1     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
2     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
10    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
11    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
12    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
13    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
14    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
15    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
16    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
17    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
18    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
19    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
20    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
21    M         1.554   1.638   1.742   1.763   1.877   2.045   1.702   1.821   2.008
22    F        -0.271  -0.210  -0.280  -0.659  -0.562  -0.675  -0.444  -0.354  -0.475
23    S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
24    L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
25    Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
26    D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
27    V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
28    I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
29    T        -1.444  -1.355  -1.270  -1.286  -1.094  -1.014  -1.279  -1.161  -1.036
30    T        -1.444  -1.348  -1.286  -1.416  -1.293  -1.168  -1.279  -1.156  -1.050
31    T        -1.000  -0.973  -0.860  -1.216  -1.158  -1.018  -1.066  -1.005  -0.852
32    K        -1.423  -1.279  -1.245  -1.129  -0.959  -0.865  -1.270  -1.099  -1.015
33    T        -1.109  -1.149  -1.199  -0.958  -1.016  -1.081  -0.933  -0.968  -0.969
34    T        -1.774  -1.572  -1.586  -1.917  -1.600  -1.664  -1.412  -1.207  -1.148
35    L         0.830   1.034   0.683   0.581   0.847   0.390   0.863   1.161   0.574
36    A        -0.318  -0.148  -0.242  -0.349  -0.115  -0.245  -0.574  -0.362  -0.434
37    A        -2.107  -1.931  -1.889  -1.862  -1.581  -1.535  -1.532  -1.350  -1.250
38    M        -1.442  -1.417  -1.266  -1.639  -1.605  -1.381  -1.292  -1.214  -1.034
39    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
40    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
41    P        -1.423  -1.309  -1.254  -1.146  -0.975  -0.870  -1.270  -1.127  -1.023
42    K        -0.983  -0.968  -0.830  -0.835  -0.762  -0.574  -1.053  -0.995  -0.823
43    G         0.830   0.744   0.644   0.918   0.806   0.633   0.863   0.711   0.502
44    Y        -0.318  -0.174  -0.243  -0.674  -0.554  -0.559  -0.574  -0.397  -0.435
45    L         0.830   0.744   0.644   0.581   0.476   0.327   0.863   0.711   0.502
46    P         0.141   0.182  -0.113   0.429   0.483   0.028   0.145   0.186  -0.230
47    K        -0.776  -0.702  -0.789  -0.556  -0.488  -0.561  -0.813  -0.727  -0.779
48    W         0.830   0.679   0.635   1.105   0.906   0.803   0.863   0.601   0.486
49    L         0.141   0.038  -0.135   0.017  -0.097  -0.297   0.145  -0.001  -0.262
50    L         0.141  -0.132  -0.172  -0.058  -0.448  -0.519   0.145  -0.242  -0.316
51    F         0.141   0.038  -0.135   0.241   0.100  -0.177   0.145  -0.001  -0.262
52    I         0.283   0.304   0.437   0.039   0.036   0.237  -0.095  -0.097   0.097
53    S         1.554   1.638   1.742   1.469   1.601   1.758   1.702   1.821   2.008
54    I         0.222   0.307   0.436  -0.091   0.047   0.238  -0.215  -0.090   0.095
55    V         0.141   0.038  -0.135   0.238   0.094  -0.195   0.145  -0.001  -0.262
56    S         0.283   0.304   0.437  -0.001   0.015   0.233  -0.095  -0.097   0.097
57    V        -1.316  -1.399  -1.257  -1.370  -1.486  -1.320  -1.173  -1.197  -1.025
58    F         0.141  -0.019  -0.160   0.194  -0.043  -0.327   0.145  -0.087  -0.298
59    N         1.554   1.638   1.742   1.720   1.831   2.003   1.702   1.821   2.008
60    S         0.141  -0.132  -0.172   0.183  -0.205  -0.310   0.145  -0.242  -0.316
61    I        -0.776  -0.717  -0.781  -0.935  -0.906  -0.991  -0.813  -0.741  -0.771
62    Q         1.554   1.638   1.742   1.729   1.843   2.012   1.702   1.821   2.008
63    T        -0.508  -0.759  -0.776  -0.452  -0.802  -0.833  -0.454  -0.749  -0.757
64    Y         0.830   0.744   0.644   0.875   0.757   0.601   0.863   0.711   0.502
65    V        -1.442  -1.334  -1.265  -1.571  -1.473  -1.360  -1.292  -1.143  -1.033
66    S        -0.983  -0.897  -0.833  -1.151  -1.047  -0.925  -1.053  -0.926  -0.827
67    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
68    G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
69    L        -0.776  -0.750  -0.762  -1.071  -0.984  -1.013  -0.813  -0.738  -0.744
70    E        -1.774  -1.586  -1.605  -1.290  -1.015  -1.042  -1.412  -1.212  -1.161
71    L         0.141  -0.019  -0.160  -0.044  -0.272  -0.465   0.145  -0.087  -0.298
72    T         1.554   1.638   1.742   1.408   1.531   1.698   1.702   1.821   2.008
73    R        -0.175  -0.164  -0.221   0.016   0.022  -0.072  -0.334  -0.318  -0.399
74    K         0.830   0.994   0.676   1.100   1.309   0.902   0.863   1.103   0.562
75    V         0.830   0.679   0.635   0.840   0.602   0.491   0.863   0.601   0.486
76    Y         1.554   1.638   1.742   1.519   1.629   1.807   1.702   1.821   2.008
77    E        -0.175  -0.351  -0.263  -0.035  -0.313  -0.224  -0.334  -0.568  -0.459
78    R        -1.109  -0.987  -1.178  -0.716  -0.578  -0.848  -0.933  -0.795  -0.948
79    K        -1.649  -1.664  -1.613  -1.207  -1.266  -1.160  -1.292  -1.273  -1.166
80    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
81    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
82    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
83    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
84    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
85    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
86    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
87    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
88    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
89    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
90    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
91    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
92    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
93    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
94    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
95    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
96    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
97    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
98    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
99    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
100   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
101   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
102   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
103   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
104   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
105   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
106   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
107   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
108   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
109   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
110   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
111   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
112   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
113   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
114   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
115   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
116   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
117   P         0.024  -0.198  -0.225   0.268  -0.096  -0.190  -0.019  -0.342  -0.394
118   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
119   T        -1.109  -1.069  -1.193  -0.722  -0.642  -0.882  -0.933  -0.879  -0.963
120   E         0.474   0.465   0.477   0.621   0.598   0.580   0.265   0.216   0.179
121   T         0.283   0.473   0.505  -0.054   0.288   0.294  -0.095   0.231   0.234
122   T         0.141   0.159  -0.119   0.153   0.194  -0.207   0.145   0.157  -0.238
123   H        -1.649  -1.503  -1.552  -1.208  -1.008  -1.075  -1.292  -1.127  -1.116
124   L         1.554   1.638   1.742   1.226   1.346   1.521   1.702   1.821   2.008
125   S        -0.175  -0.351  -0.263  -0.204  -0.443  -0.306  -0.334  -0.568  -0.459
126   A         0.830   0.744   0.644   0.962   0.834   0.695   0.863   0.711   0.502
127   R         1.554   1.638   1.742   1.720   1.831   2.003   1.702   1.821   2.008
128   T         0.830   0.679   0.635   0.765   0.565   0.485   0.863   0.601   0.486
129   F         1.554   1.638   1.742   1.514   1.629   1.802   1.702   1.821   2.008
130   G         1.554   1.638   1.742   1.569   1.684   1.855   1.702   1.821   2.008
131   T         0.830   0.744   0.644   0.770   0.672   0.512   0.863   0.711   0.502
132   W         0.830   0.679   0.635   1.105   0.906   0.803   0.863   0.601   0.486
133   T         1.554   1.638   1.742   1.408   1.531   1.698   1.702   1.821   2.008
134   F         0.283   0.371   0.452  -0.159  -0.025   0.054  -0.095   0.035   0.128
135   I        -0.983  -0.982  -0.838  -1.226  -1.213  -1.007  -1.053  -1.008  -0.830
136   S        -0.175  -0.186  -0.204  -0.329  -0.297  -0.380  -0.334  -0.320  -0.367
137   C        -0.983  -0.990  -0.844  -0.906  -0.932  -0.731  -1.053  -1.016  -0.837
138   V         0.474   0.676   0.575   0.392   0.718   0.518   0.265   0.595   0.371
139   I         0.283   0.365   0.452   0.039   0.170   0.273  -0.095   0.023   0.128
140   R         1.554   1.638   1.742   1.720   1.831   2.003   1.702   1.821   2.008
141   F         0.830   1.040   0.683   0.829   1.108   0.573   0.863   1.169   0.574
142   Y         1.554   1.638   1.742   1.519   1.629   1.807   1.702   1.821   2.008
143   G         0.141  -0.132  -0.172   0.353  -0.012  -0.060   0.145  -0.242  -0.316
144   A         0.830   0.679   0.635   0.948   0.719   0.645   0.863   0.601   0.486
145   M        -0.175   0.106  -0.162  -0.316   0.133  -0.280  -0.334   0.080  -0.306
146   Y         0.141  -0.132  -0.172   0.322  -0.029  -0.063   0.145  -0.242  -0.316
147   L         0.474   0.514   0.486   0.078   0.139   0.076   0.265   0.307   0.195
148   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
149   N        -1.109  -0.987  -1.178  -0.938  -0.772  -0.981  -0.933  -0.795  -0.948
150   E        -0.318  -0.189  -0.217  -0.173   0.048   0.035  -0.574  -0.360  -0.392
151   P        -0.858  -0.821  -0.799  -0.645  -0.574  -0.510  -0.933  -0.867  -0.790
152   H        -0.776  -0.886  -0.807  -0.419  -0.571  -0.469  -0.813  -0.895  -0.793
153   I        -0.318  -0.391  -0.256  -0.553  -0.688  -0.496  -0.574  -0.632  -0.453
154   F         0.830   0.994   0.676   0.875   1.085   0.656   0.863   1.103   0.562
155   E        -1.316  -1.390  -1.251  -0.947  -1.040  -0.834  -1.173  -1.188  -1.020
156   L         1.554   1.638   1.742   1.226   1.346   1.521   1.702   1.821   2.008
157   V        -0.776  -0.819  -0.786  -0.775  -0.816  -0.741  -0.813  -0.849  -0.777
158   F        -1.316  -1.318  -1.250  -1.247  -1.257  -1.141  -1.173  -1.139  -1.021
159   M        -1.774  -1.667  -1.599  -1.419  -1.202  -1.134  -1.412  -1.273  -1.156
160   S         0.283   0.306   0.435  -0.104  -0.101   0.084  -0.095  -0.092   0.093
161   Y        -0.175  -0.186  -0.204  -0.199  -0.165  -0.207  -0.334  -0.320  -0.367
162   M        -1.774  -1.665  -1.596  -1.745  -1.627  -1.496  -1.412  -1.274  -1.154
163   V        -0.318  -0.331  -0.241  -0.553  -0.564  -0.463  -0.574  -0.551  -0.433
164   A         1.554   1.638   1.742   1.598   1.695   1.884   1.702   1.821   2.008
165   L        -1.316  -1.299  -1.245  -1.463  -1.365  -1.242  -1.173  -1.121  -1.016
166   F        -1.316  -1.212  -1.228  -1.354  -1.209  -1.234  -1.173  -1.045  -1.001
167   H         1.554   1.638   1.742   1.810   1.924   2.091   1.702   1.821   2.008
168   F         1.554   1.638   1.742   1.514   1.629   1.802   1.702   1.821   2.008
169   G        -1.316  -1.318  -1.250  -1.436  -1.500  -1.363  -1.173  -1.139  -1.021
170   S         1.554   1.638   1.742   1.469   1.601   1.758   1.702   1.821   2.008
171   E         1.554   1.638   1.742   1.729   1.854   2.012   1.702   1.821   2.008
172   L        -0.525  -0.468  -0.325  -0.870  -0.736  -0.538  -0.813  -0.725  -0.539
173   L         0.830   0.679   0.635   0.580   0.378   0.308   0.863   0.601   0.486
174   I        -0.175  -0.134  -0.196  -0.270  -0.190  -0.370  -0.334  -0.244  -0.355
175   F         0.830   0.679   0.635   0.870   0.660   0.583   0.863   0.601   0.486
176   R        -0.443  -0.370  -0.298  -0.409  -0.305  -0.216  -0.694  -0.598  -0.502
177   T         0.830   1.015   0.679   0.794   1.033   0.624   0.863   1.134   0.568
178   C        -0.508  -0.759  -0.776  -0.156  -0.625  -0.742  -0.454  -0.749  -0.757
179   K         0.141  -0.132  -0.172   0.479   0.121   0.050   0.145  -0.242  -0.316
180   L         0.830   0.679   0.635   0.580   0.378   0.308   0.863   0.601   0.486
181   G         0.474   0.413   0.471   0.384   0.244   0.290   0.265   0.117   0.165
182   K        -0.776  -0.788  -0.804  -0.632  -0.679  -0.713  -0.813  -0.831  -0.795
183   G         0.474   0.413   0.471   0.460   0.349   0.423   0.265   0.117   0.165
184   F        -0.858  -0.900  -0.811  -1.179  -1.196  -1.058  -0.933  -0.929  -0.801
185   M        -1.442  -1.251  -1.256  -1.561  -1.308  -1.304  -1.292  -1.086  -1.026
186   G        -0.508  -0.759  -0.776  -0.334  -0.737  -0.789  -0.454  -0.749  -0.757
187   P         1.554   1.638   1.742   1.705   1.828   1.989   1.702   1.821   2.008
188   L        -0.508  -0.759  -0.776  -0.625  -0.976  -0.959  -0.454  -0.749  -0.757
189   V        -0.318  -0.388  -0.253  -0.553  -0.678  -0.489  -0.574  -0.626  -0.449
190   V         0.830   0.679   0.635   0.892   0.686   0.621   0.863   0.601   0.486
191   S         0.474   0.473   0.476   0.329   0.317   0.289   0.265   0.230   0.176
192   T        -0.318  -0.336  -0.239  -0.656  -0.631  -0.507  -0.574  -0.545  -0.425
193   T        -0.175  -0.314  -0.248  -0.349  -0.552  -0.468  -0.334  -0.511  -0.437
194   S         0.830   0.679   0.635   0.832   0.646   0.559   0.863   0.601   0.486
195   L        -0.175  -0.351  -0.263  -0.545  -0.808  -0.676  -0.334  -0.568  -0.459
196   V        -0.776  -0.774  -0.781  -0.898  -0.933  -0.931  -0.813  -0.808  -0.771
197   W         0.830   0.744   0.644   1.104   1.003   0.817   0.863   0.711   0.502
198   M         1.554   1.638   1.742   1.763   1.877   2.045   1.702   1.821   2.008
199   Y        -0.175  -0.327  -0.263  -0.237  -0.503  -0.395  -0.334  -0.545  -0.458
200   K        -0.776  -0.553  -0.768  -0.893  -0.627  -0.769  -0.813  -0.563  -0.756
201   Q         0.830   0.744   0.644   1.115   1.016   0.870   0.863   0.711   0.502
202   R        -0.175  -0.261  -0.237  -0.012  -0.138  -0.131  -0.334  -0.431  -0.421
203   E        -0.858  -0.966  -0.819  -0.588  -0.742  -0.528  -0.933  -0.992  -0.811
204   Y        -0.858  -0.868  -0.796  -0.957  -0.943  -0.820  -0.933  -0.894  -0.787
205   Y         0.830   0.744   0.644   0.881   0.770   0.617   0.863   0.711   0.502
206   T        -0.525  -0.454  -0.316  -1.121  -1.008  -0.790  -0.813  -0.704  -0.526
207   G        -0.776  -0.802  -0.791  -0.659  -0.669  -0.668  -0.813  -0.802  -0.776
208   V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
209   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
210   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
211   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
212   W        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/P40030
Output conservation file - output/P40030
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
