1     M         1.431   1.457   1.532   1.610   1.645   1.756   1.562   1.600   1.716
2     V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     S        -1.746  -1.733  -1.638  -1.547  -1.546  -1.382  -1.307  -1.284  -1.151
4     L        -1.060  -1.135  -1.048  -1.055  -1.158  -1.043  -0.988  -1.042  -0.922
5     F        -1.060  -1.136  -1.058  -1.030  -1.132  -1.021  -0.988  -1.043  -0.931
6     K        -0.771  -0.746  -0.691  -0.911  -0.859  -0.809  -0.882  -0.839  -0.756
7     R        -0.771  -0.761  -0.690  -0.864  -0.835  -0.727  -0.882  -0.861  -0.755
8     G        -1.348  -1.278  -1.336  -1.048  -0.959  -1.038  -1.095  -1.020  -1.030
9     K        -1.348  -1.383  -1.354  -1.118  -1.187  -1.156  -1.095  -1.119  -1.045
10    A        -2.035  -1.987  -1.866  -1.799  -1.727  -1.559  -1.413  -1.366  -1.217
11    P        -0.193  -0.260  -0.188  -0.376  -0.451  -0.336  -0.457  -0.522  -0.423
12    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
13    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
14    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
15    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
16    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
17    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
18    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
19    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
20    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
21    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
22    -        -0.400  -0.357  -0.256  -0.606  -0.540  -0.387  -0.705  -0.644  -0.509
23    -        -1.170  -1.183  -1.086  -1.244  -1.260  -1.127  -1.083  -1.086  -0.955
24    P        -1.746  -1.669  -1.617  -1.629  -1.516  -1.445  -1.307  -1.234  -1.137
25    L        -1.457  -1.372  -1.360  -1.444  -1.303  -1.265  -1.201  -1.116  -1.051
26    T        -1.457  -1.481  -1.365  -1.315  -1.365  -1.167  -1.201  -1.203  -1.055
27    K        -1.169  -1.091  -1.062  -1.186  -1.055  -1.017  -1.095  -1.016  -0.936
28    E        -0.771  -0.746  -0.701  -0.922  -0.902  -0.799  -0.882  -0.858  -0.767
29    G        -1.746  -1.733  -1.638  -1.627  -1.612  -1.468  -1.307  -1.284  -1.151
30    P        -1.060  -1.021  -1.038  -0.816  -0.796  -0.803  -0.988  -0.952  -0.915
31    T         0.205   0.144  -0.067   0.267   0.181  -0.140   0.181   0.081  -0.230
32    S         0.205   0.045  -0.082   0.245   0.023  -0.192   0.181  -0.052  -0.252
33    K        -0.302  -0.275  -0.237  -0.431  -0.395  -0.370  -0.563  -0.527  -0.483
34    K        -0.193  -0.218  -0.187  -0.319  -0.344  -0.277  -0.457  -0.484  -0.424
35    P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
36    P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
37    N         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
38    T         0.803   0.878   0.621   0.825   0.922   0.560   0.818   0.931   0.474
39    A         0.803   0.775   0.611   0.899   0.857   0.612   0.818   0.769   0.454
40    F         1.431   1.457   1.532   1.471   1.507   1.621   1.562   1.600   1.716
41    R         1.431   1.457   1.532   1.485   1.517   1.634   1.562   1.600   1.716
42    Q         1.431   1.457   1.532   1.537   1.578   1.686   1.562   1.600   1.716
43    Q         1.431   1.457   1.532   1.537   1.578   1.686   1.562   1.600   1.716
44    R         1.431   1.457   1.532   1.485   1.517   1.634   1.562   1.600   1.716
45    L         0.205   0.045  -0.082   0.216   0.016  -0.171   0.181  -0.052  -0.252
46    K         0.803   0.677   0.595   0.828   0.673   0.546   0.818   0.607   0.426
47    A         0.493   0.519   0.464   0.438   0.468   0.338   0.287   0.323   0.171
48    W         1.431   1.457   1.532   1.614   1.650   1.761   1.562   1.600   1.716
49    Q         1.431   1.457   1.532   1.537   1.578   1.686   1.562   1.600   1.716
50    P         0.803   0.677   0.595   0.885   0.731   0.628   0.818   0.607   0.426
51    I        -0.070  -0.168  -0.162  -0.181  -0.315  -0.347  -0.244  -0.372  -0.381
52    L         0.803   0.794   0.617   0.741   0.738   0.497   0.818   0.801   0.467
53    S         0.328   0.403   0.439   0.057   0.194   0.221  -0.032   0.103   0.120
54    P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
55    Q         0.328   0.403   0.439   0.142   0.270   0.308  -0.032   0.103   0.120
56    S        -0.359  -0.522  -0.610  -0.316  -0.570  -0.740  -0.351  -0.556  -0.656
57    V         0.803   0.677   0.595   0.898   0.725   0.590   0.818   0.607   0.426
58    L        -0.070  -0.119  -0.142  -0.233  -0.280  -0.334  -0.244  -0.295  -0.346
59    P         0.803   0.677   0.595   0.845   0.672   0.536   0.818   0.607   0.426
60    L         0.803   0.677   0.595   0.727   0.564   0.429   0.818   0.607   0.426
61    L         0.493   0.411   0.439   0.308   0.169   0.201   0.287   0.119   0.121
62    I        -0.591  -0.697  -0.655  -0.682  -0.834  -0.790  -0.670  -0.780  -0.716
63    F        -1.169  -1.117  -1.065  -1.147  -1.055  -0.981  -1.095  -1.034  -0.939
64    V        -0.771  -0.680  -0.678  -0.969  -0.840  -0.815  -0.882  -0.774  -0.741
65    A        -0.070  -0.082  -0.152  -0.064  -0.084  -0.207  -0.244  -0.254  -0.365
66    C        -0.880  -0.849  -0.729  -0.893  -0.865  -0.684  -0.988  -0.947  -0.793
67    I         1.431   1.457   1.532   1.374   1.419   1.527   1.562   1.600   1.716
68    F         0.803   0.677   0.595   0.925   0.760   0.630   0.818   0.607   0.426
69    T        -0.662  -0.742  -0.659  -0.742  -0.863  -0.729  -0.776  -0.840  -0.723
70    P         0.803   0.677   0.595   0.859   0.691   0.567   0.818   0.607   0.426
71    I        -0.193  -0.245  -0.189  -0.456  -0.497  -0.412  -0.457  -0.497  -0.421
72    G         1.431   1.457   1.532   1.450   1.484   1.600   1.562   1.600   1.716
73    I        -0.591  -0.653  -0.658  -0.593  -0.692  -0.679  -0.670  -0.746  -0.718
74    G        -0.193  -0.262  -0.188  -0.271  -0.361  -0.243  -0.457  -0.525  -0.423
75    L         0.493   0.579   0.516   0.275   0.414   0.289   0.287   0.433   0.273
76    I         0.205   0.045  -0.082   0.251   0.030  -0.203   0.181  -0.052  -0.252
77    V        -0.880  -0.693  -0.960  -0.730  -0.450  -0.893  -0.776  -0.559  -0.832
78    S        -1.060  -1.133  -1.054  -1.110  -1.226  -1.103  -0.988  -1.040  -0.928
79    A        -0.771  -0.711  -0.692  -0.861  -0.789  -0.748  -0.882  -0.814  -0.757
80    T        -1.746  -1.733  -1.638  -1.631  -1.611  -1.498  -1.307  -1.284  -1.151
81    K        -1.348  -1.383  -1.354  -1.223  -1.286  -1.247  -1.095  -1.119  -1.045
82    V         1.431   1.457   1.532   1.456   1.487   1.606   1.562   1.600   1.716
83    Q         0.205   0.139  -0.062   0.466   0.374   0.084   0.181   0.075  -0.223
84    D        -0.591  -0.525  -0.632  -0.551  -0.475  -0.610  -0.670  -0.602  -0.689
85    L         0.493   0.420   0.443   0.275   0.145   0.154   0.287   0.135   0.128
86    T        -0.771  -0.746  -0.681  -0.952  -0.897  -0.804  -0.882  -0.838  -0.745
87    I         0.493   0.514   0.471   0.389   0.424   0.326   0.287   0.315   0.185
88    D         1.431   1.457   1.532   1.410   1.442   1.562   1.562   1.600   1.716
89    Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
90    S         0.493   0.411   0.439   0.347   0.196   0.212   0.287   0.119   0.121
91    H        -0.193  -0.150  -0.178  -0.188  -0.157  -0.178  -0.457  -0.415  -0.412
92    C         1.431   1.457   1.532   1.631   1.667   1.776   1.562   1.600   1.716
93    D        -1.746  -1.733  -1.638  -1.576  -1.569  -1.414  -1.307  -1.284  -1.151
94    T        -0.591  -0.628  -0.645  -0.574  -0.623  -0.648  -0.670  -0.708  -0.704
95    K        -0.698  -0.723  -0.666  -0.861  -0.878  -0.784  -0.797  -0.808  -0.725
96    A         0.803   0.881   0.626   0.935   1.023   0.716   0.818   0.936   0.484
97    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
98    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
99    S        -0.070  -0.049  -0.158  -0.151  -0.141  -0.294  -0.244  -0.239  -0.377
100   T        -0.153  -0.213  -0.192  -0.227  -0.332  -0.310  -0.342  -0.434  -0.416
101   T        -0.771  -0.683  -0.678  -0.887  -0.758  -0.746  -0.882  -0.776  -0.741
102   A        -1.169  -1.160  -1.066  -1.189  -1.169  -1.030  -1.095  -1.072  -0.941
103   F        -0.591  -0.657  -0.638  -0.509  -0.595  -0.581  -0.670  -0.729  -0.695
104   E        -1.457  -1.417  -1.355  -1.389  -1.330  -1.248  -1.201  -1.153  -1.048
105   D        -1.457  -1.483  -1.371  -1.444  -1.487  -1.319  -1.201  -1.205  -1.060
106   I        -0.070  -0.076  -0.153  -0.086  -0.084  -0.189  -0.244  -0.250  -0.367
107   P         0.803   0.794   0.617   0.853   0.841   0.591   0.818   0.801   0.467
108   K        -1.457  -1.449  -1.365  -1.478  -1.466  -1.333  -1.201  -1.180  -1.055
109   K         0.803   0.677   0.595   0.817   0.657   0.521   0.818   0.607   0.426
110   Y         0.205   0.045  -0.082   0.345   0.120  -0.101   0.181  -0.052  -0.252
111   I        -0.771  -0.724  -0.676  -0.893  -0.803  -0.736  -0.882  -0.810  -0.737
112   K        -1.169  -1.095  -1.062  -1.171  -1.086  -1.000  -1.095  -1.022  -0.937
113   Y        -1.060  -1.134  -1.040  -0.910  -1.032  -0.889  -0.988  -1.042  -0.916
114   H         0.205   0.234  -0.050   0.496   0.536   0.089   0.181   0.219  -0.205
115   F         1.431   1.457   1.532   1.471   1.507   1.621   1.562   1.600   1.716
116   K        -0.880  -0.980  -1.011  -0.772  -0.937  -0.988  -0.776  -0.882  -0.884
117   S        -1.457  -1.417  -1.357  -1.311  -1.258  -1.147  -1.201  -1.153  -1.049
118   K         0.205   0.226  -0.042   0.296   0.327  -0.041   0.181   0.209  -0.193
119   V        -1.746  -1.738  -1.638  -1.595  -1.594  -1.457  -1.307  -1.287  -1.151
120   E        -1.348  -1.343  -1.328  -1.209  -1.243  -1.220  -1.095  -1.085  -1.024
121   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
122   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
123   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
124   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
125   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
126   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
127   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
128   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
129   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
130   -        -0.790  -0.701  -0.689  -0.943  -0.791  -0.806  -0.886  -0.775  -0.748
131   N        -1.457  -1.455  -1.368  -1.428  -1.426  -1.288  -1.201  -1.185  -1.057
132   K        -1.348  -1.347  -1.344  -1.176  -1.161  -1.164  -1.095  -1.088  -1.037
133   P        -1.457  -1.481  -1.376  -1.371  -1.427  -1.257  -1.201  -1.203  -1.063
134   Q        -0.359  -0.451  -0.589  -0.080  -0.225  -0.445  -0.351  -0.473  -0.631
135   W         1.431   1.457   1.532   1.614   1.650   1.761   1.562   1.600   1.716
136   R        -0.591  -0.654  -0.633  -0.527  -0.581  -0.548  -0.670  -0.725  -0.690
137   L        -0.193  -0.143  -0.180  -0.404  -0.344  -0.346  -0.457  -0.401  -0.414
138   T        -0.880  -0.764  -0.952  -0.677  -0.506  -0.830  -0.776  -0.641  -0.824
139   E        -1.060  -1.072  -1.040  -1.041  -1.053  -1.014  -0.988  -0.993  -0.916
140   N        -1.170  -1.168  -1.072  -1.253  -1.251  -1.115  -1.083  -1.071  -0.943
141   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
142   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
143   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
144   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
145   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
146   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
147   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
148   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
149   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
150   E        -1.152  -1.150  -1.067  -1.099  -1.113  -0.977  -1.075  -1.060  -0.940
151   N        -1.028  -1.070  -1.038  -0.919  -0.990  -0.943  -0.936  -0.976  -0.910
152   G        -1.152  -1.170  -1.064  -1.189  -1.224  -1.066  -1.075  -1.077  -0.937
153   E        -1.482  -1.492  -1.385  -1.356  -1.371  -1.238  -1.214  -1.209  -1.069
154   Q        -1.060  -0.962  -1.014  -1.008  -0.862  -0.943  -0.988  -0.875  -0.892
155   S        -1.060  -1.087  -1.044  -1.105  -1.135  -1.085  -0.988  -1.001  -0.919
156   C         1.431   1.457   1.532   1.631   1.667   1.776   1.562   1.600   1.716
157   E        -1.457  -1.383  -1.353  -1.375  -1.265  -1.218  -1.201  -1.129  -1.047
158   L         0.275   0.305   0.401  -0.116  -0.058   0.085  -0.138  -0.094   0.044
159   Q        -1.457  -1.448  -1.360  -1.286  -1.292  -1.160  -1.201  -1.180  -1.052
160   F         1.431   1.457   1.532   1.471   1.507   1.621   1.562   1.600   1.716
161   E        -1.060  -1.136  -1.058  -0.989  -1.106  -1.007  -0.988  -1.043  -0.931
162   I        -0.373  -0.325  -0.239  -0.650  -0.567  -0.446  -0.670  -0.605  -0.487
163   P         0.803   0.879   0.629   0.860   0.952   0.625   0.818   0.933   0.489
164   N        -1.746  -1.735  -1.633  -1.524  -1.491  -1.352  -1.307  -1.285  -1.148
165   D         0.205   0.045  -0.082   0.335   0.117  -0.069   0.181  -0.052  -0.252
166   I        -0.193  -0.206  -0.184  -0.407  -0.428  -0.358  -0.457  -0.472  -0.421
167   K         0.205   0.062  -0.077   0.278   0.085  -0.135   0.181  -0.029  -0.246
168   K        -1.060  -0.906  -1.019  -1.019  -0.783  -0.955  -0.988  -0.819  -0.895
169   S         0.328   0.403   0.439   0.075   0.210   0.238  -0.032   0.103   0.120
170   I         0.275   0.300   0.399   0.010   0.046   0.200  -0.138  -0.104   0.040
171   F        -0.070  -0.166  -0.165  -0.054  -0.196  -0.223  -0.244  -0.369  -0.386
172   I        -0.591  -0.656  -0.643  -0.628  -0.689  -0.672  -0.670  -0.728  -0.698
173   Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
174   Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
175   K        -0.070  -0.201  -0.178  -0.079  -0.249  -0.214  -0.244  -0.425  -0.403
176   I         0.803   0.886   0.624   0.727   0.838   0.476   0.818   0.944   0.479
177   T         0.803   0.677   0.595   0.833   0.665   0.535   0.818   0.607   0.426
178   N         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
179   F         1.431   1.457   1.532   1.471   1.507   1.621   1.562   1.600   1.716
180   Y         0.493   0.515   0.468   0.471   0.503   0.398   0.287   0.317   0.179
181   Q         1.431   1.457   1.532   1.537   1.578   1.686   1.562   1.600   1.716
182   N         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
183   H         1.431   1.457   1.532   1.609   1.647   1.755   1.562   1.600   1.716
184   R         1.431   1.457   1.532   1.485   1.517   1.634   1.562   1.600   1.716
185   R         0.328   0.399   0.438   0.154   0.282   0.313  -0.032   0.094   0.120
186   Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
187   V         0.803   0.775   0.611   0.910   0.871   0.642   0.818   0.769   0.454
188   Q        -1.348  -1.388  -1.348  -1.139  -1.224  -1.186  -1.095  -1.124  -1.040
189   S         1.431   1.457   1.532   1.354   1.394   1.508   1.562   1.600   1.716
190   F        -0.193  -0.197  -0.184  -0.256  -0.251  -0.223  -0.457  -0.447  -0.417
191   D         0.493   0.420   0.443   0.401   0.256   0.267   0.287   0.135   0.128
192   T        -1.457  -1.412  -1.369  -1.421  -1.331  -1.277  -1.201  -1.153  -1.058
193   K        -0.591  -0.516  -0.616  -0.575  -0.458  -0.597  -0.670  -0.565  -0.666
194   Q         1.431   1.457   1.532   1.537   1.578   1.686   1.562   1.600   1.716
195   I         0.803   0.886   0.624   0.727   0.838   0.476   0.818   0.944   0.479
196   L        -1.060  -1.032  -1.034  -1.125  -1.070  -1.054  -0.988  -0.945  -0.910
197   G         1.431   1.457   1.532   1.450   1.484   1.600   1.562   1.600   1.716
198   E        -1.060  -1.107  -1.039  -0.987  -1.060  -0.973  -0.988  -1.022  -0.916
199   P         0.205   0.251  -0.037   0.356   0.408  -0.008   0.181   0.245  -0.185
200   I        -0.662  -0.623  -0.640  -0.815  -0.755  -0.767  -0.776  -0.728  -0.704
201   K        -0.591  -0.491  -0.615  -0.672  -0.530  -0.713  -0.670  -0.552  -0.670
202   K        -1.060  -0.965  -1.032  -1.055  -0.929  -1.010  -0.988  -0.896  -0.908
203   D         0.205   0.246  -0.037   0.352   0.404   0.032   0.181   0.238  -0.185
204   D        -0.070  -0.166  -0.166  -0.063  -0.200  -0.206  -0.244  -0.368  -0.386
205   L        -0.070  -0.169  -0.162  -0.217  -0.357  -0.357  -0.244  -0.374  -0.381
206   D        -1.169  -1.099  -1.062  -1.265  -1.168  -1.097  -1.095  -1.024  -0.937
207   T        -0.771  -0.724  -0.694  -0.895  -0.831  -0.778  -0.882  -0.831  -0.759
208   S        -1.457  -1.384  -1.353  -1.397  -1.303  -1.241  -1.201  -1.130  -1.047
209   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
210   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
211   C         1.431   1.457   1.532   1.631   1.667   1.776   1.562   1.600   1.716
212   S        -0.359  -0.282  -0.563  -0.247  -0.137  -0.549  -0.351  -0.253  -0.598
213   P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
214   I         0.803   0.886   0.624   0.727   0.838   0.476   0.818   0.944   0.479
215   R        -1.060  -1.136  -1.044  -0.968  -1.077  -0.944  -0.988  -1.044  -0.920
216   S        -1.746  -1.630  -1.617  -1.573  -1.429  -1.372  -1.307  -1.203  -1.137
217   R        -1.457  -1.378  -1.355  -1.369  -1.263  -1.227  -1.201  -1.122  -1.048
218   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
219   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
220   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
221   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
222   E        -0.591  -0.589  -0.632  -0.560  -0.566  -0.622  -0.670  -0.656  -0.689
223   D        -0.193  -0.150  -0.177  -0.298  -0.257  -0.247  -0.457  -0.413  -0.412
224   K         1.431   1.457   1.532   1.370   1.414   1.523   1.562   1.600   1.716
225   I        -1.060  -1.070  -1.043  -1.089  -1.109  -1.064  -0.988  -0.995  -0.919
226   I        -0.302  -0.266  -0.230  -0.460  -0.404  -0.360  -0.563  -0.514  -0.472
227   Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
228   P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
229   C         1.431   1.457   1.532   1.631   1.667   1.776   1.562   1.600   1.716
230   G         1.431   1.457   1.532   1.450   1.484   1.600   1.562   1.600   1.716
231   L         0.205   0.145  -0.066   0.230   0.141  -0.119   0.181   0.082  -0.228
232   I         0.803   0.677   0.595   0.829   0.672   0.540   0.818   0.607   0.426
233   A         0.803   0.881   0.626   0.899   0.992   0.639   0.818   0.936   0.484
234   N         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
235   S         1.431   1.457   1.532   1.354   1.394   1.508   1.562   1.600   1.716
236   M        -0.302  -0.242  -0.217  -0.329  -0.227  -0.244  -0.563  -0.476  -0.453
237   F         1.431   1.457   1.532   1.471   1.507   1.621   1.562   1.600   1.716
238   N         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
239   D         1.431   1.457   1.532   1.410   1.442   1.562   1.562   1.600   1.716
240   T         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
241   F         0.328   0.399   0.438   0.144   0.275   0.304  -0.032   0.094   0.120
242   S         0.205   0.252  -0.041   0.290   0.359  -0.036   0.181   0.246  -0.191
243   Q        -1.169  -1.131  -1.064  -1.237  -1.187  -1.098  -1.095  -1.049  -0.938
244   V        -0.880  -0.774  -0.980  -0.745  -0.604  -0.921  -0.776  -0.653  -0.853
245   L        -0.662  -0.742  -0.671  -0.767  -0.857  -0.736  -0.776  -0.841  -0.735
246   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
247   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
248   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
249   S        -1.556  -1.523  -1.396  -1.605  -1.550  -1.370  -1.272  -1.231  -1.077
250   G        -1.170  -1.150  -1.086  -1.120  -1.106  -1.021  -1.083  -1.055  -0.955
251   I        -1.482  -1.393  -1.364  -1.479  -1.335  -1.312  -1.214  -1.124  -1.053
252   -        -0.640  -0.693  -0.674  -0.611  -0.699  -0.700  -0.705  -0.769  -0.731
253   D        -0.591  -0.554  -0.638  -0.560  -0.525  -0.635  -0.670  -0.647  -0.698
254   D        -1.060  -0.993  -1.031  -1.046  -0.954  -0.996  -0.988  -0.915  -0.909
255   T         0.205   0.144  -0.067   0.274   0.178  -0.144   0.181   0.081  -0.230
256   E        -1.060  -1.102  -1.043  -0.992  -1.069  -0.986  -0.988  -1.019  -0.919
257   D        -0.662  -0.639  -0.657  -0.760  -0.728  -0.733  -0.776  -0.742  -0.721
258   Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
259   N        -1.348  -1.387  -1.342  -1.146  -1.220  -1.184  -1.095  -1.123  -1.035
260   L        -0.302  -0.334  -0.251  -0.460  -0.489  -0.355  -0.563  -0.612  -0.501
261   T         0.328   0.317   0.403   0.057   0.018   0.145  -0.032  -0.070   0.048
262   N        -0.302  -0.270  -0.224  -0.501  -0.458  -0.399  -0.563  -0.519  -0.463
263   K         0.205   0.246  -0.037   0.288   0.348  -0.050   0.181   0.238  -0.185
264   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
265   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
266   H        -1.348  -1.337  -1.331  -1.116  -1.127  -1.102  -1.095  -1.080  -1.026
267   I         1.431   1.457   1.532   1.374   1.419   1.527   1.562   1.600   1.716
268   S         0.493   0.471   0.462   0.371   0.328   0.294   0.287   0.233   0.167
269   W         1.431   1.457   1.532   1.614   1.650   1.761   1.562   1.600   1.716
270   S        -0.880  -0.980  -1.011  -0.749  -0.893  -0.940  -0.776  -0.882  -0.884
271   I        -0.771  -0.797  -0.696  -0.953  -0.970  -0.828  -0.882  -0.891  -0.761
272   D         0.803   0.677   0.595   0.840   0.660   0.518   0.818   0.607   0.426
273   R         0.328   0.307   0.401   0.154   0.085   0.223  -0.032  -0.090   0.043
274   H        -1.457  -1.454  -1.364  -1.382  -1.379  -1.227  -1.201  -1.184  -1.055
275   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
276   R        -0.070  -0.119  -0.142  -0.075  -0.143  -0.222  -0.244  -0.295  -0.346
277   F         0.328   0.336   0.409   0.186   0.187   0.287  -0.032  -0.031   0.059
278   K         0.205   0.045  -0.082   0.258   0.041  -0.184   0.181  -0.052  -0.252
279   T         0.205   0.144  -0.067   0.284   0.208  -0.106   0.181   0.081  -0.230
280   T         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
281   K        -0.591  -0.561  -0.628  -0.624  -0.578  -0.670  -0.670  -0.628  -0.685
282   Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
283   N        -0.193  -0.149  -0.182  -0.398  -0.355  -0.368  -0.457  -0.414  -0.418
284   A        -0.193  -0.265  -0.191  -0.290  -0.386  -0.264  -0.457  -0.530  -0.427
285   S        -0.591  -0.635  -0.649  -0.649  -0.715  -0.736  -0.670  -0.718  -0.709
286   D        -0.193  -0.120  -0.163  -0.245  -0.149  -0.172  -0.457  -0.360  -0.389
287   I         0.328   0.342   0.413   0.102   0.121   0.221  -0.032  -0.018   0.068
288   V        -0.359  -0.358  -0.576  -0.180  -0.187  -0.528  -0.351  -0.349  -0.614
289   P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
290   P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
291   P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
292   N         0.803   0.794   0.617   0.842   0.835   0.591   0.818   0.801   0.467
293   W         1.431   1.457   1.532   1.614   1.650   1.761   1.562   1.600   1.716
294   M        -1.746  -1.666  -1.626  -1.461  -1.352  -1.290  -1.307  -1.235  -1.143
295   K        -0.662  -0.742  -0.653  -0.716  -0.813  -0.693  -0.776  -0.841  -0.717
296   K        -0.771  -0.803  -0.691  -0.765  -0.806  -0.636  -0.882  -0.897  -0.756
297   Y        -0.070  -0.157  -0.160  -0.005  -0.108  -0.127  -0.244  -0.354  -0.377
298   P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
299   D         0.493   0.456   0.454   0.401   0.322   0.289   0.287   0.205   0.150
300   G         1.431   1.457   1.532   1.450   1.484   1.600   1.562   1.600   1.716
301   Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
302   T         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
303   D        -1.060  -1.032  -1.030  -0.951  -0.910  -0.910  -0.988  -0.950  -0.906
304   E        -0.070  -0.080  -0.150  -0.082  -0.095  -0.214  -0.244  -0.250  -0.362
305   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
306   N         0.803   0.677   0.595   0.827   0.659   0.522   0.818   0.607   0.426
307   L        -0.302  -0.239  -0.215  -0.502  -0.397  -0.362  -0.563  -0.472  -0.450
308   P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
309   D         0.493   0.531   0.474   0.401   0.452   0.328   0.287   0.345   0.190
310   I        -0.193  -0.119  -0.175  -0.460  -0.350  -0.400  -0.457  -0.358  -0.405
311   H        -1.169  -1.168  -1.066  -1.079  -1.099  -0.933  -1.095  -1.079  -0.940
312   T        -0.070  -0.157  -0.160  -0.100  -0.221  -0.241  -0.244  -0.354  -0.377
313   W         0.803   0.775   0.611   1.089   1.058   0.836   0.818   0.769   0.454
314   E         0.205   0.062  -0.077   0.436   0.245   0.034   0.181  -0.029  -0.246
315   E        -0.591  -0.669  -0.648  -0.430  -0.542  -0.528  -0.670  -0.742  -0.705
316   F         0.275   0.302   0.401  -0.043   0.006   0.156  -0.138  -0.098   0.043
317   Q         1.431   1.457   1.532   1.537   1.578   1.686   1.562   1.600   1.716
318   V         0.275   0.303   0.400   0.018   0.052   0.208  -0.138  -0.097   0.042
319   W         1.431   1.457   1.532   1.614   1.650   1.761   1.562   1.600   1.716
320   M         1.431   1.457   1.532   1.610   1.645   1.756   1.562   1.600   1.716
321   R         0.803   0.677   0.595   0.961   0.803   0.694   0.818   0.607   0.426
322   T         0.803   0.677   0.595   0.815   0.640   0.494   0.818   0.607   0.426
323   A         1.431   1.457   1.532   1.459   1.488   1.609   1.562   1.600   1.716
324   A         0.328   0.364   0.417   0.173   0.222   0.291  -0.032   0.026   0.075
325   F         0.205   0.144  -0.067   0.188   0.095  -0.205   0.181   0.081  -0.230
326   P         0.803   0.881   0.626   0.860   0.954   0.620   0.818   0.936   0.484
327   K        -0.662  -0.683  -0.661  -0.801  -0.822  -0.782  -0.776  -0.787  -0.724
328   F         1.431   1.457   1.532   1.471   1.507   1.621   1.562   1.600   1.716
329   Y         0.493   0.471   0.462   0.434   0.387   0.329   0.287   0.233   0.167
330   K         1.431   1.457   1.532   1.370   1.414   1.523   1.562   1.600   1.716
331   L         1.431   1.457   1.532   1.285   1.325   1.440   1.562   1.600   1.716
332   T        -0.771  -0.721  -0.686  -0.811  -0.756  -0.686  -0.882  -0.829  -0.751
333   L        -1.169  -1.163  -1.075  -1.112  -1.076  -0.947  -1.095  -1.074  -0.947
334   K        -0.070  -0.044  -0.148  -0.093  -0.069  -0.195  -0.244  -0.226  -0.359
335   N         0.803   0.794   0.617   0.851   0.846   0.612   0.818   0.801   0.467
336   E        -0.070  -0.044  -0.148  -0.022  -0.003  -0.170  -0.244  -0.226  -0.359
337   S        -0.880  -0.975  -1.011  -0.716  -0.855  -0.910  -0.776  -0.878  -0.884
338   A        -1.457  -1.372  -1.360  -1.332  -1.224  -1.187  -1.201  -1.116  -1.051
339   S        -1.060  -1.086  -1.033  -1.088  -1.121  -1.042  -0.988  -1.000  -0.910
340   L        -0.070  -0.138  -0.164  -0.155  -0.246  -0.273  -0.244  -0.347  -0.385
341   P        -1.169  -1.165  -1.068  -1.273  -1.251  -1.108  -1.095  -1.072  -0.941
342   K        -1.060  -1.136  -1.058  -1.088  -1.184  -1.068  -0.988  -1.043  -0.931
343   G         1.431   1.457   1.532   1.450   1.484   1.600   1.562   1.600   1.716
344   K        -0.359  -0.369  -0.569  -0.268  -0.294  -0.609  -0.351  -0.372  -0.605
345   Y         1.431   1.457   1.532   1.454   1.492   1.605   1.562   1.600   1.716
346   Q        -0.771  -0.797  -0.690  -0.759  -0.781  -0.636  -0.882  -0.891  -0.755
347   M        -0.591  -0.510  -0.623  -0.535  -0.413  -0.573  -0.670  -0.557  -0.674
348   N        -1.746  -1.733  -1.638  -1.655  -1.623  -1.494  -1.307  -1.284  -1.151
349   I         0.493   0.526   0.472   0.389   0.442   0.327   0.287   0.336   0.186
350   E        -1.060  -1.101  -1.039  -0.945  -1.012  -0.928  -0.988  -1.018  -0.915
351   L        -0.070  -0.119  -0.142  -0.148  -0.211  -0.237  -0.244  -0.295  -0.346
352   N        -0.359  -0.358  -0.576  -0.187  -0.191  -0.479  -0.351  -0.349  -0.614
353   Y         0.328   0.307   0.401   0.180   0.126   0.269  -0.032  -0.090   0.043
354   P         0.803   0.677   0.595   0.849   0.677   0.546   0.818   0.607   0.426
355   I        -0.070  -0.113  -0.146  -0.083  -0.133  -0.219  -0.244  -0.285  -0.352
356   S        -1.348  -1.391  -1.347  -1.262  -1.348  -1.272  -1.095  -1.127  -1.039
357   L        -1.348  -1.383  -1.354  -1.242  -1.290  -1.266  -1.095  -1.119  -1.045
358   F         0.493   0.420   0.443   0.482   0.346   0.355   0.287   0.135   0.128
359   G        -0.070  -0.201  -0.178  -0.075  -0.287  -0.271  -0.244  -0.425  -0.403
360   G         1.431   1.457   1.532   1.450   1.484   1.600   1.562   1.600   1.716
361   T        -0.193  -0.246  -0.175  -0.356  -0.386  -0.282  -0.457  -0.499  -0.405
362   K         1.431   1.457   1.532   1.370   1.414   1.523   1.562   1.600   1.716
363   S         0.803   0.881   0.626   0.798   0.902   0.549   0.818   0.936   0.484
364   F        -1.169  -1.098  -1.065  -1.205  -1.127  -1.028  -1.095  -1.023  -0.939
365   V         0.803   0.878   0.621   0.898   0.990   0.634   0.818   0.931   0.474
366   L         0.493   0.579   0.516   0.275   0.414   0.289   0.287   0.433   0.273
367   T         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
368   T         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
369   N        -0.070  -0.201  -0.178  -0.110  -0.309  -0.286  -0.244  -0.425  -0.403
370   G        -0.070  -0.050  -0.153  -0.163  -0.159  -0.298  -0.244  -0.240  -0.368
371   A        -0.373  -0.340  -0.252  -0.570  -0.516  -0.380  -0.670  -0.622  -0.503
372   I        -1.060  -1.136  -1.058  -1.008  -1.090  -0.987  -0.988  -1.043  -0.931
373   G         1.431   1.457   1.532   1.450   1.484   1.600   1.562   1.600   1.716
374   G         0.803   0.677   0.595   0.904   0.737   0.612   0.818   0.607   0.426
375   R         0.803   0.775   0.611   0.926   0.890   0.641   0.818   0.769   0.454
376   N         1.431   1.457   1.532   1.385   1.422   1.538   1.562   1.600   1.716
377   M        -0.070  -0.201  -0.178   0.072  -0.145  -0.149  -0.244  -0.425  -0.403
378   S        -0.070  -0.201  -0.178  -0.098  -0.270  -0.231  -0.244  -0.425  -0.403
379   L         0.803   0.677   0.595   0.732   0.568   0.439   0.818   0.607   0.426
380   G         1.431   1.457   1.532   1.450   1.484   1.600   1.562   1.600   1.716
381   V         0.275   0.314   0.408   0.010   0.068   0.212  -0.138  -0.075   0.057
382   L        -0.771  -0.705  -0.694  -0.898  -0.804  -0.786  -0.882  -0.807  -0.758
383   Y         0.803   0.677   0.595   0.910   0.749   0.620   0.818   0.607   0.426
384   L        -0.193  -0.187  -0.184  -0.460  -0.437  -0.413  -0.457  -0.438  -0.417
385   I         0.493   0.471   0.462   0.389   0.351   0.310   0.287   0.233   0.167
386   V         1.431   1.457   1.532   1.456   1.487   1.606   1.562   1.600   1.716
387   A        -0.070  -0.166  -0.166  -0.075  -0.219  -0.249  -0.244  -0.368  -0.386
388   G        -0.591  -0.523  -0.616  -0.482  -0.387  -0.490  -0.670  -0.574  -0.666
389   L        -0.302  -0.235  -0.210  -0.533  -0.412  -0.402  -0.563  -0.467  -0.443
390   C        -0.070   0.054  -0.119   0.107   0.294   0.002  -0.244  -0.063  -0.316
391   A        -1.060  -0.999  -1.034  -1.111  -1.029  -1.051  -0.988  -0.920  -0.910
392   L        -0.193  -0.245  -0.189  -0.389  -0.437  -0.367  -0.457  -0.497  -0.421
393   F        -0.070  -0.021  -0.125  -0.194  -0.111  -0.264  -0.244  -0.160  -0.323
394   G         0.205   0.145  -0.066   0.359   0.263  -0.039   0.181   0.082  -0.228
395   I        -0.591  -0.562  -0.635  -0.686  -0.636  -0.761  -0.670  -0.629  -0.693
396   I        -1.060  -1.136  -1.058  -1.059  -1.164  -1.058  -0.988  -1.043  -0.931
397   F         1.431   1.457   1.532   1.471   1.507   1.621   1.562   1.600   1.716
398   L        -0.591  -0.600  -0.643  -0.708  -0.730  -0.778  -0.670  -0.687  -0.703
399   V        -0.591  -0.507  -0.625  -0.712  -0.576  -0.743  -0.670  -0.555  -0.679
400   K        -0.591  -0.669  -0.648  -0.573  -0.678  -0.650  -0.670  -0.742  -0.705
401   L        -0.662  -0.683  -0.661  -0.657  -0.658  -0.614  -0.776  -0.787  -0.724
402   I        -0.373  -0.318  -0.241  -0.659  -0.557  -0.447  -0.670  -0.595  -0.488
403   F        -0.070  -0.016  -0.123  -0.110  -0.013  -0.181  -0.244  -0.152  -0.317
404   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
405   Q        -0.591  -0.525  -0.627  -0.566  -0.457  -0.609  -0.670  -0.574  -0.680
406   P         1.431   1.457   1.532   1.405   1.439   1.557   1.562   1.600   1.716
407   R         1.431   1.457   1.532   1.485   1.517   1.634   1.562   1.600   1.716
408   A        -0.302  -0.226  -0.204  -0.449  -0.330  -0.306  -0.563  -0.453  -0.435
409   M        -0.193  -0.150  -0.186  -0.259  -0.249  -0.274  -0.457  -0.415  -0.422
410   G         0.803   0.775   0.611   0.904   0.869   0.636   0.818   0.769   0.454
411   D         1.431   1.457   1.532   1.410   1.442   1.562   1.562   1.600   1.716
412   H         0.803   0.677   0.595   1.055   0.887   0.742   0.818   0.607   0.426
413   T        -1.457  -1.377  -1.359  -1.435  -1.323  -1.280  -1.201  -1.121  -1.050
414   Y         0.328   0.401   0.432   0.180   0.306   0.329  -0.032   0.100   0.106
415   L         1.431   1.457   1.532   1.285   1.325   1.440   1.562   1.600   1.716
416   N        -1.169  -1.091  -1.061  -1.143  -1.053  -0.979  -1.095  -1.016  -0.935
417   F        -0.662  -0.561  -0.650  -0.556  -0.399  -0.525  -0.776  -0.659  -0.712
418   D        -0.662  -0.576  -0.643  -0.759  -0.651  -0.712  -0.776  -0.682  -0.706
419   D        -1.169  -1.166  -1.065  -1.172  -1.154  -1.008  -1.095  -1.078  -0.940
420   E        -0.880  -0.852  -0.990  -0.598  -0.578  -0.780  -0.776  -0.748  -0.863
421   E        -0.790  -0.722  -0.694  -0.806  -0.693  -0.680  -0.886  -0.801  -0.755
422   N        -0.328  -0.309  -0.233  -0.525  -0.500  -0.382  -0.614  -0.583  -0.479
423   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
424   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
425   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
426   Y        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
427   E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
428   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
429   V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
430   H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
431   A        -0.785  -0.733  -0.702  -0.885  -0.811  -0.765  -0.894  -0.830  -0.765
432   E        -1.170  -1.161  -1.071  -1.181  -1.195  -1.038  -1.083  -1.065  -0.942
433   N        -1.812  -1.762  -1.647  -1.851  -1.773  -1.610  -1.353  -1.302  -1.157
434   T        -0.698  -0.732  -0.679  -0.794  -0.852  -0.777  -0.797  -0.832  -0.743
435   T        -0.698  -0.660  -0.660  -0.681  -0.610  -0.613  -0.797  -0.741  -0.720
436   L        -1.028  -0.998  -1.035  -1.022  -0.968  -1.024  -0.936  -0.904  -0.907
437   R        -0.162  -0.261  -0.201  -0.207  -0.369  -0.300  -0.381  -0.510  -0.437
438   E        -0.698  -0.734  -0.678  -0.692  -0.754  -0.682  -0.797  -0.834  -0.741
439   I        -1.152  -1.180  -1.081  -1.135  -1.180  -1.037  -1.075  -1.087  -0.951
440   L        -0.591  -0.661  -0.657  -0.735  -0.845  -0.830  -0.670  -0.750  -0.719
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/P25656
Output conservation file - output/P25656
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
