1     M         1.729   1.740   1.828   1.986   1.998   2.135   1.905   1.923   2.070
2     T        -0.518  -0.473  -0.506  -0.548  -0.492  -0.555  -0.563  -0.513  -0.552
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
9     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
10    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
11    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
12    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
13    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
14    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
15    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
16    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
17    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
18    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
19    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
20    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
21    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
22    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
23    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
24    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
25    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
26    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
27    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
28    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
29    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
30    T         0.533   0.579   0.638   0.117   0.197   0.283   0.170   0.248   0.307
31    V         0.399   0.337   0.132   0.525   0.435   0.096   0.401   0.305  -0.012
32    S        -0.778  -0.712  -0.872  -0.773  -0.678  -0.900  -0.640  -0.573  -0.731
33    I         0.399   0.277   0.108   0.591   0.425   0.156   0.401   0.219  -0.048
34    N        -0.465  -0.474  -0.512  -0.641  -0.664  -0.687  -0.525  -0.550  -0.570
35    K        -1.286  -1.367  -1.328  -1.161  -1.316  -1.285  -0.988  -1.058  -0.989
36    P        -1.405  -1.273  -1.295  -1.318  -1.101  -1.172  -1.103  -0.995  -0.965
37    N        -0.660  -0.646  -0.557  -0.808  -0.797  -0.664  -0.756  -0.732  -0.620
38    L         0.101   0.037  -0.004  -0.065  -0.154  -0.201  -0.062  -0.162  -0.232
39    L        -0.541  -0.540  -0.532  -0.788  -0.743  -0.728  -0.640  -0.622  -0.589
40    K        -1.405  -1.355  -1.311  -1.413  -1.373  -1.266  -1.103  -1.056  -0.976
41    F         0.101   0.021   0.005   0.077  -0.034  -0.088  -0.062  -0.177  -0.217
42    K        -0.660  -0.667  -0.585  -0.577  -0.563  -0.445  -0.756  -0.756  -0.653
43    H         0.399   0.586   0.185   0.641   0.879   0.347   0.401   0.661   0.068
44    V        -0.778  -0.912  -0.930  -0.610  -0.836  -0.889  -0.640  -0.789  -0.790
45    K         1.729   1.740   1.828   1.766   1.783   1.921   1.905   1.923   2.070
46    S        -0.465  -0.578  -0.545  -0.596  -0.733  -0.659  -0.525  -0.655  -0.607
47    F         0.712   0.648   0.665   0.608   0.482   0.453   0.517   0.384   0.361
48    Q        -0.660  -0.679  -0.588  -0.552  -0.579  -0.446  -0.756  -0.769  -0.655
49    P        -0.580  -0.505  -0.553  -0.486  -0.350  -0.424  -0.664  -0.567  -0.611
50    Q        -0.973  -0.941  -0.953  -0.875  -0.791  -0.819  -0.872  -0.829  -0.814
51    E        -1.091  -1.057  -0.982  -0.929  -0.865  -0.765  -0.988  -0.947  -0.845
52    K        -0.660  -0.688  -0.604  -0.716  -0.747  -0.624  -0.756  -0.780  -0.671
53    D        -0.680  -0.697  -0.623  -0.702  -0.754  -0.658  -0.761  -0.789  -0.689
54    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
55    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
56    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
57    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
58    C        -0.680  -0.576  -0.578  -0.676  -0.506  -0.530  -0.761  -0.652  -0.638
59    G        -0.973  -0.964  -0.957  -0.974  -0.953  -0.968  -0.872  -0.863  -0.820
60    P        -0.465  -0.562  -0.546  -0.429  -0.555  -0.551  -0.525  -0.632  -0.604
61    V         0.712   0.716   0.674   0.699   0.703   0.597   0.517   0.514   0.380
62    T         1.048   0.965   0.851   1.082   0.962   0.777   1.095   0.957   0.726
63    S         1.729   1.740   1.828   1.538   1.555   1.699   1.905   1.923   2.070
64    L         0.399   0.439   0.154   0.360   0.406   0.024   0.401   0.441   0.021
65    N        -0.778  -0.594  -0.868  -0.614  -0.389  -0.768  -0.640  -0.448  -0.726
66    F         1.729   1.740   1.828   1.768   1.787   1.923   1.905   1.923   2.070
67    D         1.729   1.740   1.828   1.727   1.738   1.882   1.905   1.923   2.070
68    D         1.729   1.740   1.828   1.727   1.738   1.882   1.905   1.923   2.070
69    N        -1.405  -1.367  -1.313  -1.343  -1.327  -1.229  -1.103  -1.063  -0.977
70    G         1.729   1.740   1.828   1.762   1.776   1.917   1.905   1.923   2.070
71    Q         0.101  -0.000  -0.021   0.272   0.107   0.060  -0.062  -0.225  -0.256
72    F        -0.660  -0.582  -0.570  -0.739  -0.674  -0.606  -0.756  -0.686  -0.637
73    L        -0.465  -0.526  -0.540  -0.569  -0.631  -0.654  -0.525  -0.611  -0.603
74    L        -0.465  -0.514  -0.541  -0.556  -0.609  -0.611  -0.525  -0.587  -0.603
75    T        -0.151  -0.125  -0.074  -0.429  -0.393  -0.331  -0.409  -0.377  -0.324
76    S         0.533   0.570   0.617   0.136   0.199   0.267   0.170   0.231   0.264
77    S        -0.973  -0.929  -0.953  -0.952  -0.828  -0.875  -0.872  -0.822  -0.815
78    S        -0.778  -0.719  -0.618  -1.054  -0.971  -0.827  -0.872  -0.809  -0.684
79    N         0.101   0.310   0.083  -0.005   0.332  -0.018  -0.062   0.246  -0.089
80    D        -0.151  -0.168  -0.098  -0.264  -0.283  -0.186  -0.409  -0.442  -0.357
81    T        -0.033   0.074  -0.012  -0.320  -0.194  -0.259  -0.293  -0.180  -0.249
82    M        -0.033  -0.013   0.003  -0.028   0.008   0.012  -0.293  -0.233  -0.215
83    Q         0.712   0.862   0.791   0.843   1.069   0.955   0.517   0.780   0.610
84    L         1.048   0.965   0.851   0.953   0.850   0.695   1.095   0.957   0.726
85    Y         1.729   1.740   1.828   1.846   1.861   1.999   1.905   1.923   2.070
86    S        -0.151  -0.174  -0.107  -0.395  -0.439  -0.370  -0.409  -0.451  -0.371
87    A        -0.660  -0.602  -0.585  -0.690  -0.605  -0.583  -0.756  -0.710  -0.653
88    T        -0.973  -0.941  -0.953  -0.762  -0.693  -0.727  -0.872  -0.829  -0.814
89    N        -0.973  -0.885  -0.944  -0.988  -0.852  -0.943  -0.872  -0.790  -0.810
90    C         0.533   0.652   0.696   0.458   0.648   0.711   0.170   0.392   0.425
91    K        -0.660  -0.637  -0.587  -0.657  -0.642  -0.566  -0.756  -0.733  -0.655
92    F         0.475   0.508   0.606   0.334   0.399   0.547   0.054   0.105   0.241
93    L        -1.286  -1.367  -1.328  -1.283  -1.392  -1.312  -0.988  -1.058  -0.989
94    D        -0.541  -0.477  -0.519  -0.525  -0.422  -0.465  -0.640  -0.565  -0.582
95    T        -0.228  -0.165  -0.083  -0.632  -0.545  -0.417  -0.525  -0.438  -0.336
96    I         0.101  -0.000  -0.021   0.014  -0.195  -0.276  -0.062  -0.225  -0.256
97    A        -0.465  -0.538  -0.544  -0.406  -0.520  -0.536  -0.525  -0.606  -0.602
98    S         1.729   1.740   1.828   1.538   1.555   1.699   1.905   1.923   2.070
99    K         0.712   0.736   0.714   0.716   0.757   0.706   0.517   0.551   0.460
100   K         1.729   1.740   1.828   1.766   1.783   1.921   1.905   1.923   2.070
101   Y         1.729   1.740   1.828   1.846   1.861   1.999   1.905   1.923   2.070
102   G         1.729   1.740   1.828   1.762   1.776   1.917   1.905   1.923   2.070
103   C        -0.033  -0.013  -0.005  -0.025   0.011   0.030  -0.293  -0.234  -0.227
104   H         1.048   0.965   0.851   1.300   1.188   1.020   1.095   0.957   0.726
105   S        -0.541  -0.493  -0.525  -0.869  -0.779  -0.788  -0.640  -0.585  -0.589
106   A         1.048   0.966   0.858   1.145   1.034   0.883   1.095   0.959   0.738
107   I        -0.033   0.073  -0.017  -0.031   0.122   0.013  -0.293  -0.160  -0.254
108   F         1.729   1.740   1.828   1.768   1.787   1.923   1.905   1.923   2.070
109   T         1.729   1.740   1.828   1.715   1.723   1.871   1.905   1.923   2.070
110   H         1.729   1.740   1.828   1.904   1.912   2.055   1.905   1.923   2.070
111   A        -1.286  -1.367  -1.328  -1.149  -1.294  -1.255  -0.988  -1.058  -0.989
112   Q        -0.228  -0.165  -0.083  -0.431  -0.365  -0.241  -0.525  -0.438  -0.336
113   N        -0.660  -0.661  -0.586  -0.943  -0.917  -0.772  -0.756  -0.752  -0.652
114   E        -0.660  -0.688  -0.604  -0.743  -0.817  -0.704  -0.756  -0.780  -0.671
115   C         0.101  -0.016  -0.020   0.284   0.073   0.022  -0.062  -0.239  -0.253
116   I         0.101   0.081   0.020   0.057   0.034  -0.094  -0.062  -0.089  -0.188
117   Y         1.048   0.966   0.858   1.263   1.163   1.016   1.095   0.959   0.738
118   S         0.533   0.652   0.696   0.212   0.456   0.499   0.170   0.392   0.425
119   S         1.729   1.740   1.828   1.538   1.555   1.699   1.905   1.923   2.070
120   T         1.729   1.740   1.828   1.715   1.723   1.871   1.905   1.923   2.070
121   M        -0.228  -0.165  -0.083  -0.250  -0.169  -0.058  -0.525  -0.438  -0.336
122   K        -0.541  -0.536  -0.535  -0.465  -0.410  -0.407  -0.640  -0.619  -0.593
123   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
124   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
125   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
126   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
127   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
128   N        -0.973  -0.810  -0.927  -0.962  -0.721  -0.901  -0.872  -0.720  -0.795
129   F        -0.228  -0.206  -0.107  -0.414  -0.375  -0.235  -0.525  -0.496  -0.371
130   D        -0.228  -0.206  -0.103  -0.483  -0.453  -0.293  -0.525  -0.496  -0.366
131   I         1.048   0.966   0.858   1.189   1.085   0.925   1.095   0.959   0.738
132   K         1.048   1.145   0.881   1.293   1.404   1.061   1.095   1.243   0.781
133   Y         0.712   0.862   0.791   0.795   1.020   0.910   0.517   0.780   0.610
134   L         1.729   1.740   1.828   1.553   1.568   1.713   1.905   1.923   2.070
135   N        -0.541  -0.598  -0.556  -0.725  -0.807  -0.739  -0.640  -0.682  -0.617
136   L         0.399   0.244   0.112   0.346   0.132  -0.068   0.401   0.171  -0.042
137   E        -0.660  -0.688  -0.604  -0.688  -0.725  -0.614  -0.756  -0.780  -0.671
138   T        -0.151  -0.168  -0.098  -0.325  -0.367  -0.263  -0.409  -0.442  -0.357
139   N         1.729   1.740   1.828   1.800   1.814   1.953   1.905   1.923   2.070
140   Q        -1.091  -1.057  -0.982  -1.090  -1.053  -0.966  -0.988  -0.947  -0.845
141   Y         1.048   0.965   0.851   1.243   1.139   0.966   1.095   0.957   0.726
142   L         0.712   0.648   0.660   0.476   0.369   0.376   0.517   0.383   0.351
143   R         1.729   1.740   1.828   1.896   1.901   2.048   1.905   1.923   2.070
144   Y         1.729   1.740   1.828   1.846   1.861   1.999   1.905   1.923   2.070
145   F         1.729   1.740   1.828   1.768   1.787   1.923   1.905   1.923   2.070
146   S        -1.718  -1.641  -1.607  -1.447  -1.319  -1.288  -1.219  -1.159  -1.082
147   G         1.729   1.740   1.828   1.762   1.776   1.917   1.905   1.923   2.070
148   H         1.729   1.740   1.828   1.904   1.912   2.055   1.905   1.923   2.070
149   G        -0.033  -0.013  -0.005  -0.122  -0.040  -0.027  -0.293  -0.234  -0.227
150   A         0.101   0.024   0.004   0.105  -0.008  -0.045  -0.062  -0.173  -0.218
151   L        -0.973  -1.059  -0.997  -1.085  -1.203  -1.109  -0.872  -0.944  -0.857
152   V         1.729   1.740   1.828   1.766   1.778   1.921   1.905   1.923   2.070
153   N        -0.541  -0.478  -0.520  -0.731  -0.611  -0.637  -0.640  -0.567  -0.583
154   D        -0.541  -0.577  -0.557  -0.763  -0.802  -0.754  -0.640  -0.660  -0.618
155   L         0.712   0.740   0.676   0.632   0.678   0.499   0.517   0.558   0.383
156   K        -1.405  -1.402  -1.331  -1.144  -1.151  -1.063  -1.103  -1.091  -0.991
157   M        -0.033  -0.013  -0.005  -0.048  -0.018  -0.022  -0.293  -0.234  -0.227
158   N        -0.151  -0.126  -0.096  -0.397  -0.351  -0.290  -0.409  -0.380  -0.355
159   P         1.729   1.740   1.828   1.819   1.837   1.972   1.905   1.923   2.070
160   V        -0.973  -0.966  -0.943  -0.952  -0.938  -0.927  -0.872  -0.866  -0.809
161   N        -0.660  -0.605  -0.560  -0.919  -0.860  -0.790  -0.756  -0.697  -0.623
162   D         0.399   0.332   0.143   0.548   0.462   0.194   0.401   0.297   0.004
163   T        -0.778  -0.780  -0.883  -0.720  -0.727  -0.940  -0.640  -0.652  -0.742
164   F         1.048   1.004   0.858   1.135   1.080   0.840   1.095   1.021   0.738
165   L         1.729   1.740   1.828   1.553   1.568   1.713   1.905   1.923   2.070
166   S         1.729   1.740   1.828   1.538   1.555   1.699   1.905   1.923   2.070
167   S         0.101   0.083   0.025   0.052   0.055  -0.079  -0.062  -0.076  -0.188
168   S         1.729   1.740   1.828   1.538   1.555   1.699   1.905   1.923   2.070
169   Y        -0.033  -0.058  -0.029  -0.158  -0.215  -0.142  -0.293  -0.325  -0.274
170   D         1.729   1.740   1.828   1.727   1.738   1.882   1.905   1.923   2.070
171   E        -1.286  -1.367  -1.328  -0.919  -1.056  -1.009  -0.988  -1.058  -0.989
172   S         0.533   0.652   0.696   0.181   0.424   0.468   0.170   0.392   0.425
173   V         1.048   0.966   0.858   1.167   1.061   0.908   1.095   0.959   0.738
174   R         0.712   0.736   0.714   0.800   0.828   0.767   0.517   0.551   0.460
175   L         1.048   1.161   0.882   0.950   1.088   0.735   1.095   1.266   0.782
176   W         1.729   1.740   1.828   2.001   2.008   2.149   1.905   1.923   2.070
177   D         1.729   1.740   1.828   1.727   1.738   1.882   1.905   1.923   2.070
178   L         1.729   1.740   1.828   1.553   1.568   1.713   1.905   1.923   2.070
179   K         0.101   0.083   0.025   0.241   0.225   0.100  -0.062  -0.076  -0.188
180   I         0.399   0.586   0.185   0.336   0.578   0.042   0.401   0.661   0.068
181   S        -0.465  -0.538  -0.545  -0.585  -0.670  -0.655  -0.525  -0.621  -0.607
182   K        -0.660  -0.673  -0.601  -0.793  -0.798  -0.683  -0.756  -0.766  -0.667
183   P        -0.660  -0.678  -0.588  -0.551  -0.536  -0.410  -0.756  -0.769  -0.656
184   Q         0.533   0.532   0.610   0.462   0.450   0.550   0.170   0.155   0.249
185   V        -0.033   0.073  -0.017  -0.156  -0.005  -0.109  -0.293  -0.160  -0.254
186   I        -1.091  -1.094  -0.991  -1.180  -1.174  -1.035  -0.988  -0.977  -0.852
187   I        -0.033  -0.013  -0.005  -0.302  -0.246  -0.227  -0.293  -0.234  -0.227
188   P        -0.973  -0.997  -0.983  -0.785  -0.813  -0.785  -0.872  -0.894  -0.844
189   S        -1.091  -0.989  -0.984  -1.307  -1.147  -1.097  -0.988  -0.894  -0.847
190   L        -1.091  -1.103  -0.992  -1.311  -1.316  -1.154  -0.988  -0.983  -0.853
191   V        -0.660  -0.688  -0.604  -0.769  -0.828  -0.699  -0.756  -0.780  -0.671
192   P         1.048   1.064   0.873   1.221   1.247   0.985   1.095   1.118   0.767
193   N        -0.541  -0.559  -0.517  -0.638  -0.658  -0.602  -0.640  -0.650  -0.580
194   C        -0.228  -0.206  -0.107  -0.367  -0.380  -0.244  -0.525  -0.496  -0.371
195   I         0.712   0.630   0.653   0.693   0.542   0.548   0.517   0.349   0.338
196   A         1.048   1.064   0.873   1.145   1.162   0.908   1.095   1.118   0.767
197   Y        -0.033  -0.013  -0.005  -0.043   0.033   0.059  -0.293  -0.234  -0.227
198   D         1.729   1.740   1.828   1.727   1.738   1.882   1.905   1.923   2.070
199   P         1.048   0.966   0.858   1.213   1.110   0.946   1.095   0.959   0.738
200   S        -0.973  -1.038  -0.984  -0.996  -1.065  -0.936  -0.872  -0.928  -0.846
201   G         1.729   1.740   1.828   1.762   1.776   1.917   1.905   1.923   2.070
202   L         0.399   0.428   0.140   0.360   0.401   0.002   0.401   0.438  -0.000
203   V         0.399   0.278   0.119   0.609   0.451   0.234   0.401   0.221  -0.032
204   F         1.729   1.740   1.828   1.768   1.787   1.923   1.905   1.923   2.070
205   A         0.399   0.372   0.142   0.587   0.546   0.243   0.401   0.357   0.002
206   L        -0.660  -0.646  -0.554  -0.880  -0.837  -0.714  -0.756  -0.730  -0.616
207   G         0.101  -0.016  -0.020   0.102  -0.091  -0.106  -0.062  -0.239  -0.253
208   N        -0.465  -0.562  -0.546  -0.489  -0.660  -0.685  -0.525  -0.632  -0.604
209   P        -0.778  -0.846  -0.931  -0.437  -0.533  -0.658  -0.640  -0.719  -0.791
210   E        -0.973  -1.035  -0.982  -0.886  -0.997  -0.929  -0.872  -0.926  -0.844
211   N        -1.405  -1.400  -1.310  -1.308  -1.304  -1.151  -1.103  -1.088  -0.975
212   F        -2.031  -1.949  -1.859  -1.613  -1.505  -1.376  -1.335  -1.273  -1.158
213   E        -0.465  -0.565  -0.543  -0.429  -0.608  -0.615  -0.525  -0.644  -0.606
214   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
215   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
216   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
217   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
218   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
219   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
220   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
221   I        -0.033  -0.027  -0.012  -0.164  -0.140  -0.135  -0.293  -0.271  -0.249
222   G        -0.541  -0.536  -0.535  -0.798  -0.806  -0.801  -0.640  -0.619  -0.593
223   L         1.048   1.071   0.871   0.950   0.983   0.718   1.095   1.129   0.762
224   Y         1.729   1.740   1.828   1.846   1.861   1.999   1.905   1.923   2.070
225   N        -0.033  -0.056  -0.038  -0.185  -0.226  -0.211  -0.293  -0.321  -0.285
226   L        -0.973  -1.018  -0.955  -1.005  -1.052  -0.986  -0.872  -0.906  -0.821
227   K        -0.465  -0.475  -0.507  -0.415  -0.439  -0.498  -0.525  -0.538  -0.564
228   K        -1.718  -1.607  -1.588  -1.606  -1.486  -1.399  -1.219  -1.132  -1.069
229   I        -0.973  -0.920  -0.954  -0.920  -0.782  -0.833  -0.872  -0.807  -0.815
230   Q        -0.580  -0.503  -0.554  -0.589  -0.460  -0.528  -0.664  -0.563  -0.612
231   E        -1.405  -1.346  -1.307  -1.331  -1.270  -1.191  -1.103  -1.052  -0.973
232   G        -0.973  -1.024  -0.979  -0.885  -0.956  -0.884  -0.872  -0.917  -0.840
233   P         1.729   1.740   1.828   1.819   1.837   1.972   1.905   1.923   2.070
234   F         1.729   1.740   1.828   1.768   1.787   1.923   1.905   1.923   2.070
235   L        -0.212  -0.387  -0.480  -0.201  -0.439  -0.570  -0.178  -0.403  -0.520
236   I        -1.405  -1.398  -1.312  -1.223  -1.213  -1.076  -1.103  -1.086  -0.977
237   I         0.101   0.081   0.020   0.137   0.115   0.005  -0.062  -0.089  -0.188
238   K        -1.405  -1.389  -1.329  -1.210  -1.185  -1.105  -1.103  -1.084  -0.990
239   I        -0.228  -0.221  -0.115  -0.499  -0.508  -0.347  -0.525  -0.517  -0.382
240   N        -1.718  -1.617  -1.589  -1.492  -1.377  -1.320  -1.219  -1.140  -1.070
241   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
242   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
243   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
244   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
245   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
246   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
247   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
248   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
249   D        -0.676  -0.643  -0.587  -0.829  -0.786  -0.713  -0.769  -0.730  -0.651
250   A        -0.660  -0.573  -0.564  -0.773  -0.657  -0.607  -0.756  -0.671  -0.629
251   T        -1.286  -1.118  -1.252  -1.130  -0.860  -1.125  -0.988  -0.833  -0.924
252   F        -0.033  -0.077  -0.041  -0.115  -0.158  -0.090  -0.293  -0.343  -0.289
253   S        -1.405  -1.356  -1.308  -1.262  -1.176  -1.139  -1.103  -1.060  -0.974
254   Q        -0.973  -0.996  -0.983  -0.815  -0.866  -0.870  -0.872  -0.894  -0.844
255   W         1.048   0.966   0.858   1.400   1.289   1.129   1.095   0.959   0.738
256   N         0.101  -0.016  -0.020   0.127  -0.071  -0.094  -0.062  -0.239  -0.253
257   K         0.399   0.278   0.119   0.537   0.370   0.096   0.401   0.221  -0.032
258   L         0.712   0.648   0.665   0.467   0.358   0.371   0.517   0.384   0.361
259   E         1.729   1.740   1.828   1.877   1.897   2.029   1.905   1.923   2.070
260   F         1.729   1.740   1.828   1.768   1.787   1.923   1.905   1.923   2.070
261   S         1.729   1.740   1.828   1.538   1.555   1.699   1.905   1.923   2.070
262   N         1.048   0.966   0.858   1.189   1.082   0.917   1.095   0.959   0.738
263   N         0.533   0.579   0.625   0.331   0.410   0.466   0.170   0.249   0.281
264   G         1.729   1.740   1.828   1.762   1.776   1.917   1.905   1.923   2.070
265   K         1.729   1.740   1.828   1.766   1.783   1.921   1.905   1.923   2.070
266   Y         0.101   0.050   0.014   0.136   0.073  -0.012  -0.062  -0.130  -0.198
267   L         0.475   0.502   0.601   0.096   0.151   0.307   0.054   0.092   0.231
268   L         1.729   1.740   1.828   1.553   1.568   1.713   1.905   1.923   2.070
269   V         0.101   0.198   0.048  -0.081   0.050  -0.145  -0.062   0.060  -0.145
270   G        -0.660  -0.679  -0.588  -0.878  -0.910  -0.767  -0.756  -0.769  -0.655
271   S         0.533   0.652   0.696   0.181   0.424   0.468   0.170   0.392   0.425
272   S        -0.973  -1.059  -0.997  -1.056  -1.137  -1.011  -0.872  -0.944  -0.857
273   I        -1.718  -1.641  -1.607  -1.676  -1.579  -1.483  -1.219  -1.159  -1.082
274   G        -0.778  -0.846  -0.931  -0.542  -0.647  -0.781  -0.640  -0.719  -0.791
275   K        -0.973  -1.059  -0.997  -0.807  -0.908  -0.822  -0.872  -0.944  -0.857
276   H         1.048   1.161   0.882   1.319   1.447   1.105   1.095   1.266   0.782
277   L        -0.541  -0.577  -0.557  -0.630  -0.614  -0.568  -0.640  -0.660  -0.618
278   I        -0.033  -0.013  -0.005  -0.169  -0.112  -0.122  -0.293  -0.234  -0.227
279   F        -0.660  -0.586  -0.580  -0.821  -0.731  -0.659  -0.756  -0.695  -0.647
280   D         1.729   1.740   1.828   1.727   1.738   1.882   1.905   1.923   2.070
281   A         0.712   0.799   0.695   0.584   0.729   0.497   0.517   0.668   0.423
282   F         0.101   0.005   0.000   0.149   0.013  -0.008  -0.062  -0.204  -0.224
283   T        -0.660  -0.637  -0.585  -0.969  -0.956  -0.879  -0.756  -0.733  -0.653
284   G         1.729   1.740   1.828   1.762   1.776   1.917   1.905   1.923   2.070
285   Q        -1.091  -1.023  -0.977  -1.005  -0.925  -0.850  -0.988  -0.923  -0.842
286   Q        -0.033  -0.013   0.003  -0.210  -0.162  -0.122  -0.293  -0.233  -0.215
287   L         0.399   0.277   0.108   0.346   0.181  -0.074   0.401   0.219  -0.048
288   F        -0.973  -1.021  -0.978  -0.944  -1.034  -0.968  -0.872  -0.914  -0.840
289   E        -1.286  -1.367  -1.328  -0.944  -1.069  -1.044  -0.988  -1.058  -0.989
290   L         0.712   0.677   0.676   0.467   0.407   0.390   0.517   0.440   0.383
291   I        -1.074  -0.947  -0.967  -0.982  -0.783  -0.832  -0.966  -0.851  -0.831
292   G        -0.357  -0.441  -0.525  -0.282  -0.421  -0.593  -0.362  -0.474  -0.575
293   T        -0.939  -1.033  -1.002  -0.806  -0.949  -0.903  -0.815  -0.914  -0.860
294   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
295   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
296   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
297   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
298   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
299   R        -1.074  -1.067  -0.986  -0.898  -0.869  -0.751  -0.966  -0.950  -0.846
300   A        -0.212  -0.111  -0.406   0.028   0.170  -0.281  -0.178  -0.054  -0.428
301   F        -0.973  -1.022  -0.982  -1.109  -1.226  -1.188  -0.872  -0.915  -0.844
302   P        -0.778  -0.846  -0.931  -0.542  -0.645  -0.822  -0.640  -0.719  -0.791
303   M        -1.718  -1.710  -1.617  -1.502  -1.477  -1.295  -1.219  -1.204  -1.089
304   R        -0.973  -1.022  -0.982  -0.910  -1.023  -0.976  -0.872  -0.915  -0.844
305   E        -0.778  -0.912  -0.930  -0.444  -0.654  -0.706  -0.640  -0.789  -0.790
306   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
307   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
308   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
309   -         0.010   0.050   0.012  -0.021   0.035  -0.036  -0.168  -0.119  -0.193
310   -        -0.680  -0.688  -0.608  -0.557  -0.601  -0.499  -0.761  -0.772  -0.673
311   -         0.010  -0.037  -0.021   0.264   0.173   0.174  -0.168  -0.247  -0.243
312   -        -0.680  -0.630  -0.577  -0.945  -0.868  -0.779  -0.761  -0.704  -0.636
313   -         0.512   0.574   0.639   0.338   0.442   0.537   0.128   0.238   0.310
314   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
315   F        -0.222  -0.217  -0.115  -0.485  -0.510  -0.357  -0.513  -0.512  -0.382
316   L        -1.074  -1.067  -1.007  -0.921  -0.919  -0.868  -0.966  -0.954  -0.865
317   D        -0.541  -0.577  -0.557  -0.596  -0.625  -0.614  -0.640  -0.660  -0.618
318   S         0.399   0.332   0.143   0.346   0.262  -0.006   0.401   0.297   0.004
319   G         0.399   0.278   0.119   0.553   0.383   0.131   0.401   0.221  -0.032
320   S        -0.212  -0.312  -0.449  -0.173  -0.306  -0.465  -0.178  -0.310  -0.481
321   A         0.101   0.034  -0.002   0.168   0.067   0.022  -0.062  -0.167  -0.228
322   C        -0.465  -0.427  -0.497  -0.303  -0.228  -0.406  -0.525  -0.470  -0.552
323   F         1.048   0.966   0.858   1.197   1.105   0.968   1.095   0.959   0.738
324   T         0.475   0.508   0.604   0.026   0.071   0.226   0.054   0.105   0.237
325   P         1.048   1.004   0.858   1.216   1.164   0.950   1.095   1.021   0.738
326   D         0.712   0.736   0.714   0.706   0.740   0.708   0.517   0.551   0.460
327   G         1.048   0.966   0.858   1.127   1.013   0.831   1.095   0.959   0.738
328   E        -0.541  -0.402  -0.517  -0.422  -0.260  -0.346  -0.640  -0.505  -0.580
329   F        -0.465  -0.423  -0.502  -0.388  -0.346  -0.447  -0.525  -0.498  -0.559
330   V        -0.151  -0.071  -0.026  -0.392  -0.271  -0.222  -0.409  -0.305  -0.255
331   L         0.101  -0.016  -0.020  -0.091  -0.264  -0.264  -0.062  -0.239  -0.253
332   G        -0.973  -0.982  -0.958  -0.988  -1.032  -0.992  -0.872  -0.880  -0.821
333   T        -0.541  -0.576  -0.549  -0.612  -0.640  -0.587  -0.640  -0.660  -0.609
334   D        -0.973  -1.038  -0.984  -1.060  -1.168  -1.087  -0.872  -0.928  -0.846
335   Y        -0.973  -1.059  -0.997  -0.789  -0.917  -0.830  -0.872  -0.944  -0.857
336   D        -0.973  -0.932  -0.946  -0.904  -0.852  -0.851  -0.872  -0.840  -0.813
337   G        -0.357  -0.426  -0.525  -0.198  -0.295  -0.467  -0.362  -0.456  -0.575
338   R        -1.286  -1.299  -1.290  -1.025  -1.059  -1.036  -0.988  -1.001  -0.957
339   I         0.101   0.051  -0.005   0.057  -0.071  -0.163  -0.062  -0.163  -0.232
340   A        -0.973  -1.024  -0.979  -0.956  -1.034  -0.950  -0.872  -0.917  -0.840
341   I        -0.465  -0.537  -0.545  -0.352  -0.463  -0.460  -0.525  -0.621  -0.607
342   W         0.101   0.088   0.001   0.360   0.321   0.172  -0.062  -0.099  -0.223
343   N        -0.033  -0.013   0.003  -0.127  -0.056  -0.021  -0.293  -0.233  -0.215
344   H        -0.541  -0.540  -0.537  -0.634  -0.660  -0.641  -0.640  -0.623  -0.595
345   S        -1.718  -1.667  -1.588  -1.746  -1.671  -1.546  -1.219  -1.177  -1.069
346   D        -0.660  -0.677  -0.583  -0.654  -0.654  -0.513  -0.756  -0.767  -0.649
347   S        -0.973  -0.907  -0.954  -1.194  -1.070  -1.117  -0.872  -0.800  -0.816
348   I        -0.973  -1.025  -0.981  -0.829  -0.900  -0.826  -0.872  -0.917  -0.843
349   S        -0.973  -1.021  -0.978  -1.006  -1.033  -0.924  -0.872  -0.914  -0.840
350   N        -0.973  -0.916  -0.948  -0.935  -0.865  -0.916  -0.872  -0.824  -0.814
351   K        -0.973  -0.987  -0.955  -0.798  -0.833  -0.793  -0.872  -0.883  -0.820
352   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
353   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
354   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
355   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
356   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
357   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
358   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
359   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
360   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
361   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
362   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
363   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
364   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
365   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
366   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
367   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
368   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
369   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
370   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
371   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
372   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
373   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
374   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
375   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
376   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
377   V         0.001  -0.012  -0.020  -0.071  -0.092  -0.097  -0.211  -0.229  -0.254
378   L         0.987   0.906   0.831   0.884   0.779   0.682   0.998   0.857   0.687
379   R        -0.973  -1.020  -0.951  -0.737  -0.779  -0.687  -0.872  -0.902  -0.812
380   P         1.048   1.064   0.873   1.209   1.235   0.962   1.095   1.118   0.767
381   Q        -0.973  -1.021  -0.978  -0.893  -1.008  -0.981  -0.872  -0.914  -0.840
382   G        -1.286  -1.367  -1.328  -1.016  -1.145  -1.074  -0.988  -1.058  -0.989
383   F        -1.405  -1.360  -1.313  -1.341  -1.294  -1.218  -1.103  -1.058  -0.977
384   I        -0.541  -0.503  -0.537  -0.693  -0.641  -0.651  -0.640  -0.601  -0.601
385   P        -0.179  -0.076  -0.075  -0.235  -0.092  -0.074  -0.465  -0.344  -0.331
386   C        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
387   V        -0.660  -0.611  -0.588  -0.792  -0.742  -0.683  -0.756  -0.717  -0.656
388   S        -1.091  -1.031  -0.977  -1.195  -1.091  -1.010  -0.988  -0.932  -0.842
389   H        -1.718  -1.620  -1.592  -1.488  -1.393  -1.317  -1.219  -1.143  -1.072
390   E        -1.091  -1.044  -0.980  -0.970  -0.900  -0.805  -0.988  -0.933  -0.843
391   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
392   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
393   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
394   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
395   T        -1.405  -1.397  -1.329  -1.298  -1.271  -1.172  -1.103  -1.088  -0.990
396   C        -0.973  -1.059  -0.997  -0.757  -0.910  -0.859  -0.872  -0.944  -0.857
397   P         1.729   1.740   1.828   1.819   1.837   1.972   1.905   1.923   2.070
398   R        -0.973  -1.059  -0.997  -0.820  -0.973  -0.896  -0.872  -0.944  -0.857
399   S        -0.465  -0.356  -0.492  -0.520  -0.330  -0.606  -0.525  -0.381  -0.536
400   I        -0.033   0.016   0.003  -0.169  -0.066  -0.106  -0.293  -0.198  -0.214
401   A        -1.286  -1.323  -1.282  -1.157  -1.203  -1.188  -0.988  -1.023  -0.951
402   F         0.399   0.277   0.108   0.584   0.427   0.167   0.401   0.219  -0.048
403   N         1.048   1.064   0.873   1.165   1.189   0.894   1.095   1.118   0.767
404   P         1.048   1.071   0.871   1.234   1.270   1.008   1.095   1.129   0.762
405   K         0.101  -0.000  -0.021   0.158  -0.002  -0.030  -0.062  -0.225  -0.256
406   Y        -0.973  -0.981  -0.978  -0.892  -0.926  -0.943  -0.872  -0.880  -0.840
407   S        -0.778  -0.847  -0.929  -0.781  -0.865  -0.988  -0.640  -0.719  -0.789
408   M        -0.151  -0.167  -0.098  -0.059  -0.098  -0.020  -0.409  -0.441  -0.359
409   F        -0.033  -0.081  -0.032  -0.266  -0.346  -0.264  -0.293  -0.350  -0.278
410   V         0.475   0.508   0.606   0.219   0.270   0.426   0.054   0.105   0.241
411   T         1.729   1.740   1.828   1.715   1.723   1.871   1.905   1.923   2.070
412   A         1.729   1.740   1.828   1.748   1.757   1.903   1.905   1.923   2.070
413   D         1.048   0.966   0.858   1.144   1.041   0.904   1.095   0.959   0.738
414   E        -0.660  -0.654  -0.599  -0.772  -0.796  -0.732  -0.756  -0.753  -0.666
415   T        -0.465  -0.479  -0.527  -0.468  -0.491  -0.577  -0.525  -0.564  -0.587
416   V         0.712   0.648   0.660   0.606   0.472   0.440   0.517   0.383   0.351
417   D        -0.973  -1.035  -0.982  -0.956  -1.031  -0.962  -0.872  -0.926  -0.844
418   F         0.712   0.736   0.714   0.608   0.651   0.562   0.517   0.551   0.460
419   Y         0.533   0.652   0.696   0.593   0.811   0.860   0.170   0.392   0.425
420   V        -0.973  -0.996  -0.983  -1.062  -1.142  -1.119  -0.872  -0.894  -0.844
421   Y         0.001   0.195   0.017  -0.012   0.296  -0.010  -0.211   0.073  -0.190
422   D        -1.093  -1.025  -0.983  -0.990  -0.898  -0.846  -0.975  -0.914  -0.842
423   E        -1.093  -1.099  -1.015  -1.092  -1.181  -1.030  -0.975  -0.981  -0.872
424   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
425   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
426   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
427   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
428   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
429   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
430   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
431   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
432   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/P36104
Output conservation file - output/P36104
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
