1     M         2.382   2.392   2.480   2.772   2.788   2.943   2.735   2.750   2.907
2     V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
3     S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
4     -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
5     S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
6     F         0.112   0.117   0.152  -0.162  -0.165  -0.094  -0.170  -0.163  -0.114
7     S        -0.976  -0.949  -0.958  -0.944  -0.899  -0.919  -0.795  -0.765  -0.758
8     V         2.382   2.392   2.480   2.500   2.520   2.664   2.735   2.750   2.907
9     P         2.382   2.392   2.480   2.593   2.605   2.759   2.735   2.750   2.907
10    M        -0.976  -0.952  -0.963  -0.689  -0.655  -0.661  -0.795  -0.769  -0.764
11    P         1.413   1.434   1.319   1.654   1.681   1.521   1.474   1.510   1.284
12    V         0.206   0.236   0.201  -0.022   0.036  -0.059  -0.039   0.001  -0.042
13    K         2.382   2.392   2.480   2.472   2.490   2.635   2.735   2.750   2.907
14    R        -0.976  -0.961  -0.959  -0.787  -0.761  -0.752  -0.795  -0.778  -0.759
15    I        -0.479  -0.467  -0.457  -0.607  -0.581  -0.588  -0.543  -0.529  -0.503
16    F         2.382   2.392   2.480   2.590   2.605   2.756   2.735   2.750   2.907
17    D         2.382   2.392   2.480   2.573   2.588   2.738   2.735   2.750   2.907
18    T        -0.976  -0.978  -0.962  -0.823  -0.821  -0.796  -0.795  -0.796  -0.763
19    F         1.413   1.434   1.319   1.654   1.686   1.524   1.474   1.510   1.284
20    P         2.382   2.392   2.480   2.593   2.605   2.759   2.735   2.750   2.907
21    L         1.413   1.425   1.319   1.150   1.165   1.013   1.474   1.495   1.283
22    Q        -0.976  -0.981  -0.968  -0.795  -0.799  -0.776  -0.795  -0.799  -0.769
23    T         0.515   0.472   0.373   0.669   0.603   0.454   0.466   0.399   0.241
24    Y         0.515   0.495   0.384   0.735   0.689   0.499   0.466   0.432   0.258
25    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
26    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
27    A        -0.976  -0.992  -0.969  -0.743  -0.770  -0.722  -0.795  -0.810  -0.770
28    A        -0.976  -0.948  -0.960  -0.676  -0.638  -0.644  -0.795  -0.765  -0.761
29    Q        -0.479  -0.459  -0.460  -0.784  -0.763  -0.748  -0.543  -0.521  -0.506
30    T        -0.291  -0.303  -0.368  -0.094  -0.118  -0.228  -0.291  -0.306  -0.381
31    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
32    D        -0.976  -0.990  -0.979  -0.759  -0.791  -0.761  -0.795  -0.807  -0.779
33    K        -0.479  -0.472  -0.458  -0.583  -0.570  -0.553  -0.543  -0.534  -0.504
34    D        -0.479  -0.467  -0.466  -0.441  -0.426  -0.413  -0.543  -0.529  -0.512
35    E        -0.976  -0.981  -0.986  -0.774  -0.784  -0.792  -0.795  -0.799  -0.786
36    A        -0.479  -0.467  -0.466  -0.575  -0.566  -0.559  -0.543  -0.529  -0.512
37    V        -0.976  -0.948  -0.960  -0.689  -0.649  -0.652  -0.795  -0.765  -0.761
38    A        -0.976  -0.949  -0.964  -0.677  -0.640  -0.650  -0.795  -0.766  -0.765
39    L        -1.474  -1.471  -1.436  -1.309  -1.292  -1.249  -1.047  -1.043  -0.991
40    E        -0.479  -0.471  -0.468  -0.505  -0.489  -0.469  -0.543  -0.533  -0.513
41    I        -0.291  -0.317  -0.359  -0.218  -0.254  -0.334  -0.291  -0.323  -0.370
42    Q        -0.479  -0.458  -0.467  -0.520  -0.486  -0.500  -0.543  -0.520  -0.513
43    R        -0.601  -0.596  -0.550  -0.647  -0.653  -0.569  -0.669  -0.662  -0.601
44    R         1.172   1.130   1.134   1.347   1.273   1.268   1.033   0.948   0.921
45    S         0.145   0.117   0.152  -0.027  -0.075  -0.013  -0.102  -0.145  -0.101
46    Y         0.145   0.186   0.170   0.246   0.318   0.285  -0.102  -0.039  -0.074
47    T         0.145   0.158   0.164   0.176   0.202   0.192  -0.102  -0.082  -0.084
48    F         2.382   2.392   2.480   2.605   2.623   2.772   2.735   2.750   2.907
49    T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
50    E        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
51    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
52    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
53    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
54    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
55    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
56    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
57    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
58    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
59    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
60    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
61    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
62    R        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
63    G         1.305   1.297   1.238   1.552   1.539   1.443   1.283   1.264   1.127
64    G        -0.485  -0.460  -0.468  -0.406  -0.370  -0.392  -0.533  -0.502  -0.505
65    G         0.112   0.145   0.149  -0.041   0.005   0.019  -0.170  -0.129  -0.118
66    S        -0.485  -0.460  -0.468  -0.639  -0.606  -0.614  -0.533  -0.502  -0.505
67    S        -1.081  -1.075  -1.037  -1.123  -1.104  -1.057  -0.896  -0.888  -0.835
68    E         0.337   0.372   0.307   0.520   0.582   0.466   0.193   0.246   0.137
69    L        -0.485  -0.471  -0.462  -0.798  -0.769  -0.777  -0.533  -0.515  -0.498
70    T        -0.485  -0.505  -0.483  -0.646  -0.677  -0.642  -0.533  -0.558  -0.523
71    V        -0.485  -0.432  -0.464  -0.397  -0.301  -0.367  -0.533  -0.467  -0.500
72    E         0.145   0.186   0.170   0.082   0.146   0.113  -0.102  -0.039  -0.074
73    G         0.145   0.131   0.153   0.202   0.177   0.214  -0.102  -0.124  -0.100
74    T        -0.601  -0.596  -0.550  -0.541  -0.514  -0.460  -0.669  -0.662  -0.601
75    Y         1.413   1.427   1.317   1.684   1.706   1.565   1.474   1.498   1.281
76    K        -0.479  -0.499  -0.480  -0.395  -0.417  -0.384  -0.543  -0.562  -0.527
77    L         1.413   1.434   1.319   1.150   1.177   1.013   1.474   1.510   1.284
78    G         0.515   0.479   0.383   0.862   0.808   0.672   0.466   0.409   0.257
79    V         1.413   1.358   1.295   1.561   1.487   1.389   1.474   1.376   1.239
80    Y         1.013   1.027   1.051   1.142   1.166   1.201   0.718   0.743   0.750
81    N        -0.291  -0.304  -0.366  -0.126  -0.142  -0.244  -0.291  -0.308  -0.379
82    V         0.206   0.178   0.201   0.166   0.142   0.170  -0.039  -0.071  -0.044
83    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
84    -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
85    F         0.891   0.896   0.965   0.749   0.767   0.865   0.466   0.473   0.569
86    L        -0.601  -0.596  -0.550  -0.819  -0.815  -0.745  -0.669  -0.662  -0.601
87    E        -1.474  -1.471  -1.436  -1.316  -1.314  -1.255  -1.047  -1.043  -0.991
88    A        -0.479  -0.460  -0.459  -0.450  -0.421  -0.417  -0.543  -0.522  -0.505
89    N        -0.479  -0.456  -0.456  -0.311  -0.274  -0.261  -0.543  -0.518  -0.502
90    T        -0.291  -0.317  -0.380  -0.163  -0.202  -0.305  -0.291  -0.323  -0.397
91    G         0.515   0.530   0.406   0.824   0.846   0.659   0.466   0.488   0.292
92    A        -0.976  -0.989  -0.978  -0.778  -0.798  -0.771  -0.795  -0.807  -0.778
93    A        -1.474  -1.471  -1.436  -1.418  -1.405  -1.360  -1.047  -1.043  -0.991
94    L         1.013   1.027   1.051   0.503   0.524   0.546   0.718   0.743   0.750
95    A         0.206   0.173   0.192   0.204   0.144   0.171  -0.039  -0.079  -0.055
96    T         0.206   0.224   0.217   0.066   0.099   0.090  -0.039  -0.011  -0.020
97    D         1.413   1.358   1.295   1.639   1.560   1.470   1.474   1.376   1.239
98    P         2.382   2.392   2.480   2.593   2.605   2.759   2.735   2.750   2.907
99    W        -0.479  -0.500  -0.480  -0.452  -0.486  -0.476  -0.543  -0.563  -0.527
100   C         0.206   0.236   0.201   0.186   0.224   0.202  -0.039   0.001  -0.042
101   L         1.413   1.425   1.316   1.170   1.183   1.038   1.474   1.495   1.279
102   F        -0.479  -0.500  -0.480  -0.279  -0.309  -0.265  -0.543  -0.563  -0.527
103   V        -0.479  -0.467  -0.468  -0.395  -0.378  -0.367  -0.543  -0.529  -0.514
104   Q        -0.291  -0.253  -0.348  -0.027   0.038  -0.121  -0.291  -0.240  -0.356
105   L         2.382   2.392   2.480   2.085   2.095   2.237   2.735   2.750   2.907
106   A        -0.976  -0.989  -0.978  -1.186  -1.229  -1.205  -0.795  -0.807  -0.778
107   L         2.382   2.392   2.480   2.085   2.095   2.237   2.735   2.750   2.907
108   C         0.206   0.211   0.207   0.289   0.289   0.278  -0.039  -0.035  -0.038
109   Q         0.206   0.225   0.201   0.329   0.366   0.328  -0.039  -0.009  -0.042
110   K         1.413   1.358   1.295   1.556   1.482   1.395   1.474   1.376   1.239
111   N         1.413   1.358   1.295   1.626   1.557   1.479   1.474   1.376   1.239
112   G        -0.485  -0.498  -0.483  -0.434  -0.461  -0.432  -0.533  -0.548  -0.523
113   L         2.382   2.392   2.480   2.080   2.089   2.232   2.735   2.750   2.907
114   V        -0.485  -0.493  -0.473  -0.424  -0.436  -0.401  -0.533  -0.543  -0.512
115   L         2.382   2.392   2.480   2.080   2.089   2.232   2.735   2.750   2.907
116   P         2.382   2.392   2.480   2.616   2.629   2.782   2.735   2.750   2.907
117   T         0.934   0.947   0.989   0.659   0.686   0.725   0.556   0.579   0.620
118   H        -0.485  -0.483  -0.473  -0.468  -0.467  -0.457  -0.533  -0.530  -0.512
119   S        -0.485  -0.493  -0.473  -0.335  -0.346  -0.324  -0.533  -0.543  -0.512
120   Q        -1.081  -1.080  -1.037  -0.831  -0.825  -0.758  -0.896  -0.893  -0.835
121   E         0.112   0.104   0.142   0.034   0.022   0.088  -0.170  -0.179  -0.127
122   Q        -0.485  -0.472  -0.472  -0.280  -0.256  -0.261  -0.533  -0.517  -0.510
123   T        -0.485  -0.498  -0.483  -0.374  -0.394  -0.365  -0.533  -0.548  -0.523
124   P        -0.485  -0.483  -0.473  -0.389  -0.388  -0.384  -0.533  -0.530  -0.512
125   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
126   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
127   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
128   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
129   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
130   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
131   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
132   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
133   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
134   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
135   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
136   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
137   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
138   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
139   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
140   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
141   H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
142   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
143   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
144   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
145   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
146   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
147   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
148   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
149   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
150   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
151   T         0.337   0.416   0.310   0.398   0.523   0.356   0.193   0.314   0.143
152   C        -1.081  -1.075  -1.037  -1.202  -1.188  -1.139  -0.896  -0.888  -0.835
153   N        -1.081  -1.075  -1.037  -1.036  -1.042  -0.968  -0.896  -0.888  -0.835
154   H         0.337   0.288   0.281   0.602   0.512   0.499   0.193   0.116   0.098
155   E        -0.976  -0.989  -0.969  -0.923  -0.935  -0.901  -0.795  -0.806  -0.770
156   M        -0.479  -0.500  -0.480  -0.488  -0.536  -0.511  -0.543  -0.563  -0.527
157   L        -1.474  -1.471  -1.436  -1.258  -1.252  -1.196  -1.047  -1.043  -0.991
158   V        -0.479  -0.471  -0.467  -0.554  -0.536  -0.537  -0.543  -0.533  -0.513
159   L         0.515   0.479   0.383   0.245   0.187   0.038   0.466   0.409   0.257
160   S         2.382   2.392   2.480   2.338   2.351   2.497   2.735   2.750   2.907
161   R        -1.474  -1.471  -1.436  -1.018  -1.011  -0.949  -1.047  -1.043  -0.991
162   L        -0.479  -0.459  -0.471  -0.589  -0.583  -0.583  -0.543  -0.521  -0.518
163   S         1.413   1.427   1.317   1.620   1.638   1.473   1.474   1.498   1.281
164   N         0.206   0.201   0.194   0.060   0.048   0.059  -0.039  -0.051  -0.056
165   P        -0.291  -0.304  -0.366  -0.021  -0.035  -0.134  -0.291  -0.308  -0.379
166   D         1.013   1.039   1.046   0.963   1.012   0.998   0.718   0.767   0.739
167   E        -0.479  -0.488  -0.479  -0.460  -0.466  -0.450  -0.543  -0.552  -0.526
168   A        -1.474  -1.471  -1.436  -1.263  -1.257  -1.201  -1.047  -1.043  -0.991
169   L         2.382   2.392   2.480   2.085   2.095   2.237   2.735   2.750   2.907
170   P         2.382   2.392   2.480   2.593   2.605   2.759   2.735   2.750   2.907
171   I         1.013   0.998   1.025   0.685   0.645   0.638   0.718   0.684   0.696
172   L         2.382   2.392   2.480   2.085   2.095   2.237   2.735   2.750   2.907
173   V         0.891   0.897   0.965   0.637   0.653   0.751   0.466   0.473   0.569
174   E         0.515   0.479   0.383   0.720   0.667   0.530   0.466   0.409   0.257
175   G         0.145   0.117   0.152   0.196   0.144   0.193  -0.102  -0.145  -0.101
176   Y        -0.601  -0.596  -0.550  -0.536  -0.530  -0.455  -0.669  -0.662  -0.601
177   K        -0.601  -0.596  -0.550  -0.802  -0.815  -0.728  -0.669  -0.662  -0.601
178   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
179   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
180   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
181   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
182   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
183   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
184   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
185   K         0.337   0.274   0.260   0.384   0.290   0.256   0.193   0.096   0.065
186   R         0.515   0.479   0.383   0.889   0.835   0.698   0.466   0.409   0.257
187   I        -1.474  -1.471  -1.436  -1.273  -1.281  -1.211  -1.047  -1.043  -0.991
188   I        -0.479  -0.496  -0.466  -0.543  -0.560  -0.522  -0.543  -0.559  -0.513
189   R         2.382   2.392   2.480   2.678   2.695   2.847   2.735   2.750   2.907
190   S         1.013   0.998   1.025   0.746   0.715   0.743   0.718   0.684   0.696
191   T        -0.976  -0.990  -0.979  -0.997  -1.015  -1.014  -0.795  -0.807  -0.779
192   V        -0.479  -0.458  -0.461  -0.752  -0.739  -0.727  -0.543  -0.520  -0.507
193   A        -0.291  -0.315  -0.358  -0.310  -0.353  -0.415  -0.291  -0.321  -0.369
194   I         0.515   0.472   0.371   0.718   0.659   0.523   0.466   0.399   0.237
195   S         0.515   0.531   0.398   0.708   0.735   0.534   0.466   0.490   0.280
196   E        -0.976  -0.990  -0.979  -0.830  -0.862  -0.831  -0.795  -0.807  -0.779
197   I         0.515   0.537   0.386   0.583   0.622   0.364   0.466   0.499   0.261
198   M        -0.479  -0.499  -0.480  -0.649  -0.665  -0.620  -0.543  -0.562  -0.527
199   R        -0.976  -0.948  -0.960  -0.731  -0.693  -0.694  -0.795  -0.765  -0.761
200   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
201   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
202   S         0.891   0.897   0.965   0.557   0.570   0.671   0.466   0.474   0.569
203   R        -0.976  -0.990  -0.979  -0.892  -0.937  -0.924  -0.795  -0.807  -0.779
204   I        -0.479  -0.500  -0.470  -0.802  -0.829  -0.786  -0.543  -0.563  -0.517
205   L        -0.601  -0.597  -0.550  -0.923  -0.912  -0.852  -0.669  -0.663  -0.601
206   D        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
207   D        -0.479  -0.472  -0.458  -0.474  -0.464  -0.438  -0.543  -0.534  -0.504
208   A        -0.976  -0.978  -0.962  -0.798  -0.807  -0.777  -0.795  -0.796  -0.763
209   E        -0.976  -0.990  -0.979  -0.928  -0.951  -0.941  -0.795  -0.807  -0.779
210   Q        -0.976  -0.981  -0.986  -0.706  -0.722  -0.714  -0.795  -0.799  -0.786
211   L        -0.976  -0.978  -0.977  -1.179  -1.180  -1.159  -0.795  -0.796  -0.778
212   M        -0.976  -0.990  -0.979  -0.819  -0.844  -0.855  -0.795  -0.807  -0.779
213   Y         0.206   0.178   0.199   0.067   0.016   0.031  -0.039  -0.070  -0.046
214   Y        -0.976  -0.981  -0.986  -0.993  -1.002  -1.028  -0.795  -0.799  -0.786
215   T        -0.976  -0.981  -0.986  -0.974  -0.990  -1.005  -0.795  -0.799  -0.786
216   L         1.413   1.434   1.319   1.142   1.169   1.002   1.474   1.510   1.284
217   L         0.018   0.023   0.080  -0.463  -0.448  -0.369  -0.291  -0.284  -0.210
218   D         0.515   0.495   0.384   0.759   0.729   0.560   0.466   0.432   0.258
219   T         1.413   1.358   1.295   1.589   1.516   1.441   1.474   1.376   1.239
220   V        -1.474  -1.471  -1.436  -1.388  -1.375  -1.330  -1.047  -1.043  -0.991
221   L         0.206   0.230   0.218  -0.206  -0.175  -0.181  -0.039  -0.003  -0.018
222   Y         1.413   1.425   1.316   1.732   1.751   1.606   1.474   1.495   1.279
223   D         1.413   1.358   1.295   1.681   1.608   1.534   1.474   1.376   1.239
224   C        -0.976  -0.949  -0.958  -0.835  -0.791  -0.810  -0.795  -0.765  -0.758
225   W         0.515   0.553   0.404   1.037   1.094   0.878   0.466   0.523   0.289
226   I         0.515   0.537   0.408   0.529   0.569   0.330   0.466   0.499   0.296
227   T         0.206   0.207   0.197  -0.240  -0.240  -0.245  -0.039  -0.040  -0.052
228   Q        -0.291  -0.303  -0.368   0.122   0.102  -0.005  -0.291  -0.306  -0.381
229   I         0.206   0.224   0.217  -0.149  -0.106  -0.144  -0.039  -0.011  -0.020
230   I         1.013   1.024   1.047   0.503   0.519   0.540   0.718   0.738   0.742
231   F        -0.485  -0.493  -0.473  -0.266  -0.279  -0.261  -0.533  -0.543  -0.512
232   C        -1.081  -1.079  -1.037  -0.842  -0.836  -0.769  -0.896  -0.892  -0.835
233   A        -0.485  -0.461  -0.468  -0.565  -0.522  -0.560  -0.533  -0.503  -0.505
234   S        -0.976  -0.989  -0.969  -0.758  -0.776  -0.746  -0.795  -0.806  -0.770
235   D        -0.291  -0.270  -0.334  -0.276  -0.246  -0.337  -0.291  -0.262  -0.338
236   A        -0.976  -0.989  -0.978  -0.853  -0.866  -0.857  -0.795  -0.807  -0.778
237   Q        -0.976  -0.949  -0.964  -0.964  -0.907  -0.968  -0.795  -0.766  -0.765
238   F        -0.291  -0.271  -0.353  -0.080  -0.046  -0.185  -0.291  -0.264  -0.363
239   M        -1.474  -1.471  -1.436  -1.166  -1.172  -1.102  -1.047  -1.043  -0.991
240   E        -0.291  -0.317  -0.380  -0.123  -0.165  -0.263  -0.291  -0.323  -0.397
241   L        -0.479  -0.467  -0.464  -0.792  -0.765  -0.750  -0.543  -0.529  -0.510
242   Y        -0.291  -0.317  -0.380   0.011  -0.028  -0.134  -0.291  -0.323  -0.397
243   S        -1.474  -1.471  -1.436  -1.552  -1.579  -1.498  -1.047  -1.043  -0.991
244   C        -0.479  -0.488  -0.479  -0.581  -0.606  -0.566  -0.543  -0.552  -0.526
245   Q        -0.976  -0.981  -0.968  -0.952  -0.956  -0.932  -0.795  -0.799  -0.769
246   K         1.305   1.335   1.251   1.385   1.436   1.301   1.283   1.334   1.154
247   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
248   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
249   G        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
250   S        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
251   I        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
252   V        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
253   T        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
254   P        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
255   L        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
256   D        -0.601  -0.597  -0.550  -0.664  -0.659  -0.586  -0.669  -0.663  -0.601
257   V         0.145   0.184   0.174   0.140   0.205   0.184  -0.102  -0.043  -0.068
258   E         1.172   1.168   1.157   1.153   1.144   1.112   1.033   1.021   0.968
259   N        -0.601  -0.597  -0.550  -0.752  -0.746  -0.677  -0.669  -0.663  -0.601
260   S         0.145   0.118   0.152  -0.043  -0.081  -0.029  -0.102  -0.143  -0.101
261   L         0.145   0.184   0.174  -0.054   0.021  -0.035  -0.102  -0.043  -0.068
262   L         0.145   0.142   0.164  -0.105  -0.107  -0.108  -0.102  -0.108  -0.084
263   Q         0.145   0.142   0.164   0.103   0.096   0.123  -0.102  -0.108  -0.084
264   K         0.145   0.140   0.172   0.204   0.194   0.255  -0.102  -0.110  -0.072
265   L         0.145   0.158   0.169  -0.294  -0.276  -0.264  -0.102  -0.082  -0.076
266   S         0.145   0.142   0.164  -0.052  -0.057  -0.048  -0.102  -0.108  -0.084
267   A         1.172   1.207   1.173   1.204   1.258   1.201   1.033   1.096   1.000
268   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
269   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
270   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
271   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
272   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
273   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
274   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
275   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
276   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
277   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
278   K        -0.976  -0.949  -0.964  -0.879  -0.837  -0.860  -0.795  -0.766  -0.765
279   S         0.206   0.172   0.197   0.099   0.049   0.070  -0.039  -0.081  -0.051
280   L         0.206   0.224   0.219  -0.258  -0.235  -0.240  -0.039  -0.011  -0.016
281   K         0.206   0.178   0.199  -0.224  -0.261  -0.224  -0.039  -0.070  -0.046
282   I        -0.976  -0.961  -0.959  -0.803  -0.779  -0.769  -0.795  -0.778  -0.759
283   S        -0.479  -0.499  -0.480  -0.553  -0.581  -0.556  -0.543  -0.562  -0.527
284   L        -0.479  -0.496  -0.470  -0.731  -0.741  -0.694  -0.543  -0.559  -0.517
285   T        -0.976  -0.981  -0.986  -1.062  -1.069  -1.121  -0.795  -0.799  -0.786
286   K        -0.976  -0.978  -0.977  -0.788  -0.783  -0.779  -0.795  -0.796  -0.778
287   R         0.206   0.173   0.192   0.411   0.358   0.386  -0.039  -0.079  -0.055
288   N         0.515   0.472   0.371   0.710   0.646   0.492   0.466   0.399   0.237
289   K        -0.976  -0.949  -0.958  -0.768  -0.718  -0.744  -0.795  -0.765  -0.758
290   F         1.413   1.358   1.295   1.576   1.485   1.364   1.474   1.376   1.239
291   Q        -0.976  -0.990  -0.979  -0.609  -0.633  -0.602  -0.795  -0.807  -0.779
292   F        -0.976  -0.949  -0.958  -1.062  -1.010  -1.046  -0.795  -0.765  -0.758
293   R         2.382   2.392   2.480   2.678   2.695   2.847   2.735   2.750   2.907
294   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
295   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
296   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
297   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
298   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
299   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
300   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
301   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
302   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
303   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
304   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
305   H         2.382   2.392   2.480   2.719   2.733   2.888   2.735   2.750   2.907
306   R        -0.291  -0.257  -0.338  -0.087  -0.036  -0.166  -0.291  -0.246  -0.343
307   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
308   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
309   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
310   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
311   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
312   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
313   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
314   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
315   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
316   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
317   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
318   E        -0.485  -0.460  -0.468  -0.614  -0.574  -0.607  -0.533  -0.502  -0.505
319   I         0.934   0.952   0.994   0.521   0.560   0.586   0.556   0.589   0.630
320   V         0.337   0.314   0.282   0.188   0.148   0.091   0.193   0.155   0.100
321   K         0.112   0.122   0.146  -0.130  -0.111  -0.089  -0.170  -0.155  -0.122
322   S        -0.601  -0.596  -0.550  -0.917  -0.913  -0.846  -0.669  -0.662  -0.601
323   M        -0.601  -0.596  -0.550  -0.896  -0.888  -0.825  -0.669  -0.662  -0.601
324   Q         0.145   0.186   0.170  -0.230  -0.165  -0.192  -0.102  -0.039  -0.074
325   G         0.891   0.896   0.965   0.770   0.778   0.886   0.466   0.473   0.569
326   V         0.145   0.170   0.172  -0.051   0.020  -0.031  -0.102  -0.063  -0.072
327   Y        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
328   H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
329   N        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
330   H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
331   H        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
332   N        -1.081  -1.075  -1.037  -0.877  -0.877  -0.805  -0.896  -0.888  -0.835
333   S        -0.485  -0.495  -0.482  -0.595  -0.604  -0.584  -0.533  -0.547  -0.522
334   V        -1.081  -1.075  -1.037  -0.846  -0.822  -0.773  -0.896  -0.888  -0.835
335   N         0.112   0.117   0.152  -0.026  -0.015   0.022  -0.170  -0.163  -0.114
336   Q        -0.976  -0.981  -0.986  -0.796  -0.799  -0.805  -0.795  -0.799  -0.786
337   E        -0.479  -0.499  -0.462  -0.461  -0.482  -0.423  -0.543  -0.563  -0.508
338   Q        -0.291  -0.317  -0.380  -0.075  -0.114  -0.239  -0.291  -0.323  -0.397
339   V        -0.479  -0.499  -0.480  -0.804  -0.822  -0.797  -0.543  -0.562  -0.527
340   L        -0.479  -0.467  -0.468  -0.643  -0.649  -0.617  -0.543  -0.529  -0.514
341   -        -0.485  -0.504  -0.491  -0.407  -0.438  -0.411  -0.533  -0.556  -0.533
342   -         0.934   0.954   1.000   0.595   0.637   0.680   0.556   0.593   0.643
343   -        -0.485  -0.504  -0.491  -0.414  -0.447  -0.449  -0.533  -0.556  -0.533
344   -        -0.485  -0.466  -0.467  -0.600  -0.572  -0.573  -0.533  -0.510  -0.503
345   N        -0.976  -0.990  -0.979  -0.829  -0.847  -0.831  -0.795  -0.807  -0.779
346   V        -0.976  -0.949  -0.958  -1.212  -1.176  -1.178  -0.795  -0.765  -0.758
347   L         1.413   1.452   1.324   1.142   1.195   1.011   1.474   1.541   1.295
348   F        -0.976  -0.989  -0.978  -1.179  -1.191  -1.160  -0.795  -0.807  -0.778
349   E         1.413   1.425   1.319   1.492   1.509   1.323   1.474   1.495   1.283
350   N        -0.485  -0.468  -0.491  -0.363  -0.330  -0.381  -0.533  -0.511  -0.533
351   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
352   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
353   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
354   S         0.934   0.928   0.982   0.294   0.277   0.351   0.556   0.540   0.605
355   K        -0.485  -0.500  -0.473  -0.446  -0.471  -0.430  -0.533  -0.551  -0.512
356   Q        -0.485  -0.490  -0.491  -0.776  -0.795  -0.765  -0.533  -0.539  -0.533
357   V         0.337   0.310   0.266   0.025  -0.017  -0.082   0.193   0.151   0.075
358   L        -1.081  -1.079  -1.037  -1.203  -1.197  -1.139  -0.896  -0.892  -0.835
359   L        -1.081  -1.079  -1.037  -1.288  -1.283  -1.227  -0.896  -0.892  -0.835
360   G        -0.485  -0.490  -0.491  -0.223  -0.237  -0.230  -0.533  -0.539  -0.533
361   L        -0.601  -0.597  -0.550  -0.683  -0.675  -0.606  -0.669  -0.663  -0.601
362   K         2.382   2.392   2.480   2.458   2.477   2.621   2.735   2.750   2.907
363   D         0.145   0.158   0.169   0.184   0.202   0.216  -0.102  -0.082  -0.076
364   M         0.145   0.142   0.164  -0.028  -0.039   0.004  -0.102  -0.108  -0.084
365   L        -0.485  -0.505  -0.483  -0.749  -0.766  -0.759  -0.533  -0.558  -0.523
366   K        -0.485  -0.521  -0.484  -0.588  -0.650  -0.602  -0.533  -0.577  -0.524
367   S        -0.485  -0.521  -0.484  -0.560  -0.616  -0.547  -0.533  -0.577  -0.524
368   D         0.112   0.082   0.142   0.063   0.025   0.116  -0.170  -0.206  -0.127
369   G        -0.601  -0.593  -0.550  -0.678  -0.689  -0.601  -0.669  -0.659  -0.601
370   Q        -0.601  -0.593  -0.550  -0.559  -0.552  -0.478  -0.669  -0.659  -0.601
371   P         0.145   0.131   0.153  -0.039  -0.067  -0.027  -0.102  -0.126  -0.100
372   T         0.145   0.110   0.152   0.099   0.044   0.109  -0.102  -0.156  -0.101
373   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
374   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
375   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
376   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
377   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
378   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
379   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
380   Y         0.206   0.173   0.192   0.187   0.136   0.149  -0.039  -0.079  -0.055
381   L         0.891   0.897   0.966   0.330   0.331   0.429   0.466   0.475   0.570
382   H        -0.976  -0.961  -0.959  -0.681  -0.657  -0.645  -0.795  -0.778  -0.759
383   L         1.413   1.358   1.295   1.210   1.137   1.067   1.474   1.376   1.239
384   K         0.515   0.495   0.384   0.656   0.626   0.457   0.466   0.432   0.258
385   I         0.206   0.201   0.194  -0.245  -0.249  -0.254  -0.039  -0.050  -0.057
386   A         1.013   1.035   1.045   0.985   1.025   1.019   0.718   0.759   0.737
387   S         0.206   0.173   0.192   0.096   0.051   0.090  -0.039  -0.079  -0.055
388   Y         1.013   0.995   1.018   1.085   1.048   1.070   0.718   0.677   0.680
389   I         1.413   1.425   1.319   1.531   1.556   1.398   1.474   1.495   1.283
390   L         0.206   0.173   0.192  -0.208  -0.246  -0.210  -0.039  -0.079  -0.055
391   C        -0.976  -0.989  -0.978  -0.800  -0.829  -0.808  -0.795  -0.807  -0.778
392   I         0.206   0.200   0.199  -0.058  -0.086  -0.084  -0.039  -0.052  -0.050
393   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
394   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
395   T        -1.474  -1.471  -1.436  -1.479  -1.479  -1.423  -1.047  -1.043  -0.991
396   N        -0.479  -0.470  -0.461  -0.450  -0.445  -0.413  -0.543  -0.531  -0.507
397   V         0.515   0.474   0.372   0.276   0.212   0.064   0.466   0.401   0.240
398   K        -0.976  -0.981  -0.986  -1.109  -1.117  -1.088  -0.795  -0.799  -0.786
399   E        -0.291  -0.321  -0.368  -0.277  -0.320  -0.390  -0.291  -0.329  -0.382
400   P        -1.081  -1.079  -1.037  -1.053  -1.045  -0.985  -0.896  -0.892  -0.835
401   I        -0.485  -0.460  -0.467  -0.619  -0.569  -0.606  -0.533  -0.502  -0.503
402   K        -0.485  -0.460  -0.467  -0.510  -0.457  -0.508  -0.533  -0.502  -0.503
403   L         0.515   0.530   0.406   0.335   0.350   0.192   0.466   0.488   0.292
404   K        -0.291  -0.257  -0.338  -0.046   0.011  -0.128  -0.291  -0.246  -0.343
405   T        -1.474  -1.471  -1.436  -1.206  -1.191  -1.143  -1.047  -1.043  -0.991
406   F        -0.976  -0.978  -0.977  -0.759  -0.757  -0.761  -0.795  -0.796  -0.778
407   V         0.206   0.224   0.219  -0.159  -0.116  -0.152  -0.039  -0.011  -0.016
408   E        -0.976  -0.961  -0.959  -0.629  -0.602  -0.594  -0.795  -0.778  -0.759
409   N        -0.976  -0.992  -0.969  -0.845  -0.869  -0.830  -0.795  -0.810  -0.770
410   E         0.112   0.130   0.135  -0.049  -0.028  -0.014  -0.170  -0.148  -0.136
411   C         0.112   0.148   0.146   0.262   0.308   0.321  -0.170  -0.125  -0.121
412   K        -0.976  -0.977  -0.964  -0.859  -0.863  -0.825  -0.795  -0.795  -0.764
413   E        -1.474  -1.471  -1.436  -1.294  -1.292  -1.233  -1.047  -1.043  -0.991
414   L         1.413   1.425   1.316   1.170   1.183   1.038   1.474   1.495   1.279
415   V         0.206   0.172   0.197  -0.285  -0.339  -0.301  -0.039  -0.081  -0.051
416   Q        -0.479  -0.471  -0.467  -0.517  -0.511  -0.500  -0.543  -0.533  -0.513
417   F        -1.474  -1.471  -1.436  -1.206  -1.198  -1.143  -1.047  -1.043  -0.991
418   A         0.206   0.200   0.197   0.115   0.104   0.127  -0.039  -0.051  -0.051
419   Q        -0.291  -0.321  -0.374  -0.007  -0.055  -0.145  -0.291  -0.328  -0.389
420   D        -0.976  -0.952  -0.963  -0.951  -0.921  -0.924  -0.795  -0.769  -0.764
421   T        -0.479  -0.499  -0.463  -0.846  -0.864  -0.818  -0.543  -0.562  -0.509
422   L         0.206   0.200   0.199  -0.256  -0.263  -0.261  -0.039  -0.052  -0.049
423   K        -0.291  -0.317  -0.380  -0.153  -0.192  -0.291  -0.291  -0.323  -0.397
424   N        -0.976  -0.989  -0.969  -1.050  -1.068  -1.055  -0.795  -0.806  -0.770
425   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
426   F         0.145   0.152   0.174   0.309   0.316   0.356  -0.102  -0.092  -0.068
427   -        -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000  -1.000     *
428   V        -1.081  -1.078  -1.037  -0.935  -0.938  -0.865  -0.896  -0.891  -0.835
429   Q        -1.081  -1.078  -1.037  -1.072  -1.060  -1.005  -0.896  -0.891  -0.835
* gap fraction no less than  0.50; conservation set to M-S
  M: mean;  S: standard deviation

al2co - The parameters are:

Input alignment file - ../mafft-mac/clustal/P14693
Output conservation file - output/P14693
All 9 methods are used - true 
   1. unweighted entropy measure; 2. Henikoff entropy measure;
   3. independent count entropy measure;
   4. unweighted variance measure; 5. Henikoff variance measure;
   6. independent count variance measure;
   7. unweighted matrix-based sum-of-pairs measure;
   8. Henikoff matrix-based sum-of-pairs measure;
   9. independent count matrix-based sum-of-pairs measure;
Window size - 1
Conservation normalized to zero mean and unity variance
Gap fraction to suppress calculation -  0.50
