1     M         2.688   2.694   2.766   3.198   3.197   3.328   3.181   3.189   3.322
2     N         0.148   0.145   0.150   0.351   0.341   0.365  -0.058  -0.062  -0.059
3     V         1.314   1.309   1.284   1.539   1.528   1.476   1.237   1.227   1.156
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     I         2.688   2.694   2.766   2.824   2.824   2.946   3.181   3.189   3.322
7     D         2.688   2.694   2.766   2.831   2.843   2.953   3.181   3.189   3.322
8     L         1.133   1.122   1.146   0.785   0.766   0.787   0.878   0.853   0.873
9     S         2.688   2.694   2.766   2.810   2.818   2.933   3.181   3.189   3.322
10    D         1.133   1.149   1.156   1.218   1.249   1.242   0.878   0.908   0.895
11    P         1.133   1.149   1.156   0.856   0.874   0.898   0.878   0.908   0.895
12    A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
13    I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
14    N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
15    V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
16    D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
17    Y        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
18    D        -1.245  -1.242  -1.222  -1.005  -1.009  -0.959  -0.965  -0.961  -0.927
19    S         0.110   0.099   0.128  -0.388  -0.418  -0.366  -0.136  -0.149  -0.106
20    L        -1.245  -1.242  -1.222  -1.114  -1.080  -1.069  -0.965  -0.961  -0.927
21    I         1.044   1.048   1.087   0.591   0.607   0.650   0.693   0.700   0.749
22    G        -0.567  -0.591  -0.580  -0.046  -0.090  -0.056  -0.550  -0.578  -0.557
23    I        -0.567  -0.555  -0.566  -0.652  -0.614  -0.635  -0.550  -0.535  -0.539
24    D        -0.567  -0.567  -0.575  -0.716  -0.722  -0.742  -0.550  -0.549  -0.551
25    N        -1.245  -1.242  -1.222  -0.885  -0.881  -0.837  -0.965  -0.961  -0.927
26    E        -1.245  -1.242  -1.222  -1.372  -1.358  -1.333  -0.965  -0.961  -0.927
27    E         0.366   0.355   0.310   0.119   0.088   0.027   0.279   0.261   0.190
28    S         0.110   0.134   0.129  -0.049  -0.035  -0.034  -0.136  -0.106  -0.106
29    Q         0.110   0.123   0.130   0.281   0.310   0.319  -0.136  -0.119  -0.104
30    E         0.366   0.319   0.293   0.119   0.034  -0.002   0.279   0.206   0.163
31    I         1.044   1.048   1.087   1.034   1.039   1.095   0.693   0.700   0.749
32    F         0.366   0.355   0.310   0.961   0.936   0.888   0.279   0.261   0.190
33    E         1.465   1.436   1.400   1.305   1.251   1.209   1.522   1.466   1.384
34    N        -0.567  -0.554  -0.563  -0.588  -0.574  -0.578  -0.550  -0.534  -0.537
35    E         0.366   0.373   0.315   0.271   0.288   0.168   0.279   0.288   0.197
36    V         0.148   0.140   0.145   0.052   0.039   0.044  -0.058  -0.070  -0.066
37    K         0.148   0.140   0.145   0.232   0.213   0.215  -0.058  -0.070  -0.066
38    E         1.314   1.284   1.277   1.064   1.007   0.998   1.237   1.177   1.142
39    D        -0.699  -0.697  -0.669  -1.134  -1.119  -1.091  -0.706  -0.702  -0.661
40    G        -0.699  -0.697  -0.669  -0.518  -0.518  -0.461  -0.706  -0.702  -0.661
41    Q        -0.699  -0.697  -0.669  -0.712  -0.724  -0.660  -0.706  -0.702  -0.661
42    Q        -0.699  -0.697  -0.669  -1.040  -1.033  -0.994  -0.706  -0.702  -0.661
43    E         0.148   0.161   0.150  -0.326  -0.310  -0.334  -0.058  -0.037  -0.059
44    E        -0.699  -0.697  -0.669  -0.715  -0.710  -0.663  -0.706  -0.702  -0.661
45    Q        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
46    E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
47    E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
48    A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
49    S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
50    S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
51    R        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
52    K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
53    D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
54    G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
55    L        -0.699  -0.697  -0.669  -0.651  -0.633  -0.597  -0.706  -0.702  -0.661
56    I         0.148   0.132   0.142  -0.170  -0.200  -0.212  -0.058  -0.081  -0.070
57    V         0.994   0.998   1.048   1.009   1.016   1.096   0.590   0.595   0.667
58    E         1.314   1.322   1.283   1.029   1.041   0.962   1.237   1.250   1.153
59    P         0.004   0.006   0.044   0.495   0.500   0.571  -0.274  -0.270  -0.219
60    G         0.004   0.006   0.044   0.011   0.014   0.077  -0.274  -0.270  -0.219
61    R         0.004   0.006   0.044  -0.065  -0.053   0.000  -0.274  -0.270  -0.219
62    D         2.688   2.694   2.766   2.813   2.820   2.935   3.181   3.189   3.322
63    V         1.133   1.134   1.148   1.057   1.059   1.077   0.878   0.878   0.878
64    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
65    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
66    E         1.465   1.480   1.405   1.243   1.255   1.138   1.522   1.549   1.394
67    S         0.110   0.097   0.127  -0.173  -0.194  -0.129  -0.136  -0.152  -0.108
68    L         1.044   1.048   1.087   0.683   0.694   0.733   0.693   0.700   0.749
69    R         0.148   0.151   0.154   0.404   0.400   0.406  -0.058  -0.053  -0.052
70    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
71    R        -0.567  -0.555  -0.566  -0.571  -0.558  -0.565  -0.550  -0.535  -0.539
72    A        -0.567  -0.577  -0.578  -0.324  -0.350  -0.341  -0.550  -0.562  -0.554
73    I        -0.567  -0.569  -0.573  -0.718  -0.728  -0.742  -0.550  -0.551  -0.548
74    R         1.465   1.508   1.413   1.309   1.360   1.232   1.522   1.600   1.408
75    D        -1.245  -1.242  -1.222  -1.005  -0.987  -0.959  -0.965  -0.961  -0.927
76    Q        -0.567  -0.557  -0.569  -0.321  -0.301  -0.315  -0.550  -0.537  -0.543
77    L         0.366   0.373   0.315   0.166   0.183   0.088   0.279   0.288   0.197
78    L        -0.567  -0.588  -0.573  -0.656  -0.671  -0.647  -0.550  -0.575  -0.548
79    F         1.044   1.030   1.072   1.295   1.259   1.328   0.693   0.662   0.716
80    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
81    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
82    K        -0.699  -0.697  -0.669  -0.990  -0.980  -0.944  -0.706  -0.702  -0.661
83    I        -0.699  -0.697  -0.669  -0.497  -0.503  -0.440  -0.706  -0.702  -0.661
84    H         0.148   0.161   0.150   0.227   0.250   0.201  -0.058  -0.037  -0.059
85    R        -0.699  -0.697  -0.669  -0.448  -0.447  -0.391  -0.706  -0.702  -0.661
86    Q        -0.699  -0.697  -0.669  -0.718  -0.699  -0.666  -0.706  -0.702  -0.661
87    N        -0.699  -0.697  -0.669  -0.636  -0.615  -0.582  -0.706  -0.702  -0.661
88    Q        -0.699  -0.697  -0.669  -0.604  -0.588  -0.550  -0.706  -0.702  -0.661
89    S        -0.699  -0.697  -0.669  -0.737  -0.714  -0.686  -0.706  -0.702  -0.661
90    D         0.110   0.120   0.128   0.183   0.213   0.220  -0.136  -0.122  -0.106
91    C        -1.245  -1.242  -1.222  -0.601  -0.615  -0.547  -0.965  -0.961  -0.927
92    A        -0.567  -0.577  -0.578  -0.506  -0.524  -0.517  -0.550  -0.562  -0.554
93    D        -0.567  -0.577  -0.578  -0.360  -0.393  -0.397  -0.550  -0.562  -0.554
94    A         0.110   0.096   0.124   0.177   0.155   0.204  -0.136  -0.153  -0.112
95    R         1.044   1.049   1.082   1.254   1.267   1.309   0.693   0.703   0.738
96    K         0.366   0.351   0.302   0.459   0.435   0.362   0.279   0.255   0.177
97    L         2.688   2.694   2.766   2.545   2.567   2.662   3.181   3.189   3.322
98    -         0.004   0.006   0.044  -0.202  -0.196  -0.140  -0.274  -0.270  -0.219
99    -         0.148   0.154   0.151   0.319   0.323   0.323  -0.058  -0.049  -0.056
100   -         1.314   1.304   1.287   1.116   1.116   1.065   1.237   1.217   1.161
101   -        -0.699  -0.697  -0.669  -0.390  -0.391  -0.331  -0.706  -0.702  -0.661
102   -        -0.699  -0.697  -0.669  -0.738  -0.733  -0.687  -0.706  -0.702  -0.661
103   -         0.148   0.129   0.145   0.184   0.128   0.145  -0.058  -0.086  -0.066
104   S         0.366   0.358   0.299   0.431   0.419   0.330   0.279   0.266   0.172
105   N        -1.245  -1.242  -1.222  -1.295  -1.310  -1.254  -0.965  -0.961  -0.927
106   D        -1.245  -1.242  -1.222  -0.748  -0.734  -0.697  -0.965  -0.961  -0.927
107   E        -1.245  -1.242  -1.222  -1.107  -1.097  -1.063  -0.965  -0.961  -0.927
108   E        -0.567  -0.567  -0.575  -0.625  -0.632  -0.614  -0.550  -0.549  -0.551
109   D        -0.567  -0.531  -0.561  -0.759  -0.696  -0.757  -0.550  -0.505  -0.533
110   E         0.366   0.319   0.293   0.069  -0.018  -0.062   0.279   0.206   0.163
111   S        -0.567  -0.577  -0.578  -0.155  -0.156  -0.151  -0.550  -0.562  -0.554
112   R        -0.567  -0.591  -0.580  -0.233  -0.268  -0.241  -0.550  -0.578  -0.557
113   Q        -0.567  -0.531  -0.561  -0.676  -0.617  -0.669  -0.550  -0.505  -0.533
114   Q         0.110   0.099   0.124  -0.223  -0.251  -0.208  -0.136  -0.149  -0.112
115   K         0.366   0.358   0.299   0.318   0.293   0.188   0.279   0.266   0.172
116   L         2.688   2.694   2.766   2.545   2.567   2.662   3.181   3.189   3.322
117   E        -0.567  -0.569  -0.573  -0.593  -0.604  -0.577  -0.550  -0.551  -0.548
118   R         0.366   0.319   0.293   0.459   0.366   0.303   0.279   0.206   0.163
119   I         2.688   2.694   2.766   2.855   2.857   2.978   3.181   3.189   3.322
120   R         1.465   1.480   1.405   1.742   1.767   1.642   1.522   1.549   1.394
121   E        -0.567  -0.577  -0.578  -0.650  -0.667  -0.693  -0.550  -0.562  -0.554
122   E         1.465   1.439   1.388   1.309   1.260   1.195   1.522   1.473   1.361
123   L         2.688   2.694   2.766   2.545   2.567   2.662   3.181   3.189   3.322
124   E         0.366   0.358   0.299  -0.016  -0.032  -0.154   0.279   0.266   0.172
125   E         1.465   1.439   1.388   1.364   1.319   1.266   1.522   1.473   1.361
126   L         1.044   1.055   1.087   0.591   0.620   0.652   0.693   0.715   0.750
127   K         0.366   0.355   0.310   0.425   0.412   0.335   0.279   0.261   0.190
128   I        -1.245  -1.242  -1.222  -1.344  -1.339  -1.304  -0.965  -0.961  -0.927
129   E        -0.567  -0.552  -0.571  -0.685  -0.646  -0.712  -0.550  -0.532  -0.547
130   N        -0.567  -0.555  -0.566  -0.663  -0.645  -0.662  -0.550  -0.535  -0.539
131   L        -0.567  -0.557  -0.569  -0.819  -0.794  -0.815  -0.550  -0.537  -0.543
132   T        -0.567  -0.588  -0.573  -0.308  -0.340  -0.310  -0.550  -0.575  -0.548
133   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
134   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
135   S        -1.245  -1.242  -1.222  -0.752  -0.730  -0.700  -0.965  -0.961  -0.927
136   E         0.110   0.118   0.126  -0.049  -0.039  -0.022  -0.136  -0.125  -0.109
137   M        -1.245  -1.242  -1.222  -0.901  -0.921  -0.853  -0.965  -0.961  -0.927
138   Q         0.110   0.098   0.123  -0.042  -0.053  -0.021  -0.136  -0.150  -0.113
139   T        -0.567  -0.557  -0.569  -0.308  -0.301  -0.301  -0.550  -0.537  -0.543
140   E         1.465   1.480   1.405   1.243   1.255   1.138   1.522   1.549   1.394
141   I         0.366   0.409   0.328   0.171   0.252   0.109   0.279   0.345   0.218
142   K        -0.567  -0.577  -0.578  -0.321  -0.323  -0.328  -0.550  -0.562  -0.554
143   E        -0.567  -0.552  -0.571  -0.627  -0.595  -0.649  -0.550  -0.532  -0.547
144   L         1.044   1.041   1.075   0.714   0.725   0.766   0.693   0.686   0.723
145   C        -1.245  -1.242  -1.222  -1.020  -1.015  -0.973  -0.965  -0.961  -0.927
146   E         1.044   1.048   1.087   0.756   0.763   0.805   0.693   0.700   0.749
147   I        -0.567  -0.577  -0.578  -0.611  -0.607  -0.604  -0.550  -0.562  -0.554
148   Q         0.366   0.413   0.323   0.300   0.381   0.248   0.279   0.351   0.210
149   S        -1.245  -1.242  -1.222  -1.476  -1.469  -1.439  -0.965  -0.961  -0.927
150   K        -1.245  -1.242  -1.222  -1.032  -1.020  -0.986  -0.965  -0.961  -0.927
151   L         2.688   2.694   2.766   2.545   2.567   2.662   3.181   3.189   3.322
152   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
153   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
154   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
155   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
156   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
157   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
158   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
159   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
160   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
161   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
162   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
163   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
164   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
165   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
166   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
167   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
168   A         0.110   0.120   0.128   0.188   0.197   0.209  -0.136  -0.122  -0.106
169   T        -0.567  -0.567  -0.575  -0.481  -0.477  -0.501  -0.550  -0.549  -0.551
170   E        -0.567  -0.569  -0.573  -0.887  -0.879  -0.893  -0.550  -0.551  -0.548
171   S        -1.245  -1.242  -1.222  -1.183  -1.175  -1.140  -0.965  -0.961  -0.927
172   S         0.366   0.358   0.299   0.236   0.219   0.097   0.279   0.266   0.172
173   S        -0.567  -0.591  -0.580  -0.667  -0.697  -0.690  -0.550  -0.578  -0.557
174   R         0.366   0.413   0.323   0.626   0.697   0.563   0.279   0.351   0.210
175   L        -1.245  -1.242  -1.222  -1.114  -1.098  -1.069  -0.965  -0.961  -0.927
176   T         0.110   0.123   0.130  -0.078  -0.059  -0.059  -0.136  -0.119  -0.104
177   N         0.110   0.099   0.124   0.113   0.093   0.135  -0.136  -0.149  -0.112
178   L        -1.245  -1.242  -1.222  -0.963  -0.938  -0.915  -0.965  -0.961  -0.927
179   R        -1.245  -1.242  -1.222  -1.417  -1.434  -1.379  -0.965  -0.961  -0.927
180   K         1.465   1.486   1.404   1.526   1.557   1.421   1.522   1.558   1.391
181   K        -1.245  -1.242  -1.222  -1.101  -1.073  -1.056  -0.965  -0.961  -0.927
182   L         1.465   1.439   1.388   1.302   1.275   1.176   1.522   1.473   1.361
183   L        -0.567  -0.557  -0.569  -0.622  -0.601  -0.646  -0.550  -0.537  -0.543
184   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
185   -         0.004   0.006   0.044   0.118   0.123   0.187  -0.274  -0.270  -0.219
186   E        -0.699  -0.696  -0.669  -0.753  -0.735  -0.701  -0.706  -0.702  -0.661
187   T        -0.567  -0.552  -0.571  -0.645  -0.622  -0.652  -0.550  -0.532  -0.547
188   Y        -0.567  -0.552  -0.571  -0.633  -0.616  -0.644  -0.550  -0.532  -0.547
189   E         0.366   0.409   0.328   0.332   0.415   0.255   0.279   0.345   0.218
190   G        -0.567  -0.555  -0.566  -0.442  -0.422  -0.441  -0.550  -0.535  -0.539
191   Q        -0.567  -0.557  -0.569  -1.017  -1.012  -1.028  -0.550  -0.537  -0.543
192   D        -1.245  -1.242  -1.222  -1.200  -1.193  -1.158  -0.965  -0.961  -0.927
193   T         0.110   0.133   0.128  -0.258  -0.232  -0.227  -0.136  -0.108  -0.107
194   V        -0.567  -0.591  -0.580  -0.412  -0.450  -0.440  -0.550  -0.578  -0.557
195   I        -0.567  -0.552  -0.571  -0.636  -0.604  -0.624  -0.550  -0.532  -0.547
196   L        -0.567  -0.591  -0.580  -0.877  -0.921  -0.896  -0.550  -0.578  -0.557
197   P        -0.567  -0.591  -0.580  -0.239  -0.292  -0.270  -0.550  -0.578  -0.557
198   N         0.366   0.351   0.302   0.556   0.514   0.447   0.279   0.255   0.177
199   I         1.465   1.436   1.400   1.595   1.542   1.486   1.522   1.466   1.384
200   I        -1.245  -1.242  -1.222  -1.355  -1.359  -1.316  -0.965  -0.961  -0.927
201   L         0.366   0.391   0.313   0.104   0.156   0.006   0.279   0.317   0.194
202   D         0.110   0.123   0.130  -0.108  -0.083  -0.086  -0.136  -0.119  -0.104
203   T         0.110   0.123   0.130  -0.002   0.009   0.028  -0.136  -0.119  -0.104
204   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
205   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
206   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
207   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
208   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
209   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
210   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
211   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
212   S        -1.245  -1.242  -1.222  -0.901  -0.883  -0.853  -0.965  -0.961  -0.927
213   N        -0.567  -0.588  -0.573  -0.427  -0.465  -0.435  -0.550  -0.575  -0.548
214   I        -0.567  -0.555  -0.566  -0.532  -0.508  -0.507  -0.550  -0.535  -0.539
215   K         0.110   0.097   0.127  -0.044  -0.065  -0.016  -0.136  -0.151  -0.108
216   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
217   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
218   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
219   R        -0.567  -0.588  -0.573  -0.387  -0.421  -0.396  -0.550  -0.575  -0.548
220   L         1.465   1.439   1.388   1.404   1.382   1.307   1.522   1.473   1.361
221   Q        -0.567  -0.554  -0.563  -0.703  -0.684  -0.706  -0.550  -0.534  -0.537
222   K        -0.567  -0.577  -0.578  -0.832  -0.859  -0.874  -0.550  -0.562  -0.554
223   L         1.465   1.486   1.404   1.302   1.346   1.202   1.522   1.558   1.391
224   D         1.044   1.048   1.087   0.543   0.544   0.601   0.693   0.700   0.749
225   Q        -0.567  -0.554  -0.563  -0.321  -0.309  -0.306  -0.550  -0.534  -0.537
226   K         1.044   1.064   1.093   0.961   1.006   1.034   0.693   0.734   0.761
227   I         1.044   1.041   1.075   0.683   0.677   0.700   0.693   0.686   0.723
228   S         0.366   0.319   0.293   0.463   0.393   0.358   0.279   0.206   0.163
229   L        -1.245  -1.242  -1.222  -1.265  -1.245  -1.224  -0.965  -0.961  -0.927
230   M         1.465   1.508   1.413   1.394   1.465   1.330   1.522   1.600   1.408
231   E         2.688   2.694   2.766   2.510   2.507   2.626   3.181   3.189   3.322
232   R         0.366   0.376   0.304   0.378   0.390   0.276   0.279   0.293   0.181
233   F        -1.245  -1.242  -1.222  -0.845  -0.859  -0.795  -0.965  -0.961  -0.927
234   V         1.044   1.042   1.080   1.034   1.025   1.078   0.693   0.687   0.733
235   G         2.688   2.694   2.766   3.213   3.225   3.344   3.181   3.189   3.322
236   I        -1.245  -1.242  -1.222  -0.657  -0.656  -0.603  -0.965  -0.961  -0.927
237   P        -1.245  -1.242  -1.222  -0.765  -0.760  -0.714  -0.965  -0.961  -0.927
238   E        -0.567  -0.588  -0.573  -0.689  -0.717  -0.679  -0.550  -0.575  -0.548
239   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
240   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
241   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
242   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
243   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
244   E         0.004   0.006   0.044  -0.313  -0.298  -0.252  -0.274  -0.270  -0.219
245   D         0.148   0.140   0.145   0.132   0.124   0.109  -0.058  -0.070  -0.066
246   R        -0.699  -0.697  -0.669  -0.510  -0.505  -0.453  -0.706  -0.702  -0.661
247   K        -0.567  -0.591  -0.580  -0.768  -0.827  -0.804  -0.550  -0.578  -0.557
248   S         1.465   1.436   1.400   1.618   1.576   1.539   1.522   1.466   1.384
249   V         0.110   0.134   0.129  -0.189  -0.160  -0.158  -0.136  -0.106  -0.106
250   H        -1.245  -1.242  -1.222  -0.782  -0.784  -0.731  -0.965  -0.961  -0.927
251   S        -0.567  -0.591  -0.580  -0.770  -0.810  -0.803  -0.550  -0.578  -0.557
252   K        -1.245  -1.242  -1.222  -1.589  -1.604  -1.554  -0.965  -0.961  -0.927
253   V         0.366   0.373   0.315   0.404   0.405   0.308   0.279   0.288   0.197
254   N         2.688   2.694   2.766   2.957   2.962   3.083   3.181   3.189   3.322
255   E        -0.567  -0.591  -0.580  -0.978  -1.024  -1.003  -0.550  -0.578  -0.557
256   L         0.366   0.319   0.293   0.301   0.247   0.209   0.279   0.206   0.163
257   Y        -0.567  -0.569  -0.573  -0.028  -0.038  -0.026  -0.550  -0.551  -0.548
258   R         0.366   0.319   0.293   0.459   0.366   0.303   0.279   0.206   0.163
259   S         0.366   0.413   0.323   0.235   0.315   0.137   0.279   0.351   0.210
260   I         1.465   1.436   1.400   1.535   1.482   1.410   1.522   1.466   1.384
261   Q        -1.245  -1.242  -1.222  -1.568  -1.582  -1.533  -0.965  -0.961  -0.927
262   L         1.044   1.049   1.082   0.683   0.697   0.719   0.693   0.703   0.738
263   L         0.110   0.097   0.127  -0.189  -0.190  -0.149  -0.136  -0.151  -0.108
264   Q        -0.567  -0.552  -0.571  -0.885  -0.869  -0.889  -0.550  -0.532  -0.547
265   G        -1.245  -1.242  -1.222  -1.133  -1.120  -1.089  -0.965  -0.961  -0.927
266   D         1.314   1.322   1.283   1.473   1.485   1.433   1.237   1.250   1.153
267   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
268   K        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
269   A        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
270   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
271   E         1.044   1.030   1.072   0.624   0.599   0.667   0.693   0.662   0.716
272   G        -1.245  -1.242  -1.222  -0.697  -0.713  -0.644  -0.965  -0.961  -0.927
273   K        -1.245  -1.242  -1.222  -0.843  -0.828  -0.793  -0.965  -0.961  -0.927
274   L        -0.567  -0.591  -0.580  -0.532  -0.557  -0.521  -0.550  -0.578  -0.557
275   Q        -1.245  -1.242  -1.222  -1.379  -1.390  -1.340  -0.965  -0.961  -0.927
276   K        -0.567  -0.588  -0.573  -0.537  -0.575  -0.541  -0.550  -0.575  -0.548
277   F         0.366   0.351   0.302   0.933   0.906   0.842   0.279   0.255   0.177
278   R        -0.567  -0.588  -0.573  -0.479  -0.521  -0.496  -0.550  -0.575  -0.548
279   D        -0.567  -0.552  -0.571  -0.613  -0.591  -0.634  -0.550  -0.532  -0.547
280   R        -0.567  -0.557  -0.569  -0.859  -0.848  -0.882  -0.550  -0.537  -0.543
281   L        -0.567  -0.567  -0.575  -0.448  -0.439  -0.426  -0.550  -0.549  -0.551
282   V        -1.245  -1.242  -1.222  -1.042  -1.030  -0.997  -0.965  -0.961  -0.927
283   E         1.044   1.064   1.093   0.607   0.648   0.671   0.693   0.734   0.761
284   L         0.366   0.355   0.310   0.125   0.121   0.027   0.279   0.261   0.190
285   N        -1.245  -1.242  -1.222  -1.011  -1.006  -0.965  -0.965  -0.961  -0.927
286   E        -0.567  -0.554  -0.563  -0.948  -0.917  -0.964  -0.550  -0.534  -0.537
287   E         0.366   0.355   0.310   0.115   0.086   0.022   0.279   0.261   0.190
288   F        -0.567  -0.557  -0.569  -0.091  -0.075  -0.087  -0.550  -0.537  -0.543
289   E         0.366   0.355   0.310   0.231   0.210   0.157   0.279   0.261   0.190
290   N        -0.567  -0.552  -0.571  -0.808  -0.796  -0.806  -0.550  -0.532  -0.547
291   S         0.366   0.351   0.302   0.300   0.283   0.179   0.279   0.255   0.177
292   L        -0.567  -0.569  -0.573  -0.825  -0.812  -0.829  -0.550  -0.551  -0.548
293   L         1.044   1.043   1.077   0.591   0.598   0.635   0.693   0.689   0.729
294   G         1.314   1.309   1.284   1.696   1.690   1.633   1.237   1.227   1.156
295   K         0.994   0.998   1.048   0.849   0.848   0.931   0.590   0.595   0.667
296   K         0.148   0.145   0.150   0.141   0.132   0.146  -0.058  -0.062  -0.059
297   I        -0.699  -0.697  -0.669  -0.580  -0.582  -0.525  -0.706  -0.702  -0.661
298   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
299   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
300   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
301   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
302   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
303   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
304   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
305   Q        -0.567  -0.591  -0.580  -0.685  -0.738  -0.731  -0.550  -0.578  -0.557
306   Q         0.110   0.118   0.128   0.026   0.039   0.059  -0.136  -0.125  -0.106
307   D         1.465   1.436   1.400   1.607   1.571   1.510   1.522   1.466   1.384
308   L        -1.245  -1.242  -1.222  -0.884  -0.869  -0.835  -0.965  -0.961  -0.927
309   R        -1.245  -1.242  -1.222  -1.240  -1.249  -1.199  -0.965  -0.961  -0.927
310   L         0.366   0.354   0.300   0.341   0.335   0.264   0.279   0.259   0.174
311   K        -0.567  -0.567  -0.575  -0.465  -0.461  -0.466  -0.550  -0.549  -0.551
312   D        -0.567  -0.588  -0.573  -0.652  -0.697  -0.668  -0.550  -0.575  -0.548
313   D         0.366   0.319   0.293   0.268   0.182   0.111   0.279   0.206   0.163
314   T        -0.567  -0.577  -0.578  -0.698  -0.727  -0.729  -0.550  -0.562  -0.554
315   V        -1.245  -1.242  -1.222  -1.610  -1.614  -1.575  -0.965  -0.961  -0.927
316   S        -0.567  -0.552  -0.571  -0.447  -0.415  -0.441  -0.550  -0.532  -0.547
317   K         0.366   0.351   0.302   0.313   0.276   0.189   0.279   0.255   0.177
318   L         0.366   0.354   0.300   0.315   0.312   0.234   0.279   0.259   0.174
319   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
320   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
321   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
322   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
323   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
324   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
325   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
326   V        -0.567  -0.569  -0.573  -0.252  -0.247  -0.254  -0.550  -0.551  -0.548
327   M        -0.567  -0.552  -0.571  -0.221  -0.198  -0.213  -0.550  -0.532  -0.547
328   P        -1.245  -1.242  -1.222  -1.203  -1.226  -1.160  -0.965  -0.961  -0.927
329   E         0.366   0.354   0.300   0.127   0.099   0.018   0.279   0.259   0.174
330   N        -0.567  -0.552  -0.571  -0.548  -0.517  -0.552  -0.550  -0.532  -0.547
331   K         0.366   0.319   0.293   0.426   0.348   0.308   0.279   0.206   0.163
332   V         0.366   0.354   0.300   0.532   0.510   0.395   0.279   0.259   0.174
333   K        -1.245  -1.242  -1.222  -1.178  -1.171  -1.135  -0.965  -0.961  -0.927
334   E        -0.567  -0.588  -0.573  -0.574  -0.599  -0.556  -0.550  -0.575  -0.548
335   I         1.044   1.064   1.093   0.591   0.636   0.660   0.693   0.734   0.761
336   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
337   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
338   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
339   N        -0.567  -0.577  -0.578  -0.140  -0.168  -0.156  -0.550  -0.562  -0.554
340   S        -0.567  -0.567  -0.575  -0.861  -0.861  -0.894  -0.550  -0.549  -0.551
341   M         0.110   0.096   0.124   0.198   0.175   0.229  -0.136  -0.153  -0.112
342   Y         1.044   1.040   1.080   1.018   1.005   1.048   0.693   0.684   0.734
343   S        -0.567  -0.552  -0.571  -0.206  -0.179  -0.217  -0.550  -0.532  -0.547
344   M        -1.245  -1.242  -1.222  -0.983  -0.986  -0.936  -0.965  -0.961  -0.927
345   F        -0.567  -0.557  -0.569  -0.595  -0.578  -0.578  -0.550  -0.537  -0.543
346   K        -0.567  -0.577  -0.578  -0.685  -0.718  -0.726  -0.550  -0.562  -0.554
347   Q         0.110   0.098   0.123  -0.133  -0.157  -0.126  -0.136  -0.150  -0.113
348   Y         2.688   2.694   2.766   3.229   3.231   3.360   3.181   3.189   3.322
349   Q        -1.245  -1.242  -1.222  -0.949  -0.938  -0.901  -0.965  -0.961  -0.927
350   D        -0.567  -0.557  -0.569  -0.678  -0.661  -0.663  -0.550  -0.537  -0.543
351   S        -0.567  -0.577  -0.578  -0.295  -0.309  -0.309  -0.550  -0.562  -0.554
352   L        -0.567  -0.567  -0.575  -0.511  -0.499  -0.494  -0.550  -0.549  -0.551
353   P         2.688   2.694   2.766   3.237   3.240   3.368   3.181   3.189   3.322
354   L        -0.567  -0.567  -0.575  -0.592  -0.581  -0.581  -0.550  -0.549  -0.551
355   L         1.465   1.486   1.404   1.302   1.346   1.202   1.522   1.558   1.391
356   A        -0.567  -0.552  -0.571  -0.529  -0.503  -0.509  -0.550  -0.532  -0.547
357   E         0.366   0.354   0.300   0.129   0.097   0.021   0.279   0.259   0.174
358   R         2.688   2.694   2.766   3.010   3.019   3.136   3.181   3.189   3.322
359   M         0.366   0.413   0.323   0.322   0.397   0.273   0.279   0.351   0.210
360   K         0.366   0.358   0.299   0.300   0.277   0.167   0.279   0.266   0.172
361   S         1.465   1.480   1.405   1.556   1.579   1.469   1.522   1.549   1.394
362   L         1.465   1.439   1.388   1.402   1.380   1.306   1.522   1.473   1.361
363   N         1.465   1.436   1.400   1.737   1.690   1.640   1.522   1.466   1.384
364   K        -1.245  -1.242  -1.222  -1.196  -1.186  -1.153  -0.965  -0.961  -0.927
365   M         0.110   0.121   0.129   0.102   0.113   0.119  -0.136  -0.122  -0.106
366   N         0.366   0.376   0.304   0.832   0.842   0.724   0.279   0.293   0.181
367   N         0.110   0.118   0.128   0.170   0.182   0.206  -0.136  -0.125  -0.106
368   R        -1.245  -1.242  -1.222  -1.469  -1.469  -1.432  -0.965  -0.961  -0.927
369   V         0.366   0.351   0.302   0.849   0.827   0.774   0.279   0.255   0.177
370   I        -1.245  -1.242  -1.222  -0.955  -0.941  -0.907  -0.965  -0.961  -0.927
371   E        -0.567  -0.567  -0.575  -0.670  -0.672  -0.662  -0.550  -0.549  -0.551
372   V        -1.245  -1.242  -1.222  -0.782  -0.785  -0.731  -0.965  -0.961  -0.927
373   Y         0.110   0.121   0.126   0.262   0.266   0.294  -0.136  -0.122  -0.109
374   E        -0.567  -0.577  -0.578  -0.757  -0.767  -0.791  -0.550  -0.562  -0.554
375   T        -0.567  -0.591  -0.580  -0.634  -0.679  -0.680  -0.550  -0.578  -0.557
376   T        -1.245  -1.242  -1.222  -0.662  -0.644  -0.609  -0.965  -0.961  -0.927
377   K        -1.245  -1.242  -1.222  -1.403  -1.390  -1.364  -0.965  -0.961  -0.927
378   G         1.044   1.043   1.077   0.985   0.974   1.005   0.693   0.689   0.729
379   L         0.110   0.096   0.124  -0.301  -0.318  -0.286  -0.136  -0.153  -0.112
380   D         0.110   0.123   0.130  -0.069  -0.049  -0.034  -0.136  -0.119  -0.104
381   S        -0.567  -0.555  -0.566  -0.548  -0.515  -0.543  -0.550  -0.535  -0.539
382   Q        -1.245  -1.242  -1.222  -0.826  -0.821  -0.776  -0.965  -0.961  -0.927
383   I        -0.567  -0.555  -0.566  -0.342  -0.317  -0.348  -0.550  -0.535  -0.539
384   T        -0.567  -0.557  -0.569  -0.417  -0.402  -0.403  -0.550  -0.537  -0.543
385   S        -0.567  -0.591  -0.580  -0.645  -0.680  -0.666  -0.550  -0.578  -0.557
386   I        -0.567  -0.577  -0.578  -0.402  -0.419  -0.425  -0.550  -0.562  -0.554
387   Q         0.366   0.358   0.299   0.703   0.692   0.614   0.279   0.266   0.172
388   E         0.110   0.118   0.128  -0.485  -0.472  -0.470  -0.136  -0.125  -0.106
389   Q         0.366   0.351   0.302   0.418   0.390   0.282   0.279   0.255   0.177
390   G        -0.567  -0.552  -0.571  -0.647  -0.619  -0.636  -0.550  -0.532  -0.547
391   K         0.110   0.123   0.130  -0.133  -0.112  -0.110  -0.136  -0.119  -0.104
392   V        -0.567  -0.554  -0.563  -0.585  -0.580  -0.586  -0.550  -0.534  -0.537
393   W         2.688   2.694   2.766   3.326   3.331   3.459   3.181   3.189   3.322
394   L        -1.245  -1.242  -1.222  -1.337  -1.308  -1.297  -0.965  -0.961  -0.927
395   K        -1.245  -1.242  -1.222  -1.127  -1.110  -1.083  -0.965  -0.961  -0.927
396   A        -0.567  -0.552  -0.571  -0.289  -0.262  -0.287  -0.550  -0.532  -0.547
397   L         0.366   0.351   0.302   0.204   0.196   0.107   0.279   0.255   0.177
398   N        -0.567  -0.555  -0.566  -0.856  -0.851  -0.849  -0.550  -0.535  -0.539
399   E        -0.567  -0.554  -0.563  -0.762  -0.731  -0.766  -0.550  -0.534  -0.537
400   L         1.465   1.486   1.404   1.340   1.384   1.250   1.522   1.558   1.391
401   D        -0.567  -0.567  -0.575  -0.757  -0.763  -0.786  -0.550  -0.549  -0.551
402   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
403   K        -1.245  -1.242  -1.222  -1.220  -1.208  -1.178  -0.965  -0.961  -0.927
404   K         0.366   0.391   0.313   0.459   0.499   0.380   0.279   0.317   0.194
405   F        -0.567  -0.567  -0.575  -0.255  -0.252  -0.277  -0.550  -0.549  -0.551
406   D        -1.245  -1.242  -1.222  -1.120  -1.122  -1.076  -0.965  -0.961  -0.927
407   E         0.110   0.096   0.124  -0.258  -0.279  -0.232  -0.136  -0.153  -0.112
408   Q         0.366   0.391   0.313   0.699   0.740   0.632   0.279   0.317   0.194
409   E         0.366   0.319   0.293   0.059  -0.029  -0.074   0.279   0.206   0.163
410   V        -0.567  -0.567  -0.575  -0.350  -0.344  -0.365  -0.550  -0.549  -0.551
411   K        -0.699  -0.697  -0.669  -0.999  -0.993  -0.953  -0.706  -0.702  -0.661
412   I         0.994   0.998   1.048   0.994   0.986   1.078   0.590   0.595   0.667
413   R        -0.699  -0.697  -0.669  -0.344  -0.333  -0.284  -0.706  -0.702  -0.661
414   E        -0.567  -0.567  -0.575  -0.859  -0.867  -0.867  -0.550  -0.549  -0.551
415   N        -0.567  -0.588  -0.573  -0.609  -0.669  -0.633  -0.550  -0.575  -0.548
416   M        -0.567  -0.567  -0.575  -0.397  -0.404  -0.428  -0.550  -0.549  -0.551
417   E        -1.245  -1.242  -1.222  -1.013  -1.008  -0.967  -0.965  -0.961  -0.927
418   Q        -0.567  -0.591  -0.580  -0.578  -0.628  -0.613  -0.550  -0.578  -0.557
419   I         0.110   0.118   0.128  -0.189  -0.174  -0.156  -0.136  -0.125  -0.106
420   R        -0.567  -0.557  -0.569  -0.811  -0.810  -0.807  -0.550  -0.537  -0.543
421   R        -0.567  -0.569  -0.573  -0.744  -0.737  -0.785  -0.550  -0.551  -0.548
422   K        -0.567  -0.554  -0.563  -0.383  -0.354  -0.375  -0.550  -0.534  -0.537
423   I         0.110   0.097   0.127  -0.189  -0.201  -0.156  -0.136  -0.152  -0.108
424   D        -0.699  -0.697  -0.669  -0.774  -0.766  -0.723  -0.706  -0.702  -0.661
425   T         0.148   0.140   0.145   0.118   0.105   0.111  -0.058  -0.069  -0.066
426   L         2.688   2.694   2.766   2.547   2.553   2.665   3.181   3.189   3.322
427   E         1.314   1.322   1.283   1.031   1.044   0.964   1.237   1.250   1.153
428   D        -0.699  -0.697  -0.669  -0.890  -0.890  -0.842  -0.706  -0.702  -0.661
429   E         0.148   0.163   0.157   0.052   0.085   0.047  -0.058  -0.034  -0.047
430   A         0.148   0.169   0.151   0.395   0.434   0.403  -0.058  -0.025  -0.056
431   L         0.148   0.161   0.147  -0.054  -0.038  -0.045  -0.058  -0.038  -0.063
432   Q         0.148   0.163   0.157   0.003   0.028   0.009  -0.058  -0.034  -0.047
433   R         1.314   1.335   1.287   1.125   1.154   1.078   1.237   1.275   1.161
434   N         1.133   1.134   1.148   0.971   0.972   0.981   0.878   0.878   0.878
435   S         0.004   0.006   0.044   0.022   0.024   0.089  -0.274  -0.270  -0.219
436   K         0.148   0.163   0.157   0.089   0.118   0.096  -0.058  -0.034  -0.047
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/P36224
Output conservation file - output/P36224
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
