.274  -0.534
153   N         0.843   0.862   0.924   0.812   0.861   0.942   0.891   0.918   1.004
154   E        -0.573  -0.573  -0.387  -0.734  -0.788  -0.491  -0.944  -0.958  -0.658
155   V         0.037  -0.076  -0.309  -0.038  -0.168  -0.536   0.034  -0.132  -0.522
156   V        -0.732  -0.710  -1.084  -0.737  -0.711  -1.260  -0.700  -0.682  -1.126
157   I         0.843   0.862   0.924   0.875   0.894   0.995   0.891   0.918   1.004
158   H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
159   P         0.843   0.862   0.924   0.998   1.019   1.098   0.891   0.918   1.004
160   N         0.843   0.862   0.924   0.812   0.861   0.942   0.891   0.918   1.004
161   Q         0.843   0.862   0.924   0.940   0.964   1.050   0.891   0.918   1.004
162   G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
163   E         0.843   0.862   0.924   0.943   0.963   1.052   0.891   0.918   1.004
164   L        -0.361  -0.447  -0.378  -0.509  -0.665  -0.542  -0.577  -0.734  -0.642
165   I         0.037  -0.076  -0.309   0.168   0.009  -0.379   0.034  -0.132  -0.522
166   S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
167   C         0.843   0.862   0.924   1.002   1.020   1.102   0.891   0.918   1.004
168   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
169   R        -0.573  -0.534  -0.387  -0.686  -0.646  -0.425  -0.944  -0.887  -0.657
170   D        -1.455  -1.684  -1.681  -1.311  -1.685  -1.687  -1.311  -1.562  -1.474
171   G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
172   N        -0.732  -1.021  -1.110  -0.592  -1.005  -1.200  -0.700  -1.073  -1.159
173   I         0.037  -0.076  -0.309   0.160   0.002  -0.402   0.034  -0.132  -0.522
174   R         0.843   0.862   0.924   0.860   0.884   0.983   0.891   0.918   1.004
175   I        -1.455  -1.568  -1.666  -1.236  -1.470  -1.666  -1.311  -1.451  -1.459
176   W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
177   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
178   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
179   G         0.037  -0.169  -0.316   0.166  -0.122  -0.387   0.034  -0.274  -0.534
180   E         0.843   0.862   0.924   0.943   0.963   1.052   0.891   0.918   1.004
181   N         0.843   0.862   0.924   0.812   0.861   0.942   0.891   0.918   1.004
182   Q        -1.383  -1.377  -1.158  -1.537  -1.589  -1.272  -1.556  -1.541  -1.217
183   C         0.843   0.862   0.924   1.002   1.020   1.102   0.891   0.918   1.004
184   T         0.037  -0.169  -0.316   0.041  -0.248  -0.520   0.034  -0.274  -0.534
185   H         0.037   0.187  -0.292   0.185   0.367  -0.310   0.034   0.240  -0.494
186   Q        -1.084  -1.026  -1.110  -0.927  -0.824  -0.979  -1.189  -1.080  -1.159
187   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
188   T        -0.573  -0.411  -0.358  -0.795  -0.518  -0.460  -0.944  -0.672  -0.606
189   P         0.843   0.862   0.924   0.998   1.019   1.098   0.891   0.918   1.004
190   E         0.843   0.862   0.924   0.943   0.963   1.052   0.891   0.918   1.004
191   D        -0.573  -0.573  -0.387  -0.796  -0.790  -0.480  -0.944  -0.958  -0.658
192   D         0.037   0.187  -0.292   0.070   0.267  -0.398   0.034   0.240  -0.494
193   T        -0.361  -0.182  -0.332  -0.602  -0.313  -0.561  -0.577  -0.295  -0.561
194   S        -0.361  -0.404  -0.377  -0.324  -0.433  -0.487  -0.577  -0.659  -0.640
195   L        -1.985  -1.932  -1.695  -2.117  -2.032  -1.618  -1.923  -1.828  -1.487
196   Q        -2.356  -2.386  -2.121  -2.221  -2.316  -1.951  -2.045  -2.020  -1.658
197   S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
198   L        -1.383  -1.389  -1.158  -1.658  -1.703  -1.310  -1.556  -1.555  -1.218
199   S        -0.361  -0.498  -0.385  -0.642  -0.886  -0.683  -0.577  -0.824  -0.654
200   M         0.037   0.178  -0.291   0.012   0.193  -0.366   0.034   0.229  -0.492
201   A         0.037  -0.076  -0.309   0.063  -0.084  -0.414   0.034  -0.132  -0.522
202   S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
203   D         0.037   0.157  -0.294   0.089   0.246  -0.348   0.034   0.201  -0.496
204   G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
205   S         0.037  -0.169  -0.316  -0.074  -0.339  -0.565   0.034  -0.274  -0.534
206   M         0.037  -0.169  -0.316   0.357   0.062  -0.250   0.034  -0.274  -0.534
207   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
208   A        -1.455  -1.601  -1.667  -1.344  -1.541  -1.599  -1.311  -1.481  -1.461
209   A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
210   A        -0.573  -0.534  -0.387  -0.806  -0.768  -0.533  -0.944  -0.887  -0.657
211   N         0.843   0.862   0.924   0.812   0.861   0.942   0.891   0.918   1.004
212   T        -0.361  -0.404  -0.377  -0.464  -0.535  -0.545  -0.577  -0.659  -0.640
213   K         0.037  -0.169  -0.316   0.260  -0.024  -0.316   0.034  -0.274  -0.534
214   G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
215   N         0.843   0.862   0.924   0.812   0.861   0.942   0.891   0.918   1.004
216   C         0.037  -0.169  -0.316   0.288  -0.011  -0.320   0.034  -0.274  -0.534
217   Y         0.037  -0.169  -0.316   0.344   0.083  -0.163   0.034  -0.274  -0.534
218   V         0.843   0.862   0.924   0.670   0.717   0.823   0.891   0.918   1.004
219   W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
220   E        -2.356  -2.345  -2.112  -2.058  -2.060  -1.757  -2.045  -1.991  -1.651
221   M         0.037  -0.169  -0.316   0.357   0.062  -0.250   0.034  -0.274  -0.534
222   P        -2.356  -2.386  -2.121  -2.044  -2.138  -1.776  -2.045  -2.020  -1.658
223   N        -0.732  -0.795  -1.090  -0.537  -0.621  -1.032  -0.700  -0.802  -1.134
224   H        -1.754  -1.749  -1.676  -1.621  -1.639  -1.552  -1.678  -1.635  -1.470
225   T        -2.356  -2.360  -2.117  -2.160  -2.144  -1.753  -2.045  -2.004  -1.655
226   D         0.037  -0.076  -0.309   0.078  -0.050  -0.403   0.034  -0.132  -0.522
227   A        -1.455  -1.512  -1.661  -1.309  -1.428  -1.632  -1.311  -1.380  -1.455
228   S        -0.641  -0.570  -0.389  -1.131  -1.005  -0.682  -1.067  -0.953  -0.661
229   H        -3.238  -3.029  -2.759  -3.196  -2.880  -2.491  -2.412  -2.223  -1.849
230   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
231   K        -2.867  -2.786  -2.470  -2.541  -2.447  -1.986  -2.290  -2.174  -1.772
232   P         0.843   0.862   0.924   0.998   1.019   1.098   0.891   0.918   1.004
233   V        -1.455  -1.495  -1.659  -1.401  -1.487  -1.703  -1.311  -1.363  -1.453
234   T         0.037  -0.076  -0.309   0.047  -0.101  -0.489   0.034  -0.132  -0.522
235   K         0.037  -0.169  -0.316   0.278   0.008  -0.262   0.034  -0.274  -0.534
236   F         0.843   0.862   0.924   1.045   1.063   1.137   0.891   0.918   1.004
237   R        -1.754  -1.843  -1.678  -1.614  -1.773  -1.530  -1.678  -1.729  -1.471
238   A        -0.641  -0.553  -0.384  -1.140  -0.977  -0.677  -1.067  -0.921  -0.653
239   H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
240   S        -2.727  -2.634  -2.454  -2.559  -2.424  -2.125  -2.167  -2.066  -1.761
241   T        -2.125  -2.140  -2.105  -1.756  -1.820  -1.851  -1.800  -1.811  -1.646
242   Y         0.037  -0.169  -0.316   0.287  -0.009  -0.332   0.034  -0.274  -0.534
243   I         0.843   0.862   0.924   0.875   0.894   0.995   0.891   0.918   1.004
244   T         0.843   0.862   0.924   0.762   0.792   0.900   0.891   0.918   1.004
245   R         0.037   0.065  -0.301   0.187   0.221  -0.279   0.034   0.074  -0.509
246   I        -1.084  -1.202  -1.130  -1.171  -1.325  -1.154  -1.189  -1.329  -1.185
247   L        -0.361  -0.356  -0.370  -0.576  -0.579  -0.638  -0.577  -0.579  -0.627
248   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
249   S         0.037   0.157  -0.294  -0.079   0.084  -0.540   0.034   0.201  -0.496
250   S        -1.985  -1.675  -1.674  -2.066  -1.543  -1.611  -1.923  -1.569  -1.468
251   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
252   V        -0.361  -0.174  -0.331  -0.501  -0.226  -0.421  -0.577  -0.283  -0.560
253   K         0.037   0.157  -0.294   0.276   0.423  -0.230   0.034   0.201  -0.496
254   H         0.037  -0.169  -0.316   0.207  -0.056  -0.289   0.034  -0.274  -0.534
255   L         0.037   0.179  -0.292   0.070   0.234  -0.324   0.034   0.229  -0.494
256   A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
257   T         0.843   0.862   0.924   0.762   0.792   0.900   0.891   0.918   1.004
258   C         0.843   0.862   0.924   1.002   1.020   1.102   0.891   0.918   1.004
259   S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
260   A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
261   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
262   H        -0.732  -0.819  -1.095  -0.512  -0.642  -1.095  -0.700  -0.812  -1.139
263   T         0.843   0.862   0.924   0.762   0.792   0.900   0.891   0.918   1.004
264   A         0.037  -0.076  -0.309   0.034  -0.121  -0.499   0.034  -0.132  -0.522
265   R         0.037  -0.076  -0.309   0.165   0.020  -0.355   0.034  -0.132  -0.522
266   V        -0.361  -0.182  -0.332  -0.431  -0.155  -0.449  -0.577  -0.295  -0.561
267   W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
268   S        -0.732  -0.795  -1.090  -0.730  -0.814  -1.182  -0.700  -0.802  -1.134
269   I        -1.474  -1.406  -1.159  -1.771  -1.691  -1.292  -1.678  -1.575  -1.218
270   D        -1.455  -1.495  -1.660  -1.084  -1.180  -1.439  -1.311  -1.364  -1.454
271   D        -1.754  -1.749  -1.676  -1.670  -1.641  -1.525  -1.678  -1.635  -1.470
272   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
273   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
274   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
275   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
276   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
277   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
278   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
279   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
280   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
281   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
282   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
283   D        -2.125  -2.211  -2.111  -1.948  -2.144  -2.022  -1.800  -1.871  -1.650
284   F         0.843   0.862   0.924   1.045   1.063   1.137   0.891   0.918   1.004
285   K        -2.867  -2.749  -2.463  -2.614  -2.415  -1.984  -2.290  -2.152  -1.768
286   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
287   E         0.843   0.862   0.924   0.943   0.963   1.052   0.891   0.918   1.004
288   T        -1.455  -1.601  -1.666  -1.330  -1.581  -1.701  -1.311  -1.481  -1.460
289   T         0.037  -0.076  -0.309   0.074  -0.067  -0.409   0.034  -0.132  -0.522
290   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
291   D        -2.356  -2.320  -2.114  -2.198  -2.136  -1.824  -2.045  -1.977  -1.653
292   G         0.037  -0.169  -0.316   0.194  -0.076  -0.306   0.034  -0.274  -0.534
293   H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
294   Q         0.843   0.862   0.924   0.940   0.964   1.050   0.891   0.918   1.004
295   R         0.843   0.862   0.924   0.860   0.884   0.983   0.891   0.918   1.004
296   W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
297   V         0.843   0.862   0.924   0.670   0.717   0.823   0.891   0.918   1.004
298   W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
299   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
300   C         0.843   0.862   0.924   1.002   1.020   1.102   0.891   0.918   1.004
301   A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
302   F         0.843   0.862   0.924   1.045   1.063   1.137   0.891   0.918   1.004
303   S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
304   A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
305   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
306   S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
307   A         0.037  -0.076  -0.309   0.048  -0.105  -0.460   0.034  -0.132  -0.522
308   Y         0.843   0.862   0.924   1.007   1.033   1.106   0.891   0.918   1.004
309   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
310   V         0.843   0.862   0.924   0.670   0.717   0.823   0.891   0.918   1.004
311   T         0.843   0.862   0.924   0.762   0.792   0.900   0.891   0.918   1.004
312   A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
313   S        -0.641  -0.573  -0.390  -0.948  -0.844  -0.534  -1.067  -0.958  -0.662
314   S         0.843   0.862   0.924   0.629   0.670   0.789   0.891   0.918   1.004
315   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
316   H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
317   Y         0.037  -0.076  -0.309   0.292   0.140  -0.301   0.034  -0.132  -0.522
318   V        -0.361  -0.498  -0.385  -0.606  -0.855  -0.663  -0.577  -0.824  -0.654
319   R         0.843   0.862   0.924   0.860   0.884   0.983   0.891   0.918   1.004
320   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
321   W         0.843   0.862   0.924   0.998   1.020   1.098   0.891   0.918   1.004
322   D        -0.573  -0.573  -0.387  -0.796  -0.790  -0.480  -0.944  -0.958  -0.658
323   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
324   S        -0.732  -0.901  -1.103  -0.751  -0.979  -1.253  -0.700  -0.926  -1.149
325   T        -1.383  -1.267  -1.143  -1.674  -1.513  -1.324  -1.556  -1.404  -1.199
326   R        -2.496  -2.374  -2.117  -2.443  -2.243  -1.845  -2.167  -2.015  -1.655
327   E        -1.455  -1.495  -1.659  -1.114  -1.227  -1.497  -1.311  -1.363  -1.453
328   I        -1.243  -1.314  -1.136  -1.400  -1.514  -1.238  -1.433  -1.472  -1.193
329   V        -0.641  -0.534  -0.376  -1.015  -0.800  -0.546  -1.067  -0.887  -0.637
330   R         0.843   0.862   0.924   0.860   0.884   0.983   0.891   0.918   1.004
331   Q         0.843   0.862   0.924   0.940   0.964   1.050   0.891   0.918   1.004
332   Y         0.843   0.862   0.924   1.007   1.033   1.106   0.891   0.918   1.004
333   G        -1.474  -1.394  -1.154  -1.758  -1.648  -1.282  -1.678  -1.560  -1.212
334   G         0.843   0.862   0.924   0.870   0.895   0.991   0.891   0.918   1.004
335   H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
336   H         0.843   0.862   0.924   0.880   0.907   0.999   0.891   0.918   1.004
337   K         0.037  -0.169  -0.316   0.276   0.003  -0.270   0.034  -0.274  -0.534
338   G         0.037  -0.076  -0.309   0.166   0.013  -0.373   0.034  -0.132  -0.522
339   A         0.037  -0.169  -0.316   0.064  -0.213  -0.424   0.034  -0.274  -0.534
340   V         0.037   0.065  -0.301  -0.038   0.019  -0.522   0.034   0.074  -0.509
341   C         0.037   0.065  -0.301   0.282   0.310  -0.304   0.034   0.074  -0.509
342   V         0.843   0.862   0.924   0.670   0.717   0.823   0.891   0.918   1.004
343   A         0.843   0.862   0.924   0.750   0.772   0.890   0.891   0.918   1.004
344   L         0.843   0.862   0.924   0.727   0.757   0.871   0.891   0.918   1.004
345   N         0.843   0.862   0.924   0.812   0.861   0.942   0.891   0.918   1.004
346   D         0.843   0.862   0.924   0.765   0.807   0.902   0.891   0.918   1.004
347   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
348   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
349   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
350   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
351   V        -0.732  -1.021  -1.110  -0.693  -1.077  -1.191  -0.700  -1.073  -1.159
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/P41318
Output conservation file - output/P41318
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
