1     M         1.414   1.464   1.531   1.644   1.714   1.812   1.513   1.585   1.692
2     S        -0.391  -0.333  -0.358  -0.475  -0.381  -0.465  -0.536  -0.459  -0.505
3     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
7     L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
8     E        -1.753  -1.794  -1.666  -1.516  -1.626  -1.461  -1.346  -1.363  -1.189
9     R         1.414   1.464   1.531   1.588   1.654   1.760   1.513   1.585   1.692
10    E        -0.296  -0.343  -0.364  -0.323  -0.395  -0.450  -0.431  -0.477  -0.520
11    E        -0.625  -0.666  -0.843  -0.370  -0.422  -0.640  -0.545  -0.588  -0.785
12    P        -0.625  -0.782  -0.864  -0.349  -0.599  -0.772  -0.545  -0.734  -0.809
13    Q        -1.424  -1.445  -1.320  -1.149  -1.201  -1.000  -1.231  -1.224  -1.055
14    H        -0.296  -0.313  -0.330  -0.101  -0.111  -0.161  -0.431  -0.425  -0.468
15    F         0.698   0.697   0.478   0.913   0.919   0.614   0.713   0.707   0.317
16    G         0.698   0.544   0.460   0.690   0.472   0.324   0.713   0.465   0.284
17    A         1.414   1.464   1.531   1.243   1.300   1.436   1.513   1.585   1.692
18    G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
19    P         1.414   1.464   1.531   1.502   1.572   1.679   1.513   1.585   1.692
20    A         1.414   1.464   1.531   1.243   1.300   1.436   1.513   1.585   1.692
21    Q        -0.641  -0.623  -0.452  -0.899  -0.928  -0.654  -0.888  -0.855  -0.634
22    M         0.346   0.324   0.321   0.210   0.179   0.195   0.141   0.084   0.027
23    P         0.698   0.544   0.460   0.878   0.673   0.519   0.713   0.465   0.284
24    T         0.017   0.076  -0.256   0.213   0.301  -0.231   0.027   0.107  -0.362
25    P        -0.970  -1.004  -0.916  -0.944  -0.978  -0.853  -1.003  -1.002  -0.871
26    V         1.414   1.464   1.531   1.360   1.426   1.545   1.513   1.585   1.692
27    L         0.017  -0.163  -0.293   0.001  -0.249  -0.456   0.027  -0.221  -0.414
28    Q         0.158   0.146   0.279   0.086   0.008   0.207  -0.202  -0.247  -0.053
29    Q        -0.890  -0.998  -0.911  -0.670  -0.849  -0.748  -0.888  -0.994  -0.866
30    A         0.698   0.544   0.460   0.641   0.437   0.341   0.713   0.465   0.284
31    A         0.698   0.544   0.460   0.614   0.394   0.274   0.713   0.465   0.284
32    K        -0.890  -0.899  -0.888  -0.880  -0.863  -0.864  -0.888  -0.865  -0.838
33    D         0.017  -0.090  -0.286   0.199   0.050  -0.305   0.027  -0.116  -0.404
34    L         0.017  -0.163  -0.293   0.077  -0.147  -0.292   0.027  -0.221  -0.414
35    I        -0.296  -0.442  -0.391  -0.379  -0.633  -0.580  -0.431  -0.632  -0.558
36    N        -0.625  -0.537  -0.822  -0.375  -0.253  -0.680  -0.545  -0.439  -0.762
37    F         0.158   0.187   0.289   0.109   0.142   0.286  -0.202  -0.169  -0.034
38    N        -0.890  -0.624  -0.844  -0.693  -0.281  -0.660  -0.888  -0.558  -0.789
39    D         0.158   0.280   0.317  -0.082   0.118   0.163  -0.202   0.005   0.020
40    I        -1.548  -1.466  -1.344  -1.639  -1.522  -1.322  -1.346  -1.245  -1.076
41    G         0.346   0.495   0.396   0.223   0.448   0.284   0.141   0.383   0.168
42    L        -0.436  -0.509  -0.389  -0.661  -0.707  -0.511  -0.660  -0.716  -0.557
43    G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
44    I        -0.296  -0.356  -0.367  -0.379  -0.487  -0.536  -0.431  -0.517  -0.527
45    G         0.346   0.234   0.304   0.161  -0.080   0.012   0.141  -0.080  -0.006
46    E         1.414   1.464   1.531   1.367   1.436   1.552   1.513   1.585   1.692
47    I         0.698   0.627   0.470   0.777   0.707   0.499   0.713   0.598   0.303
48    S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
49    H         1.414   1.464   1.531   1.613   1.681   1.783   1.513   1.585   1.692
50    R         1.414   1.464   1.531   1.588   1.654   1.760   1.513   1.585   1.692
51    S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
52    K         0.017  -0.090  -0.286   0.049  -0.083  -0.408   0.027  -0.116  -0.404
53    D        -1.548  -1.478  -1.348  -1.424  -1.302  -1.172  -1.346  -1.252  -1.078
54    A         0.698   0.544   0.460   0.614   0.394   0.274   0.713   0.465   0.284
55    T        -1.095  -1.123  -0.938  -1.221  -1.269  -1.012  -1.117  -1.115  -0.894
56    K        -0.296  -0.356  -0.367  -0.432  -0.530  -0.561  -0.431  -0.517  -0.527
57    V         0.098   0.179   0.294  -0.233  -0.090   0.084  -0.317  -0.184  -0.025
58    I         0.698   0.544   0.460   0.740   0.540   0.394   0.713   0.465   0.284
59    E        -1.095  -1.034  -0.945  -1.076  -1.000  -0.868  -1.117  -1.053  -0.901
60    D        -0.890  -0.998  -0.911  -0.825  -1.008  -0.909  -0.888  -0.994  -0.866
61    S        -0.436  -0.260  -0.351  -0.652  -0.419  -0.497  -0.660  -0.423  -0.506
62    K         0.698   0.544   0.460   0.673   0.481   0.336   0.713   0.465   0.284
63    K        -1.548  -1.557  -1.351  -1.728  -1.728  -1.422  -1.346  -1.316  -1.081
64    H        -0.970  -0.930  -0.898  -0.839  -0.778  -0.753  -1.003  -0.934  -0.852
65    L         0.698   0.544   0.460   0.643   0.453   0.343   0.713   0.465   0.284
66    I        -1.877  -1.852  -1.681  -1.824  -1.767  -1.534  -1.460  -1.411  -1.200
67    E        -0.890  -0.993  -0.909  -0.868  -1.015  -0.883  -0.888  -0.988  -0.865
68    L         0.698   0.627   0.470   0.644   0.565   0.361   0.713   0.598   0.303
69    L        -0.890  -0.872  -0.876  -0.822  -0.793  -0.751  -0.888  -0.845  -0.827
70    N        -0.436  -0.356  -0.373  -0.527  -0.415  -0.435  -0.660  -0.565  -0.540
71    I         0.017  -0.090  -0.286   0.147   0.018  -0.286   0.027  -0.116  -0.404
72    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
73    P         1.414   1.464   1.531   1.502   1.572   1.679   1.513   1.585   1.692
74    D         0.346   0.234   0.304   0.332   0.115   0.189   0.141  -0.080  -0.006
75    T         0.017  -0.223  -0.306   0.278  -0.035  -0.177   0.027  -0.301  -0.432
76    H         0.017  -0.223  -0.306   0.417   0.096  -0.058   0.027  -0.301  -0.432
77    E         0.698   0.544   0.460   0.778   0.594   0.485   0.713   0.465   0.284
78    V         0.698   0.544   0.460   0.735   0.529   0.391   0.713   0.465   0.284
79    F         0.346   0.234   0.304   0.341   0.096   0.161   0.141  -0.080  -0.006
80    Y         0.698   0.850   0.496   0.913   1.098   0.642   0.713   0.931   0.349
81    L        -0.436  -0.369  -0.363  -0.485  -0.322  -0.366  -0.660  -0.538  -0.520
82    Q         1.414   1.464   1.531   1.583   1.656   1.755   1.513   1.585   1.692
83    G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
84    G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
85    G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
86    T         0.698   0.697   0.478   0.850   0.860   0.528   0.713   0.707   0.317
87    T        -0.296  -0.473  -0.390  -0.263  -0.555  -0.466  -0.431  -0.660  -0.556
88    G         0.017  -0.223  -0.306   0.127  -0.186  -0.317   0.027  -0.301  -0.432
89    F         1.414   1.464   1.531   1.515   1.583   1.691   1.513   1.585   1.692
90    S         0.158   0.146   0.279  -0.165  -0.249  -0.022  -0.202  -0.247  -0.053
91    S         0.158   0.146   0.279  -0.165  -0.249  -0.022  -0.202  -0.247  -0.053
92    V        -1.424  -1.447  -1.334  -1.369  -1.343  -1.226  -1.231  -1.226  -1.067
93    A        -0.890  -1.045  -0.915  -0.992  -1.219  -0.998  -0.888  -1.032  -0.869
94    T        -0.296  -0.087  -0.311  -0.164   0.151  -0.206  -0.431  -0.130  -0.442
95    N         1.414   1.464   1.531   1.433   1.508   1.614   1.513   1.585   1.692
96    L         0.698   0.544   0.460   0.619   0.416   0.286   0.713   0.465   0.284
97    A        -2.535  -2.435  -2.226  -2.323  -2.156  -1.905  -1.689  -1.594  -1.363
98    A         0.346   0.303   0.326   0.103   0.002   0.034   0.141   0.047   0.037
99    A        -0.296  -0.332  -0.343  -0.395  -0.415  -0.415  -0.431  -0.452  -0.487
100   Y        -0.296  -0.411  -0.379  -0.054  -0.202  -0.149  -0.431  -0.584  -0.543
101   V        -1.424  -1.241  -1.299  -1.462  -1.236  -1.254  -1.231  -1.046  -1.038
102   G        -1.424  -1.447  -1.334  -1.578  -1.619  -1.480  -1.231  -1.226  -1.067
103   K        -0.436  -0.421  -0.382  -0.536  -0.499  -0.427  -0.660  -0.622  -0.549
104   H        -0.625  -0.751  -0.851  -0.274  -0.458  -0.582  -0.545  -0.701  -0.794
105   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
106   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
107   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
108   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
109   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
110   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
111   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
112   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
113   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
114   K        -0.436  -0.520  -0.384  -0.663  -0.749  -0.546  -0.660  -0.732  -0.553
115   I        -1.424  -1.447  -1.334  -1.538  -1.595  -1.429  -1.231  -1.227  -1.066
116   A        -0.436  -0.516  -0.386  -0.741  -0.855  -0.652  -0.660  -0.726  -0.554
117   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
118   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
119   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
120   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
121   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
122   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
123   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
124   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
125   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
126   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
127   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
128   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
129   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
130   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
131   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
132   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
133   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
134   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
135   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
136   P        -0.890  -0.859  -0.883  -0.889  -0.837  -0.867  -0.888  -0.828  -0.832
137   A        -0.296  -0.239  -0.355  -0.480  -0.450  -0.580  -0.431  -0.388  -0.509
138   G        -1.095  -1.123  -0.944  -1.287  -1.287  -1.028  -1.117  -1.116  -0.899
139   Y         1.414   1.464   1.531   1.522   1.593   1.698   1.513   1.585   1.692
140   L        -1.095  -1.066  -0.944  -1.367  -1.290  -1.094  -1.117  -1.066  -0.899
141   V         0.098   0.152   0.282  -0.233  -0.146   0.060  -0.317  -0.235  -0.048
142   T         1.414   1.464   1.531   1.474   1.548   1.652   1.513   1.585   1.692
143   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
144   S         0.017  -0.163  -0.293   0.128  -0.137  -0.349   0.027  -0.221  -0.414
145   W         1.414   1.464   1.531   1.692   1.764   1.857   1.513   1.585   1.692
146   S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
147   Q        -1.424  -1.309  -1.303  -1.428  -1.268  -1.298  -1.231  -1.091  -1.039
148   K         1.414   1.464   1.531   1.297   1.379   1.487   1.513   1.585   1.692
149   S         0.346   0.492   0.387   0.116   0.327   0.165   0.141   0.378   0.152
150   F        -1.424  -1.255  -1.290  -1.254  -0.982  -1.076  -1.231  -1.041  -1.029
151   E        -0.890  -1.025  -0.916  -0.816  -1.024  -0.853  -0.888  -1.017  -0.871
152   E         1.414   1.464   1.531   1.367   1.436   1.552   1.513   1.585   1.692
153   A         0.346   0.473   0.358   0.116   0.297   0.113   0.141   0.346   0.097
154   K        -1.424  -1.429  -1.327  -1.425  -1.441  -1.262  -1.231  -1.218  -1.062
155   R         0.698   0.697   0.478   0.954   0.956   0.607   0.713   0.707   0.317
156   L         1.414   1.464   1.531   1.245   1.316   1.438   1.513   1.585   1.692
157   H        -0.296  -0.245  -0.320  -0.312  -0.237  -0.360  -0.431  -0.332  -0.454
158   V        -0.970  -1.004  -0.916  -1.005  -1.038  -0.935  -1.003  -1.002  -0.871
159   P        -0.296  -0.169  -0.341  -0.186  -0.003  -0.284  -0.431  -0.260  -0.489
160   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
161   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
162   A        -1.095  -1.070  -0.926  -1.168  -1.065  -0.870  -1.117  -1.055  -0.880
163   E        -1.424  -1.341  -1.314  -1.214  -1.073  -1.023  -1.231  -1.132  -1.049
164   V        -0.296  -0.265  -0.329  -0.382  -0.319  -0.463  -0.431  -0.361  -0.467
165   I        -0.436  -0.480  -0.379  -0.651  -0.698  -0.559  -0.660  -0.670  -0.542
166   F        -0.970  -1.004  -0.916  -0.888  -0.912  -0.767  -1.003  -1.002  -0.871
167   N         0.158   0.146   0.279   0.006  -0.028   0.174  -0.202  -0.247  -0.053
168   A        -1.548  -1.529  -1.344  -1.546  -1.490  -1.239  -1.346  -1.299  -1.076
169   K         0.346   0.303   0.326   0.241   0.182   0.214   0.141   0.047   0.037
170   D        -1.111  -1.140  -0.946  -1.210  -1.240  -0.968  -1.130  -1.132  -0.899
171   Y        -1.116  -1.091  -0.940  -1.111  -1.113  -0.887  -1.122  -1.082  -0.892
172   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
173   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
174   N        -0.625  -0.754  -0.853  -0.427  -0.642  -0.827  -0.545  -0.705  -0.796
175   G        -0.625  -0.344  -0.794  -0.485  -0.112  -0.739  -0.545  -0.197  -0.730
176   K         0.017   0.215  -0.238   0.105   0.366  -0.220   0.027   0.295  -0.336
177   F         0.346   0.310   0.319   0.428   0.358   0.341   0.141   0.061   0.023
178   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
179   K        -1.548  -1.562  -1.346  -1.541  -1.560  -1.260  -1.346  -1.321  -1.078
180   I         0.698   0.544   0.460   0.723   0.515   0.354   0.713   0.465   0.284
181   P         0.698   0.697   0.478   0.861   0.863   0.512   0.713   0.707   0.317
182   D        -0.641  -0.599  -0.448  -0.774  -0.713  -0.492  -0.888  -0.825  -0.628
183   E        -1.424  -1.435  -1.328  -1.249  -1.247  -1.097  -1.231  -1.212  -1.061
184   S         0.017  -0.163  -0.293   0.137  -0.116  -0.330   0.027  -0.221  -0.414
185   L        -1.424  -1.320  -1.309  -1.280  -1.112  -1.116  -1.231  -1.114  -1.044
186   W         0.698   0.544   0.460   1.051   0.835   0.649   0.713   0.465   0.284
187   E        -1.219  -1.009  -1.259  -1.114  -0.802  -1.198  -1.003  -0.767  -0.996
188   D        -1.877  -1.751  -1.673  -1.602  -1.433  -1.331  -1.460  -1.330  -1.195
189   K        -1.548  -1.497  -1.354  -1.563  -1.465  -1.242  -1.346  -1.273  -1.084
190   I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
191   K         0.205   0.368   0.360   0.033   0.330   0.258  -0.113   0.164   0.100
192   G        -0.777  -0.718  -0.864  -0.749  -0.658  -0.925  -0.727  -0.651  -0.809
193   K        -0.436  -0.324  -0.375  -0.663  -0.516  -0.533  -0.660  -0.533  -0.541
194   A        -1.011  -0.846  -0.909  -1.102  -0.817  -0.975  -1.026  -0.823  -0.861
195   F        -1.753  -1.551  -1.631  -1.401  -1.146  -1.262  -1.346  -1.146  -1.161
196   S         0.098   0.145   0.279  -0.312  -0.254  -0.022  -0.317  -0.248  -0.054
197   Y         0.698   0.544   0.460   0.881   0.666   0.497   0.713   0.465   0.284
198   V         0.346   0.495   0.396   0.189   0.424   0.230   0.141   0.383   0.168
199   Y         1.414   1.464   1.531   1.522   1.593   1.698   1.513   1.585   1.692
200   L        -1.095  -1.099  -0.945  -1.218  -1.165  -0.938  -1.117  -1.095  -0.900
201   C         1.414   1.464   1.531   1.692   1.761   1.857   1.513   1.585   1.692
202   E         0.158   0.292   0.332  -0.017   0.226   0.249  -0.202   0.027   0.048
203   N         1.414   1.464   1.531   1.433   1.508   1.614   1.513   1.585   1.692
204   E         1.414   1.464   1.531   1.367   1.436   1.552   1.513   1.585   1.692
205   T         1.414   1.464   1.531   1.474   1.548   1.652   1.513   1.585   1.692
206   V         1.414   1.464   1.531   1.360   1.426   1.545   1.513   1.585   1.692
207   H        -0.625  -0.659  -0.835  -0.232  -0.289  -0.616  -0.545  -0.581  -0.777
208   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
209   V         0.698   0.818   0.490   0.745   0.896   0.465   0.713   0.886   0.338
210   E         1.414   1.464   1.531   1.367   1.436   1.552   1.513   1.585   1.692
211   W         0.158   0.292   0.332   0.195   0.397   0.449  -0.202   0.027   0.048
212   P        -0.890  -0.845  -0.881  -0.655  -0.593  -0.649  -0.888  -0.819  -0.832
213   E        -0.890  -0.728  -0.870  -0.857  -0.643  -0.828  -0.888  -0.708  -0.822
214   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
215   L        -1.011  -1.031  -0.938  -1.108  -1.110  -0.958  -1.026  -1.034  -0.893
216   P         1.414   1.464   1.531   1.502   1.572   1.679   1.513   1.585   1.692
217   K        -0.890  -0.874  -0.884  -0.908  -0.853  -0.850  -0.888  -0.848  -0.833
218   C        -1.548  -1.428  -1.343  -1.327  -1.196  -1.064  -1.346  -1.221  -1.075
219   L        -0.401  -0.340  -0.390  -0.589  -0.523  -0.545  -0.578  -0.522  -0.557
220   V        -1.530  -1.430  -1.342  -1.450  -1.331  -1.204  -1.325  -1.216  -1.073
221   N        -1.116  -1.081  -0.965  -1.285  -1.215  -1.044  -1.122  -1.075  -0.918
222   D        -0.436  -0.422  -0.372  -0.460  -0.402  -0.362  -0.660  -0.600  -0.532
223   P        -0.890  -0.859  -0.883  -0.864  -0.822  -0.875  -0.888  -0.828  -0.832
224   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
225   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
226   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
227   N        -0.296  -0.087  -0.311  -0.372  -0.056  -0.406  -0.431  -0.130  -0.442
228   I        -0.890  -0.984  -0.894  -0.916  -1.051  -0.932  -0.888  -0.958  -0.843
229   E        -0.296  -0.325  -0.379  -0.327  -0.429  -0.462  -0.431  -0.513  -0.543
230   I        -0.970  -1.081  -0.925  -1.108  -1.214  -0.983  -1.003  -1.076  -0.880
231   V         1.414   1.464   1.531   1.360   1.426   1.545   1.513   1.585   1.692
232   A        -0.296  -0.434  -0.375  -0.402  -0.577  -0.470  -0.431  -0.602  -0.537
233   D         1.414   1.464   1.531   1.467   1.543   1.646   1.513   1.585   1.692
234   L        -0.436  -0.480  -0.379  -0.462  -0.470  -0.364  -0.660  -0.670  -0.542
235   S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
236   S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
237   D         0.158   0.292   0.332   0.006   0.237   0.271  -0.202   0.027   0.048
238   I         0.698   0.544   0.460   0.762   0.577   0.449   0.713   0.465   0.284
239   L         0.698   0.544   0.460   0.620   0.419   0.288   0.713   0.465   0.284
240   S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
241   R         0.158   0.238   0.307   0.056   0.197   0.255  -0.202  -0.073   0.000
242   K        -0.890  -0.899  -0.888  -0.925  -0.893  -0.893  -0.888  -0.865  -0.838
243   I         0.698   0.697   0.478   0.723   0.734   0.388   0.713   0.707   0.317
244   D         0.017   0.011  -0.269   0.258   0.260  -0.153   0.027   0.015  -0.381
245   V         0.698   0.544   0.460   0.757   0.562   0.444   0.713   0.465   0.284
246   S        -0.625  -0.782  -0.864  -0.465  -0.690  -0.853  -0.545  -0.734  -0.809
247   Q        -0.625  -0.540  -0.816  -0.473  -0.360  -0.720  -0.545  -0.443  -0.755
248   Y         0.017  -0.163  -0.293   0.344   0.118  -0.078   0.027  -0.221  -0.414
249   G        -0.296  -0.437  -0.378  -0.363  -0.562  -0.493  -0.431  -0.606  -0.541
250   V        -0.296  -0.313  -0.330  -0.472  -0.471  -0.520  -0.431  -0.425  -0.468
251   I         0.698   0.627   0.470   0.723   0.637   0.374   0.713   0.598   0.303
252   M         0.158   0.146   0.279   0.214   0.151   0.346  -0.202  -0.247  -0.053
253   A         0.017  -0.090  -0.286   0.021  -0.127  -0.399   0.027  -0.116  -0.404
254   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
255   A         1.414   1.464   1.531   1.243   1.300   1.436   1.513   1.585   1.692
256   Q         1.414   1.464   1.531   1.583   1.656   1.755   1.513   1.585   1.692
257   K         1.414   1.464   1.531   1.297   1.379   1.487   1.513   1.585   1.692
258   N         1.414   1.464   1.531   1.433   1.508   1.614   1.513   1.585   1.692
259   I         0.017  -0.223  -0.306   0.082  -0.277  -0.464   0.027  -0.301  -0.432
260   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
261   L        -0.625  -0.866  -0.883  -0.508  -0.812  -0.818  -0.545  -0.823  -0.830
262   A         0.698   0.627   0.470   0.634   0.540   0.342   0.713   0.598   0.303
263   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
264   L        -0.296  -0.473  -0.390  -0.472  -0.745  -0.622  -0.431  -0.660  -0.556
265   T         0.017  -0.090  -0.286   0.213   0.063  -0.285   0.027  -0.116  -0.404
266   L        -1.095  -1.066  -0.944  -1.303  -1.238  -1.037  -1.117  -1.066  -0.899
267   Y         0.017  -0.223  -0.306   0.259  -0.097  -0.286   0.027  -0.301  -0.432
268   I         0.698   0.544   0.460   0.762   0.577   0.449   0.713   0.465   0.284
269   I         0.017  -0.223  -0.306   0.102  -0.241  -0.420   0.027  -0.301  -0.432
270   K         0.698   0.544   0.460   0.706   0.532   0.416   0.713   0.465   0.284
271   K         0.698   0.544   0.460   0.688   0.506   0.372   0.713   0.465   0.284
272   S        -0.625  -0.539  -0.815  -0.434  -0.320  -0.719  -0.545  -0.442  -0.754
273   I        -0.970  -1.081  -0.925  -1.127  -1.254  -1.013  -1.003  -1.076  -0.880
274   L         1.414   1.464   1.531   1.245   1.316   1.438   1.513   1.585   1.692
275   K        -1.548  -1.507  -1.351  -1.560  -1.493  -1.282  -1.346  -1.279  -1.082
276   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
277   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
278   I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
279   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
280   G        -1.424  -1.362  -1.319  -1.227  -1.122  -1.111  -1.231  -1.162  -1.055
281   A        -0.890  -0.814  -0.894  -0.898  -0.833  -0.849  -0.888  -0.834  -0.850
282   S        -0.296  -0.390  -0.360  -0.287  -0.401  -0.380  -0.431  -0.535  -0.516
283   D        -0.970  -0.863  -0.888  -0.878  -0.715  -0.745  -1.003  -0.867  -0.843
284   E        -1.095  -0.891  -0.919  -1.305  -1.007  -1.041  -1.117  -0.868  -0.874
285   T        -1.424  -1.336  -1.318  -1.356  -1.244  -1.213  -1.231  -1.130  -1.054
286   L         1.414   1.464   1.531   1.245   1.316   1.438   1.513   1.585   1.692
287   H        -0.890  -0.761  -0.875  -0.615  -0.454  -0.637  -0.888  -0.757  -0.829
288   E        -1.095  -0.891  -0.908  -1.267  -0.937  -0.968  -1.117  -0.868  -0.860
289   L        -0.625  -0.376  -0.790  -0.585  -0.254  -0.827  -0.545  -0.235  -0.724
290   G        -1.753  -1.644  -1.653  -1.504  -1.369  -1.407  -1.346  -1.231  -1.179
291   V        -0.296  -0.195  -0.346  -0.401  -0.276  -0.519  -0.431  -0.315  -0.498
292   P         0.698   0.697   0.478   0.861   0.863   0.512   0.713   0.707   0.317
293   I        -0.641  -0.544  -0.420  -0.975  -0.812  -0.635  -0.888  -0.760  -0.594
294   T        -0.436  -0.478  -0.381  -0.498  -0.546  -0.396  -0.660  -0.691  -0.550
295   P         1.414   1.464   1.531   1.502   1.572   1.679   1.513   1.585   1.692
296   I         0.017  -0.163  -0.293   0.142  -0.091  -0.308   0.027  -0.221  -0.414
297   A        -0.296  -0.409  -0.390  -0.444  -0.651  -0.566  -0.431  -0.602  -0.558
298   F        -1.219  -1.370  -1.321  -0.863  -1.123  -1.070  -1.003  -1.145  -1.054
299   D        -0.296  -0.265  -0.329  -0.124  -0.051  -0.152  -0.431  -0.361  -0.467
300   Y         0.698   0.697   0.478   0.919   0.927   0.618   0.713   0.707   0.317
301   P        -0.296  -0.473  -0.390  -0.236  -0.534  -0.452  -0.431  -0.660  -0.556
302   T         0.158   0.146   0.279  -0.011  -0.069   0.131  -0.202  -0.247  -0.053
303   V        -0.296  -0.473  -0.390  -0.305  -0.550  -0.426  -0.431  -0.660  -0.556
304   V         0.158   0.156   0.279  -0.177  -0.233  -0.028  -0.202  -0.228  -0.053
305   K         0.698   0.544   0.460   0.688   0.506   0.372   0.713   0.465   0.284
306   N         1.414   1.464   1.531   1.433   1.508   1.614   1.513   1.585   1.692
307   N         0.017  -0.064  -0.280   0.249   0.154  -0.148   0.027  -0.096  -0.396
308   S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
309   A         0.346   0.234   0.304   0.074  -0.167  -0.060   0.141  -0.080  -0.006
310   Y         1.414   1.464   1.531   1.522   1.593   1.698   1.513   1.585   1.692
311   N         1.414   1.464   1.531   1.433   1.508   1.614   1.513   1.585   1.692
312   T         1.414   1.464   1.531   1.474   1.548   1.652   1.513   1.585   1.692
313   I        -0.296  -0.409  -0.390  -0.401  -0.631  -0.606  -0.431  -0.602  -0.558
314   P         0.346   0.303   0.326   0.368   0.277   0.269   0.141   0.047   0.037
315   I         0.698   0.544   0.460   0.740   0.540   0.394   0.713   0.465   0.284
316   F         0.017  -0.163  -0.293   0.275   0.006  -0.216   0.027  -0.221  -0.414
317   T         0.017  -0.090  -0.286   0.228   0.089  -0.252   0.027  -0.116  -0.404
318   L        -0.561  -0.506  -0.417  -0.723  -0.674  -0.508  -0.774  -0.701  -0.587
319   H         0.346   0.303   0.326   0.520   0.437   0.432   0.141   0.047   0.037
320   V        -0.890  -0.915  -0.883  -0.880  -0.946  -0.869  -0.888  -0.902  -0.836
321   M        -1.424  -1.360  -1.305  -1.338  -1.266  -1.223  -1.231  -1.140  -1.040
322   D        -1.424  -1.429  -1.334  -1.333  -1.350  -1.250  -1.231  -1.218  -1.067
323   L         0.017  -0.090  -0.286   0.029  -0.098  -0.384   0.027  -0.116  -0.404
324   V         0.698   0.544   0.460   0.731   0.520   0.380   0.713   0.465   0.284
325   F        -0.890  -0.720  -0.845  -0.927  -0.687  -0.843  -0.888  -0.666  -0.790
326   Q        -1.095  -0.990  -0.925  -1.155  -1.033  -0.900  -1.117  -1.005  -0.881
327   H        -1.424  -1.425  -1.326  -1.181  -1.168  -0.998  -1.231  -1.201  -1.059
328   I         0.017  -0.028  -0.269   0.051   0.005  -0.313   0.027  -0.052  -0.380
329   L        -0.436  -0.309  -0.363  -0.675  -0.494  -0.505  -0.660  -0.489  -0.526
330   K        -1.548  -1.427  -1.337  -1.683  -1.528  -1.351  -1.346  -1.226  -1.072
331   K        -1.753  -1.741  -1.664  -1.518  -1.470  -1.374  -1.346  -1.321  -1.187
332   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
333   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
334   G         0.698   0.627   0.470   0.718   0.634   0.408   0.713   0.598   0.303
335   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
336   V        -0.561  -0.531  -0.433  -0.822  -0.813  -0.668  -0.774  -0.739  -0.608
337   E        -1.424  -1.465  -1.322  -1.457  -1.498  -1.300  -1.231  -1.240  -1.056
338   A        -1.219  -1.177  -1.277  -1.187  -1.156  -1.298  -1.003  -0.948  -1.013
339   Q        -0.625  -0.604  -0.839  -0.219  -0.233  -0.570  -0.545  -0.530  -0.781
340   Q         0.098   0.145   0.279  -0.067   0.006   0.211  -0.317  -0.248  -0.054
341   A        -0.970  -0.793  -0.877  -1.160  -0.947  -0.972  -1.003  -0.816  -0.835
342   E        -1.219  -1.270  -1.303  -1.074  -1.191  -1.258  -1.003  -1.053  -1.037
343   N        -0.296  -0.473  -0.390  -0.333  -0.638  -0.544  -0.431  -0.660  -0.556
344   E        -0.296  -0.225  -0.349  -0.366  -0.292  -0.483  -0.431  -0.364  -0.503
345   E        -0.436  -0.327  -0.366  -0.616  -0.459  -0.463  -0.660  -0.520  -0.530
346   K         1.414   1.464   1.531   1.297   1.379   1.487   1.513   1.585   1.692
347   A         0.698   0.544   0.460   0.620   0.404   0.289   0.713   0.465   0.284
348   K        -0.890  -0.819  -0.876  -0.980  -0.888  -0.968  -0.888  -0.803  -0.829
349   I        -0.890  -0.908  -0.910  -0.943  -1.034  -0.998  -0.888  -0.920  -0.865
350   L         0.698   0.627   0.470   0.620   0.535   0.306   0.713   0.598   0.303
351   Y         1.414   1.464   1.531   1.522   1.593   1.698   1.513   1.585   1.692
352   E        -1.753  -1.793  -1.667  -1.622  -1.706  -1.550  -1.346  -1.363  -1.190
353   A         0.698   0.544   0.460   0.634   0.429   0.326   0.713   0.465   0.284
354   L         1.414   1.464   1.531   1.245   1.316   1.438   1.513   1.585   1.692
355   D         0.098   0.150   0.280  -0.153  -0.065   0.134  -0.317  -0.240  -0.051
356   A        -1.095  -0.985  -0.927  -1.357  -1.214  -1.090  -1.117  -0.991  -0.883
357   N        -0.970  -0.786  -0.891  -0.738  -0.470  -0.608  -1.003  -0.790  -0.846
358   S        -0.098  -0.064  -0.309   0.089   0.129  -0.288  -0.130  -0.087  -0.436
359   D        -0.890  -0.852  -0.885  -0.821  -0.775  -0.851  -0.888  -0.840  -0.839
360   F        -0.296  -0.442  -0.391  -0.278  -0.573  -0.537  -0.431  -0.632  -0.558
361   Y         1.414   1.464   1.531   1.522   1.593   1.698   1.513   1.585   1.692
362   N        -0.436  -0.519  -0.391  -0.607  -0.705  -0.531  -0.660  -0.732  -0.561
363   V        -1.219  -1.267  -1.286  -1.121  -1.221  -1.212  -1.003  -1.050  -1.022
364   P         0.346   0.234   0.304   0.364   0.138   0.213   0.141  -0.080  -0.006
365   V         0.698   0.627   0.470   0.755   0.671   0.456   0.713   0.598   0.303
366   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
367   D        -1.095  -1.104  -0.931  -1.192  -1.193  -0.968  -1.117  -1.092  -0.886
368   P        -1.424  -1.321  -1.313  -1.287  -1.158  -1.146  -1.231  -1.122  -1.050
369   K        -1.095  -1.030  -0.945  -1.300  -1.251  -1.047  -1.117  -1.048  -0.901
370   C        -1.877  -1.706  -1.672  -1.733  -1.546  -1.411  -1.460  -1.295  -1.194
371   R         1.414   1.464   1.531   1.588   1.654   1.760   1.513   1.585   1.692
372   S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
373   K        -0.436  -0.327  -0.371  -0.522  -0.378  -0.386  -0.660  -0.536  -0.538
374   M         1.414   1.464   1.531   1.644   1.714   1.812   1.513   1.585   1.692
375   N         1.414   1.464   1.531   1.433   1.508   1.614   1.513   1.585   1.692
376   V         0.346   0.303   0.326   0.227   0.139   0.148   0.141   0.047   0.037
377   V         0.017  -0.223  -0.306   0.191  -0.114  -0.214   0.027  -0.301  -0.432
378   F         1.414   1.464   1.531   1.515   1.583   1.691   1.513   1.585   1.692
379   T        -0.436  -0.360  -0.377  -0.382  -0.282  -0.272  -0.660  -0.577  -0.545
380   L        -0.436  -0.480  -0.384  -0.724  -0.760  -0.600  -0.660  -0.693  -0.551
381   K        -1.424  -1.524  -1.351  -1.337  -1.459  -1.203  -1.231  -1.287  -1.080
382   K        -0.890  -0.953  -0.897  -0.921  -0.973  -0.918  -0.888  -0.927  -0.847
383   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
384   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
385   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
386   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
387   D        -0.890  -0.916  -0.899  -0.798  -0.812  -0.837  -0.888  -0.903  -0.852
388   G        -1.095  -0.988  -0.932  -1.199  -1.070  -0.953  -1.117  -1.004  -0.887
389   L         0.698   0.627   0.470   0.602   0.508   0.263   0.713   0.598   0.303
390   D         0.158   0.292   0.332  -0.052   0.170   0.216  -0.202   0.027   0.048
391   D        -1.548  -1.485  -1.342  -1.658  -1.558  -1.346  -1.346  -1.265  -1.074
392   Q        -0.625  -0.751  -0.851  -0.532  -0.742  -0.876  -0.545  -0.701  -0.794
393   F         1.414   1.464   1.531   1.515   1.583   1.691   1.513   1.585   1.692
394   L         0.017   0.223  -0.245   0.001   0.271  -0.378   0.027   0.305  -0.347
395   K        -0.890  -0.793  -0.886  -1.034  -0.924  -1.048  -0.888  -0.788  -0.841
396   E         1.414   1.464   1.531   1.367   1.436   1.552   1.513   1.585   1.692
397   A         0.698   0.627   0.470   0.620   0.520   0.307   0.713   0.598   0.303
398   A        -0.296  -0.437  -0.378  -0.428  -0.640  -0.538  -0.431  -0.606  -0.541
399   A        -0.970  -0.820  -0.883  -1.160  -0.982  -0.978  -1.003  -0.846  -0.840
400   R        -1.753  -1.797  -1.670  -1.377  -1.456  -1.349  -1.346  -1.366  -1.192
401   H        -1.095  -1.058  -0.929  -1.106  -1.015  -0.860  -1.117  -1.056  -0.885
402   L         1.414   1.464   1.531   1.245   1.316   1.438   1.513   1.585   1.692
403   T         0.017  -0.032  -0.272   0.210   0.132  -0.265   0.027  -0.056  -0.385
404   G         0.698   0.544   0.460   0.740   0.555   0.444   0.713   0.465   0.284
405   L         1.414   1.464   1.531   1.245   1.316   1.438   1.513   1.585   1.692
406   K         1.414   1.464   1.531   1.297   1.379   1.487   1.513   1.585   1.692
407   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
408   H         0.698   0.544   0.460   1.009   0.814   0.669   0.713   0.465   0.284
409   R         1.414   1.464   1.531   1.588   1.654   1.760   1.513   1.585   1.692
410   S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
411   V         1.414   1.464   1.531   1.360   1.426   1.545   1.513   1.585   1.692
412   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
413   G         1.414   1.464   1.531   1.332   1.401   1.520   1.513   1.585   1.692
414   F        -0.436  -0.252  -0.350  -0.470  -0.217  -0.288  -0.660  -0.408  -0.501
415   R         1.414   1.464   1.531   1.588   1.654   1.760   1.513   1.585   1.692
416   A         0.698   0.697   0.478   0.618   0.612   0.317   0.713   0.707   0.317
417   S         1.414   1.464   1.531   1.373   1.443   1.558   1.513   1.585   1.692
418   I        -0.641  -0.610  -0.445  -0.967  -0.913  -0.663  -0.888  -0.838  -0.625
419   Y         1.414   1.464   1.531   1.522   1.593   1.698   1.513   1.585   1.692
420   N         1.414   1.464   1.531   1.433   1.508   1.614   1.513   1.585   1.692
421   A         0.698   0.627   0.470   0.620   0.520   0.307   0.713   0.598   0.303
422   L        -0.561  -0.527  -0.421  -0.822  -0.781  -0.636  -0.774  -0.737  -0.594
423   S        -0.970  -0.949  -0.888  -0.956  -0.915  -0.817  -1.003  -0.959  -0.845
424   V         0.158   0.166   0.282  -0.218  -0.222  -0.028  -0.202  -0.208  -0.048
425   K        -0.890  -0.751  -0.852  -0.892  -0.649  -0.823  -0.888  -0.699  -0.801
426   A        -0.625  -0.751  -0.851  -0.463  -0.641  -0.827  -0.545  -0.701  -0.794
427   V        -0.296  -0.473  -0.390  -0.385  -0.677  -0.560  -0.431  -0.660  -0.556
428   Q        -0.890  -0.861  -0.872  -0.777  -0.713  -0.739  -0.888  -0.831  -0.823
429   N        -1.219  -1.248  -1.282  -1.134  -1.177  -1.226  -1.003  -1.033  -1.018
430   L         1.414   1.464   1.531   1.245   1.316   1.438   1.513   1.585   1.692
431   V        -0.625  -0.866  -0.883  -0.528  -0.911  -0.997  -0.545  -0.823  -0.830
432   D        -0.296  -0.262  -0.333  -0.270  -0.174  -0.353  -0.431  -0.357  -0.476
433   F         0.346   0.322   0.322   0.341   0.275   0.205   0.141   0.081   0.029
434   I        -0.436  -0.526  -0.387  -0.651  -0.785  -0.576  -0.660  -0.743  -0.557
435   K        -1.424  -1.460  -1.335  -1.308  -1.323  -1.157  -1.231  -1.234  -1.067
436   E        -1.095  -1.072  -0.922  -1.224  -1.161  -0.966  -1.117  -1.057  -0.875
437   F         1.414   1.464   1.531   1.515   1.583   1.691   1.513   1.585   1.692
438   A         1.414   1.464   1.531   1.243   1.300   1.436   1.513   1.585   1.692
439   E         0.098   0.174   0.291  -0.278  -0.148   0.032  -0.317  -0.193  -0.030
440   K        -1.388  -1.241  -1.318  -1.366  -1.143  -1.270  -1.175  -1.013  -1.050
441   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
442   N         0.635   0.450   0.417   0.729   0.462   0.383   0.617   0.307   0.207
443   A        -1.424  -1.433  -1.311  -1.489  -1.491  -1.289  -1.231  -1.211  -1.048
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/P33330
Output conservation file - output/P33330
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
